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ClinicalTrials.gov public records Last synced Nov 7, 2026, 6:11 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 73–96 of 212 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: OUD Clear all

Conditions: Opioid Use Disorder
Interventions: Active repetitive Transcranial Magnetic Stimulation (rTMS), Sham repetitive Transcranial Magnetic Stimulation (rTMS), High Ventral Striatal Reactivity, Low Ventral Striatal Reactivity; Device · Diagnostic Test
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Opioid Use Disorder
Interventions: HOPE; Behavioral
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years and older
Enrollment: 640 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Irvine, California

Conditions: Opioid Use Disorder
Interventions: Bridge™ active device, Bridge™ sham device; Device
Lead sponsor: Masimo Corporation; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Wernersville, Pennsylvania

Conditions: Opioid Use Disorder
Interventions: Overcoming and Addressing Stigma in Substance Use Disorders (OASIS); Behavioral
Lead sponsor: Center for Social Innovation, Massachusetts; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Opioid Use Disorder
Interventions: Naltrexone implant, 14.4 grams, Naltrexone implant, 9.6 grams, Extended-release naltrexone injection, 380 mg; Drug
Lead sponsor: Akyso Therapeutics, LLC; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Millcreek, Utah

Conditions: Opioid Use Disorder, Opioid Overdose, Death
Interventions: No intervention, observational retrospective study; Other
Lead sponsor: Kaiser Permanente; Other
Eligibility: 16 Years and older
Enrollment: 27,257 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Substance-Related Disorders, Substance Use Disorders, Substance Abuse, Intravenous, Substance Withdrawal, Substance Abuse, Opioid-use Disorder, Opioid Use Disorder, Severe, Opioid Use
Interventions: Non invasive VN stimulation (nVNS), Oxygen (15-O) Water, Sham Stimulation; Device · Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Opioid Use Disorder
Interventions: CBT4CBT-Buprenorphine; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 230 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Substance-Related Disorders, Opioid Medication Assisted Treatment, Opioid Use Disorder, Opioid Use, Opioid Addiction, Treatment Adherence, Retention in Care
Interventions: Peer-Delivered Behavioral Activation ("Peer Activate"); Behavioral
Lead sponsor: University of Maryland, College Park; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 2
States / cities: Baltimore, Maryland • College Park, Maryland

Conditions: Opioid Use Disorder, Peer Recovery Supporters, Peer Recovery Coaching, Primary Care, Buprenorphine
Interventions: Peer Support; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Opioid-use Disorder, Substance Use Disorders
Interventions: Exablate Model 4000 Type 2.0/2.1; Device
Lead sponsor: InSightec; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2027
U.S. locations: 4
States / cities: Tampa, Florida • Baltimore, Maryland • New York, New York + 1 more

Conditions: Drug Use, Opioid-use Disorder
Interventions: Buprenorphine and Outpatient Parenteral Antibiotic Therapy, Buprenorphine and standard of care antibiotic treatment; Drug
Lead sponsor: Laura Fanucchi; Other
Eligibility: 18 Years to 99 Years
Enrollment: 71 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Posttraumatic Stress Disorder, Substance Use Disorders
Interventions: Written Exposure Therapy, Treatment as Usual; Behavioral
Lead sponsor: Potomac Health Foundations; Other
Eligibility: 18 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid Use Disorder
Interventions: Recovery Connect; Device
Lead sponsor: Bright Therapeutics; Industry
Eligibility: 18 Years and older
Enrollment: 1,524 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 9
States / cities: Anchorage, Alaska • Wasilla, Alaska • Billings, Montana + 6 more

Conditions: Opioid Use Disorder
Interventions: Telemedicine Buprenorphine Treatment; Drug
Lead sponsor: Boulder Care; Industry
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Stimulant Use & Co-occuring Opioid Use Disorders
Interventions: Intranasal oxytocin, Intranasal placebo; Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 3
States / cities: Sacramento, California • San Francisco, California • Portland, Oregon

Conditions: Opioid Use Disorder
Interventions: PRC supported text + AI driven SDH-enhanced text, AI driven SDH-enhanced text only, Treatment as Usual (TAU); Behavioral
Lead sponsor: Friends Research Institute, Inc.; Other
Eligibility: 18 Years to 99 Years
Enrollment: 94 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Opioid Use Disorder, Healthy
Interventions: Magnetic Resonance Imaging (MRI), Computer Tasks; Other · Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 55 Years
Enrollment: 185 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Opioid Use Disorder
Interventions: PRC supported text + AI driven CSDH-enhanced text, AI driven CSDH-enhanced text only, Treatment as Usual (TAU); Behavioral
Lead sponsor: Friends Research Institute, Inc.; Other
Eligibility: 18 Years to 99 Years
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Opioid Use Disorder, Alcohol Intoxication, Pain
Interventions: Alcohol, Placebo; Drug
Lead sponsor: Ohio State University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Post-traumatic Stress Disorder (PTSD), Post-traumatic Stress Symptoms, Opioid Use Disorder (OUD), Stimulant Use Disorder, Stimulant Use & Co-occuring Opioid Use Disorders, Co-occurring Mental and Substance Use Disorders, Medications for Opioid Use Disorder
Interventions: Cognitive Processing Therapy (CPT), Written Exposure Therapy (WET); Other
Lead sponsor: University of Arkansas; Other
Eligibility: 18 Years and older
Enrollment: 338 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 2
States / cities: Little Rock, Arkansas

Conditions: Opioid-use Disorder
Interventions: Prescriber Recruitment Bundle (PRB); Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: Not listed
Enrollment: 76 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 3
States / cities: Tallahassee, Florida • Columbus, Ohio • Madison, Wisconsin

Conditions: Opiate Dependence, Cocaine Dependence
Interventions: 11UCB-J PET Scan; Diagnostic Test
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Stress Disorders, Post-Traumatic, Opioid Use Disorder
Interventions: Written Exposure Therapy - Integrated; Behavioral
Lead sponsor: Jesse McCann; Other
Eligibility: 18 Years to 100 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Lexington, Kentucky

Search by objective public record fields.

OUD (Opioid Use Disorder) Target Trial

Adapting the HOPE Online Support Intervention to Increase Uptake of Medications for Opioid Use Disorder

Impact of Bridge™ Device to Treat Opioid Withdrawal Symptoms

Overcoming Stigma and Improving Outcomes for SUDs Through Education, Engagement, and Empowerment

iSTEP-N 101b: Pharmacokinetics and Safety Study of Low- and High-Dose Naltrexone Implants vs Monthly Vivitrol in Healthy Volunteers

Health Insurance Instability and Mortality Among Patients Receiving Bup Tx for OUD

Non-Invasive Vagal Nerve Stimulation in Opioid Use Disorders

Social Functioning in Opioid Use Disorder

Peer Activate: Trial of Peer-Delivered Behavioral Activation for Methadone Adherence

Peer Recovery Support for Opioid Use Disorder Treatment Retention

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)

Integrated Outpatient Treatment of Opioid Use Disorder and Severe Injection Related Infections

Adaptation of Written Exposure Therapy in Substance Treatment

A Stepped-Wedge Cluster Randomized Trial of a Digital App to Support Medication-Assisted Treatment in Individuals With Opioid Use Disorder

Right Tools, Right Time, Right Place: Telehealth for Opioid Use Disorder in Vulnerable Settings

Stimulant Oxytocin Study

Using AI and Peer Coaching to Address Racial Disparities Among People Who Use Opioids

Adversity, Brain and Opioid Use Study

Addressing Racial Disparities in Opioid Overdose Using Peer Recovery Coach Training and mHealth Platform

Pain Sensitivity, Alcohol-Induced Analgesia, and Heavy Drinking in Individuals With Opioid Use Disorder

Developing and Testing Innovative Care Pathways for Screening and Treatment of OUD/PTSD in Jails

Intervention to Expand Opioid Use Disorder Treatment Pharmacotherapy Prescribers

Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET

New Beginnings Following Trauma