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ClinicalTrials.gov public records Last synced Sep 10, 2026, 2:08 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Open Loop Clear all
Enrolling by invitation Not applicable Interventional

Movement State-dependent Adaptive DBS for PD

NCT07424508
View directory record Official record
Conditions
Parkinson's Disease (PD)
Interventions
Summit RC+S
Device
Lead sponsor
Doris Wang, MD, PhD
Other
Eligibility
21 Years to 75 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Sep 10, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional

CARED : A Novel Rapid Treatment Paradigm for Depression

NCT07507370
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Intermittent Theta Burst Stimulation (iTBS), Transcranial Alternating Current Stimulation (tACS), Psychotherapy, Sham (Placebo) Transcranial Alternating Current Stimulation (tACS)
Device · Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 10, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional

Clinical Decision Support Tool in PARDS Pilot Study

NCT04068012
View directory record Official record
Conditions
Ventilation Therapy; Complications, Ventilator-Induced Lung Injury, Ards
Interventions
Ventilator protocol
Other
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
1 Month to 18 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
6
States / cities
Chicago, Illinois • Indianapolis, Indiana • Hershey, Pennsylvania + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 10, 2026, 2:08 AM EDT
Completed No phase listed Observational

Loop T2D Observational Study

NCT05951569
View directory record Official record
Conditions
Diabetes Mellitus, Type 2
Interventions
Community-Derived Open-Source Automated Insulin Delivery Loop System
Device
Lead sponsor
Jaeb Center for Health Research
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Oct 11, 2023 · Synced Sep 10, 2026, 2:08 AM EDT
Completed Not applicable Interventional Results available

HIRREM in Military Personnel

NCT03230890
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
HIRREM
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 13, 2023 · Synced Sep 10, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional

Simplified, Scalable, 24-hour Adaptive DBS in Parkinson's Disease

NCT07398157
View directory record Official record
Conditions
PD - Parkinson's Disease
Interventions
Medtronic Percept Deep Brain Stimulation (cDBS), Medtronic Percept Deep Brain Stimulation (daytime aDBS), Medtronic Percept Deep Brain Stimulation (nighttime aDBS)
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 10, 2026, 2:08 AM EDT
Not yet recruiting Not applicable Interventional

Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder

NCT07282678
View directory record Official record
Conditions
Depression - Major Depressive Disorder, Transcranial Alternating Current Stimulation
Interventions
Closed-loop tACS, Sham Comparator
Device
Lead sponsor
Pulvinar Neuro, LLC
Industry
Eligibility
22 Years and older
Enrollment
214 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 10, 2026, 2:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Hybrid Closed-Loop Hotel Studies With Medtronic PID Controller

NCT02280863
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
Medtronic Hybrid Closed-loop System - Android Platform, Medtronic Hybrid Closed-loop Integrated System
Device
Lead sponsor
Stanford University
Other
Eligibility
14 Years to 40 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
3
States / cities
Stanford, California • Aurora, Colorado • New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 2, 2018 · Synced Sep 10, 2026, 2:08 AM EDT
Completed Phase 2 Interventional Results available

Pilot Study of Loop Diuretics Among Individuals Receiving Hemodialysis

NCT04622709
View directory record Official record
Conditions
Chronic Kidney Disease Requiring Chronic Dialysis
Interventions
Furosemide (loop diuretic) Tablets
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
5
States / cities
Carrboro, North Carolina • Pittsboro, North Carolina • Sanford, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 12, 2022 · Synced Sep 10, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Enhancing Attention in Elderly Using a Brain-Computer-Interface

NCT07441122
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI)
Interventions
transcranial electrical stimulation, Mindfulness Meditation
Device · Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
2
States / cities
Austin, Texas • Georgetown, Texas
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 10, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Personalized Theta-burst Stimulation for Long-lasting Changes in Approach/Avoidance Behavior

NCT07161505
View directory record Official record
Conditions
Approach/Avoidance Behavior
Interventions
TBS-EEG, TBS-EEG / Spatial Control, TBS / Temporal Control, TBS-EEG / Dose Control
Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 10, 2026, 2:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Three-way, Cross-over Closed-loop Exercise Study

NCT02241889
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
Insulin pump therapy, Closed-loop Artificial Pancreas Controller
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
21 Years to 45 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 21, 2017 · Synced Sep 10, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Outpatient Control-to-Range: System and Monitoring Testing

NCT01697150
View directory record Official record
Conditions
Type 1 Diabetes Mellitus
Interventions
DiAs Diabetes Assistant Wearable Artificial Pancreas Platform
Device
Lead sponsor
Sansum Diabetes Research Institute
Other
Eligibility
21 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Apr 20, 2016 · Synced Sep 10, 2026, 2:08 AM EDT
Completed Phase 3 Interventional

At Home Study of a Zone-Model Predictive Control (MPC) Controller and a Health Monitoring System (HMS) With the Diabetes Assistant (DiAs) System and Run-to-Run Adaptation

NCT02705053
View directory record Official record
Conditions
Type 1 Diabetes Mellitus
Interventions
CGM and Insulin Pump, Closed-Loop Control System
Device
Lead sponsor
Sansum Diabetes Research Institute
Other
Eligibility
21 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
3
States / cities
Santa Barbara, California • Rochester, Minnesota • Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 13, 2016 · Synced Sep 10, 2026, 2:08 AM EDT
Recruiting No phase listed Observational

Commercial or Open Source Closed Loop Impact on Pregnancy Study

NCT06654713
View directory record Official record
Conditions
Type 1 Diabetes, Pregnancy, High Risk, Insulin Dependent Diabetes, Pregnancy Related
Interventions
Commercial AID system, Open source AID system
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Female only
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 10, 2026, 2:08 AM EDT
Completed Not applicable Interventional Results available

Electrically Evoked Compound Action Potentials Human Observation Medtronic Algorithm Comparison Study

NCT04765735
View directory record Official record
Conditions
Chronic Pain
Interventions
Open-loop testing, Closed-loop testing - External Spinal Cord Stimulator (SCS)
Device
Lead sponsor
MedtronicNeuro
Industry
Eligibility
22 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
9
States / cities
Carlsbad, California • Duluth, Minnesota • Edina, Minnesota + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 25, 2024 · Synced Sep 10, 2026, 2:08 AM EDT
Terminated Not applicable Interventional

A Sham-Controlled Study to Evaluate the Safety and Efficacy of a Smart, Self-Adjusting, Surgery-Free, Wearable Bladder Neuromodulation System for Overactive Bladder

NCT05381116
View directory record Official record
Conditions
Overactive Bladder, Urinary Urge Incontinence, Urge Incontinence
Interventions
Avation System, Sham Avation System
Device
Lead sponsor
Avation Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
6
States / cities
Tucson, Arizona • Oak Lawn, Illinois • New Orleans, Louisiana + 3 more
Source: ClinicalTrials.gov public record
Updated May 28, 2024 · Synced Sep 10, 2026, 2:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Toward a Generalizable Closed-loop Neurofeedback-based BCI for Attention Training

NCT05908253
View directory record Official record
Conditions
Neurofeedback
Interventions
sham neurofeedback, nonadaptive neurofeedback, adaptive neurofeedback
Behavioral
Lead sponsor
University of Rhode Island
Other
Eligibility
18 Years to 70 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Kingston, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Sep 10, 2026, 2:08 AM EDT
Terminated Not applicable Interventional Results available

Bovine Carotid Artery Biologic Graft and Expanded Polytetrafluoroethylene for Permanent Hemodialysis Access

NCT03300024
View directory record Official record
Conditions
End Stage Renal Disease, Hemolysis, Arteriovenous Graft
Interventions
Expanded polytetrafluoroethylene Graft, Bovine Carotid Artery Graft
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 90 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 20, 2019 · Synced Sep 10, 2026, 2:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lipiflow vs iLux Patient Acceptance and Comfort Study

NCT04454983
View directory record Official record
Conditions
Meibomian Gland Dysfunction, Dry Eye
Interventions
Lipiflow Thermal Pulsation System, iLux System
Device
Lead sponsor
Epstein, Arthur B., OD, FAAO
Individual
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 18, 2020 · Synced Sep 10, 2026, 2:08 AM EDT
Completed Not applicable Interventional Results available

Early Feasibility Study 2 of Outpatient Control-to-Range - Testing System Efficacy

NCT01714505
View directory record Official record
Conditions
Diabetes Mellitus, Type 1
Interventions
Diabetes Assistant (DiAs)
Device
Lead sponsor
University of Virginia
Other
Eligibility
21 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Santa Barbara, California • Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 8, 2014 · Synced Sep 10, 2026, 2:08 AM EDT
Completed Not applicable Interventional

Bilateral Closed Loop Deep Brain Stimulation for Freezing of Gait Using Neural and Kinematic Feedback

NCT04043403
View directory record Official record
Conditions
Parkinson Disease
Interventions
Open Loop DBS, Adaptive (Closed Loop) DBS, Intermittent Open Loop DBS
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Sep 10, 2026, 2:08 AM EDT
Completed Not applicable Interventional Results available

HIRREM Developmental Study

NCT02709369
View directory record Official record
Conditions
Sleep Initiation and Maintenance Disorders, Anxiety, Post-Traumatic Stress Disorder, Hot Flashes, Headache, Traumatic Brain Injury, Post Concussion Symptoms
Interventions
HIRREM
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
11 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 23, 2019 · Synced Sep 10, 2026, 2:08 AM EDT
Recruiting Not applicable Interventional

Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder

NCT06660225
View directory record Official record
Conditions
Obsessive-Compulsive Disorder
Interventions
Medtronic Percept Deep Brain Stimulation Therapy [Sham Control Stimulation], Medtronic Percept Deep Brain Stimulation Therapy [Therapeutic stimulation]
Device
Lead sponsor
Nader Pouratian
Other
Eligibility
22 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 10, 2026, 2:08 AM EDT