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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 3 Interventional Accepts healthy volunteers Results available

Safety and Efficacy of Generic Diclofenac Epolamine Acute Pain Due to Minor Ankle Sprain

NCT02324270
View directory record Official record
Conditions
Ankle Sprain
Interventions
Diclofenac epolamine, Placebo
Drug · Other
Lead sponsor
Actavis Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
658 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
31
States / cities
Birmingham, Alabama • Goodyear, Arizona • Carlsbad, California + 26 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2020 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 3 Interventional

Study Evaluating the Efficacy and Safety of Topical Diclofenac Spray in Osteoarthritis of the Knee: Trial I

NCT00546507
View directory record Official record
Conditions
Osteoarthritis
Interventions
TDS-943 (topical diclofenac sodium 4% spray), celecoxib, placebo
Drug · Other
Lead sponsor
Mika Pharma GmbH
Industry
Eligibility
40 Years and older
Enrollment
650 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
43
States / cities
Huntsville, Alabama • Mobile, Alabama • Mesa, Arizona + 35 more
Source: ClinicalTrials.gov public record
Updated Oct 12, 2010 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 3 Interventional Results available

Protocol to Monitor the Neurological Development of Infants With Exposure in Utero From Birth to 15 Months in Tanezumab Clinical Studies

NCT03031938
View directory record Official record
Conditions
Osteoarthritis, Cancer Pain, Recurrent Low Back Pain
Interventions
Investigational medical product (IMP) administered in parent study
Drug
Lead sponsor
Pfizer
Industry
Eligibility
0 Years to 2 Months
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
6
States / cities
Los Angeles, California • Sarasota, Florida • Tampa, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 24, 2021 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 4 Interventional Results available

Pharmacokinetics & Safety of Cambia® in Migraine With or Without Aura in 12-17 Year Olds

NCT02287376
View directory record Official record
Conditions
Migraine
Interventions
Diclofenac Potassium for Oral Solution
Drug
Lead sponsor
Depomed
Industry
Eligibility
12 Years to 17 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
2
States / cities
Tampa, Florida • Amherst, New York
Source: ClinicalTrials.gov public record
Updated Jul 24, 2017 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Irritation and Sensitization Study of HP-5000 Topical System

NCT04882319
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
HP-5000 Topical Patch, HP-5000 Placebo Patch, Saline Patch
Drug
Lead sponsor
Noven Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Fair Lawn, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 22, 2022 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 2 Interventional Results available

Bonipar for Acute and Chronic Musculoskeletal Pain

NCT03471507
View directory record Official record
Conditions
Chronic Pain, Musculoskeletal Pain
Interventions
Bonipar, Diclofenac sodium topical solution 1.5%
Drug
Lead sponsor
Winston Parris, MD
Other
Eligibility
18 Years to 80 Years
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 17, 2023 · Synced Sep 10, 2026, 2:50 PM EDT
Not listed Phase 3 Interventional

ACL-R Opioid Sparing Study

NCT06561035
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
Opiate Sparing, Opiate Based
Drug
Lead sponsor
Campbell Clinic
Other
Eligibility
14 Years to 85 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 18, 2024 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 3 Interventional Results available

An Open-Label Safety Study Of DIC075V (Intravenous Diclofenac Sodium) In Patients With Acute Post-Operative Pain

NCT00726388
View directory record Official record
Conditions
Pain, Postoperative
Interventions
DIC075V (intravenous diclofenac sodium)
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 85 Years
Enrollment
1,050 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
46
States / cities
Birmingham, Alabama • Florence, Alabama • Mobile, Alabama + 37 more
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 4 Interventional Results available

The Efficacy of Diclofenac Gel for Breakthrough Pain and the Neuropathic Components of Pain in Knee Osteoarthritis

NCT01383954
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Diclofenac Gel
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
20 Years to 75 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 14, 2017 · Synced Sep 10, 2026, 2:50 PM EDT
Terminated No phase listed Observational

Cross-linking of Corneal Collagen (CXL) With Ultraviolet-A in Asymmetric Corneas

NCT01189864
View directory record Official record
Conditions
Keratoconus, Ectasia, Degeneration
Interventions
Ciprofloxicin or Vigamox or other., Nonsteroidal (Acular, Acuvail, Voltaren Xibrom, etc), Steroid (FML, Pred Forte, Flarex, etc.)
Drug
Lead sponsor
Cxlusa
Industry
Eligibility
12 Years and older
Enrollment
3,493 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
16
States / cities
Scottsdale, Arizona • Laguna Hills, California • San Diego, California + 13 more
Source: ClinicalTrials.gov public record
Updated Oct 11, 2018 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 2Phase 3 Interventional Results available

AMZ001 for the Treatment of Knee Osteoarthritis Symptoms

NCT03691844
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
AMZ001, Placebo, Comparator
Drug
Lead sponsor
Amzell
Industry
Eligibility
40 Years to 85 Years
Enrollment
444 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
3
States / cities
Milford, Connecticut • The Villages, Florida • Williamsville, New York
Source: ClinicalTrials.gov public record
Updated Oct 5, 2020 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 3 Interventional

Diclofenac Patch for Treatment of Acute Pain Due to Mild to Moderate Soft Tissue Injuries (TAPED)

NCT00931866
View directory record Official record
Conditions
Acute Pain, Soft Tissue Injury
Interventions
Diclofenac Sodium, Matching Placebo Patch
Drug
Lead sponsor
Cerimon Pharmaceuticals
Industry
Eligibility
18 Years to 75 Years
Enrollment
407 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Aug 15, 2010 · Synced Sep 10, 2026, 2:50 PM EDT
Terminated No phase listed Observational

Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas

NCT01024322
View directory record Official record
Conditions
Keratoconus, Ectasia, Degeneration
Interventions
Ciprofloxicine or Vigamox or other., Nonsteroidal (Acular, Voltaren Xibrom, etc), Steroid (FML, Pred Forte, Flarex, etc.)
Drug
Lead sponsor
Cxlusa
Industry
Eligibility
8 Years and older
Enrollment
1,189 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2017
U.S. locations
3
States / cities
Miami, Florida • Rockville, Maryland • Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 3 Interventional Results available

A Study to Assess the Efficacy and Tolerability of Diclofenac Potassium Soft Gelatin Capsules Compared With Ibuprofen Tablets in Patients With Moderate to Severe Postoperative Dental Pain

NCT02476422
View directory record Official record
Conditions
Post Operative Dental Pain
Interventions
Diclofenac potassium, Ibuprofen, Placebo to ibuprofen, Placebo to diclofenac potassium
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years to 75 Years
Enrollment
328 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 16, 2016 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis

NCT04391842
View directory record Official record
Conditions
Osteo Arthritis Knee, Arthritis
Interventions
Sustained Acoustic Device with 1% Diclofenac patch
Combination Product
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
45 Years to 85 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Dryden, New York
Source: ClinicalTrials.gov public record
Updated Jun 26, 2023 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 3 Interventional

Evaluation of Clinical Endpoints of Two Diclofenac Sodium Gel 1%

NCT01456611
View directory record Official record
Conditions
Osteo Arthritis of the Knee
Interventions
Diclofenac, Placebo
Drug
Lead sponsor
Anchen Pharmaceuticals, Inc
Industry
Eligibility
35 Years and older
Enrollment
749 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
57
States / cities
Birmingham, Alabama • Huntsville, Alabama • Chandler, Arizona + 54 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2012 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study to Assess Effects of Age, Weight, and Body Composition on the Pharmacokinetics of IV Diclofenac Sodium

NCT00509743
View directory record Official record
Conditions
Healthy
Interventions
Intravenous diclofenac sodium (DIC075V)
Drug
Lead sponsor
Javelin Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
2
States / cities
Miramar, Florida • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 11, 2009 · Synced Sep 10, 2026, 2:50 PM EDT
Withdrawn Not applicable Interventional

Efficacy of PENNSAID® for Pain Management in the Emergency Department

NCT01350622
View directory record Official record
Conditions
Pain, Ankle Sprain
Interventions
PENNSAID, Diclofenac hydroxyethylpyrrolidine
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 20, 2016 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Pharmacokinetics Study Comparing Topical Diclofenac/Menthol Gels With Voltaren Gel and Oral Diclofenac Sodium

NCT02201238
View directory record Official record
Conditions
Pain
Interventions
Diclofenac sodium, Menthol
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 50 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 28, 2017 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 3 Interventional Results available

A Study to Evaluate Efficacy and Safety of AMZ001 for the Treatment of Knee Osteoarthritis Symptoms

NCT06693648
View directory record Official record
Conditions
Osteoarthritis of Knee, Osteoarthritis, Knee
Interventions
AMZ001 Diclofenac gel, Placebo gel
Drug
Lead sponsor
Amzell
Industry
Eligibility
40 Years to 85 Years
Enrollment
549 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
7
States / cities
Thousand Oaks, California • Hialeah, Florida • Longwood, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Pharmacokinetics, Bioavailability and Safety of PENNSAID® Gel

NCT01202799
View directory record Official record
Conditions
Pain
Interventions
2% w/w diclofenac sodium topical gel, 1.5% w/w diclofenac sodium topical solution, 75 mg diclofenac sodium delayed release tablet
Drug
Lead sponsor
Mallinckrodt
Industry
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Miramar, Florida
Source: ClinicalTrials.gov public record
Updated Sep 22, 2014 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 3 Interventional

Diclofenac Patch for the Treatment of Acute Pain Due to Mild to Moderate Wrist Sprain, Strain or Contusion

NCT00869063
View directory record Official record
Conditions
Acute Pain
Interventions
Diclofenac Sodium Patch, Matching Placebo Patch
Drug
Lead sponsor
Cerimon Pharmaceuticals
Industry
Eligibility
17 Years to 75 Years
Enrollment
214 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jan 27, 2010 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 2 Interventional Results available

Exploratory Study of PENNSAID Gel to Treat Symptoms of Knee Osteoarthritis

NCT01119898
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
PENNSAID Gel, Vehicle
Drug
Lead sponsor
Mallinckrodt
Industry
Eligibility
40 Years to 85 Years
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
26
States / cities
Tucson, Arizona • Sacramento, California • Clearwater, Florida + 22 more
Source: ClinicalTrials.gov public record
Updated Oct 21, 2019 · Synced Sep 10, 2026, 2:50 PM EDT
Completed Phase 4 Interventional Results available

Safety and Tolerability of Zipsor® in Pediatric Subjects (Ages 12-17 Years) With Mild to Moderate Acute

NCT01982539
View directory record Official record
Conditions
Pain
Interventions
Zipsor®
Drug
Lead sponsor
Depomed
Industry
Eligibility
12 Years to 17 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
2
States / cities
Sheffield, Alabama • Stanford, California
Source: ClinicalTrials.gov public record
Updated May 6, 2020 · Synced Sep 10, 2026, 2:50 PM EDT