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ClinicalTrials.gov public records Last synced Oct 27, 2026, 6:46 PM EDT

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Showing 505–528 of 1,547 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Open Surgery Clear all
Completed Phase 4 Interventional

Safety and Efficacy of Activated Recombinant Human Factor VII in Haemophilia Patients With Inhibitors During and After Major Surgery

NCT01561391
View directory record Official record
Conditions
Congenital Bleeding Disorder, Haemophilia A With Inhibitors, Haemophilia B With Inhibitors
Interventions
activated recombinant human factor VII, factor IX, factor VIII
Drug · Other
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
5 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2004
U.S. locations
14
States / cities
Los Angeles, California • Chicago, Illinois • New Orleans, Louisiana + 9 more
Source: ClinicalTrials.gov public record
Updated Dec 29, 2023 · Synced Oct 27, 2026, 6:46 PM EDT
Completed No phase listed Observational

Evaluation of Clinical Outcomes in Robotic-Assisted Inguinal Hernia Repair

NCT02684448
View directory record Official record
Conditions
Hernia, Inguinal, Hernia, Inguinal, Direct, Hernia, Inguinal, Indirect
Interventions
Inguinal Hernia Repair
Procedure
Lead sponsor
Intuitive Surgical
Industry
Eligibility
18 Years and older
Enrollment
1,258 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
2
States / cities
New Lenox, Illinois • Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 28, 2017 · Synced Oct 27, 2026, 6:46 PM EDT
Not yet recruiting Not applicable Interventional

Quadratus Lumborum Versus Placebo in Open Ventral Hernia Repair

NCT06953635
View directory record Official record
Conditions
Hernia, Ventral, Pain Management
Interventions
Quadratus Lumborum (QL) Block, Placebo
Procedure
Lead sponsor
University of Tennessee Graduate School of Medicine
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Oct 27, 2026, 6:46 PM EDT
Completed Not applicable Interventional

Evaluating Sexual Function After Vaginal Repair With Perineorrhaphy

NCT01779739
View directory record Official record
Conditions
Sexual Function
Interventions
Perineorrhaphy
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
19 Years to 105 Years · Female only
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
2
States / cities
Birmingham, Alabama • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 22, 2018 · Synced Oct 27, 2026, 6:46 PM EDT
Terminated Phase 1Phase 2 Interventional

AuriNovo for Auricular Reconstruction

NCT04399239
View directory record Official record
Conditions
Microtia
Interventions
AuriNovo
Combination Product
Lead sponsor
3DBio Therapeutics
Industry
Eligibility
6 Years to 25 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
2
States / cities
Beverly Hills, California • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 4, 2024 · Synced Oct 27, 2026, 6:46 PM EDT
Terminated Phase 3 Interventional Results available

BAX 802 in CHA With Inhibitors

NCT02895945
View directory record Official record
Conditions
Hemophilia A
Interventions
Antihemophilic Factor (Recombinant), Porcine Sequence (BAX 802)
Biological
Lead sponsor
Baxalta now part of Shire
Industry
Eligibility
12 Years to 75 Years · Male only
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
3
States / cities
Peoria, Illinois • Winston-Salem, North Carolina • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 20, 2021 · Synced Oct 27, 2026, 6:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Autoimmune Dysregulation in Pigmentary Glaucoma

NCT00280345
View directory record Official record
Conditions
Pigmentary Glaucoma, Primary Open Angle Glaucoma, Cataract
Interventions
Trabeculectomy, Trabeculectomy and cataract surgery, Cataract surgery
Procedure
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 85 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 15, 2023 · Synced Oct 27, 2026, 6:46 PM EDT
Active, not recruiting Not applicable Interventional Results available

Cervical Spondylotic Myelopathy Surgical Trial

NCT02076113
View directory record Official record
Conditions
Cervical Spondylosis With Myelopathy
Interventions
Ventral (Front) decompression with Fusion, Dorsal (Back) Decompression with Fusion, Dorsal (back) Laminoplasty
Procedure
Lead sponsor
Lahey Clinic
Other
Eligibility
45 Years to 80 Years
Enrollment
269 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2026
U.S. locations
15
States / cities
San Francisco, California • Atlanta, Georgia • Kansas City, Kansas + 10 more
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Oct 27, 2026, 6:46 PM EDT
Terminated No phase listed Observational Results available

Study of Possible Brain Hormone Problems After Open Heart Surgery in Infants

NCT00850720
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Blood draws
Other
Lead sponsor
Emory University
Other
Eligibility
Up to 1 Year
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 7, 2014 · Synced Oct 27, 2026, 6:46 PM EDT
Terminated Phase 2 Interventional

Emergency Preservation and Resuscitation (EPR) for Cardiac Arrest From Trauma

NCT01042015
View directory record Official record
Conditions
Cardiac Arrest From Trauma
Interventions
Emergency preservation and resuscitation, Standard resuscitation
Combination Product · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Oct 27, 2026, 6:46 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Mandibular Advancement Device (MAD) in Pregnant Women With Obstructive Sleep Apnea (OSA)

NCT06256640
View directory record Official record
Conditions
Obstructive Sleep Apnea of Adult, Pregnancy Related
Interventions
Mandibular advancement Device
Device
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 40 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Oct 27, 2026, 6:46 PM EDT
Completed Phase 4 Interventional

Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Corneal Transplant Surgery

NCT04521140
View directory record Official record
Conditions
Corneal Edema, Corneal Defect, Corneal Transplant, Penetrating KeratoPlasty, Anterior Chamber Inflammation, Ocular Pain, Intraocular Pressure
Interventions
Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate 1% Oph Susp
Drug
Lead sponsor
Nicole Fram M.D.
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Oct 27, 2026, 6:46 PM EDT
Recruiting Not applicable Interventional

A Trial of Hydrus Microstent Versus Goniotomy

NCT06289491
View directory record Official record
Conditions
Glaucoma, Glaucoma, Open-Angle
Interventions
Hydrus Microstent, Incisional goniotomy, Excisional goniotomy
Procedure
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
40 Years to 85 Years
Enrollment
243 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 27, 2026, 6:46 PM EDT
Not yet recruiting No phase listed Observational

Clinical Outcomes After Treatment of Distal Humerus Fractures With the LORRAINE 2.5/3.5 mm Distal Humerus System

NCT07774091
View directory record Official record
Conditions
Intra-Articular or Extra-Articular Distal Humerus Fracture, Distal Humerus Fracture
Interventions
LORRAINE 2.5/3.5 mm Distal Humerus System
Device
Lead sponsor
Bonebridge AG
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 21, 2026 · Synced Oct 27, 2026, 6:46 PM EDT
Terminated Phase 4 Interventional Results available

A Health Economic Trial in Adult Patients Undergoing Open Colectomy MA402S23B301

NCT01507220
View directory record Official record
Conditions
Bowel Obstruction
Interventions
morphine sulfate, bupivacaine liposome extended-release injectable suspension
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 6, 2014 · Synced Oct 27, 2026, 6:46 PM EDT
Completed Phase 1 Interventional

Safety and Pharmacokinetics of Atezolizumab Combination Treatments in Participants With HER2-Positive and HER2-Negative Breast Cancer

NCT02605915
View directory record Official record
Conditions
HER2-Positive Metastatic Breast Cancer, HER2-Negative Metastatic Breast Cancer, Locally Advanced or Early Breast Cancer
Interventions
Atezolizumab, Carboplatin, Docetaxel, Pertuzumab, Trastuzumab, Trastuzumab emtansine, Doxorubicin, Cyclophosphamide
Drug
Lead sponsor
Hoffmann-La Roche
Industry
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
20
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Joliet, Illinois + 17 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2020 · Synced Oct 27, 2026, 6:46 PM EDT
Completed Phase 3 Interventional Results available

Comparison of Efficacy and Safety of TachoSil® Versus Surgicel® Original for the Secondary Hemostatic Treatment of Needle Hole Bleeding in Vascular Surgery

NCT01500135
View directory record Official record
Conditions
Bleeding
Interventions
TachoSil®, Surgicel® Original
Drug
Lead sponsor
Takeda
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
37
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Long Beach, California + 25 more
Source: ClinicalTrials.gov public record
Updated Feb 8, 2017 · Synced Oct 27, 2026, 6:46 PM EDT
Completed Not applicable Interventional Results available

Magnetic Correction of Eye Lid Paralysis

NCT02988856
View directory record Official record
Conditions
Blepharoptosis, Lagophthalmos, Facial Paralysis
Interventions
Magnetic lid system
Device
Lead sponsor
Kevin Houston
Other
Eligibility
5 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 30, 2020 · Synced Oct 27, 2026, 6:46 PM EDT
Terminated Not applicable Interventional Results available

Hemodynamic Response During Goal Directed Fluid Therapy in the OR

NCT02365688
View directory record Official record
Conditions
Hemodynamic Instability
Interventions
Initial bolus pre-incision
Procedure
Lead sponsor
Medtronic - MITG
Industry
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 18, 2017 · Synced Oct 27, 2026, 6:46 PM EDT
Completed Not applicable Interventional Results available

Cryovagotomy Diabetes Trial

NCT04276051
View directory record Official record
Conditions
Diabetes Type 2, Diabetes Mellitus, Obesity
Interventions
Cryoablation of the Vagus Nerve, Lifestyle Intervention
Device · Behavioral
Lead sponsor
Emory University
Other
Eligibility
22 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
5
States / cities
Atlanta, Georgia • Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 8, 2023 · Synced Oct 27, 2026, 6:46 PM EDT
Completed No phase listed Observational Results available

Obtain Additional Information on Use of CorMatrix ECM (Extracellular Matrix)

NCT02073331
View directory record Official record
Conditions
Coronary Disease
Interventions
Not listed
Lead sponsor
Elutia Inc.
Industry
Eligibility
Not listed
Enrollment
1,420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
43
States / cities
Birmingham, Alabama • Glendale, Arizona • Phoenix, Arizona + 36 more
Source: ClinicalTrials.gov public record
Updated Jul 21, 2023 · Synced Oct 27, 2026, 6:46 PM EDT
Completed Early Phase 1 Interventional

Chemokine Modulation Therapy and Pembrolizumab in Treating Participants With Metastatic Triple-Negative Breast Cancer

NCT03599453
View directory record Official record
Conditions
Triple -Negative Breast Cancer, Estrogen Receptor Negative, HER2/Neu Negative, Anatomic Stage IV Breast Cancer AJCC, Progesterone Receptor Negative
Interventions
Biopsy, Chemokine Modulation Therapy, Celecoxib, Recombinant Interferon Alfa-2b, Rintatolimod, Pembrolizumab
Procedure · Drug · Biological
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jul 18, 2023 · Synced Oct 27, 2026, 6:46 PM EDT
Completed Phase 2 Interventional Results available

A Study of the Drug Letermovir (LTV) as Prevention for Recurrent of Cytomegalovirus (CMV) Infection

NCT04017962
View directory record Official record
Conditions
CMV, CMV Infection, Hematopoietic Cell Transplant
Interventions
Letermovir Pill, blood draw
Drug · Other
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
12 Years and older
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
2
States / cities
Minneapolis, Minnesota • New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 11, 2025 · Synced Oct 27, 2026, 6:46 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Preemptive Use of the Nicotine Patch for Postoperative Pain Relief After Open Abdominal Surgery

NCT00790829
View directory record Official record
Conditions
Postoperative Pain
Interventions
transdermal nicotine patch
Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jan 21, 2022 · Synced Oct 27, 2026, 6:46 PM EDT