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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:02 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 73–96 of 100 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Oral Probiotics Clear all

Conditions: Periodontitis, Probiotic, Oral Hygiene, Oral Health, Periodontal Therapy
Interventions: non surgical periodontal therapy; Procedure
Lead sponsor: Medipol University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Healthy Aging, Anti Aging
Interventions: Bifidobacterium adolescentis iVS-1, Placebo; Dietary Supplement
Lead sponsor: Synbiotic Health; Industry
Eligibility: 40 Years to 75 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New Port Richey, Florida

Conditions: Alzheimer Disease
Interventions: Probiotic, Placebo; Drug · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 60 Years and older
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Bipolar Depression
Interventions: Probiotic Supplement, Inert Compound; Biological
Lead sponsor: Sheppard Pratt Health System; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: Towson, Maryland

Conditions: Schizophrenia, Schizoaffective Disorder
Interventions: Probiotic Supplement, Identical-appearing Placebo; Dietary Supplement
Lead sponsor: Sheppard Pratt Health System; Other
Eligibility: 18 Years to 65 Years
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Towson, Maryland

Conditions: HIV-1 Infection
Interventions: Visbiome Extra Strength, Placebo; Drug
Lead sponsor: Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections; Network
Eligibility: 18 Years and older
Enrollment: 93 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 24
States / cities: Birmingham, Alabama • Los Angeles, California • San Diego, California + 18 more

Conditions: Bacteriuria
Interventions: Lactobacillus reuteri RC-14 and Lactobacillus rhamnosus GR-1; Dietary Supplement
Lead sponsor: Baylor College of Medicine; Other
Eligibility: Up to 18 Years · Female only
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Menopausal Osteoporosis
Interventions: VSL#3, Placebo; Drug · Other
Lead sponsor: Emory University; Other
Eligibility: 50 Years to 65 Years · Female only
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Childhood Obesity, Maternal Obesity During Childbirth, Insulin Resistance, Inflammation
Interventions: Probiotics, Placebo; Dietary Supplement
Lead sponsor: Arkansas Children's Hospital Research Institute; Other
Eligibility: 18 Years and older · Female only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Antibiotic-associated Diarrhea
Interventions: Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet, BB-12, Control; Drug · Biological · Other
Lead sponsor: Georgetown University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Prosthetic-joint Infection
Interventions: Culturelle Digestive Daily Probiotic Capsule; Dietary Supplement
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 90 Years
Enrollment: 152 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Radiation Injuries
Interventions: Pendulum Glucose Control (PGC); Biological
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Chronic Pain, Body Mass Index >=85th Percentile
Interventions: Lactobacillus Plantarum; Dietary Supplement
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 13 Years to 17 Years
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Mental Health Wellness
Interventions: Lactobacillus reuteri, Placebo; Dietary Supplement · Other
Lead sponsor: Elizabeth Austen Lawson; Other
Eligibility: 18 Years and older · Female only
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Healthy Adult Subjects
Interventions: Complex oligosaccharide, Probiotic, PPI, H2 Blocker; Dietary Supplement · Other
Lead sponsor: Prolacta Bioscience; Industry
Eligibility: 18 Years to 44 Years
Enrollment: 62 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020
U.S. locations: 1
States / cities: Cypress, California

Conditions: Healthy, Elderly
Interventions: Lactobacillus Rhamnosus GG, ATCC 53103 (LGG); Biological
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 65 Years to 80 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Gastrointestinal Discomfort, Bloating
Interventions: Active: Multi-strain probiotic dietary supplement, Placebo: Placebo; Dietary Supplement
Lead sponsor: Daily Nouri; Industry
Eligibility: 25 Years to 45 Years · Female only
Enrollment: 160 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Ventilator Associated Pneumonia, Infections, C-Difficile, Antibiotic-associated Diarrhea, Diarrhea
Interventions: L. rhamnosus GG - Probiotic, Placebo - Microcrystalline Cellulose; Drug
Lead sponsor: McMaster University; Other
Eligibility: 18 Years and older
Enrollment: 2,650 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 2
States / cities: Rochester, Minnesota • St Louis, Missouri

Conditions: Autism
Interventions: Synbiotic, Prebiotic; Dietary Supplement
Lead sponsor: University of California, Davis; Other
Eligibility: 2 Years to 11 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Healthy
Interventions: Placebo, Dietary Supplement with actives; Dietary Supplement
Lead sponsor: Olly, PBC; Industry
Eligibility: 18 Years to 50 Years
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: St. Petersburg, Florida

Conditions: Antibiotic-associated Diarrhea
Interventions: Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet, BB-12, Control Yogurt; Drug · Biological · Other
Lead sponsor: Georgetown University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 118 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Clostridium Difficile Infection
Interventions: FZ002, Placebo for FZ002; Biological · Other
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 18 Years to 75 Years
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Knoxville, Tennessee

Conditions: Enteric Hyperoxaluria
Interventions: SYNB8802v1, Placebo; Drug · Other
Lead sponsor: Synlogic; Industry
Eligibility: 18 Years to 74 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Group B Streptococcus Carrier in Childbirth, Gastrointestinal Symptoms
Interventions: Florajen3; Biological
Lead sponsor: Marquette University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 109 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Search by objective public record fields.

Patient-Reported Probiotic Use During Periodontal Therapy in Periodontitis

iVS-1 Probiotic Intervention Targeting Biological Aging in Midlife Adults

The Gut - PRO Study

Probiotics to Prevent Relapse After Hospitalization for Bipolar Depression

Double-Blind Trial of a Probiotic Supplement to Reduce the Symptoms of Schizophrenia

Effects of the Probiotic Visbiome Extra Strength on Gut Microbiome & Immune Activation Markers

Bacteriuria Eradication Through Probiotics

Effect of VSL#3 on Bone Mineral Density in Postmenopausal Women

Prenatal Probiotic Intervention

Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics

The Effect of Peri-Operative Adjunctive Probiotics on Immunological Markers in Cases of Prosthetic Joint Infection of the Hip and Knee

Oral 5 Strain Probiotic for GI Toxicity Mitigation During Pelvic Radiation

Probiotics for Inflammation in Pediatric Chronic Pain

Study of Probiotic Use After Childbirth in Relation to Emotional Well-Being

Dietary Supplement With and Without a Probiotic

Study to Evaluate the Safety of Lactobacillus Rhamnosus GG ATCC 53103 (LGG) in Elderly Subjects

Multi-strain Probiotic Supplement for Digestive Comfort and Well-being in Healthy Women

Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial

Effect of Milk Oligosaccharides and Bifidobacteria on the Intestinal Microflora of Children With Autism

Clinical Study to Assess the Effects of Prebiotic and Probiotic Supplement

Mechanisms of Probiotics and Antibiotic-Associated Diarrhea

A Safety Trial to Evaluate an Orally Ingested Yeast Modified to Express a Tetra-specific Anti-toxin for Clostridioides Difficile

Safety, Tolerability, and Pharmacodynamics of SYNB8802v1 in Subjects With History of Gastric Bypass Surgery or Short-bowel Syndrome

The Efficacy of Probiotics to Reduce Antepartum Group B Streptococcus Colonization.