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ClinicalTrials.gov public records Last synced Nov 7, 2026, 6:58 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 193–212 of 212 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: OUD Clear all

Conditions: Opioid-Related Disorders
Interventions: Deep Brain Stimulation; Device
Lead sponsor: West Virginia University; Other
Eligibility: 22 Years to 50 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Morgantown, West Virginia

Conditions: Opioid-use Disorder
Interventions: Integration of telemedicine for MOUD in primary care; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 80 Years
Enrollment: 36,762 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 7
States / cities: Cottonwood, Idaho • Grangeville, Idaho • Belfast, Maine + 4 more

Conditions: Polysubstance Addiction, Opioid Medication Assisted Treatment, Treatment Adherence, Retention in Care, Substance-Related Disorders
Interventions: Peer-Delivered Behavioral Activation ("Peer Activate"); Behavioral
Lead sponsor: University of Maryland, College Park; Other
Eligibility: 18 Years and older
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 4
States / cities: Washington D.C., District of Columbia • Baltimore, Maryland • College Park, Maryland + 1 more

Conditions: Normal Physiology, Opioid Use Disorders
Interventions: [11C]raclopride plus placebo, [11C]raclopride plus drug, [11C]NNC-112; Drug
Lead sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA); NIH
Eligibility: 18 Years to 80 Years
Enrollment: 153 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Opiod Use Disorder
Interventions: OUD screening, MOUD, Continuity of care; Other
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 16 Years and older
Enrollment: 271,031 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2027 – 2029
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Opioid Use Disorder
Interventions: Treatment with Ketone Supplement, Treatment with Placebo; Dietary Supplement
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 75 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Wernersville, Pennsylvania

Conditions: Opioid-use Disorder
Interventions: Core Intervention, Peer Support Specialists (PSS), Treatment as Usual (TAU); Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years and older
Enrollment: 164 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 3
States / cities: Durham, North Carolina • Philadelphia, Pennsylvania • Providence, Rhode Island

Conditions: Opioid Use Disorder
Interventions: INDV-2000, Placebo; Drug · Other
Lead sponsor: Indivior Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 35
States / cities: Hamilton, Alabama • Phoenix, Arizona • Oceanside, California + 29 more

Conditions: Hiv, Opioid Use
Interventions: Opioid Agonist Therapy; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Opioid-use Disorder
Interventions: ID/LAB, TAU; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 171 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 3
States / cities: New Haven, Connecticut • Hershey, Pennsylvania • Greenville, South Carolina

Conditions: Opioid-use Disorder
Interventions: Opioid Wizard; Other
Lead sponsor: HealthPartners Institute; Other
Eligibility: 18 Years to 75 Years
Enrollment: 10,891 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 3
States / cities: Bloomington, Minnesota • Duluth, Minnesota • Danville, Pennsylvania

Conditions: Opioid Use Disorder, Substance Use Disorders, Stigma, Social
Interventions: Words Matter - Visual Campaign, Words Matter - Visual Campaign & Narrative Vignette (Messenger: Person with Opioid Use Disorder) Experimental: Words Matter - Visual Campaign & Narrative Vignette (Messenger: Clinician), Words Matter - Visual Campaign & Narrative Vignette (Messenger: Clinician), Words Matter - Visual Campaign & Narrative Vignette (Messenger: Health System Administrator), Medication Treatment for Opioid Use Disorder Works - Visual Campaign, Medication Treatment for Opioid Use Disorder Works - Visual Campaign & Narrative Vignette (Messenger: Person with Opioid Use Disorder), Medication Treatment for Opioid Use Disorder Works - Visual Campaign & Narrative Vignette (Messenger: Clinician), Medication Treatment for Opioid Use Disorder Works - Visual Campaign & Narrative Vignette (Messenger: Health System Administrator); Behavioral
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 18 Years and older
Enrollment: 1,842 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid Use Disorder
Interventions: Mobile Phone App; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years and older
Enrollment: 1,300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 2
States / cities: Indianapolis, Indiana • Providence, Rhode Island

Conditions: Opioid-use Disorder
Interventions: Moderate Treatment Approach, Intensive Treatment Approach; Other
Lead sponsor: Boston Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 115 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Opioid Addiction
Interventions: Transitions Clinic Network Primary Care, Standard Primary Care; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 398 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 4
States / cities: New Haven, Connecticut • Minneapolis, Minnesota • The Bronx, New York + 1 more

Conditions: Opiod Use Disorder
Interventions: Not listed
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 22 Years to 85 Years
Enrollment: 70 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 3
States / cities: Pomona, California • Chicago, Illinois • Cambridge, Massachusetts

Conditions: Opioid Use, Opioid Abuse
Interventions: Sociobehavioral Intervention; Behavioral
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 163 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Opioid-use Disorder, Mental Health Disorder
Interventions: Collaborative Care for Mental Health Symptoms, Collaborative Care for Opioid Use Disorder and Mental Health Symptoms; Other
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 254 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 33
States / cities: Washington D.C., District of Columbia • Atlanta, Georgia • Dunwoody, Georgia + 22 more

Conditions: Opioid Use Disorder
Interventions: ERPs with electroencephalography (EEG), MIO; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 45 Years · Female only
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Opioid Use Disorder, Social Determinants of Health (SDOH)
Interventions: ED-Based Clinical Decision Support for Opioid Use Disorder, Social Care-Enhanced Clinical Decision Support for Opioid Use Disorder; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: San Francisco, California

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Deep Brain Stimulation as a Novel Treatment for Refractory Opioid Use Disorder

Rural MOUD Telemedicine in Primary Care Phase 1

Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention

Brain Dopaminergic Signaling in Opioid Use Disorders

Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System

Ketones for Opioid Craving

Opioid Treatment and Peer Recovery Support

Proof of Concept and Dose-ranging Study of INDV-2000 in Individuals With Moderate to Severe Opioid Use Disorder

PRIDE III Prison Interventions and HIV Prevention Collaboration

Coordinating Opioid Use Treatment Through Medical Management With Infection Treatment (Project COMMIT)

Clinical Decision Support for Opioid Use Disorders in Medical Settings (COMPUTE 2.0)

Strategies to Reduce Addiction Stigma Among Health Professionals

Mobile Peer Support for OUD Recovery

Response to Relapse in Office-Based Opioid Treatment Trial

Transitions Clinic Network: Post Incarceration Addiction Treatment, Healthcare, and Social Support

EEG Biomarkers for OUD: Diagnostic, Prognostic, and Predictive Applications

Rural Expanded Access to OUD Care & Linkage Using Toxicologists for Telehealth Initiated Treatment

Collaborating to Heal Addiction and Mental Health in Primary Care

Neuroplasticity in Maternal Opioid Use Disorder (OUD)

Using Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency Department