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Showing 1–24 of 34 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Intervention: Ozone Clear all
Completed Early Phase 1 Interventional Results available

ONES Grant: CXCL10/CXCR3 Regulation of Ozone-Induced Epithelial Permeability

NCT03599206
View directory record Official record
Conditions
Environmental and Genetic Factors on Lung Function
Interventions
Ozone, Filtered Air
Drug · Other
Lead sponsor
Robert Tighe, MD
Other
Eligibility
18 Years to 45 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 5, 2026, 11:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Human Biological Responses to Low Level Ozone

NCT02857283
View directory record Official record
Conditions
Environmental Exposure, Nasal Inflammation
Interventions
Ozone, Filtered Air, Health and Exposure Tracker (HET)
Other · Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 50 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 13, 2021 · Synced Sep 5, 2026, 11:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ozone Cardiovascular Effects in Genetically Susceptible People

NCT01192477
View directory record Official record
Conditions
Healthy
Interventions
Ozone
Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 40 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 3, 2013 · Synced Sep 5, 2026, 11:29 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pathogenesis and Genetics of Environmental Asthma Ozone Study

NCT00574158
View directory record Official record
Conditions
Asthma, Inflammation
Interventions
Not listed
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
NIH
Eligibility
18 Years to 35 Years
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2012
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 28, 2014 · Synced Sep 5, 2026, 11:29 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Lung Mucus Hypersecretion and NQO1

NCT00729352
View directory record Official record
Conditions
Environmental Exposure, Ozone, Air Pollution, Genetic Susceptibility
Interventions
Not listed
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
NIH
Eligibility
18 Years to 35 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 28, 2014 · Synced Sep 5, 2026, 11:29 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries

NCT00495495
View directory record Official record
Conditions
Dental Caries
Interventions
Ozone treatment, Placebo treatment
Device
Lead sponsor
Indiana University
Other
Eligibility
10 Years to 40 Years
Enrollment
394 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
3
States / cities
Indianapolis, Indiana • Boston, Massachusetts • Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Feb 19, 2015 · Synced Sep 5, 2026, 11:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Genetic Susceptibility TO Ozone-induced Airway Inflammation in Humans

NCT00840528
View directory record Official record
Conditions
Healthy Control
Interventions
ozone
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 40 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 24, 2017 · Synced Sep 5, 2026, 11:29 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Ozone and Rhinovirus-Induced Disease in Asthmatics

NCT00013715
View directory record Official record
Conditions
Asthma
Interventions
Not listed
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
NIH
Eligibility
18 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2003
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 10, 2008 · Synced Sep 5, 2026, 11:29 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Pulmonary and Inflammatory Responses Following Exposure to a Low Concentration of Ozone or Clean Air at Rest

NCT06943989
View directory record Official record
Conditions
Lung Inflammation, Experimental Lung Inflammation
Interventions
Ozone Exposure, Clean air (0.0 ppm ozone)
Other
Lead sponsor
Environmental Protection Agency (EPA)
Federal
Eligibility
18 Years to 35 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 26, 2025 · Synced Sep 5, 2026, 11:29 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Cardiovascular Effects of Exposure to Ozone

NCT01487005
View directory record Official record
Conditions
Cardiovascular Injury
Interventions
Not listed
Lead sponsor
Health Effects Institute
Other
Eligibility
55 Years to 70 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
4
States / cities
San Francisco, California • Watertown, Massachusetts • Rochester, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2012 · Synced Sep 5, 2026, 11:29 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Savannah Environmental Nutrition Study (SENS): Nutrition Intervention to Reduce Air Pollution-Related Airway Inflammation and Oxidative Stress

NCT07797413
View directory record Official record
Conditions
Air Pollution Exposure, Oxidative Stress, Airway Inflammation
Interventions
Antioxidant- and Nutrient-Rich Food-Based Nutrition Intervention
Other
Lead sponsor
Georgia Southern University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Savannah, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 5, 2026, 11:29 AM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Pulmonary and Inflammatory Responses Following Exposure to a Low Concentration of Ozone or Clean Air

NCT05680831
View directory record Official record
Conditions
Lung Injury, Acute, Symptoms and Signs, Neutrophilia Acute
Interventions
0.070 ppm ozone concentration, Clean air (0.0 ppm ozone)
Biological
Lead sponsor
Martin W. Case
Federal
Eligibility
18 Years to 35 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 10, 2023 · Synced Sep 5, 2026, 11:29 AM EDT
Completed Not applicable Interventional Results available

Genetic Susceptibility to Ozone in Mild Asthmatic Volunteers

NCT00287365
View directory record Official record
Conditions
Mild Asthma
Interventions
ozone
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 50 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 12, 2017 · Synced Sep 5, 2026, 11:29 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Efficacy of Fish Oil or Olive Oil Supplementation on the Health Effects of Ozone Exposure in Healthy Young Subjects

NCT03395119
View directory record Official record
Conditions
Healthy, Dietary Supplement
Interventions
Ozone, Fish Oil, Olive Oil
Drug · Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 14, 2021 · Synced Sep 5, 2026, 11:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interaction Effects of Temperature and Ozone

NCT01981135
View directory record Official record
Conditions
Exposure to Environmental Pollution, Non-occupational
Interventions
Clean Air, Ozone
Other
Lead sponsor
Environmental Protection Agency (EPA)
Federal
Eligibility
18 Years to 55 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 9, 2015 · Synced Sep 5, 2026, 11:29 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Functional Implications of TNF

NCT00729131
View directory record Official record
Conditions
Bronchitis
Interventions
Etanercept inhibition of ozone-induced airway hyper-responsiveness.
Drug
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
NIH
Eligibility
18 Years to 35 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 28, 2014 · Synced Sep 5, 2026, 11:29 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Role of Macrophage Activation in Lung Injury Following Ozone Exposure

NCT05794087
View directory record Official record
Conditions
Air Pollution
Interventions
Clean Air, Ozone
Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 40 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Sep 5, 2026, 11:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Bronchiolitis Recovery and the Use of High Efficiency Particulate Air (HEPA) Filters

NCT05615870
View directory record Official record
Conditions
Bronchiolitis
Interventions
Winix 5500-2 HEPA filtration units
Other
Lead sponsor
IDeA States Pediatric Clinical Trials Network
Network
Eligibility
1 Week to 12 Months
Enrollment
230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
17
States / cities
Anchorage, Alaska • Little Rock, Arkansas • Honolulu, Hawaii + 14 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Sep 5, 2026, 11:29 AM EDT
Terminated Not applicable Interventional

Effect of Ozone on Airway Inflammation in Allergic Asthmatics Treated With Omalizumab

NCT00287378
View directory record Official record
Conditions
Asthma, Allergy
Interventions
omalizumab
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 50 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 29, 2009 · Synced Sep 5, 2026, 11:29 AM EDT
Not listed No phase listed Observational

Medication-related Osteonecrosis of the Jaw (MRONJ) Registry

NCT02932501
View directory record Official record
Conditions
Medication-related Osteonecrosis of the Jaw, Bisphosphonate-Associated Osteonecrosis of the Jaw
Interventions
Conservative treatment, Surgical treatment, Adjuvant non-surgical treatment
Procedure
Lead sponsor
AO Clinical Investigation and Publishing Documentation
Other
Eligibility
18 Years and older
Enrollment
518 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced Sep 5, 2026, 11:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect Of Obesity On Ozone-Induced Airway Inflammation

NCT00839943
View directory record Official record
Conditions
Obesity
Interventions
ozone, 0.4 ppm
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 26, 2012 · Synced Sep 5, 2026, 11:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Epigenetic Effect Modifications With Ozone Exposure on Healthy Volunteers

NCT02469428
View directory record Official record
Conditions
Exposure to Environmental Pollution, Non-occupational
Interventions
Clean air, Ozone
Other
Lead sponsor
Environmental Protection Agency (EPA)
Federal
Eligibility
18 Years to 40 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 29, 2019 · Synced Sep 5, 2026, 11:29 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Ozone Exposure and Dose Delivered to Human Lungs

NCT00013780
View directory record Official record
Conditions
Lung Disease
Interventions
Not listed
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
NIH
Eligibility
18 Years to 30 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1998 – 2003
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 22, 2006 · Synced Sep 5, 2026, 11:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Sulforaphane-rich Broccoli Sprout Homogenate on Ozone Induced Inflammation Through Modulation of NRF2

NCT01625130
View directory record Official record
Conditions
Healthy
Interventions
Broccoli sprout homogenate, alfalfa sprout homogenate
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 40 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 10, 2015 · Synced Sep 5, 2026, 11:29 AM EDT