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ClinicalTrials.gov public records Last synced Sep 7, 2026, 2:43 PM EDT

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Showing 1–24 of 43 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: PBM treatment Clear all
Recruiting Not applicable Interventional

Impact of Photobiomodulation (PBM) on Biomarkers of Radiation Lymphedema and Fibrosis in Head and Neck Cancer Patients

NCT06708754
View directory record Official record
Conditions
Radiation Lymphedema, Radiation Fibrosis, Head and Neck Cancer
Interventions
Photobiomodulation (PBM) Therapy, Sham PBM
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 7, 2026, 2:43 PM EDT
Completed Phase 1 Interventional

Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depression

NCT00961454
View directory record Official record
Conditions
Major Depression, Anxiety Disorder, Post-Traumatic Stress Disorder, Substance Abuse Disorder
Interventions
Photobiomodulation with a super-luminous light emitting diode
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 18, 2009 · Synced Sep 7, 2026, 2:43 PM EDT
Not yet recruiting Not applicable Interventional

A Clinical Trial of the Administration of Light Therapy to Prevent Mouth Sores in Children With Cancer

NCT06623305
View directory record Official record
Conditions
Mucositis Oral
Interventions
Photobiomodulation for prevention arm, Photobiomodulation for exploratory arm
Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
Up to 30 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 7, 2026, 2:43 PM EDT
Recruiting Not applicable Interventional

Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery

NCT06574152
View directory record Official record
Conditions
Apical Periodontitis, Endodontically Treated Teeth, Endodontic Disease, Apical Cyst, Apical Granuloma, Periradicular Disease, Previous Endodontic Treatment
Interventions
PBM treatment, PBM sham treatment, EMS
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 7, 2026, 2:43 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Beet-root Juice and PBM Treatments on Muscle Fatigue

NCT05596474
View directory record Official record
Conditions
Health Care Utilization, Healthy Aging
Interventions
Beet-root juice, red-light therapy, Placebo, sham light
Dietary Supplement · Radiation
Lead sponsor
Wake Forest University
Other
Eligibility
65 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced Sep 7, 2026, 2:43 PM EDT
Completed Phase 1 Interventional

A Study Evaluating the Efficacy of the Vielight Neuro RX Gamma in the Treatment of Post COVID-19 Cognitive Impairment

NCT05857124
View directory record Official record
Conditions
Post COVID-19 Cognitive Impairment
Interventions
Vielight Neuro RX Gamma active device, Vielight Neuro RX Gamma sham device
Device
Lead sponsor
Vielight Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Fullerton, California
Source: ClinicalTrials.gov public record
Updated Jun 14, 2025 · Synced Sep 7, 2026, 2:43 PM EDT
Recruiting Not applicable Interventional

Assessing the Effects of Photobiomodulation on Clinical Recovery From Concussion in Adolescents

NCT06239818
View directory record Official record
Conditions
Sports-related Concussion
Interventions
Photobiomodulation therapy (PBMt), Standard of Care
Device · Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
13 Years to 18 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Sep 7, 2026, 2:43 PM EDT
Completed Not applicable Interventional Results available

Low-Level Laser Therapy for Plantar Fasciitis

NCT05763381
View directory record Official record
Conditions
Plantar Fascitis
Interventions
Photobiomodulation Therapy (PBMT), Sham-Photobiomodualtion Therapy (Sham-PBMT)
Device
Lead sponsor
The Geneva Foundation
Other
Eligibility
18 Years to 64 Years
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jun 3, 2025 · Synced Sep 7, 2026, 2:43 PM EDT
Terminated Not applicable Interventional

Investigating Orthobiologics After PRP and Photobiomodulation for Knee Osteoarthritis

NCT06122116
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Physical Therapy, Platelet-Rich Plasma Injection, Photobiomodulation Therapy
Other · Biological · Device
Lead sponsor
Musculoskeletal Injury Rehabilitation Research for Operational Readiness
Federal
Eligibility
18 Years to 64 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Nov 7, 2024 · Synced Sep 7, 2026, 2:43 PM EDT
Active, not recruiting Not applicable Interventional

Study of Photobiomodulation to Treat Dry Age-Related Macular Degeneration (LIGHTSITE III)

NCT04065490
View directory record Official record
Conditions
Dry Age-related Macular Degeneration
Interventions
Valeda PBM treatment, Valeda Sham treatment
Device
Lead sponsor
LumiThera, Inc.
Industry
Eligibility
50 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
11
States / cities
Beverly Hills, California • Palo Alto, California • Altamonte Springs, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2021 · Synced Sep 7, 2026, 2:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

PBM or Dry Float Therapy on Sleep Quality in Middle-aged and Elderly

NCT05963555
View directory record Official record
Conditions
Sleep Quality
Interventions
NovoThor, VieLight, ZeroBody
Device
Lead sponsor
West Virginia University
Other
Eligibility
50 Years to 85 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Apr 23, 2025 · Synced Sep 7, 2026, 2:43 PM EDT
Completed Not applicable Interventional Results available

Effects of Photobiomodulation on Postoperative Pain After Primary Endodontic Therapy in Molars With Symptomatic Apical Periodontitis

NCT05032612
View directory record Official record
Conditions
Postoperative Pain
Interventions
PBM Therapy, PBM Sham
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2023 · Synced Sep 7, 2026, 2:43 PM EDT
Completed Not applicable Interventional Results available

Revitalize Cognition: Near Infrared Stimulation in Parkinson Patients

NCT06688357
View directory record Official record
Conditions
Parkinson Disease
Interventions
Active NIR-PBM (MedX 1116, MCT502), Sham NIR-PBM (MedX 1116, MCT502)
Device
Lead sponsor
University of Florida
Other
Eligibility
62 Years to 89 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 16, 2025 · Synced Sep 7, 2026, 2:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Examining the Differential Effects of Photobiomodulation on Sleep and Performance

NCT05116605
View directory record Official record
Conditions
Sleep Quality
Interventions
Photobiomodulation (PBM)
Other
Lead sponsor
West Virginia University
Other
Eligibility
18 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Apr 24, 2025 · Synced Sep 7, 2026, 2:43 PM EDT
Completed Not applicable Interventional

Bioactive Knee Sleeves After ACL Reconstruction

NCT07707128
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Reconstruction Surgery
Interventions
Bioactive Knee Sleeve
Device
Lead sponsor
Western Kentucky Heart and Lung Research Foundation and Educational Trust
Other
Eligibility
16 Years to 40 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Bowling Green, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 7, 2026, 2:43 PM EDT
Active, not recruiting Phase 2 Interventional Accepts healthy volunteers Results available

The Revitalize Study in Older Adults at Risk for Alzheimer's Disease

NCT04018092
View directory record Official record
Conditions
Cognitive Aging, Alzheimer Disease, Protection Against
Interventions
Active NIR-PBM, Sham NIR-PBM
Device
Lead sponsor
University of Florida
Other
Eligibility
65 Years to 89 Years
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
2
States / cities
Tucson, Arizona • Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Sep 7, 2026, 2:43 PM EDT
Recruiting Not applicable Interventional

An Examination of Whether Infrared Light Therapy Can Reduce Stress in People With Epilepsy

NCT07509177
View directory record Official record
Conditions
Epilepsy
Interventions
Photobiomodulation
Other
Lead sponsor
Cynthia Kerson
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
4
States / cities
North Miami, Florida • Cincinnati, Ohio • Warren, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 7, 2026, 2:43 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

HELIOS Advanced: Human Oocyte Illumination to Enhance Development

NCT07425080
View directory record Official record
Conditions
IVF Outcomes
Interventions
Photobiomodulation
Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 48 Years · Female only
Enrollment
270 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Sep 7, 2026, 2:43 PM EDT
Completed Not applicable Interventional Results available

The Effects of Extraoral Photobiomodulation on the Rate of Orthodontic Alignment

NCT02267824
View directory record Official record
Conditions
Malocclusion
Interventions
Extraoral OrthoPulse® PBM, Fixed Orthodontic Appliance Treatment
Device · Other
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years to 40 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
Birmingham, Alabama • Suwanee, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 26, 2018 · Synced Sep 7, 2026, 2:43 PM EDT
Not listed Early Phase 1 Interventional

Photobiomodulation to Improve Cognition in TBI, With fMRI

NCT04230577
View directory record Official record
Conditions
Traumatic Brain Injury, Closed Head Injury, Cognitive Dysfunction
Interventions
Real LED Intervention, Sham LED Intervention
Device
Lead sponsor
Boston VA Research Institute, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 24, 2022 · Synced Sep 7, 2026, 2:43 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

ELIXIR MDTM Satisfaction Clinical Trial

NCT07676643
View directory record Official record
Conditions
Postoperative Complications, Plastic Surgery
Interventions
Photobiomodulation
Device
Lead sponsor
Elixir MD Inc
Industry
Eligibility
18 Years and older
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 7, 2026, 2:43 PM EDT
Completed Early Phase 1 Interventional

Photobiomodulation for the Treatment of Diabetic Macular Edema

NCT02457975
View directory record Official record
Conditions
Diabetic Retinopathy
Interventions
670nm PBM, intravitreous VEGF-inhibitors
Device · Drug
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 9, 2019 · Synced Sep 7, 2026, 2:43 PM EDT
Not listed Not applicable Interventional

Vielight RX Plus for the Treatment of COVID-19 Respiratory Symptoms

NCT04418505
View directory record Official record
Conditions
COVID-19
Interventions
Vielight RX Plus
Device
Lead sponsor
Vielight Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
295 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Port Orange, Florida
Source: ClinicalTrials.gov public record
Updated Jun 13, 2021 · Synced Sep 7, 2026, 2:43 PM EDT
Not yet recruiting Not applicable Interventional

Photobiomodulation for Cancer-Related Cognitive Impairment

NCT05855694
View directory record Official record
Conditions
Cancer-related Cognitive Impairment
Interventions
THOR LED Photobiomodulation Helmet - Therapeutic, THOR LED Photobiomodulation Helmet - Control
Device
Lead sponsor
Arash Asher, MD
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 9, 2026 · Synced Sep 7, 2026, 2:43 PM EDT