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Conditions: Perioral Dermatitis
Interventions: Seysara Oral Product; Drug
Lead sponsor: The Dermatology Institute of Boston; Other
Eligibility: 18 Years to 55 Years
Enrollment: 9 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Obesity
Interventions: Hypertonic saline infusion, Water deprivation; Other
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 18 Years to 50 Years · Male only
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2019
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Physiological Effect of Drugs, Morphine, Analgesics, Analgesics, Opioid, Central Nervous System Depressants, Narcotics
Interventions: 2% lidocaine with 1:200,000 epinephrine and epidural morphine, 3% 2-chloroprocaine and epidural morphine; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Overlap Syndrome
Interventions: Bi-level positive airway pressure (BPAP), Nocturnal oxygen; Device · Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 75 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2020
U.S. locations: 1
States / cities: San Diego, California

Conditions: Gingivitis
Interventions: Sensodyne Repair and Protect, Colgate Cavity Protection; Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 130 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: PTSD - Post Traumatic Stress Disorder, Cardiac Arrest (CA)
Interventions: Acceptance and Mindfulness Based Exposure Therapy, Present-Centered Therapy; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 18 Years to 81 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: New York, New York

Conditions: Bloodstream Infection
Interventions: Not listed
Lead sponsor: University of Nebraska; Other
Eligibility: 19 Years and older
Enrollment: 223 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2016
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Concussion, Brain
Interventions: Multidimensional Active Rehabilitation, Enhanced Graded Exertion; Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 13 Years to 99 Years
Enrollment: 251 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 7
States / cities: Durham, North Carolina • Elon, North Carolina • Hillsborough, North Carolina + 4 more

Conditions: Obesity
Interventions: Laparoscopic Greater Curvature Plication; Procedure
Lead sponsor: Singh, Kuldeep, M.D., P.A.; Individual
Eligibility: 18 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Pneumonia, Bacterial
Interventions: procalcitonin; Diagnostic Test
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 110 Years
Enrollment: 700 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 6
States / cities: Torrington, Connecticut • Atlanta, Georgia • Boston, Massachusetts + 3 more

Conditions: Morbid Obesity
Interventions: LAGB & LGCP; Procedure
Lead sponsor: Northwell Health; Other
Eligibility: 18 Years and older
Enrollment: 420 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 2
States / cities: Syosset, New York

Conditions: Moderate to Severe Upper Facial Lines (Horizontal Forehead Lines, Glabellar Frown Lines, and Lateral Canthal Lines)
Interventions: NT 201, Placebo; Drug
Lead sponsor: Merz North America, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 362 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 12
States / cities: Encino, California • Newport Beach, California • San Diego, California + 7 more

Conditions: Burn
Interventions: Vitamin and Mineral supplementation; Dietary Supplement
Lead sponsor: Southern Illinois University; Other
Eligibility: 19 Years and older
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Springfield, Illinois

Conditions: Post Operative Surgical Site Infection
Interventions: Supplemental Perioperative Oxygen; Procedure
Lead sponsor: Major Extremity Trauma Research Consortium; Other
Eligibility: 18 Years to 80 Years
Enrollment: 1,171 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2022
U.S. locations: 2
States / cities: Phoenix, Arizona • Baltimore, Maryland

Conditions: Joint Infection, Infection of Hip Joint (Disorder), Infection of Shoulder Joint, Septic Arthritis
Interventions: Synovial Alpha-defensin assay, Synovial Neutrophil elastase assay, Synovial lactate assay, Synovial C-reactive Protein (CRP), Synovial Staphylococcus spp antigen panel, Synovial Candida spp antigen panel, Synovial Enterococcus faecalis assay, Synovial bacterial culture by BacT/Alert, Synovial Cell count + differential (CBC), Synovial Gram Stain, Synovial Leukocyte Esterase Test Strips, Synovial PCR for Kingella kingae, Serum Cell count + differential (CBC), Serum erythrocyte sedimentation rate (ESR), Serum C-reactive Protein (CRP), Serum D-dimer, Serum Procalcitonin, Blood Cultures, Optional blood testing per standard of care (ASO, anti-strep, ANA, anti-DS-DNA, HLA-B27, RF, Lyme and other inflammatory/ rheumatologic markers ); Diagnostic Test
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: Up to 17 Years
Enrollment: 442 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2027
U.S. locations: 3
States / cities: Atlanta, Georgia • New York, New York • Collierville, Tennessee

Conditions: Magnetic Resonance Imaging
Interventions: Gadoxetate disodium (Eovist/Primovist, BAY86-4873); Drug
Lead sponsor: Bayer; Industry
Eligibility: Up to 2 Months
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 9
States / cities: Los Angeles, California • Palo Alto, California • Washington D.C., District of Columbia + 6 more

Conditions: Hyperinsulinemia, Insulin Resistance, Non-Alcoholic Fatty Liver Disease, Prediabetic State, Obesity
Interventions: Placebo, Diazoxide Oral Suspension, 2 mg per kg per dose, Deuterated water (2H2O/D2O), 70%, Insulin Suppression Test (IST); Drug · Diagnostic Test
Lead sponsor: Columbia University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: New York, New York

Conditions: Obesity, Diet Therapy, Weight Loss, Weight Gain, Nutrition Therapy
Interventions: Weight Loss, Overfeeding, Overfeeding Low Pro; Behavioral
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 18 Years to 60 Years
Enrollment: 83 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2023
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Polycystic Ovary Syndrome, Non-Alcoholic Fatty Liver Disease, Metabolic Syndrome
Interventions: Metformin, Placebo; Drug
Lead sponsor: Columbia University; Other
Eligibility: 13 Years to 25 Years · Female only
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: PTSD
Interventions: Cognitive Processing Therapy, Present Centered Therapy; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 75 Years · Male only
Enrollment: 79 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2015
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: College Student Drinking
Interventions: e-checkup to go, Feedback-only booster, Feedback-plus-personal-contact booster; Behavioral
Lead sponsor: Abby Braitman; Other
Eligibility: 18 Years to 24 Years
Enrollment: 249 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Norfolk, Virginia

Conditions: Heart Failure
Interventions: Behavioral Support, Usual HF Care; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 50 Years and older
Enrollment: 573 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 2
States / cities: Birmingham, Alabama

Conditions: Neuropathic Pain, Sickle Cell Disease
Interventions: Eight Percent Topical Capsaicin; Drug
Lead sponsor: Children's Hospital of Michigan; Other
Eligibility: 14 Years to 21 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Cholecystitis
Interventions: Stryker1688 Fluorescence imaging system; Device
Lead sponsor: Stryker Endoscopy; Industry
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Annapolis, Maryland

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Study to Evaluate the Efficacy, Safety, and Tolerability of Sarecycline for Treating Periorificial Dermatitis

Water Deprivation Protocol

Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine

Right Ventricular Hemodynamics Using Cardiac MRI in Patients COPD and OSA

A Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health After Twice Daily Use for 3 Weeks

Trial of Acceptance and Mindfulness-based Exposure Therapy (AMBET) and Present Centered Therapy (PCT)

Procalcitonin and Endotoxin Sequential Levels to Optimize the Treatment of Bloodstream Infections

Role of Rehabilitation in Concussion Management: A Randomized Controlled Trial

Resolution of Comorbidities, Safety and Efficacy of Greater Curvature Plication in Obese Patients.

PROcalcitonin Impact on Antibiotic Reduction, adverSe Events and AVoidable healthcarE Costs (ProSAVE): A RCT

Weight Loss & Comorbidity Resolution With LAGB Alone vs. LAGB With Gastric Plication

Safety and Efficacy Study of the Simultaneous Treatment of Upper Facial Lines (Horizontal Forehead Lines, Glabellar Frown Lines and Lateral Canthal Lines) in Subjects With Moderate to Severe Upper Facial Lines

Burn Micronutrient Repletion Pilot Study

Supplemental Perioperative Oxygen to Reduce Surgical Site Infection After High Energy Fracture Surgery

Alpha-Defensin and Synovial Proteins to Improve Detection of Pediatric Septic Arthritis

Magnetic Resonance Imaging of the Liver in Children 0-2 Months of Age With an Intravenous Injection of Eovist/Primovist Which is a Contrast Agent

Effect of Insulin Lowering on Lipogenesis

Predicting Weight Gain and Weight Loss Associated With Overeating or Fasting

Metformin for Ectopic Fat Deposition and Metabolic Markers in Polycystic Ovary Syndrome (PCOS)

A Comparison of Cognitive Processing Therapy (CPT) Versus Present Centered Therapy (PCT) for Veterans

Personalized Booster Feedback After Alcohol Health Education

ENABLE CHF-PC (Comprehensive Heartcare For Patients and Caregivers)

Sickle Cell Pain: Intervention With Capsaicin Exposure

SPY Fluorescence Imaging Systems and Indocyanine Green to Determine the Percentage of Successful Critical Anatomy Recognition in Laparoscopic Cholecystectomy Surgeries.