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Showing 1–18 of 18 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Oral L-citrulline Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Oral L-Citrulline and ADMA in Pregnancy

NCT00743210
View directory record Official record
Conditions
Blood Pressure
Interventions
L-citrulline, Placebo
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years to 40 Years · Female only
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 15, 2014 · Synced Sep 25, 2026, 3:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of 4 Weeks of Citrulline and Glutathione Supplementation on Arterial Function

NCT04672447
View directory record Official record
Conditions
Menopause, Cardiovascular Risk Factor
Interventions
L-Citrulline, Placebo, Glutathione
Dietary Supplement
Lead sponsor
Texas Tech University
Other
Eligibility
50 Years to 79 Years · Female only
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Sep 25, 2026, 3:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of 4 Weeks of L-Citrulline Supplementation on Macro- and Microvascular Function in Type 2 Diabetes

NCT06016478
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
L-citrulline, Placebo
Dietary Supplement
Lead sponsor
Texas Tech University
Other
Eligibility
40 Years to 75 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Sep 25, 2026, 3:51 PM EDT
Withdrawn Phase 1 Interventional

A Study of Oral L-citrulline in Sickle Cell Disease

NCT02659644
View directory record Official record
Conditions
Sickle Cell Disease
Interventions
Oral L-citrulline
Drug
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
10 Years to 25 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Jun 20, 2018 · Synced Sep 25, 2026, 3:51 PM EDT
Suspended Phase 1 Interventional Accepts healthy volunteers

Role of L-citrulline in Prevention of Pregnancy Associated Hypertension

NCT04979793
View directory record Official record
Conditions
Pregnancy Induced Hypertension, Preeclampsia and Eclampsia, Gestational Hypertension
Interventions
L-citrulline, Placebo
Drug
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years and older · Female only
Enrollment
338 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Sep 25, 2026, 3:51 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Nitric Oxide Production in MELAS Syndrome

NCT01339494
View directory record Official record
Conditions
MELAS Syndrome
Interventions
Arginine and citrulline supplementations
Dietary Supplement
Lead sponsor
Baylor College of Medicine
Other
Eligibility
3 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 4, 2016 · Synced Sep 25, 2026, 3:51 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

COMP-4 Supplementation and Brachial Artery FMD

NCT05595915
View directory record Official record
Conditions
Aging, Endothelial Dysfunction, Senescence
Interventions
COMP-4
Dietary Supplement
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 39 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Sep 25, 2026, 3:51 PM EDT
Completed Phase 1Phase 2 Interventional

Watermelon Supplementation and Arterial Stiffness

NCT01185041
View directory record Official record
Conditions
Hypertension
Interventions
Watermelon Extract
Dietary Supplement
Lead sponsor
Florida State University
Other
Eligibility
45 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Mar 19, 2012 · Synced Sep 25, 2026, 3:51 PM EDT
Completed Phase 2 Interventional

Chemotherapy Toxicity Reduction Via Urea Cycle Support

NCT00223730
View directory record Official record
Conditions
Cancer
Interventions
Citrulline, Placebo
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
13 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 1, 2016 · Synced Sep 25, 2026, 3:51 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

L-Citrulline and Endothelial Function

NCT05722860
View directory record Official record
Conditions
Aging
Interventions
L-Citrulline, capsule
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Sep 25, 2026, 3:51 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes

NCT03885245
View directory record Official record
Conditions
Asthma, Obesity
Interventions
L-ctirulline, Matching Placebo
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 9, 2025 · Synced Sep 25, 2026, 3:51 PM EDT
Not listed Phase 1 Interventional

PK and PD Responses to Oral L-Citrulline in Patients With Sickle Cell Disease

NCT00343954
View directory record Official record
Conditions
Sickle Cell Disease
Interventions
L-citrulline tablets, 1000 mg
Drug
Lead sponsor
Angiogenix
Industry
Eligibility
10 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 22, 2006 · Synced Sep 25, 2026, 3:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Setria Performance Blend Supplementation

NCT04090138
View directory record Official record
Conditions
Healthy
Interventions
Setria performance blend, Placebo
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
20 Years to 30 Years · Male only
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 19, 2021 · Synced Sep 25, 2026, 3:51 PM EDT
Terminated Early Phase 1 Interventional Results available

L-citrulline and Pulmonary Hypertension Associated With Bronchopulmonary Dysplasia

NCT03542812
View directory record Official record
Conditions
Infant,Premature, Bronchopulmonary Dysplasia, Pulmonary Hypertension
Interventions
L-Citrulline
Drug
Lead sponsor
University of Utah
Other
Eligibility
14 Days to 3 Months
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 9, 2024 · Synced Sep 25, 2026, 3:51 PM EDT
Terminated Not applicable Interventional

Nutraceutical Citrulline in Pregnancy

NCT02772887
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
L-Citrulline, Placebo
Dietary Supplement · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years to 40 Years · Female only
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 29, 2019 · Synced Sep 25, 2026, 3:51 PM EDT
Not yet recruiting Phase 3 Interventional

A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive Crisis

NCT06989567
View directory record Official record
Conditions
Sickle Cell Disease
Interventions
L-citrulline, Placebo
Drug · Other
Lead sponsor
Asklepion Pharmaceuticals, LLC
Industry
Eligibility
6 Years to 21 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
6
States / cities
Washington D.C., District of Columbia • Coral Gables, Florida • Atlanta, Georgia + 3 more
Source: ClinicalTrials.gov public record
Updated May 28, 2025 · Synced Sep 25, 2026, 3:51 PM EDT
Active, not recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Effect of a Daily Supplement on Plasma PAI-1 Levels

NCT07469475
View directory record Official record
Conditions
Aging, Endothelial Dysfunction, Senescence
Interventions
Supplement with ginger extract, L-citrulline, Paullinia cupana, and muira puama
Dietary Supplement
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
2
States / cities
Los Angeles, California • Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 25, 2026, 3:51 PM EDT
Recruiting Phase 2 Interventional

Study to Improve Deployment Related Asthma by Using L-Citrulline Supplementation

NCT05259904
View directory record Official record
Conditions
Post Deployment Related Asthma, Asthma
Interventions
L-citrulline, Placebo
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 70 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 5, 2023 · Synced Sep 25, 2026, 3:51 PM EDT