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ClinicalTrials.gov public records Last synced Nov 11, 2026, 3:43 AM EST

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Showing 1–24 of 53 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Opioid Overdose Education Clear all

Conditions: Overdose, Opioid Use Disorder, HIV Infections
Interventions: Overdose Education and Naloxone Distribution, Advanced Education in Safer Substance Use, Treatment, and Self-Care, Social Service and Health Navigation, Peer Social Support; Behavioral
Lead sponsor: New York University; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Carrying Naloxone/Narcan on Their Person or in Their Vehicle, Being Trained to Respond to an Opioid Overdose
Interventions: Push messages (standard), Push messages (customized); Behavioral
Lead sponsor: Indiana University; Other
Eligibility: Not listed
Enrollment: 5,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Bloomington, Indiana

Conditions: Opioid Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
Interventions: TRTME; Behavioral
Lead sponsor: T. John Winhusen, PhD; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: HIV (Human Immunodeficiency Virus), Substance Abuse Disorder
Interventions: Community Coalition CLS Workgroup/Network of Providers, Tech-mediated Training and Service Delivery, Multidisciplinary Implementation Team with Champion, Tech-mediated Peer Navigation Enhanced Case management (NCM); Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Kingston, New York

Conditions: Opiate Overdose, Opioid-Related Disorders, Narcotic-Related Disorders, Substance-related Disorders, Chemically-Induced Disorders, Mental Disorders
Interventions: Machine Learning-Based Clinical Decision Support: Overdose Prevention Alert (OPA) Intervention; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 674 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Drug Overdose
Interventions: Network overdose prevention, Standard of care health education; Behavioral
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 18 Years and older
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Substance Use, Mental Health Issue, Opioid Use, Medication Assisted Treatment
Interventions: IMANI, Telehealth MAT, Traditional MAT plus Referral and Linkage; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 525 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 8
States / cities: Bridgeport, Connecticut • Hartford, Connecticut • New Britain, Connecticut + 1 more

Conditions: Opioid-Use Disorder (OUD)
Interventions: Team Intervention; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 130 Years
Enrollment: 81 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 2
States / cities: New Haven, Connecticut

Conditions: Substance Use, HIV Infections, HCV Infection, Sexually Transmitted Infections (Not HIV or Hepatitis), Overdose, Drug, Opioid Use
Interventions: Health Linkage, Overdose Education; Behavioral
Lead sponsor: April M Young; Other
Eligibility: 18 Years and older
Enrollment: 234 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Naloxone
Interventions: Nalox-comm Training Module, Prescribe to Prevent: Overdose Prevention and Naloxone Rescue Kits for Prescribers and Pharmacists; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 99 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Asheville, North Carolina

Conditions: Overdose
Interventions: MHC Outreach Intervention; Behavioral
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years and older
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Chronic Pain, Opioid Misuse
Interventions: IPGT, Treatment as Usual; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 64 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Opioid Overdose, Drug Overdose
Interventions: PROVIDENT; Behavioral
Lead sponsor: Brown University; Other
Eligibility: Not listed
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Accidental Overdose of Opiate
Interventions: Overdose prevention resources, Overdose prevention education; Other · Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Opioid Use Disorder
Interventions: ED-LINC; Other
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Opioid Overdose
Interventions: COEST; Behavioral
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Substance Use Disorders, Recidivism
Interventions: Adolescent Community Reinforcement Approach, Assertive Continuing Care, Trauma Affect Regulation Guide for Education and Therapy, Motivational Interviewing, Opioid Education Workbook; Behavioral · Other
Lead sponsor: Seattle Children's Hospital; Other
Eligibility: 15 Years to 25 Years
Enrollment: 215 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Olympia, Washington

Conditions: Upper Extremity Trauma
Interventions: Life Care Specialist (LCS); Behavioral
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 117 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Drug Overdose, Opioid-Related Disorders, Drug Addiction, Drug Abuse, Substance Abuse
Interventions: Peer Intervention, naloxone nasal spray kit, Personally-tailored opioid overdose prevention education (information packet); Behavioral · Drug
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Sports Medicine Injuries
Interventions: LCS (Life Care Specialist), Standard of Care; Behavioral
Lead sponsor: Emory University; Other
Eligibility: 15 Years to 45 Years
Enrollment: 148 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 2
States / cities: Atlanta, Georgia

Conditions: Opioid Use Disorder, Chronic Pain
Interventions: Acceptance and Commitment Therapy + Mindfulness Based Relapse Prevention (ACT + MBRP), Enhance Usual Care (EUC); Behavioral
Lead sponsor: University of New Mexico; Other
Eligibility: 18 Years and older
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 2
States / cities: Ann Arbor, Michigan • Albuquerque, New Mexico

Conditions: Substance Use, HIV Prevention
Interventions: LINKED, Group Intervention; Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 398 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2028
U.S. locations: 3
States / cities: Los Angeles, California • Chicago, Illinois • New York, New York

Conditions: Opioid-use Disorder
Interventions: Treatment Navigation (Intervention), Control; Behavioral · Other
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 70 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 5
States / cities: Auburn, Washington • Burien, Washington • Federal Way, Washington + 2 more

Conditions: Opioid Use Disorder, Pregnancy Related, Substance Use, Drug Abuse, Drug Abuse in Pregnancy, Drug Addiction
Interventions: Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME), Control; Behavioral
Lead sponsor: T. John Winhusen, PhD; Other
Eligibility: 18 Years and older · Female only
Enrollment: 131 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 6
States / cities: Jacksonville, Florida • Pittsburgh, Pennsylvania • Charleston, South Carolina + 3 more

Search by objective public record fields.

Community-based Education, Navigation, and Support Intervention for Military Veterans

The Feasibility of Using the PulsePoint to Facilitate Overdose Education and Naloxone Distribution

TRTME: Improving Outpatient Initiation of Medication for Opioid Use Disorder Following Hospitalization

TechMPower: Advancing HIV/SUD Care and Service Delivery for People in Re-entry

Developing and Evaluating a Machine-Learning Opioid Overdose Prediction & Risk-Stratification Tool in Primary Care

Social Network Overdose Prevention and Education Intervention

Community Driven Substance Use Recovery for High Opioid Overdose Areas

SafetyNet Program for Opioid Use Disorder (OUD)

Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE)

Nalox-Comm: Naloxone Communication Training for Pharmacists

Evaluation of a Medication Health Center to Promote Opioid Safety

Integrative Psychosocial Group Treatment

Preventing Overdose Using Information and Data From the Environment

Remote Intervention to Prevent Overdose

The Emergency Department Longitudinal Integrated Care

Tailoring Overdose Education for Black Churches

Preventing OUD in Justice-Involved Youth

Upper Extremity Life Care Specialist (LCS)

A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses

Effect of Personalized Pain Coaches After Orthopaedic Surgery for Patients With Sports Medicine Injuries

Healing Opioid Misuse and Pain Through Engagement (HOPE) Trial

A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs

Treatment Navigation for Opioid Use Disorder

Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnant and Postpartum Persons in MOUD