Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Sep 2, 2026, 3:41 PM EDT

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Showing 1–24 of 28 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Completed Phase 3 Interventional Accepts healthy volunteers

Fat Gain and Cardiovascular Disease Mechanisms

NCT00589498
Conditions
Hypertension, Sleep Apnea Syndromes, Obesity
Interventions
1000 extra calories
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 40 Years
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2012
U.S. locations
1
States / cities
Rochester, Minnesota
Completed Not applicable Interventional Accepts healthy volunteers

Positive Energy I Through Overfeeding

NCT01653145
Conditions
Obesity
Interventions
Diet A, Diet B, Diet C
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Completed Not applicable Interventional Accepts healthy volunteers

Protective Effect of Exercise on Acute High-fat Overfeeding

NCT07633704
Conditions
Insulin Sensitivity/Resistance
Interventions
High Fat Overfeeding, High Fat Overfeeding + Exercise
Behavioral
Lead sponsor
George Washington University
Other
Eligibility
20 Years to 40 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Conditions
Obesity
Interventions
24-hour energy expenditure
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
50 Years to 65 Years · Female only
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Kannapolis, North Carolina
Completed Not applicable Interventional Accepts healthy volunteers

Body Composition Changes During Overfeeding Plus Resistance Training

NCT04069351
Conditions
Weight Gain, Resistance Training, Overeating
Interventions
High-calorie mass gainer supplement, Resistance Training
Dietary Supplement · Other
Lead sponsor
Texas Tech University
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Lubbock, Texas
Completed Not applicable Interventional Accepts healthy volunteers

Expandability of Aging Adipose Tissue

NCT02456870
Conditions
Aging, Obesity
Interventions
Overfeeding
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
25 Years to 75 Years · Male only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Aurora, Colorado
Conditions
Insulin Resistance, Obesity
Interventions
Over feeding
Other
Lead sponsor
Stanford University
Other
Eligibility
35 Years to 65 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Stanford, California
Conditions
Healthy
Interventions
High calorie diet, Fasting
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
21 Years to 45 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Obesity
Interventions
Vancomycin, Placebo oral tablet, Overfeeding diet (OF), Underfeeding diet (UF)
Drug · Other
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 45 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Phoenix, Arizona
Conditions
Obesity, Thinness, Weight Gain
Interventions
Not listed
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
25 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
1
States / cities
Denver, Colorado
Completed Not applicable Interventional Accepts healthy volunteers

PROOF: PROtein OverFeeding Effect on Body Weight

NCT00565149
Conditions
Obesity
Interventions
PROOF
Behavioral
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 35 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2016
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Completed No phase listed Observational

Effects of Diet Changes on Metabolism

NCT00523627
Conditions
Obesity
Interventions
Not listed
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 55 Years
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2008
U.S. locations
1
States / cities
Phoenix, Arizona
Completed Not applicable Interventional Accepts healthy volunteers

Multi-site Trial Using SMS to Improve Infant Weight

NCT02903186
Conditions
Obesity
Interventions
SMS
Behavioral
Lead sponsor
University of Puerto Rico
Other
Eligibility
Up to 2 Months
Enrollment
202 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Honolulu, Hawaii
Completed Not applicable Interventional Accepts healthy volunteers Results available

Growth Hormone as a Determinant of Weight Regulation

NCT00355784
Conditions
Obesity
Interventions
overfeeding, growth hormone treatment
Other · Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 35 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Recruiting Not applicable Interventional Accepts healthy volunteers

Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding

NCT04583514
Conditions
Overweight and Obesity, Metabolic Syndrome
Interventions
Control, Overfeeding
Behavioral
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 42 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Conditions
Obesity, Normal Physiology, Healthy Volunteers
Interventions
+200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, fasting, -50% of energy balance requirements. 50% of calories from carbohydrates, 20% from protein, and 30% from fat, +150% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, +200% of dietary requirements, 51% of the calories from carbohydrates, 46%, from fat and 3% from protein, -25% of energy balance requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, +150% of dietary requirements, 51% of the calories from carbohydrates, 46%, from fat and 3% from protein
Dietary Supplement
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 60 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Phoenix, Arizona
Conditions
Obesity
Interventions
Social network building intervention, Home visit
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older · Female only
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Nashville, Tennessee
Conditions
Obesity, Diet Therapy, Weight Loss, Weight Gain, Nutrition Therapy
Interventions
Weight Loss, Overfeeding, Overfeeding Low Pro
Behavioral
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 60 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2023
U.S. locations
1
States / cities
Phoenix, Arizona
Completed Not applicable Interventional Accepts healthy volunteers

White Adipose Tissue Clocks and High Calorie Feeding

NCT02809482
Conditions
Healthy
Interventions
Eucaloric feeding, Overfeeding
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
20 Years to 35 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Denver, Colorado
Completed Phase 2 Interventional Accepts healthy volunteers

Prevention of Overfeeding During Infancy

NCT01043978
Conditions
Obesity
Interventions
Use of baby bottle nipple
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
Up to 3 Months
Enrollment
231 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Sacramento, California
Completed No phase listed Observational Accepts healthy volunteers Results available

Unintentional Overfeeding of Formula Fed Infants

NCT02701868
Conditions
Childhood Obesity, Infant Development
Interventions
Not listed
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years and older
Enrollment
171 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Completed Not applicable Interventional Accepts healthy volunteers

Weight Gain and Adipose Tissue

NCT02703766
Conditions
Obesity
Interventions
overfeeding induced weight gain
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 40 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
2
States / cities
Rochester, Minnesota
Completed Not applicable Interventional Accepts healthy volunteers

Palatability (Energy I Pilot)

NCT01653886
Conditions
Energy Density
Interventions
Breakfast (1-2 hours, in the morning), Lunch (1-2 Hours, at midday), Dinner (1-2 hours, in the afternoon)
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Energy Imbalance on Food Intake Behaviors

NCT03112161
Conditions
Obesity
Interventions
Eucaloric Feeding Period, Overfeeding Feeding Period, Underfeeding Feeding Period
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
25 Years to 40 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2015
U.S. locations
1
States / cities
Aurora, Colorado