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ClinicalTrials.gov public records Last synced Nov 4, 2026, 10:14 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 415 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Omega 3 fatty acid Clear all

Conditions: Alzheimer's Disease
Interventions: icosapent ethyl (IPE), gel cap placebo; Drug · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 50 Years to 75 Years
Enrollment: 131 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Hypertension in Pregnancy
Interventions: Docosahexaenoic acid 200 mg, Docosahexaenoic acid 1000 mg; Dietary Supplement · Drug
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 18 Years to 45 Years · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Non-alcoholic Steatohepatitis, Fatty Liver
Interventions: Omega 3 Fish Oil supplements, Placebo; Drug
Lead sponsor: University of Virginia; Other
Eligibility: 21 Years and older
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Coronary Artery Disease, Inflammatory Response, Atherosclerosis
Interventions: eicosapentaenoic acid (EPA),; Dietary Supplement
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 19 Years and older
Enrollment: 53 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Willoughby Hills, Ohio

Conditions: Cardiovascular Disease
Interventions: Canola Oil, High Oleic Acid + DHA Canola Oil, High Oleic Acid Canola Oil, Flax Oil, Safflower Oil; Dietary Supplement
Lead sponsor: Penn State University; Other
Eligibility: 20 Years to 65 Years
Enrollment: 43 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: University Park, Pennsylvania

Conditions: Barrett's Esophagus, Obesity
Interventions: Omega-3 polyunsaturated fatty acids, Placebo; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 85 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Sellar/Parasellar Tumor, Smell Dysfunction
Interventions: Omega-3; Dietary Supplement
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 2
States / cities: Stanford, California • Atlanta, Georgia

Conditions: Retinitis Pigmentosa
Interventions: Vitamin A, Docosahexaenoic acid, Control fatty acid; Dietary Supplement
Lead sponsor: Carol Weigel DiFranco; NIH
Eligibility: 18 Years to 55 Years
Enrollment: 221 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1996 – 2002
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Anosmia, Covid19
Interventions: Omega-3 Fatty Acid Supplement, Placebo/Control; Drug
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older
Enrollment: 139 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Inflammation
Interventions: n3-PUFA, Placebo, Biopsy, Body Composition Scan; Drug · Procedure · Diagnostic Test
Lead sponsor: Mayo Clinic; Other
Eligibility: 20 Years to 85 Years
Enrollment: 63 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Diabetes Mellitus, Non-Insulin-Dependent, Hypertriglyceridemia
Interventions: Metformin Eicosapentaenoate, Metformin HCl and Vascepa; Drug
Lead sponsor: Thetis Pharmaceuticals LLC; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 1
States / cities: Baton Rouge, Louisiana

Conditions: Adiposity
Interventions: Vitamin D3 (cholecalciferol), 2000 IU per day, omega-3 fatty acids (fish oil); Dietary Supplement · Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 50 Years and older
Enrollment: 600 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Prostate Cancer
Interventions: lycopene supplement, fish oil supplement, Placebo; Dietary Supplement · Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: Male only
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2008
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Atrial Fibrillation
Interventions: Omega -3 fatty acids, Placebo; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 1,516 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Heart Disease
Interventions: EPA 600, EPA 1800, Olive Oil, DHA; Dietary Supplement
Lead sponsor: Cardiovascular Research Associates; Network
Eligibility: 21 Years to 70 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Hypertriglyceridemia
Interventions: AMR101 (ethyl icosapentate) - 4 g/day, AMR101 (ethyl icosapentate) - 2 g/day, Placebo; Drug
Lead sponsor: Amarin Pharma Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 702 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 80
States / cities: Muscle Shoals, Alabama • Scottsboro, Alabama • Phoenix, Arizona + 69 more

Conditions: Inflammation
Interventions: Omega 3 (Fish Oil) Supplementation, Placebo; Dietary Supplement
Lead sponsor: Ohio State University; Other
Eligibility: 40 Years to 88 Years
Enrollment: 138 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2011
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Moderate Hypertriglyceridemia.
Interventions: Omega 3 fatty acid (Lovaza); Dietary Supplement
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 21 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Mania
Interventions: OMega 3, Placebo; Drug
Lead sponsor: University of Cincinnati; Other
Eligibility: 10 Years to 21 Years
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Bipolar Disorder
Interventions: cytidine, omega-3 fatty acids, placebo; Dietary Supplement · Drug
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 55 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2010
U.S. locations: 2
States / cities: Belmont, Massachusetts • Neptune City, New Jersey

Conditions: Dry Eye
Interventions: Omega 3 fatty acid, Placebos; Drug
Lead sponsor: OmegaD LLC; Industry
Eligibility: 18 Years to 90 Years
Enrollment: 322 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 14
States / cities: Newport Beach, California • Westminster, California • Largo, Florida + 11 more

Conditions: Bioavailability
Interventions: EPA + DHA in SMEDS Formulation, Lovaza (active comparator; already FDA approved); Dietary Supplement · Other
Lead sponsor: Midwest Center for Metabolic and Cardiovascular Research; Other
Eligibility: 18 Years to 55 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 2
States / cities: Boca Raton, Florida • Chicago, Illinois

Conditions: Cardiovascular Disease, HIV Infection
Interventions: Lovaza, Placebo; Drug
Lead sponsor: Tufts University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Age-Related Cognitive Decline, Age-Related Memory Disorders
Interventions: DHA (nutritional supplement) or placebo; Dietary Supplement
Lead sponsor: dsm-firmenich Switzerland AG; Industry
Eligibility: 55 Years and older
Enrollment: 485 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 14
States / cities: Mesa, Arizona • San Diego, California • Vista, California + 11 more

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Brain Amyloid and Vascular Effects of Eicosapentaenoic Acid

Docosahexaenoic Acid Supplementation of Women With Hypertension in Pregnancy to Improve Endothelial Health

Omega 3 Fish Oil Supplements vs. Placebo for Patients With Non-alcoholic Steatohepatitis (NASH)

Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels

Canola Oil Multicentre Intervention Trial (COMIT)

Modulation of Esophageal Inflammation in Barrett's Esophagus by Omega-3 Fatty Acids

Omega-3 Supplementation for Smell Dysfunction

Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A

COVID-19 Anosmia Study

Enhancing Adaptations to Exercise

PK Study Comparing Metformin Eicosapentaenoate to a Combined Dose of Metformin Hydrochloride and Ethyl Ester EPA

Vitamin D and Omega-3 Adiposity Trial (VITAL Adiposity)

Lycopene or Omega-3 Fatty Acid Nutritional Supplements in Treating Patients With Stage I or Stage II Prostate Cancer

Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation

Evaluation of the Safety and Biologic Effects of an Eicosapentaenoic (EPA)-Enriched Oil

Effect of AMR101 (Ethyl Icosapentate) on Triglyceride (Tg) Levels in Patients on Statins With High Tg Levels (≥ 200 and < 500 mg/dL)

Fish Oil (Omega 3), Immune Function, and Mood

Lovaza Mechanisms of Action

Neurochemical Effects of Omega-3 Fatty Acids in Adolescents at Risk for Mania

Cytidine and Omega-3 Fatty Acids in Bipolar Disorder

Phase 3 Study of the Safety and Efficacy of OmegaD Softgels in the Treatment of Dry Eye Disease

Bioavailability of EPA + DHA in a SMEDS Formulation

Human Immunodeficiency Virus (HIV), Arterial Dysfunction, Lipids, Lovaza (HALO) Trial

Memory Improvement With Docosahexaenoic Acid Study (MIDAS)