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ClinicalTrials.gov public records Last synced Oct 17, 2026, 9:52 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 45 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Opioid Reduction Program Clear all
Completed Not applicable Interventional Results available

Secondary HIV Prevention and Adherence Among HIV-infected Drug Users

NCT01741311
View directory record Official record
Conditions
Risk Behavior, Medication Adherence, HIV
Interventions
3H+ (Holistic Health for HIV), HHRP+ (Holistic Health Recovery Program)
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 8, 2025 · Synced Oct 17, 2026, 9:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Transforming Opioid Prescribing in Primary Care

NCT01909076
View directory record Official record
Conditions
Chronic Pain, Opioid-Related Disorders
Interventions
Electronic decision support tools, Enhanced patient education materials, Nurse care management, Electronic Patient Registry, Academic detailing
Behavioral
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 3, 2016 · Synced Oct 17, 2026, 9:52 PM EDT
Completed No phase listed Observational

The Heroes Circle Opioid Project

NCT03595007
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Kids Kicking Cancer program
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 75 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 30, 2024 · Synced Oct 17, 2026, 9:52 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Living Organ Donor Recovery Enhancement Program

NCT03865264
View directory record Official record
Conditions
Living Liver and Kidney Donors
Interventions
Recovery Enhancement Program
Other
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 17, 2026, 9:52 PM EDT
Completed Not applicable Interventional Results available

EaseVRx for the Reduction of Chronic Pain and Opioid Use

NCT04139564
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
EaseVRx headset, Active control VR sham program
Device
Lead sponsor
AppliedVR Inc.
Industry
Eligibility
18 Years to 64 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Danville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 27, 2024 · Synced Oct 17, 2026, 9:52 PM EDT
Completed Not applicable Interventional Results available

Mindfulness Oriented Recovery Enhancement for Chronic Pain and Opioid Relapse

NCT04491968
View directory record Official record
Conditions
Opioid Use, Chronic Pain
Interventions
Mindfulness Oriented Recovery Enhancement, Methadone Treatment as Usual
Behavioral · Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Oct 17, 2026, 9:52 PM EDT
Completed Not applicable Interventional

Enhancing Permanency in Children and Families

NCT04700696
View directory record Official record
Conditions
Substance Abuse, Substance Use, Child Abuse, Neglect, Child
Interventions
Peer Recovery Support, Family Treatment Drug Court with Medications for Opioid Use Disorders (MOUD), Relational Skill Building based on the Nurturing Parenting Program (NPP)
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
Not listed
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Oct 17, 2026, 9:52 PM EDT
Recruiting Not applicable Interventional

A Unique, Co-Designed Family-Based Therapy

NCT07587359
View directory record Official record
Conditions
Opioid Abuse (Disorder)
Interventions
Adapted Multi-Dimensional Family Therapy, Specialty Treatment Court Program Services
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Oct 17, 2026, 9:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

We The Village Family Support Study

NCT04250077
View directory record Official record
Conditions
Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
Interventions
Community Reinforcement And Family Training (CRAFT), We The Village Peer Community Forum
Behavioral
Lead sponsor
We The Village, Inc.
Other
Eligibility
19 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Oct 17, 2026, 9:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pre-op Cognitive Behavior Therapy to Decrease Chronic Post-Surgical Pain in TKA

NCT04814992
View directory record Official record
Conditions
Chronic Post-Surgical Pain
Interventions
Computer-Assisted Preoperative CBT Intervention (PAINTrainer)
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
22 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
4
States / cities
Philadelphia, Pennsylvania • Radnor, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 17, 2024 · Synced Oct 17, 2026, 9:52 PM EDT
Completed Not applicable Interventional Results available

PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Primary Care Providers

NCT04601506
View directory record Official record
Conditions
Opioid-use Disorder, Opioid Use, Opioid Abuse
Interventions
Choice Architecture Nudge, PMP Integration & Nudge
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
Not listed
Enrollment
472 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 27, 2024 · Synced Oct 17, 2026, 9:52 PM EDT
Completed Not applicable Interventional

Opioid Reduction Program for Total Knee Replacement Patients

NCT05414942
View directory record Official record
Conditions
Knee Injuries, Knee Injuries and Disorders, Opioid Use
Interventions
Opioid Reduction Program
Behavioral
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Oct 17, 2026, 9:52 PM EDT
Recruiting Not applicable Interventional

Adaptive Interventions for Emergency Department Patients With Opioid Use Disorder

NCT06827288
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
SUN, SUN + Telebridge, ED-ITT, ED-ITT + BHS
Behavioral
Lead sponsor
RAND
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Colton, California
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Oct 17, 2026, 9:52 PM EDT
Completed Not applicable Interventional Results available

PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Current Opioid-User Population

NCT04601480
View directory record Official record
Conditions
Opioid-use Disorder, Opioid Use, Opioid Abuse
Interventions
Choice Architecture Nudge, PMP Integration & Nudge
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
Not listed
Enrollment
309 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Oct 17, 2026, 9:52 PM EDT
Completed Not applicable Interventional Results available

Life Care Specialists (LCS) With a Focus on Patient Pain Management and Prevention of Substance Misuse

NCT04154384
View directory record Official record
Conditions
Opioid Use
Interventions
Life Care Specialist (LCS) Intervention, Clinical Coordination with Referrals, Pilot Study of Pain Management Strategies
Behavioral · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
333 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Oct 17, 2026, 9:52 PM EDT
Completed Not applicable Interventional

Virtual Reality Trial Using EaseVRx For Chronic Low Back Pain

NCT04415177
View directory record Official record
Conditions
Chronic Lower Back Pain
Interventions
EaseVRx headset with active intervention, EaseVRx headset without active intervention
Device
Lead sponsor
AppliedVR Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
188 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 11, 2022 · Synced Oct 17, 2026, 9:52 PM EDT
Completed Not applicable Interventional

TechMPower: Advancing HIV/SUD Care and Service Delivery for People in Re-entry

NCT07088770
View directory record Official record
Conditions
HIV (Human Immunodeficiency Virus), Substance Abuse Disorder
Interventions
Community Coalition CLS Workgroup/Network of Providers, Tech-mediated Training and Service Delivery, Multidisciplinary Implementation Team with Champion, Tech-mediated Peer Navigation Enhanced Case management (NCM)
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Kingston, New York
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 17, 2026, 9:52 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses

NCT07631598
View directory record Official record
Conditions
Opioid Use Disorder, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate
Interventions
Standard of Care Referral, Low Threshold Buprenorphine
Other · Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
512 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
8
States / cities
Los Angeles, California • Washington D.C., District of Columbia • Baton Rouge, Louisiana + 5 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 17, 2026, 9:52 PM EDT
Completed Not applicable Interventional Results available

Cognitive Behavioral Therapy and Chronic Pain Self-Management Within the Context of Opioid Reduction: The EMPOWER Study

NCT03445988
View directory record Official record
Conditions
Chronic Pain
Interventions
Cognitive Behavioral Therapy, Chronic Pain Self Management Program, Taper Only
Behavioral · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 85 Years
Enrollment
1,462 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 17, 2026, 9:52 PM EDT
Active, not recruiting Not applicable Interventional

Counseling for Harm Reduction and Retention in Medication-assisted Treatment - Cherokee Nation

NCT05733442
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Treatment as usual (TAU), CHaRRM-CN
Other
Lead sponsor
Washington State University
Other
Eligibility
18 Years and older
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Tahlequah, Oklahoma • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 17, 2026, 9:52 PM EDT
Active, not recruiting Not applicable Interventional

Open Pilot Trial of Adapted Cognitive Processing Therapy for Comorbid PTSD and Opioid Use Disorder

NCT06872164
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Opioid Use Disorder
Interventions
Cognitive Processing Therapy
Behavioral
Lead sponsor
The City College of New York
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 17, 2026, 9:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigating Interventions to Reduce Residual Opioids in the Home Following Legitimate Opioid Prescribing in Children.

NCT04219397
View directory record Official record
Conditions
Opioid Use, Unspecified
Interventions
Medication take back, Medication home disposal
Other
Lead sponsor
Indiana University
Other
Eligibility
12 Years to 18 Years
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Indianapolis, Indiana • New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Feb 15, 2024 · Synced Oct 17, 2026, 9:52 PM EDT
Completed Not applicable Interventional

Evaluation of Pain Neuroscience Education for Patients Who Experience Chronic Pain With Concurrent Opioid Dependence

NCT06442306
View directory record Official record
Conditions
Chronic Pain, Opioid Dependence
Interventions
Pain Neuroscience Education, General Health Education
Other
Lead sponsor
Wichita State University
Other
Eligibility
18 Years to 95 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 4, 2024 · Synced Oct 17, 2026, 9:52 PM EDT
Completed Not applicable Interventional Results available

Feasibility and Preliminary Efficacy of an Opioid Stewardship Program in Hospitalized Patients With Chronic Pain

NCT05370326
View directory record Official record
Conditions
Opioid Dependence, Chronic Pain
Interventions
Enhanced Opioid Stewardship Program
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 5, 2024 · Synced Oct 17, 2026, 9:52 PM EDT