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Showing 1–24 of 36 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 1 Interventional

Safety and Feasibility Study of Methylene Blue Photodynamic Therapy to Sterilize Deep Tissue Abscess Cavities

NCT02240498
View directory record Official record
Conditions
Abscess
Interventions
Methylene Blue, 20% I.V. Fat Emulsion, Insertion of optical fiber, Laser illumination, 5 minutes, Laser illumination, 10 minutes, Laser illumination, 15 minutes, Laser illumination, 20 minutes, Laser illumination, 25 minutes, Laser illumination, 30 minutes, Optical spectroscopy measurement
Drug · Device
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2023
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 7, 2026, 10:51 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment

NCT06104280
View directory record Official record
Conditions
Opioid Use Disorder, Sleep Disturbance
Interventions
Post-Illumination Pupillary Response (PIPR), Polysomnography, Multiple Sleep Latency Test, Ecological Momentary Assessments, Actigraphy, DLMO, Melatonin Suppression Test
Other · Behavioral · Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 80 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 7, 2026, 10:51 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Amblyopia Treatment for Children Aged 8 to 12 Years

NCT07281742
View directory record Official record
Conditions
Amblyopia
Interventions
Curesight dichoptic videos
Device
Lead sponsor
Retina Foundation of the Southwest
Other
Eligibility
8 Years to 12 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Sep 7, 2026, 10:51 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection

NCT02068430
View directory record Official record
Conditions
Corneal Ulcers
Interventions
Riboflavin 0.1%, UV-X™ Illumination System
Drug · Other
Lead sponsor
Stephen Trokel
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Sep 7, 2026, 10:51 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Objectively Diagnose and Monitor Treatment of Light Sensitivity

NCT03694626
View directory record Official record
Conditions
Photophobia, Traumatic Brain Injury, Migraine
Interventions
Pupillography, Ocular Coherence Tomography (OCT), Wrist-watch sensor device, Videography, Electrophysiology
Device
Lead sponsor
Randy Kardon
Other
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Sep 7, 2026, 10:51 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Macular Pigment Measurements in Eye & Other Tissues

NCT03022773
View directory record Official record
Conditions
Macular Pigmentation, Skin Pigment
Interventions
Carotenoid measurements
Other
Lead sponsor
University of Utah
Other
Eligibility
7 Years and older
Enrollment
10,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2030
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 7, 2026, 10:51 PM EDT
Recruiting Not applicable Interventional

Automated Applanation Tonometry - Updated

NCT07298356
View directory record Official record
Conditions
Glaucoma, Glaucoma, Suspect
Interventions
Standard GAT, Fixed force GAT, Upright applanating prototype, Pneumotonometer
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Sep 7, 2026, 10:51 PM EDT
Recruiting Not applicable Interventional

Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep Chronobundle

NCT05551325
View directory record Official record
Conditions
Critical Illness, Sleep Deprivation, Circadian Rhythm Sleep Disorder, Unspecified
Interventions
Chronobundle - light, chronobundle - feeding, chronobundle - mobility, chronobundle - sleep
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Sep 7, 2026, 10:51 PM EDT
Terminated Not applicable Interventional

Automated Applanation Tonometry

NCT05235321
View directory record Official record
Conditions
Glaucoma, Glaucoma, Suspect
Interventions
Standard GAT, Fixed force GAT, Upright applanating prototype, Supine Applanating Prototype
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 12, 2025 · Synced Sep 7, 2026, 10:51 PM EDT
Recruiting Not applicable Interventional

Safety and Efficacy of Head-lice Treatments Elimax Green Lotion and Walgreens Lice Killing Shampoo

NCT07191457
View directory record Official record
Conditions
Head Lice
Interventions
Elimax Green Lotion with Emogreen, Walgreens Lice Killing Shampoo
Device · Drug
Lead sponsor
Oystershell NV
Industry
Eligibility
6 Months and older
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Enid, Oklahoma
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Sep 7, 2026, 10:51 PM EDT
Not yet recruiting Phase 2 Interventional

Efficacy of Methylene Blue Photodynamic Therapy for Treatment of Deep Tissue Abscesses

NCT06052956
View directory record Official record
Conditions
Abscess
Interventions
Methylene Blue, Lipid Emulsion, Insertion of optical fiber, Laser Illumination (pre-defined dose), Optical Spectroscopy Measurement, Laser Illumination (patient-specific dose), Standard of care abscess drainage
Drug · Device · Procedure
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
2
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 7, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

Infrared Lymphangiography as a Method of Sentinel Node Identification

NCT02057393
View directory record Official record
Conditions
Melanoma, Sentinel Node
Interventions
Indocyanine green, Technetium99, Methylene blue
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 5, 2017 · Synced Sep 7, 2026, 10:51 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms

NCT05829044
View directory record Official record
Conditions
Normal Physiology
Interventions
Pupillometry, Light box exposure
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 7, 2026, 10:51 PM EDT
Completed Not applicable Interventional

Circadian Amplification in Diabetic Retinopathy

NCT06183476
View directory record Official record
Conditions
Diabetic Retinopathy
Interventions
Amplify-RHYTHM
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
40 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 10, 2025 · Synced Sep 7, 2026, 10:51 PM EDT
Not listed Phase 2Phase 3 Interventional

Safety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Refractory Corneal Ulcers

NCT05255016
View directory record Official record
Conditions
Keratitis, Corneal Ulcer
Interventions
PXL Platinum 330 system + Riboflavin 0.25% TE Solution, Sham CXL + Artificial Tears
Combination Product · Other
Lead sponsor
Peschke GmbH
Industry
Eligibility
18 Years and older
Enrollment
488 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
12
States / cities
Littleton, Colorado • Fort Myers, Florida • Tampa, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Oct 27, 2022 · Synced Sep 7, 2026, 10:51 PM EDT
Not listed Phase 4 Interventional Results available

Descemet Endothelial Thickness Comparison Trial

NCT02373137
View directory record Official record
Conditions
Keratoplasty, Grafting, Corneal, Transplantation, Corneal, Transplantation, Cornea, Keratoplasty, Lamellar
Interventions
DSAEK, DMEK, Endoserter, Prednisolone, Ofloxacin, Tropicamide, Phenylephrine, Jones Tube
Procedure · Device · Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
3
States / cities
Palo Alto, California • San Francisco, California • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 24, 2020 · Synced Sep 7, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nurse Suicide: Physiologic Sleep Health Promotion Trial

NCT06079853
View directory record Official record
Conditions
Suicide, Nurse's Role, Work Environment Adverse Effects, Sleep, Stress, Mental Health Wellness 1
Interventions
PureSomni Sleep Health Product Kit
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
21 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Cortlandt Manor, New York
Source: ClinicalTrials.gov public record
Updated Nov 24, 2024 · Synced Sep 7, 2026, 10:51 PM EDT
Completed Phase 2 Interventional

An OCT-Guided Variable Dosing Regimen With Ranibizumab for the Treatment of Neovascular AMD

NCT00373659
View directory record Official record
Conditions
Neovascular Age-related Macular Degeneration
Interventions
Ranibizumab (Lucentis)
Drug
Lead sponsor
University of Miami
Other
Eligibility
50 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 12, 2012 · Synced Sep 7, 2026, 10:51 PM EDT
Completed Phase 1Phase 2 Interventional

A Safety Study of CNTO 2476 in Patients With Age-Related Macular Degeneration

NCT01226628
View directory record Official record
Conditions
Age-related Macular Degeneration
Interventions
CNTO 2476, iTrack Model 275 micro catheter
Biological · Procedure
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
50 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
2
States / cities
Arcadia, California • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 7, 2017 · Synced Sep 7, 2026, 10:51 PM EDT
Completed Phase 2 Interventional

Prospective OCT Study With Lucentis for Neovascular AMD (PrONTO Study)

NCT00344227
View directory record Official record
Conditions
Neovascular Age-Related Macular Degeneration
Interventions
Lucentis (Ranibizumab)
Drug
Lead sponsor
University of Miami
Other
Eligibility
50 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 25, 2006 · Synced Sep 7, 2026, 10:51 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Positive Imagery Therapy and the Incidence of Emergence Reactions With the Use of Ketamine

NCT04746079
View directory record Official record
Conditions
Procedural Sedation, Emergence Delirium
Interventions
Positive Imagery Therapy
Behavioral
Lead sponsor
Mercy Health Ohio
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Youngstown, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 22, 2022 · Synced Sep 7, 2026, 10:51 PM EDT
Recruiting Not applicable Interventional

Using Implementation Science to Adapt a Targeted Transportation Intervention for Patients With Diabetic Retinopathy (PRONTO-EYE)

NCT07296952
View directory record Official record
Conditions
Diabetic Retinopathy (DR)
Interventions
PRONTO-EYE
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 7, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

Clinical Investigation of the Clareon® Intraocular Lens (IOL)

NCT03170154
View directory record Official record
Conditions
Cataract
Interventions
Clareon aspheric hydrophobic acrylic monofocal IOL
Device
Lead sponsor
Alcon Research
Industry
Eligibility
22 Years and older
Enrollment
376 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
16
States / cities
Fresno, California • Sacramento, California • San Leandro, California + 13 more
Source: ClinicalTrials.gov public record
Updated Aug 2, 2020 · Synced Sep 7, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Light on Melatonin and Contractions in Pregnant Women

NCT01863446
View directory record Official record
Conditions
Pregnancy
Interventions
Lighting1, Lighting2
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 26, 2024 · Synced Sep 7, 2026, 10:51 PM EDT