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These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 7, 2026, 6:27 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 121–144 of 212 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: OUD Clear all

Conditions: Substance Use Disorder (SUD), Opioid Use Disorder (OUD)
Interventions: Deep Brain Stimulation; Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 22 Years to 75 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2031
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Opioid-use Disorder
Interventions: Mindful Moms Yoga Mindfulness Intervention; Behavioral
Lead sponsor: Trustees of Dartmouth College; Other
Eligibility: 18 Years and older · Female only
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Opioid Use Disorder
Interventions: Certified Peer Support Specialist Intervention; Behavioral
Lead sponsor: Prisma Health-Upstate; Other
Eligibility: 18 Years and older
Enrollment: 750 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Greenville, South Carolina

Conditions: Opioid Use Disorder (OUD)
Interventions: Methadone hydrochloride; Drug
Lead sponsor: Ashish P Thakrar, MD MS; Other
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Opioid Use Disorder
Interventions: Psilocybin; Drug
Lead sponsor: Yale University; Other
Eligibility: 25 Years to 55 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Opioid Use Disorder, Treatment Adherence
Interventions: iENDURE; Behavioral
Lead sponsor: Rhode Island Hospital; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Opioid Use Disorder
Interventions: Psilocybin; Drug
Lead sponsor: Anna Rose Childress, Ph.D.; Other
Eligibility: 18 Years to 60 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Opioid Use Disorder
Interventions: buprenorphine/naloxone; Drug
Lead sponsor: Friends Research Institute, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Dundalk, Maryland

Conditions: Post-Traumatic Stress Disorders, Opiate Use Disorder
Interventions: Buprenorphine, Cognitive Processing Therapy (CPT), Individual Drug Counseling (IDC); Drug · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 2
States / cities: West Haven, Connecticut • Bedford, Massachusetts

Conditions: Chronic Pain, Opioid Use Disorder
Interventions: CBD 300mg, CBD 600mg, Placebo 0mg; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 147 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Sleep Disorder, Restless Legs Syndrome, Opioid-use Disorder, Opioid Withdrawal
Interventions: Pramipexole, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 75 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 2
States / cities: Boston, Massachusetts • Quincy, Massachusetts

Conditions: Opioid-use Disorder
Interventions: KIOS OUD; Other
Lead sponsor: Biomedical Development Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020
U.S. locations: 2
States / cities: San Antonio, Texas

Conditions: Opioid Use Disorder
Interventions: KIOS App; Device
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years and older
Enrollment: 134 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: HIV Infections, Substance Use
Interventions: Peer Activate-LAI, Standard of Care HIV treatment or prevention with LAI-PrEP/ART; Behavioral · Other
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 88 Years
Enrollment: 186 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Baltimore, Maryland

Conditions: Opioid Use Disorder, Overdose
Interventions: Pharmacist Narcan Training, BIRT, SMC, Substance Use Counselor Narcan Training; Behavioral
Lead sponsor: University of Arkansas; Other
Eligibility: 18 Years and older
Enrollment: 267 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Opioid-use Disorder
Interventions: Recovery Management Checkups (RMC), RMC-Adaptive; Combination Product
Lead sponsor: Chestnut Health Systems; Other
Eligibility: 18 Years and older
Enrollment: 455 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Opioid Use, Opioid-use Disorder, Suicide
Interventions: OUD-CDS + Suicide Risk Model associated CDS; Other
Lead sponsor: HealthPartners Institute; Other
Eligibility: 18 Years to 75 Years
Enrollment: 115 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Bloomington, Minnesota

Conditions: Opioid Use Disorder
Interventions: Patient Decision Aid; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 7,554 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Opioid Use Disorder
Interventions: Treatment as usual (TAU), CHaRRM-CN; Other
Lead sponsor: Washington State University; Other
Eligibility: 18 Years and older
Enrollment: 136 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 2
States / cities: Tahlequah, Oklahoma • Seattle, Washington

Conditions: Opioid Use Disorder
Interventions: Psilocybin; Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 480 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 5
States / cities: Albuquerque, New Mexico • Brooklyn, New York • New York, New York + 1 more

Conditions: Clinical Decision Support, Buprenorphine, Opioid-use Disorder
Interventions: Clinical Decision Support (CDS); Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 5,047 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 22
States / cities: Birmingham, Alabama • Gardendale, Alabama • Aurora, Colorado + 17 more

Conditions: HIV Infections, Drug Use, Opioid Use, Opioid-use Disorder
Interventions: Medication for opioid-use disorder (MOUD) for opioid-use disorder (OUD), HIV testing, HIV treatment for participants living with HIV not already in care, PrEP for participants without HIV, Testing and referral for vaccination or treatment for hepatitis A virus (HAV) and hepatitis B virus (HBV), Testing and referral for treatment for hepatitis C virus (HCV), Sexually transmitted infection (STI) testing and treatment, Primary care, Harm reduction services, Peer navigation, COVID-19 testing and referral for further evaluation, care and/or treatment; Drug · Diagnostic Test · Other + 1 more
Lead sponsor: HIV Prevention Trials Network; Network
Eligibility: 18 Years and older
Enrollment: 447 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 5
States / cities: Los Angeles, California • Washington D.C., District of Columbia • The Bronx, New York + 2 more

Conditions: Healthy Adult Male and Female Volunteers
Interventions: BICX104 naltrexone implantable pellet, Bupropion 150 mg XL, Naltrexone (depot); Drug
Lead sponsor: BioCorRx Pharmaceuticals Inc; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Opioid-use Disorder
Interventions: Collaborative Care (CC), Extension for Community Healthcare Outcomes (ECHO); Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 230 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 11
States / cities: Hartford, Connecticut • New Britain, Connecticut • New Haven, Connecticut + 7 more

Search by objective public record fields.

Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder

Mindful Moms in Recovery

Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices

MethaLoad Dose-Finding Study

Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)

Digital Health Intervention to Support Opioid Use Disorder Treatment

Wellcome Leap Psilocybin for OUD

Low-dose Versus a High-dose Sublingual Buprenorphine Induction

Optimal Treatment of Veterans With PTSD and Comorbid OUD

Combined THC and CBD for OUD and Chronic Pain

Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD

mHealth for Patient Self-Management of Opioid Use Disorder

Real World Evaluation of the Effectiveness and Implementation of a Digital Health Therapeutic for OUD

Peer Behavioral Activation Utilization to Improve Substance Use and HIV Outcomes in People Receiving Long Acting Injectable-PrEP/ART (PUSH)

Pharmacist-Led Interventions to Increase Access to Medications for Opioid Use Disorders (PLI-MOUD)

Recovery Management Checkups for Opioid Use Disorder Experiment

Suicide Prediction and Prevention for People at Risk for Opioid Use Disorder: Supplement to COMPUTE 2.0

Patient Decision Aid for Opioid Use Disorder

Counseling for Harm Reduction and Retention in Medication-assisted Treatment - Cherokee Nation

Psilocybin for Opioid Use Disorder (OUD)

Clinical Decision Support to Implement ED-initiated Buprenorphine for OUD

INTEGRA: A Vanguard Study of Health Service Delivery in a Mobile Health Delivery Unit

Safety and PK Study of BICX104 With or Without Bupropion Compared to Vivitrol

Treatment of Pregnant Women With OUD