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ClinicalTrials.gov public records Last synced Oct 9, 2026, 1:46 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 303 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Osteoarthritis Intervention Clear all
Active, not recruiting Not applicable Interventional

Non-Surgical Management of Knee Osteoarthritis in the Military Health System (MHS)

NCT03747393
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
DoD/VA CPG Core Set + PT, DoD/VA CPG Core Set
Behavioral
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 60 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
3
States / cities
San Antonio, Texas • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 9, 2026, 1:46 PM EDT
Active, not recruiting No phase listed Observational

Inflammatory Response Following Intraarticular Fracture

NCT01514643
View directory record Official record
Conditions
Intraarticular Fracture and Post-traumatic Osteoarthritis
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2028
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 9, 2026, 1:46 PM EDT
Completed Not applicable Interventional

The Arthritis, Diet, and Activity Promotion Trial

NCT00979043
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Dietary Weight-loss, Exercise
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
60 Years and older
Enrollment
318 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2000
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 14, 2023 · Synced Oct 9, 2026, 1:46 PM EDT
Completed Not applicable Interventional Results available

Pain Relief for OsteoArthritis Through Combined Treatment (PROACT)

NCT03884374
View directory record Official record
Conditions
Osteoarthritis of Knee
Interventions
Focused Breathing and Attention Training (BAT), Standard Breathing and Attention Training (BAT), Transcranial Direct Current Stimulation (tDCS), Sham Transcranial Direct Current Stimulation (tDCS)
Behavioral · Device
Lead sponsor
University of Florida
Other
Eligibility
45 Years to 85 Years
Enrollment
317 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
2
States / cities
Birmingham, Alabama • Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 15, 2025 · Synced Oct 9, 2026, 1:46 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Therapeutic Joint Arthrocentesis on Pain and Quadriceps Function in Patients With Knee Osteoarthritis

NCT04146649
View directory record Official record
Conditions
Effusion Joint
Interventions
Arthrocentesis
Procedure
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
2
States / cities
Aurora, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 31, 2023 · Synced Oct 9, 2026, 1:46 PM EDT
Active, not recruiting Phase 4 Interventional

Corticosteroid Meniscectomy Randomized Trial

NCT04641351
View directory record Official record
Conditions
Osteoarthritis, Knee, Meniscus Tear, Meniscus; Degeneration, Synovitis
Interventions
Zilretta Injectable Product or Placebo
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
40 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 9, 2026, 1:46 PM EDT
Completed Not applicable Interventional

Local Infiltration Analgesia Vs. Interscalene Block in Total Shoulder Arthorplasty

NCT04415931
View directory record Official record
Conditions
Shoulder Osteoarthritis, Cuff Tear Arthropathy, Massive Rotator Cuff Tear
Interventions
Local infiltration analgesia, Interscalene block
Procedure
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 14, 2023 · Synced Oct 9, 2026, 1:46 PM EDT
Completed Not applicable Interventional

Capsulectomy vs Capsulotomy With Repair in Direct Anterior Total Hip Arthroplasty

NCT02121964
View directory record Official record
Conditions
Hip Arthrosis, Osteoarthritis, Arthritis
Interventions
Capsulectomy in Direct Anterior Total Hip Arthroplasty, Capsulotomy in Direct Anterior Total Hip Arthroplasty
Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 31, 2020 · Synced Oct 9, 2026, 1:46 PM EDT
Recruiting Phase 3 Interventional

Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis

NCT07339111
View directory record Official record
Conditions
Knee Cartilage Defects
Interventions
CARTISTEM® + Debridement, Debridement
Biological · Procedure
Lead sponsor
Medipost, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
31
States / cities
Birmingham, Alabama • Scottsdale, Arizona • Tempe, Arizona + 26 more
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 9, 2026, 1:46 PM EDT
Completed Not applicable Interventional

Race and Preference for Knee Replacement: A Patient-Centered Intervention

NCT02413411
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
DA/MI Intervention, an educational program (an NIH-developed booklet)
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
50 Years and older
Enrollment
493 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 9, 2015 · Synced Oct 9, 2026, 1:46 PM EDT
Completed Phase 2 Interventional Results available

Study to Evaluate a Procedure for Intra-articular Injection of FX006 in Patients With Osteoarthritis of the Hip

NCT04065074
View directory record Official record
Conditions
Osteoarthritis, Hip
Interventions
FX006 32 mg
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
40 Years to 80 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
5
States / cities
Tucson, Arizona • Canoga Park, California • La Mesa, California + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 24, 2024 · Synced Oct 9, 2026, 1:46 PM EDT
Active, not recruiting Not applicable Interventional

Early Feasibility Study of Cartilage Defect Repair

NCT06823089
View directory record Official record
Conditions
Osteoarthritis, Hip, Femoroacetabular Impingement, Osteonecrosis, Legg-Calvé-Perthes Disease, Osteochondral Lesion, Hip Dysplasia
Interventions
ReNew Hip Implant
Device
Lead sponsor
Cytex Therapeutics, Inc.
Other
Eligibility
14 Years to 64 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 9, 2026, 1:46 PM EDT
Active, not recruiting No phase listed Observational

Post Market Follow-Up Study of the EVOLUTION® Total Knee Arthroplasty System With Cruciate Sacrificing Inserts

NCT02351414
View directory record Official record
Conditions
Joint Disease
Interventions
Total Knee Arthroplasty (EVOLUTION®)
Device
Lead sponsor
MicroPort Orthopedics Inc.
Industry
Eligibility
21 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2028
U.S. locations
1
States / cities
Morton Grove, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 13, 2022 · Synced Oct 9, 2026, 1:46 PM EDT
Withdrawn Phase 1Phase 2 Interventional Accepts healthy volunteers

Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis

NCT05742763
View directory record Official record
Conditions
Osteoarthritis of the Knee, Degenerative Osteoarthritis, Knee Pain Chronic
Interventions
Ibuprofen and PRP, Acetaminophen and PRP, Placebo and PRP
Combination Product
Lead sponsor
QC Kinetix LLC
Industry
Eligibility
50 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 9, 2024 · Synced Oct 9, 2026, 1:46 PM EDT
Recruiting Not applicable Interventional

Remote Tai Chi for Knee Osteoarthritis

NCT06384898
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Remote Tai Chi
Other
Lead sponsor
Tufts Medical Center
Other
Eligibility
50 Years to 100 Years
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 9, 2026, 1:46 PM EDT
Recruiting Not applicable Interventional

Focused Extracorporeal Shockwave Therapy for Knee Arthritis

NCT05596591
View directory record Official record
Conditions
Bone Marrow Edema, Knee Osteoarthritis, Knee Pain Chronic
Interventions
Focused extracorporeal shockwave therapy
Device
Lead sponsor
Kessler Foundation
Other
Eligibility
30 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Cedar Knolls, New Jersey • West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 9, 2026, 1:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Feasibility of High Intensity Interval Training in Knee Osteoarthritis

NCT03281668
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
High intensity interval training (HIIT)
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
40 Years to 75 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 22, 2019 · Synced Oct 9, 2026, 1:46 PM EDT
Not yet recruiting Not applicable Interventional

Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia

NCT06264362
View directory record Official record
Conditions
Pain, Chronic, Dementia, Mild, Mobility Limitation, Physical Disability, Osteo Arthritis Knee, Mild Cognitive Impairment
Interventions
Tailored Physical Activity Program
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
60 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Oct 9, 2026, 1:46 PM EDT
Completed Not applicable Interventional Results available

Increasing Physical Activity in Older Adults With Osteoarthritis Pain: Examining a Brief Behavioral Intervention

NCT04490395
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions
Engage PA, Treatment as Usual plus (TAU+)
Behavioral · Other
Lead sponsor
Duke University
Other
Eligibility
65 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 5, 2023 · Synced Oct 9, 2026, 1:46 PM EDT
Not listed Not applicable Interventional

Long-Term Multicenter Evaluation of the E1® Tibial Bearing

NCT01374230
View directory record Official record
Conditions
Osteoarthritis of the Knee, Traumatic Arthritis of the Knee
Interventions
Total knee arthroplasty
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
20 Years to 75 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 30, 2018 · Synced Oct 9, 2026, 1:46 PM EDT
Not listed Not applicable Interventional

Impact of Sensor Technology in Knee OA

NCT05222503
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Knee Brace + OPUM Digital Knee, Knee Brace
Device
Lead sponsor
OPUM Technologies US LTD
Other
Eligibility
40 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 3, 2022 · Synced Oct 9, 2026, 1:46 PM EDT
Completed Not applicable Interventional Results available

Development of an Osteoarthritis (OA) Care Plan to Improve Process and Quality of OA Treatment Decisions

NCT03102580
View directory record Official record
Conditions
Osteo Arthritis Knee, Osteoarthritis, Hip
Interventions
OA Care Plan
Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
40 Years to 99 Years
Enrollment
5,713 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Oct 9, 2026, 1:46 PM EDT
Terminated Phase 1 Interventional

CAM Procedure With BMAC for Shoulder OA

NCT04826224
View directory record Official record
Conditions
Shoulder Osteoarthritis
Interventions
Concentrated bone marrow aspirate administration after Comprehensive Arthroscopic Management (CAM) surgical procedure.
Biological
Lead sponsor
Shane A. Shapiro
Other
Eligibility
50 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Oct 9, 2026, 1:46 PM EDT
Enrolling by invitation No phase listed Observational

Post Market Clinical Follow-Up Study for PROFEMUR® Preserve Classic Femoral Stem

NCT04147559
View directory record Official record
Conditions
Joint Diseases
Interventions
Total Hip Arthroplasty Implant
Device
Lead sponsor
MicroPort Orthopedics Inc.
Industry
Eligibility
21 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2033
U.S. locations
2
States / cities
Scottsdale, Arizona • Englewood, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 20, 2024 · Synced Oct 9, 2026, 1:46 PM EDT