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Showing 1–24 of 271 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Oxycodone + Acetaminophen Clear all
Completed Early Phase 1 Interventional

Towards Enhanced Recovery After Cesarean

NCT04612920
View directory record Official record
Conditions
Cesarean Section Complications
Interventions
Ibuprofen, acetaminophen, oxycodone
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 13, 2023 · Synced Sep 24, 2026, 7:47 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Utility of Pharmacogenomic Testing and Postoperative Dental Pain Outcomes

NCT02932579
View directory record Official record
Conditions
Pain
Interventions
Pharmacogenomic Testing, Ibuprofen, hydroxycontin/acetominophen, acetominophen, Oxycontin/acetominophen
Other · Drug
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 35 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 15, 2022 · Synced Sep 24, 2026, 7:47 PM EDT
Withdrawn Phase 4 Interventional

Randomized Trial of Two Analgesics in Elderly ED Patients

NCT02703610
View directory record Official record
Conditions
Pain
Interventions
Oxycodone/acetaminophen, Ibuprofen/acetaminophen
Drug
Lead sponsor
Albany Medical College
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Sep 20, 2023 · Synced Sep 24, 2026, 7:47 PM EDT
Terminated Phase 1Phase 2 Interventional Results available

Non-Opioid Pain Medications After Intracapsular Adenotonsillectomy

NCT04791761
View directory record Official record
Conditions
Adenotonsillectomy, Post-operative Analgesia, Opioid Use
Interventions
Oxycodone, Ibuprofen, Acetaminophen, Opioid disposal pouch, Opioid disposal education
Drug · Other
Lead sponsor
David Chi, MD
Other
Eligibility
3 Years to 17 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 29, 2024 · Synced Sep 24, 2026, 7:47 PM EDT
Terminated Phase 4 Interventional Results available

Steroids in Total Knee Arthroplasty

NCT02219581
View directory record Official record
Conditions
Postoperative Pain, Inflammation, Osteoarthritis
Interventions
Dexamethasone 10 mg, Dexamethasone 20 mg, Standard multimodal pain management regimen, Placebo
Drug
Lead sponsor
Thomas L Bradbury
Other
Eligibility
18 Years to 100 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Tucker, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 3, 2022 · Synced Sep 24, 2026, 7:47 PM EDT
Completed Not applicable Interventional

Post-Operative Pain Control Following Shoulder Surgery

NCT04622839
View directory record Official record
Conditions
Shoulder Pain
Interventions
Tylenol and NSAIDS (Ibuprofen, diclofenac)
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 90 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Columbia, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 15, 2023 · Synced Sep 24, 2026, 7:47 PM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Pain Management After Surgery

NCT05154682
View directory record Official record
Conditions
Pain, Postoperative
Interventions
OxyCODONE 5 mg Oral Tablet, Acetaminophen 500Mg Tab, Naproxen 500 Mg
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 12, 2021 · Synced Sep 24, 2026, 7:47 PM EDT
Completed Phase 4 Interventional Results available

Study to Collect Information on How Well the Study Drug Naproxen Sodium Tablets Works Compared to Hydrocodone/Acetaminophen Tablets in Order to Relieve Pain in Participants Experiencing Moderate to Severe Pain After Having Their Wisdom Teeth Removed

NCT04307940
View directory record Official record
Conditions
Pain
Interventions
Naproxen Sodium (Aleve, BAY117031), Hydrocodone/Acetaminophen, Placebo
Drug
Lead sponsor
Bayer
Industry
Eligibility
18 Years to 40 Years
Enrollment
221 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 13, 2022 · Synced Sep 24, 2026, 7:47 PM EDT
Completed Phase 4 Interventional Results available

Effect of Perioperative Gabapentin on Postoperative Opioid Requirements

NCT05494385
View directory record Official record
Conditions
Postoperative Pain
Interventions
Preoperative Gabapentin/Postoperative Placebo, Preoperative Gabapentin/Postoperative Gabapentin
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older · Female only
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 22, 2024 · Synced Sep 24, 2026, 7:47 PM EDT
Completed Phase 4 Interventional

The Comparison of Supraperiosteal Nerve Block With Opiate Analgesia in Alleviating the Pain of Toothache

NCT00574015
View directory record Official record
Conditions
Toothache
Interventions
hydrocodone/acetaminophen, bupivacaine (supraperiosteal nerve block)
Drug
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Mar 23, 2014 · Synced Sep 24, 2026, 7:47 PM EDT
Recruiting Phase 2 Interventional

Celecoxib for ENT Pain Management

NCT06505187
View directory record Official record
Conditions
Parotidectomy
Interventions
Celecoxib, Tylenol, Oxycodone, placebo
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 24, 2026, 7:47 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee

NCT02449369
View directory record Official record
Conditions
Unilateral Knee Arthroplasty
Interventions
Preop acetaminophen IV, Preop orphenadrine IV, Postop oral oxycodone & acetaminophen, Postop hydromorphone IV, Postop oral orphenadrine, Postop oral oxycodone, Postop acetaminophen IV, Postop orphenadrine IV
Drug
Lead sponsor
AdventHealth
Other
Eligibility
18 Years to 85 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Winter Park, Florida
Source: ClinicalTrials.gov public record
Updated Aug 30, 2017 · Synced Sep 24, 2026, 7:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Ultrasound-guided Transversus Abdominis Plane Block After Hysterectomy

NCT01153503
View directory record Official record
Conditions
Post Operative Pain
Interventions
TAP block
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 28, 2018 · Synced Sep 24, 2026, 7:47 PM EDT
Withdrawn Not applicable Interventional

Brief Interventions on Social Media to Reduce Suicide Risk (Intervention 2)

NCT06114862
View directory record Official record
Conditions
Stigma, Social, Mental Health Issue
Interventions
Stigma-reduction intervention
Behavioral
Lead sponsor
Harvard University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Sep 24, 2026, 7:47 PM EDT
Withdrawn Phase 4 Interventional

Pilot Study: Effect of Dexamethasone vs Vicodin in Reducing Post-operative Pain

NCT04008043
View directory record Official record
Conditions
Oral Surgery
Interventions
Vicodin, Dexamethasone
Drug
Lead sponsor
Boston University
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 12, 2019 · Synced Sep 24, 2026, 7:47 PM EDT
Recruiting Early Phase 1 Interventional

Nerve Block for Severe Abdominal Pain in the Emergency Department

NCT07826936
View directory record Official record
Conditions
Erector Spinae Plane Block
Interventions
Bupivacaine (erector spinae plane block)
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Sep 24, 2026, 7:47 PM EDT
Completed Phase 2 Interventional Results available

Hydrocodone/Acetaminophen for Acute Pain Following Third Molar Tooth Extraction

NCT00935311
View directory record Official record
Conditions
Pain
Interventions
ABT-712 Extended-release, Hydrocodone/Acetaminophen Immediate-release, Placebo
Drug
Lead sponsor
AbbVie (prior sponsor, Abbott)
Industry
Eligibility
18 Years to 65 Years
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
3
States / cities
Austin, Texas • San Marcos, Texas • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 7, 2014 · Synced Sep 24, 2026, 7:47 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Reduced Opioid Prescription After Laparoscopic Hysterectomy

NCT05548582
View directory record Official record
Conditions
Pain, Postoperative, Opioid Misuse, Opioid Use, Pain
Interventions
OxyCODONE 5 mg Oral Tablet, Acetaminophen 500 mg Tab, Ibuprofen 600 mg
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced Sep 24, 2026, 7:47 PM EDT
Completed Phase 4 Interventional Results available

Acetaminophen (APAP) +/- Oxycodone

NCT04122443
View directory record Official record
Conditions
Musculoskeletal Pain
Interventions
Acetaminophen, Oxycodone
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
393 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 27, 2024 · Synced Sep 24, 2026, 7:47 PM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Effect of Ropivacaine During Popliteal Nerve Block in Foot and Ankle Surgery

NCT04872322
View directory record Official record
Conditions
Popliteal Nerve Block, Foot Surgery, Ankle Surgery
Interventions
Ropivacaine 0.5% Injectable Solution, Ropivacaine 0.25% Injectable Solution, Percocet Pill, Norco Pill, Foot/Ankle Surgery
Drug · Procedure
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 3, 2021 · Synced Sep 24, 2026, 7:47 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Ice T Postoperative Multimodal Pain Regimen in FPMRS Surgery

NCT03052816
View directory record Official record
Conditions
Pain, Postoperative, Pelvic Organ Prolapse
Interventions
Ice T, Motrin/Percocet/Dilaudid for breakthrough
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Sep 24, 2026, 7:47 PM EDT
Completed Not applicable Interventional Results available

Emergency Department (ED) Drug Interaction in Emergency Department Patients

NCT01859715
View directory record Official record
Conditions
Drug Interactions
Interventions
Oxycodone, Hydrocodone, Ondansetron
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 95 Years
Enrollment
502 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 4, 2016 · Synced Sep 24, 2026, 7:47 PM EDT
Completed Phase 3 Interventional

The Safety and Efficacy of the Buprenorphine Transdermal Delivery System in Subjects With Osteoarthritis Pain.

NCT00315848
View directory record Official record
Conditions
Osteoarthritis
Interventions
Buprenorphine transdermal delivery system
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 1999
U.S. locations
10
States / cities
Huntsville, Alabama • Phoenix, Arizona • Westminster, Colorado + 6 more
Source: ClinicalTrials.gov public record
Updated May 2, 2006 · Synced Sep 24, 2026, 7:47 PM EDT
Completed Phase 3 Interventional Results available

Study of COV795 in Subjects With Osteoarthritis or Chronic Low Back Pain

NCT01451385
View directory record Official record
Conditions
Osteoarthritis, Low Back Pain
Interventions
COV795
Drug
Lead sponsor
Mallinckrodt
Industry
Eligibility
18 Years and older
Enrollment
376 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
42
States / cities
Tucson, Arizona • Anaheim, California • Buena Park, California + 33 more
Source: ClinicalTrials.gov public record
Updated Sep 17, 2020 · Synced Sep 24, 2026, 7:47 PM EDT