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ClinicalTrials.gov public records Last synced Nov 7, 2026, 5:30 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 212 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: OUD Clear all

Conditions: Substance Use Disorders, Alcohol Use Disorder, Opioid Use Disorder
Interventions: Not listed
Lead sponsor: Boston University; Other
Eligibility: 18 Years and older
Enrollment: 185,810 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe, Criminal Behavior
Interventions: BNI Chatbot, OUD Education & Treatment Resources; Behavioral
Lead sponsor: Center for Progressive Recovery, LLC; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Opioid Use Disorder
Interventions: OARSCM Software Application, MyMAT Software Application; Other
Lead sponsor: Q2i, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Substance Use
Interventions: Education and support for primary care providers (PCPS), Nurse Care Manager (NCM) visits, Addiction specialist consultant, Health coaching sessions, Patient educational materials; Other
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 301 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 8
States / cities: Torrance, California • New York, New York • Enterprise, Oregon + 4 more

Conditions: Opioid Use Disorder, Opioid Misuse, Chronic Pain
Interventions: TCM, TCM plus COPES; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 259 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 3
States / cities: Little Rock, Arkansas • Aurora, Colorado • West Haven, Connecticut

Conditions: Opioid Use Disorder
Interventions: CBOC offering Tele-MOUD to Veterans, CBOC not offering Tele-MOUD to Veterans; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: Not listed
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 2
States / cities: West Haven, Connecticut • Augusta, Maine

Conditions: Opioid-use Disorder
Interventions: Employ a multifaceted approach to facilitate clinical protocol implementation, Initiate BUP (SL-BUP or XR-BUP) in the ED; Behavioral · Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 390 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 4
States / cities: Claremont, New Hampshire • Manchester, New Hampshire • New York, New York

Conditions: Opioid Use Disorder, Pregnancy Related
Interventions: Buprenorphine/ Methadone exposure; Drug
Lead sponsor: Ilana Hull; Other
Eligibility: 18 Years and older · Female only
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Decision Making
Interventions: Audio-visual stimuli (Neutral-Relaxing), Audio-visual stimuli (Drug), Audio-visual stimuli (Non-Food), Audio-visual stimuli (Food); Behavioral
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years and older
Enrollment: 160 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Piscataway, New Jersey

Conditions: Opioid Use Disorder
Interventions: Psilocybin; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 70 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2028
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid-use Disorder, HIV Prevention Program
Interventions: Contingency Management with stepped care to PrEP adherence and support services (CoMPASS); Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 526 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 6
States / cities: Bridgeport, Connecticut • Danbury, Connecticut • New Haven, Connecticut + 1 more

Conditions: Opioid Use Disorder, HIV Infections, Hepatitis C
Interventions: NIATx Coaching; Behavioral
Lead sponsor: Yale University; Other
Eligibility: Not listed
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Morgantown, West Virginia

Conditions: Opioid Use Disorder, Chronic Pain
Interventions: Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT), Enhanced Treatment as Usual (ETAU); Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 4
States / cities: West Haven, Connecticut • Bedford, Massachusetts • Boston, Massachusetts + 1 more

Conditions: Posttraumatic Stress Disorder, Opioid Use Disorder
Interventions: Sparrow Ascent tAN, Sparrow Ascent Active Sham; Device
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Cape Girardeau, Missouri

Conditions: Opioid Use Disorder
Interventions: Buprenorphine; Drug
Lead sponsor: Rhode Island Hospital; Other
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Opioid-use Disorder, Pregnancy Related
Interventions: OUD; Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older · Female only
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Posttraumatic Stress Disorder (PTSD), Substance Use Disorder (SUD)
Interventions: Written Exposure Therapy, Treatment as Usual; Behavioral
Lead sponsor: Potomac Health Foundations; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid-Related Disorders, Substance-Related Disorders, Intimate Partner Violence (IPV), Stress Disorders, Post-Traumatic, Domestic Violence, Medication for Opioid Use Disorder (MOUD), Post Traumatic Stress Disorder PTSD
Interventions: Pre-Pilot WINGS++++; Behavioral
Lead sponsor: Dawn A. Goddard-Eckrich; Other
Eligibility: 18 Years and older · Female only
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: New York, New York • Newburgh, New York

Conditions: Opioid Use, Alcohol Use Disorder
Interventions: repetitive transcranial magnetic stimulation (rTMS) for AUD, repetitive transcranial magnetic stimulation (rTMS) for OUD; Device
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Hartford, Connecticut

Conditions: Opioid-use Disorder
Interventions: Opioid Wizard; Other
Lead sponsor: HealthPartners Institute; Other
Eligibility: Not listed
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Bloomington, Minnesota

Conditions: Opioid Use Disorder
Interventions: MemFlex; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 60 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Substance Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
Interventions: Extended Release Buprenorphine, Treatment as Usual; Drug
Lead sponsor: Gavin Bart; Other
Eligibility: 18 Years and older
Enrollment: 344 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 6
States / cities: New Haven, Connecticut • Baltimore, Maryland • Boston, Massachusetts + 2 more

Conditions: Opioid Use Disorder
Interventions: Managing Physical Reactions to Overwhelming Emotions (IMPROVE), Health Education Training (HET); Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Opioid Dependence, Substance Abuse Disorders, Complex Medical Patients, Primary Care Patients With Chronic Conditions
Interventions: MOUD "Plus" Intervention (treatment as usual + coordinated counseling and referral to community based peer), Treatment As Usual (primary care with low threshold MOUD prescribing); Behavioral
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Portland, Oregon

Search by objective public record fields.

Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic

A Brief Negotiation Interview Chatbot to Improve Buprenorphine Engagement Among Justice-Involved Individuals

Reward-based Technology to Improve OUD Treatment

Collaborative Care for Polysubstance Use in Primary Care Settings (Co-Care)

Pain Care at Home to Amplify Function (Pain CHAMP)

Medications for Opioid Use Disorders (MOUD) Via Telemedicine

Emergency Department Connection to Care With Buprenorphine for Opioid Use Disorder

Predicting and Preventing Adverse Maternal and Child Outcomes of Opioid Use Disorder in Pregnancy

Craving & Decision-Making

Inpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder

Promoting HIV Risk Reduction Among People Who Inject Drugs: A Stepped Care Approach Using Contingency Management With PrEP Adherence and Support Services

Buprenorphine Integration Research and Community Health

Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine

tAN for PTSD and OUD in Buprenorphine Therapy

Identifying Optimal Buprenorphine Dosing for Opioid Use Disorder Treatment and Prevention of Overdose

Quantitative Sensory Psychophysical Correlates of Pain in Pregnant Women With OUD

Written Exposure in Substance Treatment (WEST 3.0): Randomized Controlled Trial

Pre-Pilot (R61) WINGS+++: mHealth to Improve MOUD Uptake in Women Experiencing Intimate Partner Violence and PTSD

rTMS as Add on Treatment for Substance Use Disorders

Clinical Decision Support for Opioid Use Disorders in Medical Settings: Usability Testing in an EMR

Autobiographical Memory in Opioid Use Disorder

EXHIT ENTRE Comparative Effectiveness Trial

Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD

The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care