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ClinicalTrials.gov public records Last synced Oct 14, 2026, 1:17 PM EDT

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Showing 169–192 of 303 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Osteoarthritis Intervention Clear all
Not yet recruiting Not applicable Interventional

Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines

NCT07142369
View directory record Official record
Conditions
Posttraumatic Osteoarthritis, Anterior Cruciate Ligament (ACL) Rupture
Interventions
Synovial Fluid withdrawal at the preoperative clinic visit, Platelet-Rich Plasma (PRP) preparation and injection, Synovial fluid withdrawal at the time of surgery, 3mL synovial fluid withdrawn at the preoperative visit
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 50 Years
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 14, 2026, 1:17 PM EDT
Enrolling by invitation No phase listed Observational

A Post Approval Multicenter 10 Year Follow-up Observational Trial of Marketed Product - MP01 vs. Surgical Standard of Care (SSOC) Used for the Treatment of Joint Surface Lesions of the Knee

NCT06916728
View directory record Official record
Conditions
Knee Injuries, Joint Surface Knee Lesions
Interventions
Marketed Product - MP01, Surgical Standard of Care
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
La Mesa, California
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 14, 2026, 1:17 PM EDT
Recruiting Not applicable Interventional

Sleep TO Prevent Post-surgical Pain

NCT06976138
View directory record Official record
Conditions
Knee Osteoarthristis
Interventions
Cognitive-Behavioral Therapy for Insomnia, Bright Light therapy via the Re-Timer®, Negative Ion exposure via IonMi Device, Sleep / Knee Osteoarthritis Education
Behavioral · Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
60 Years and older
Enrollment
252 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
2
States / cities
Baltimore, Maryland • Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 14, 2026, 1:17 PM EDT
Active, not recruiting Not applicable Interventional

Early Feasibility Study of Cartilage Defect Repair

NCT06823089
View directory record Official record
Conditions
Osteoarthritis, Hip, Femoroacetabular Impingement, Osteonecrosis, Legg-Calvé-Perthes Disease, Osteochondral Lesion, Hip Dysplasia
Interventions
ReNew Hip Implant
Device
Lead sponsor
Cytex Therapeutics, Inc.
Other
Eligibility
14 Years to 64 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 14, 2026, 1:17 PM EDT
Completed Not applicable Interventional Results available

Genicular Artery Embolization for the Treatment of Knee Osteoarthritis

NCT03491397
View directory record Official record
Conditions
Knee Osteoarthritis, Degenerative Joint Disease of Knee
Interventions
Embozene MicroSpheres
Device
Lead sponsor
Siddharth Padia, MD
Other
Eligibility
40 Years to 79 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Nov 30, 2022 · Synced Oct 14, 2026, 1:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Osteoarthritis Care Tools for Primary Care Providers

NCT06988163
View directory record Official record
Conditions
Arthritis, Osteo Arthritis Knee
Interventions
OACareTools+
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 14, 2026, 1:17 PM EDT
Not listed Not applicable Interventional

Exercise Adherence Among Older Adults With Osteoarthritis

NCT00421681
View directory record Official record
Conditions
Osteoarthritis
Interventions
Fit and Strong! Exercise Program
Behavioral
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
60 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 14, 2009 · Synced Oct 14, 2026, 1:17 PM EDT
Completed Not applicable Interventional Results available

Geniculate Artery Embolization for Treatment of Osteoarthritis

NCT04379700
View directory record Official record
Conditions
Osteoarthritis
Interventions
Transcatheter arterial embolization, Embozene™ Microspheres
Procedure · Device
Lead sponsor
NYU Langone Health
Other
Eligibility
30 Years to 80 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 18, 2025 · Synced Oct 14, 2026, 1:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mobilizing Hispanics With Knee Osteoarthritis

NCT06522906
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Muscle Strengthening, General Physical Activity, Education
Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 90 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 14, 2026, 1:17 PM EDT
Recruiting Not applicable Interventional

Knee Biofeedback Rehabilitation Through Game Therapy

NCT06090097
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
KneeBRIGHT System, Control Exercise
Device · Other
Lead sponsor
Barron Associates, Inc.
Industry
Eligibility
30 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 3, 2025 · Synced Oct 14, 2026, 1:17 PM EDT
Recruiting Not applicable Interventional

Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial

NCT06887829
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Low dose radiotherapy, Sham comparator
Radiation · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
50 Years to 100 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 14, 2026, 1:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

TENS Effectiveness and Knee Osteoarthritis in Humans

NCT01354054
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
High Frequency TENS, Low frequency TENS, Placebo TENS
Procedure
Lead sponsor
University of Iowa
Other
Eligibility
30 Years to 95 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated May 16, 2011 · Synced Oct 14, 2026, 1:17 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Knee

NCT02844751
View directory record Official record
Conditions
Osteoarthritis
Interventions
[StroMed + platelet rich plasma (PRP)], [PRP] platelet rich plasma
Biological
Lead sponsor
VivaTech International, Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
4,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2026
U.S. locations
1
States / cities
Grove City, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 14, 2026, 1:17 PM EDT
Active, not recruiting Not applicable Interventional

Non-Surgical Management of Knee Osteoarthritis in the Military Health System (MHS)

NCT03747393
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
DoD/VA CPG Core Set + PT, DoD/VA CPG Core Set
Behavioral
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 60 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
3
States / cities
San Antonio, Texas • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 14, 2026, 1:17 PM EDT
Completed No phase listed Observational Results available

Multi-center Prospective Study to Evaluate Outcomes of the Moderate to Severely Calcified Coronary Lesions (MACE)

NCT01930214
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Percutaneous Coronary Intervention
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
34
States / cities
Little Rock, Arkansas • Glendale, California • Hartford, Connecticut + 30 more
Source: ClinicalTrials.gov public record
Updated Jul 18, 2023 · Synced Oct 14, 2026, 1:17 PM EDT
Recruiting No phase listed Observational

geniculaR Artery eMBolization for Knee Osteoarthritis (RAMBO) Registry

NCT07380906
View directory record Official record
Conditions
Knee Osteoarthristis
Interventions
Genicular Artery Embolization
Procedure
Lead sponsor
Joint & Vascular Institute
Industry
Eligibility
18 Years and older
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Libertyville, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 14, 2026, 1:17 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Knee Osteoarthritis Rehabilitation Through Rotational Inertia

NCT07424352
View directory record Official record
Conditions
Knee Arthritis, Osteoarthritis
Interventions
Eccentric resistance training
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
40 Years to 70 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Oct 14, 2026, 1:17 PM EDT
Completed Not applicable Interventional

Use of a Self-Guided Mindfulness Mobile Application to Improve Pain Outcomes in Individuals With Knee Osteoarthritis

NCT03936088
View directory record Official record
Conditions
Osteo Arthritis Knee, Pain
Interventions
Intervention -- "Headspace" mindfulness application, Control -- "My Water Balance" application
Device
Lead sponsor
jilliansylvester
Federal
Eligibility
18 Years to 74 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Scott Air Force Base, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 13, 2022 · Synced Oct 14, 2026, 1:17 PM EDT
Recruiting Phase 1 Interventional

Methylene Blue in Total Knee Arthroplasty (TKA)

NCT07324954
View directory record Official record
Conditions
Total Knee Arthroplasty, Prosthetic-joint Infection, Irrigation
Interventions
Methylene Blue 10 MG/ML (intra-articular application), Revision Arthroplasty for PJI (DAIR), Primary Total Knee Arthroplasty
Drug · Procedure
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Oct 14, 2026, 1:17 PM EDT
Not listed No phase listed Observational

Survivorship and Outcomes of Robotically Assisted Patellofemoral UKA

NCT01947686
View directory record Official record
Conditions
Patellofemoral Knee Arthroplasty
Interventions
Robotically guided patellofemoral UKA isolated patellofemoral implants
Device
Lead sponsor
St. Helena Hospital Coon Joint Replacement Institute
Other
Eligibility
21 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2023
U.S. locations
2
States / cities
St. Helena, California • Vancouver, Washington
Source: ClinicalTrials.gov public record
Updated Sep 5, 2018 · Synced Oct 14, 2026, 1:17 PM EDT
Enrolling by invitation Not applicable Interventional

Glenohumeral OsteoArthritis Therapy Trial

NCT07744542
View directory record Official record
Conditions
Glenohumeral Arthritis, Shoulder Arthritis Osteoarthritis
Interventions
Physical therapy, Home physical therapy
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 14, 2026, 1:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Hip and Core Muscle Strengthening for Patellofemoral Osteoarthritis: A Feasibility Study

NCT02825238
View directory record Official record
Conditions
Patellofemoral Osteoarthritis
Interventions
Supervised exercise program
Other
Lead sponsor
University of the Sciences in Philadelphia
Other
Eligibility
35 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 8, 2018 · Synced Oct 14, 2026, 1:17 PM EDT
Completed Not applicable Interventional

Community-Based Programs for Improving Physical Function in People With Early Knee Osteoarthritis

NCT00586300
View directory record Official record
Conditions
Osteoarthritis
Interventions
Physical training program, Self-management training program, Physical training and self-management training programs
Other · Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
35 Years to 64 Years
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 21, 2012 · Synced Oct 14, 2026, 1:17 PM EDT
Completed Phase 4 Interventional Results available

Bone Histomorphometry in Postmenopausal Men and Women With Osteoarthritis Undergoing Total Hip Replacement

NCT02576652
View directory record Official record
Conditions
Osteoporosis
Interventions
Tetracycline, Demeclocycline, Total Hip Replacement
Other · Procedure
Lead sponsor
Amgen
Industry
Eligibility
50 Years to 100 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
2
States / cities
West Haverstraw, New York
Source: ClinicalTrials.gov public record
Updated Apr 26, 2019 · Synced Oct 14, 2026, 1:17 PM EDT