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ClinicalTrials.gov public records Last synced Nov 7, 2026, 6:39 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 145–168 of 212 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: OUD Clear all

Conditions: Addiction
Interventions: Formative Interviews (not an intervention), Cognitive-behavioral therapy (CBT), Acceptance and commitment therapy (ACT), No intervention; Other · Behavioral
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 75 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid Use Disorder
Interventions: Ketamine, Mindfulness-Oriented Recovery Enhancement (MORE), Support Group; Drug · Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: La Jolla, California • Salt Lake City, Utah

Conditions: Opioid-use Disorder
Interventions: PROUD Intervention; Other
Lead sponsor: Kaiser Permanente; Other
Eligibility: 16 Years to 90 Years
Enrollment: 377,373 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 6
States / cities: Miami, Florida • Detroit, Michigan • The Bronx, New York + 3 more

Conditions: Opioid-use Disorder
Interventions: buprenorphine/naloxone oral product, injectable naltrexone, Pharmacy maintenance addiction care, oral naltrexone; Drug · Other
Lead sponsor: Lifespan; Other
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Opioid Use Disorder, Tobacco Use Disorder
Interventions: Deep TMS System With H4 Coil; Device
Lead sponsor: Payel Roy; Other
Eligibility: 22 Years to 70 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania

Conditions: Opioid Use Disorder
Interventions: Psilocybin; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 70 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid Use Disorder
Interventions: Not listed
Lead sponsor: Yale University; Other
Eligibility: Not listed
Enrollment: 495 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 3
States / cities: Oakland, California • Minneapolis, Minnesota • Camden, New Jersey

Conditions: Opioid Use Disorder, Suicidal Ideation
Interventions: Ketamine, Saline Solution; Drug · Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Opioid-use Disorder, Anxiety, Depression, Stress Related Disorder
Interventions: M-ROCC; Behavioral
Lead sponsor: Cambridge Health Alliance; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Somerville, Massachusetts

Conditions: Healthy, Opioid Use Disorder
Interventions: Carfentanil, C-11, Naloxone, Loperamide Hydrochloride; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 50 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
Interventions: Behavioral: Digital Tutorial Overview, Behavioral: Training Materials, Behavioral: Feedback and Coaching; Behavioral
Lead sponsor: We The Village, Inc.; Other
Eligibility: 19 Years and older
Enrollment: 47 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: New York, New York

Conditions: Opioid Use Disorder, Posttraumatic Stress Disorder
Interventions: Prolonged exposure therapy, Financial incentives, Treatment as usual; Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 135 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Opioid-use Disorder, Opioid Dependence, Treatment Adherence
Interventions: Contingency Management (CM), Brief Motivational Intervention + Substance Free Activities Session + Mindfulness-Based Adherence Promotion (BSM); Behavioral
Lead sponsor: Karen Derefinko, PhD; Other
Eligibility: 18 Years and older
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Substance Use Disorders, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate
Interventions: Low Intensity, High Intensity; Other
Lead sponsor: Gavin Bart; Other
Eligibility: Not listed
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 4
States / cities: Boston, Massachusetts • Minneapolis, Minnesota • New York, New York + 1 more

Conditions: Opioid Use Disorder, Anxiety, Depression
Interventions: NEAT-O program; Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 65 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Opioid Use Disorder
Interventions: Olanzapine; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania • Richmond, Virginia

Conditions: Opioid Use Disorder
Interventions: MORE-VR, Treatment as Usual; Device · Other
Lead sponsor: BehaVR LLC; Industry
Eligibility: 18 Years and older
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 2
States / cities: La Jolla, California • Salt Lake City, Utah

Conditions: Opioid Use Disorder, Pain
Interventions: Exercise, Psychotherapy Pain and Addiction (I-STOP); Other · Behavioral
Lead sponsor: Case Western Reserve University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 198 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 2
States / cities: Denver, Colorado • Cleveland, Ohio

Conditions: Opioid Use Disorder
Interventions: ConCERN intervention, Treatment as Usual; Behavioral · Other
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 700 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 2
States / cities: Ann Arbor, Michigan • Detroit, Michigan

Conditions: Opioid-Related Disorders, Drug Addiction
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 21 Years to 60 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Stress Disorders, Post-Traumatic, Opioid Use Disorder
Interventions: MDMA Assisted Therapy; Drug
Lead sponsor: University of New Mexico; Other
Eligibility: 18 Years and older · Female only
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Opioid Use Disorder, Sleep, Circadian Rhythms, fMRI Research
Interventions: AYO light glasses (experimental), AYO light glasses (comparator); Device
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 60 Years
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Opioid Use Disorder
Interventions: Mobile phone-assisted intervention, Peer navigator, Standard of care referral for out-patient MAT; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 99 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2030
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid-Related Disorders
Interventions: Deep Brain Simulator; Device
Lead sponsor: West Virginia University; Other
Eligibility: 21 Years to 50 Years
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: Morgantown, West Virginia

Search by objective public record fields.

Just-In-Time Adaptive Interventions for Addictive Behaviors

Targeting Treatment-Resistant OUD With Ketamine-Assisted Mindfulness Oriented Recovery Enhancement

PRimary Care Opioid Use Disorders Treatment (PROUD) Trial

Medication Maintenance Therapy in Community Pharmacy Settings

Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder

Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder

EMS-Initiated Buprenorphine

Ketamine for OUD and Suicidal Ideation in the ED

MINDFUL-OBOT: Effect of Mindfulness on Opioid Use and Anxiety During Primary Care Buprenorphine Treatment

Multi-System Analysis of Opioid Receptor Binding

Scalable Digital Delivery of Evidence-based Training for Professionals to Maximize Treatment Rates of OUD in Families

Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals With OUD

SMART Effectiveness Trial

EXHIT ENTRE Implementation Trial of High Intensity Versus Low Intensity Strategy

Autonomous Digital CBT Intervention for Opioid Use Disorder in Individuals With Co-Occurring Internalizing Disorders

Olanzapine in OUD Patients

Virtual Reality Cognitive-Affective Training for Opioid Use Disorder- A Phase 2 RCT

Enhancing Exercise and Psychotherapy to Treat Pain and Addiction in Adults With an Opioid Use Disorder (EXPO; R33 Phase)

The ConCERN Intervention for Loved Ones of Those With Opioid Use Disorder

Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder

MDMA for Co-occurring PTSD and OUD After Childbirth

The Effect of Light Intervention on Recovery in Individuals With Opioid Use Disorder (OUD)

Peer-led, Mobile App Supported Linkage to Opioid Use Disorder Treatment

Feasibility of Deep Brain Stimulation as a Novel Treatment for Refractory Opioid Use Disorder