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ClinicalTrials.gov public records Last synced Oct 22, 2026, 9:07 PM EDT

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Showing 49–72 of 664 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: OPTIMIZE Clear all
Recruiting Not applicable Interventional

Spatiotemporal tSCS in Spinal Cord Injury

NCT07397559
View directory record Official record
Conditions
Spinal Cord Injuries (SCI)
Interventions
No Stimulation, Conventional tSCS, Spatiotemporal tSCS
Other · Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
16 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Oct 22, 2026, 9:07 PM EDT
Recruiting No phase listed Observational

Optimizing Non-statin Agents for ASCVD

NCT07464574
View directory record Official record
Conditions
ASCVD Management
Interventions
Pharmacy Intern Counseling
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Oct 22, 2026, 9:07 PM EDT
Not listed Not applicable Interventional

Implementation of GLA:D Program in West Virginians With Osteoarthritis of the Knee

NCT04857879
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
GLA:D program (Good Life with osteoArthritis in Denmark)
Other
Lead sponsor
Marshall University
Other
Eligibility
45 Years to 90 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Huntington, West Virginia
Source: ClinicalTrials.gov public record
Updated Sep 5, 2021 · Synced Oct 22, 2026, 9:07 PM EDT
Completed No phase listed Observational

Procalcitonin and Endotoxin Sequential Levels to Optimize the Treatment of Bloodstream Infections

NCT00870623
View directory record Official record
Conditions
Bloodstream Infection
Interventions
Not listed
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
223 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 15, 2023 · Synced Oct 22, 2026, 9:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Caring for Caregivers and People Living With Dementia Under Home-Based Primary Care

NCT05849259
View directory record Official record
Conditions
Dementia, Quality of Life, Caregiver Stress
Interventions
Dementia Care Quality at Home
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
2
States / cities
Honolulu, Hawaii • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Oct 22, 2026, 9:07 PM EDT
Recruiting Not applicable Interventional

The REACH-OUT Trial

NCT07540143
View directory record Official record
Conditions
Hypertension, Reproductive Behavior, Primary Health Care, Electronic Health Record
Interventions
Health literacy-informed patient education materials, BP monitor, brief orientation, and portal tools, The MeDS assessment, Patient navigator support
Other · Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 22, 2026, 9:07 PM EDT
Completed Not applicable Interventional

Telerehabilitation for Parkinson's Disease

NCT04600011
View directory record Official record
Conditions
Parkinson Disease, Telemedicine
Interventions
Physical and occupational therapy (PT/OT), Home Safety Evaluation (HSE)
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Oct 22, 2026, 9:07 PM EDT
Terminated Not applicable Interventional

Family-Based Behavioral Treatment for Childhood Survivors of Acute Lymphoblastic Leukemia

NCT05410574
View directory record Official record
Conditions
Acute Lymphoblastic Leukemia
Interventions
Family-based Behavioral Weight Loss Treatment
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
5 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 3, 2024 · Synced Oct 22, 2026, 9:07 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

REducing pSychological diSTress To Optimize Recovery of Elderly ICU Survivors and Caregivers (RESTORE-ICU)

NCT06867367
View directory record Official record
Conditions
Relationship, Family, Well-Being, Psychological
Interventions
Isha Kriya and Naddi Shuddhi
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 22, 2026, 9:07 PM EDT
Recruiting Not applicable Interventional

Optimizing Research With Diverse Families - Feasibility and Acceptability Study (FAST)

NCT06133231
View directory record Official record
Conditions
Attention Deficit/Hyperactivity Disorder, Emotional Dysfunction, Irritable Mood
Interventions
Multinutrients; a 36-ingredient blend of vitamins, minerals, amino acids, and antioxidants
Dietary Supplement
Lead sponsor
Oregon Health and Science University
Other
Eligibility
6 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 16, 2025 · Synced Oct 22, 2026, 9:07 PM EDT
Completed Not applicable Interventional Results available

Movement Pattern Training in People With Intra-articular, Prearthritic Hip Disorders

NCT02913222
View directory record Official record
Conditions
Chronic Hip Joint Pain, Prearthritic Hip Disease
Interventions
Rehabilitation
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
15 Years to 40 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
St Louis, Missouri • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 27, 2023 · Synced Oct 22, 2026, 9:07 PM EDT
Completed Not applicable Interventional

Leucine-enriched Essential Amino Acid Intake to Optimize Protein Anabolism in Children With Cystic Fibrosis

NCT01172301
View directory record Official record
Conditions
Cystic Fibrosis
Interventions
Essential amino acid intake + Leucine vs total AA supplement
Dietary Supplement
Lead sponsor
Texas A&M University
Other
Eligibility
10 Years to 21 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Aug 11, 2015 · Synced Oct 22, 2026, 9:07 PM EDT
Completed Not applicable Interventional

A Skills-Based Program Delivered Via Secure Live Video to Patients With Acute Musculoskeletal Trauma

NCT03405610
View directory record Official record
Conditions
Musculoskeletal Injury, Fracture
Interventions
The Toolkit for Optimal Recovery after Injury
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 17, 2018 · Synced Oct 22, 2026, 9:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Grocery Assistance Program Study

NCT02643576
View directory record Official record
Conditions
Food Assistance
Interventions
F&V Bonus, Restriction, Bonus & Restriction
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
296 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 24, 2017 · Synced Oct 22, 2026, 9:07 PM EDT
Not yet recruiting Not applicable Interventional

Optimizing Medications and Lung Health in People With HIV Through Pharmacist-led Proactive E-Consults

NCT07507435
View directory record Official record
Conditions
HIV, Inhaled Corticosteroid, Proton Pump Inhibitor, Smoking Cessation, Pneumonia
Interventions
E-consult
Other
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
3
States / cities
Boise, Idaho • Minneapolis, Minnesota • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 22, 2026, 9:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Adapting an Evidenced-based Weight Management Intervention and Testing Strategies to Increase Implementation in Community Mental Health Programs

NCT03454997
View directory record Official record
Conditions
Overweight and Obesity
Interventions
training including in-person and online, organizational strategy meetings, performance coaching
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 20, 2025 · Synced Oct 22, 2026, 9:07 PM EDT
Recruiting Not applicable Interventional

How Hormones and Exposure and Response Prevention (EX/RP) Affect the Brain of People With OCD

NCT05359562
View directory record Official record
Conditions
OCD
Interventions
Exposure & Response Prevention (EX/RP)
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 45 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
2
States / cities
New York, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Oct 22, 2026, 9:07 PM EDT
Completed Not applicable Interventional

Using Artificial Intelligence to Measure and Optimize Adherence in Patients on Anticoagulation Therapy.

NCT02599259
View directory record Official record
Conditions
Stroke
Interventions
Monitored (M+)
Device
Lead sponsor
AiCure
Industry
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 12, 2016 · Synced Oct 22, 2026, 9:07 PM EDT
Completed Phase 3 Interventional

Optimizing Pharmacologic Treatment for Neonatal Opioid Withdrawal Syndrome (OPTimize NOW): A Symptom-Based Dosing Approach

NCT05980260
View directory record Official record
Conditions
Neonatal Opiate Withdrawal Syndrome
Interventions
Symptom-based Dosing Approach, Scheduled Opioid Taper Approach
Other
Lead sponsor
HELP for NOWS Consortium
Network
Eligibility
1 Hour to 48 Hours
Enrollment
626 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
23
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Wilmington, Delaware + 16 more
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 22, 2026, 9:07 PM EDT
Completed Not applicable Interventional Results available

Insulin Dosage Software Program for People With Type 1 and Type 2 Diabetes

NCT01170208
View directory record Official record
Conditions
Diabetes, Insulin
Interventions
insulin dose software
Device
Lead sponsor
HealthPartners Institute
Other
Eligibility
21 Years to 70 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 27, 2020 · Synced Oct 22, 2026, 9:07 PM EDT
Recruiting Phase 4 Interventional

Post-Operative Thoracolumosacral Orthosis for PJK

NCT06491030
View directory record Official record
Conditions
Proximal Junctional Kyphosis, Adult Spinal Deformity Surgery, Thoracolumbosacral Orthosis
Interventions
Align PJK™ TLSO brace, Standard of Care
Device · Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
30 Years to 75 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
6
States / cities
Carmel, Indiana • Overland Park, Kansas • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 22, 2026, 9:07 PM EDT
Completed Not applicable Interventional

Promoting Positive Care Interactions (PPCI) in Assisted Living

NCT05618834
View directory record Official record
Conditions
Alzheimer Disease and Related Dementias
Interventions
Promoting Positive Care Interactions (PPCI), PPCI-Staff Education Only (EO)
Behavioral
Lead sponsor
Penn State University
Other
Eligibility
65 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Oct 22, 2026, 9:07 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Improving Health Equity for COVID-19 Vaccination for At-risk Populations Using Online Social Networks

NCT04779827
View directory record Official record
Conditions
Vaccination Refusal, Covid19, Heart Diseases
Interventions
Online Social Network and Collective Intelligence Intervention, Independent Control
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
4,476 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Oct 22, 2026, 9:07 PM EDT
Recruiting Phase 1 Interventional

A Ph Ib Study of REGN5678 Plus Cemiplimab in Patients With mCRPC

NCT06826768
View directory record Official record
Conditions
Prostate Cancer
Interventions
REGN5678, Cemiplimab
Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older · Male only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 22, 2026, 9:07 PM EDT