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ClinicalTrials.gov public records Last synced Oct 26, 2026, 9:13 PM EDT

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Showing 1–24 of 435 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: OSA Treatment Clear all
Completed Phase 3 Interventional Results available

Obstructive Sleep Apnea (OSA), Sleepiness, and Activity in Diabetes Management

NCT00801892
View directory record Official record
Conditions
Sleep Apnea, Obstructive, Diabetes Mellitus, Type 2
Interventions
Continuous Positive Airway Pressure (CPAP), Sham- Continuous Positive Airway Pressure (Sham-CPAP)
Device
Lead sponsor
Eileen R. Chasens
Other
Eligibility
40 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 8, 2017 · Synced Oct 26, 2026, 9:13 PM EDT
Recruiting Phase 1 Interventional

Vascular Endothelial Dysfunction in Sleep Apnea

NCT05289063
View directory record Official record
Conditions
Obstructive Sleep Apnea of Adult
Interventions
Atorvastatin 10mg, Placebo, Continuous Positive Airway Pressure Therapy
Drug · Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 26, 2026, 9:13 PM EDT
Withdrawn Not applicable Interventional

Non-Inferiority Trial of Acute HFT Versus nCPAP

NCT01860560
View directory record Official record
Conditions
Mild-Moderate Obstructive Sleep Disordered Breathing
Interventions
High-Flow Therapy, Continuous Positive Airway Pressure
Device
Lead sponsor
Vapotherm, Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Glen Burnie, Maryland
Source: ClinicalTrials.gov public record
Updated May 3, 2023 · Synced Oct 26, 2026, 9:13 PM EDT
Recruiting Phase 3 Interventional

A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Use a Breathing Machine (PAP) (VESPER-OSA 1)

NCT07823608
View directory record Official record
Conditions
Apnea, Sleep Disorders, Overweight and/or Obesity
Interventions
Berobenatide, Placebo
Drug · Other
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
258 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
6
States / cities
Cullman, Alabama • Riverside, California • Bradenton, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 26, 2026, 9:13 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Acclimate Feature for Positive Airway Pressure (PAP) Therapy

NCT01421654
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
S9 Elite with Acclimate, S9 Elite
Device
Lead sponsor
ResMed
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 12, 2013 · Synced Oct 26, 2026, 9:13 PM EDT
Completed Phase 4 Interventional

Solriamfetol and CBT-I in Patients With Insomnia Disorder

NCT05838430
View directory record Official record
Conditions
Insomnia
Interventions
Solriamfetol 75 MG, Cognitive Behavioral Therapy for Insomnia (CBT-I), Monitoring, Placebo
Drug · Behavioral · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
25 Years to 60 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Oct 26, 2026, 9:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

User Preference/Validation Evaluation of the New Philips Respironics Positive Airway Pressure Application

NCT03748264
View directory record Official record
Conditions
Sleep Disordered Breathing
Interventions
Standard of Care, DreamMapper Application, DreamMapper Application with Therapist Assist
Other · Device
Lead sponsor
Philips Respironics
Industry
Eligibility
21 Years to 75 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
5
States / cities
Little Rock, Arkansas • Atlanta, Georgia • Indianapolis, Indiana + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2021 · Synced Oct 26, 2026, 9:13 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Comparison of Physical Activity Regimens as Treatments for Obstructive Sleep Apnea

NCT00956423
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
moderate-intensity aerobic and resistance training, low-intensity stretching
Behavioral
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years to 55 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
2
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 24, 2011 · Synced Oct 26, 2026, 9:13 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Obstructive Sleep Apnea (OSA) in Pulmonary Arterial Hypertension (PAH)

NCT01835080
View directory record Official record
Conditions
Pulmonary Arterial Hypertension, Obstructive Sleep Apnea
Interventions
Not listed
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 16, 2020 · Synced Oct 26, 2026, 9:13 PM EDT
Completed No phase listed Observational

Effect of Nasal CPAP on Cardiopulmonary Exercise Testing in Patients With Overlap Syndrome

NCT01033266
View directory record Official record
Conditions
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
Interventions
CPET
Diagnostic Test
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
2
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 14, 2020 · Synced Oct 26, 2026, 9:13 PM EDT
Completed Phase 3 Interventional Results available

Extension Study of the Safety and Efficacy of Armodafinil in the Treatment of Patients With Excessive Sleepiness

NCT00228553
View directory record Official record
Conditions
Excessive Daytime Sleepiness, Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome, Chronic Shift Work Sleep Disorder
Interventions
Armodafinil 100 to 250 mg/day
Drug
Lead sponsor
Cephalon
Industry
Eligibility
18 Years to 65 Years
Enrollment
743 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
74
States / cities
Birmingham, Alabama • Phoenix, Arizona • Hot Springs, Arkansas + 64 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2013 · Synced Oct 26, 2026, 9:13 PM EDT
Completed Phase 3 Interventional Results available

Study to Assess Patient Reported Outcomes With Armodafinil Treatment for Excessive Sleepiness in Adults With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrome

NCT00228566
View directory record Official record
Conditions
Excessive Daytime Sleepiness, Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS)
Interventions
Armodafinil
Drug
Lead sponsor
Cephalon
Industry
Eligibility
18 Years to 65 Years
Enrollment
247 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
43
States / cities
Birmingham, Alabama • Tuscaloosa, Alabama • Phoenix, Arizona + 37 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2013 · Synced Oct 26, 2026, 9:13 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Comparison of a Demand Oxygen Delivery

NCT06609694
View directory record Official record
Conditions
Obstructive Apnea
Interventions
Portable oxygen concentrator Inogen G5 model
Device
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
5 Years to 17 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 26, 2026, 9:13 PM EDT
Completed Not applicable Interventional Results available

Auto Continuous Positive Airway Pressure (CPAP) Based Energy Spectrum Analysis of Flow for Treatment of Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS)

NCT00750165
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
SleepStyle 200 Auto Series CPAP Humidifier
Device
Lead sponsor
Fisher and Paykel Healthcare
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Oct 26, 2026, 9:13 PM EDT
Completed Not applicable Interventional Results available

Etiology of Sleep Apnea-related Hyperaldosteronism - BP Treatment

NCT01897727
View directory record Official record
Conditions
Obstructive Sleep Apnea, Resistant Hypertension, Hyperaldosteronism
Interventions
Spironolactone, BP medication uptitration
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 80 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 15, 2014 · Synced Oct 26, 2026, 9:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

TranQuill™ Sling Snoreplasty for Snoring and Mild Obstructive Sleep Apnea:

NCT02364518
View directory record Official record
Conditions
Snoring, Obstructive Sleep Apnea
Interventions
Snoreplasty
Procedure
Lead sponsor
Medical University of South Carolina
Other
Eligibility
22 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 10, 2018 · Synced Oct 26, 2026, 9:13 PM EDT
Completed Early Phase 1 Interventional

3D-Printed CPAP Masks for Children With Obstructive Sleep Apnea

NCT02261857
View directory record Official record
Conditions
Sleep Apnea, Obstructive, Craniofacial Abnormalities, Pediatric Disorder
Interventions
Personalized continuous positive airway pressure (CPAP) mask
Device
Lead sponsor
Glenn Green
Other
Eligibility
1 Year to 18 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 16, 2020 · Synced Oct 26, 2026, 9:13 PM EDT
Recruiting Phase 4 Interventional

Endotype DIrected Treatment for OSA in Down Syndrome

NCT07280468
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA), Down Syndrome
Interventions
ato-oxy, Oxygen
Drug
Lead sponsor
University of Arizona
Other
Eligibility
6 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
5
States / cities
Tucson, Arizona • San Diego, California • Miami, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 26, 2026, 9:13 PM EDT
Terminated No phase listed Observational

Recovery of Ventilation After General Anesthesia in Morbidly Obese Patients

NCT03925610
View directory record Official record
Conditions
Morbid Obesity, Opioid-Related Disorders, Surgery--Complications, Sleep Apnea Syndromes
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 22, 2021 · Synced Oct 26, 2026, 9:13 PM EDT
Completed No phase listed Observational

Functional Modeling of the Pediatric Airway

NCT01690078
View directory record Official record
Conditions
Subglottic Stenosis (SGS), Pierre Robin Sequence (PRS), Micrognathia, Normal Controls From CT Scans of the Upper Airway
Interventions
Not listed
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
Up to 17 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Oct 26, 2026, 9:13 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Mandibular Advancement Device (MAD) in Pregnant Women With Obstructive Sleep Apnea (OSA)

NCT06256640
View directory record Official record
Conditions
Obstructive Sleep Apnea of Adult, Pregnancy Related
Interventions
Mandibular advancement Device
Device
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 40 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Oct 26, 2026, 9:13 PM EDT
Completed Not applicable Interventional

The POSAtive Study: Study for the Treatment of Positional Obstructive Sleep Apnea

NCT03061071
View directory record Official record
Conditions
Sleep Apnea Syndromes
Interventions
NightBalance Sleep Position Trainer (SPT), Automated Adjusting Positive Airway Pressure (APAP)
Device
Lead sponsor
NightBalance
Industry
Eligibility
20 Years to 80 Years
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
11
States / cities
Birmingham, Alabama • Glendale, Arizona • Gainesville, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 21, 2018 · Synced Oct 26, 2026, 9:13 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Analysis of the Prevalence and Characteristics of Concomitant Sleep and Headache Disorders, and the Efficacy of CPAP Treatment for Headache Among Those Patients Diagnosed With Obstructive Sleep Apnea

NCT00520156
View directory record Official record
Conditions
Headache Disorder, Sleep Disorder, Obstructive Sleep Apnea
Interventions
Continuous positive airway pressure (CPAP)
Device
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
18 Years to 80 Years
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 23, 2007 · Synced Oct 26, 2026, 9:13 PM EDT
Recruiting Phase 3 Interventional

AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

NCT07571005
View directory record Official record
Conditions
Obesity, Overweight, Obstructive Sleep Apnoea
Interventions
NNC0487-0111, Placebo (matched to NNC0487-0111)
Drug
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
17
States / cities
San Diego, California • Miami, Florida • Naples, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 26, 2026, 9:13 PM EDT