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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Pain EASE Clear all
Completed No phase listed Observational Accepts healthy volunteers

Research Protocol for Karuna Labs Inc.: Safety and Efficacy of Virtual Reality Graded Motor Imagery for Chronic Pain

NCT04060875
View directory record Official record
Conditions
Chronic Pain, Low Back Pain, Fibromyalgia, Upper Extremity Dysfunction, Complex Regional Pain Syndromes, Phantom Limb Pain, Rheumatoid Arthritis, Carpal Tunnel Syndrome, Repetitive Strain Injury
Interventions
Karuna Labs Virtual Reality Software
Device
Lead sponsor
Karuna Labs Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2021 · Synced Sep 13, 2026, 10:15 AM EDT
Completed Not applicable Interventional Results available

Procedural Sedation And Analgesia in Children in the Emergency Department: The Role of Adjunct Therapies

NCT02518919
View directory record Official record
Conditions
Conscious Sedation
Interventions
Child life intervention, Music listening
Other
Lead sponsor
Children's Hospital of Michigan
Other
Eligibility
3 Years to 15 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 26, 2018 · Synced Sep 13, 2026, 10:15 AM EDT
Completed Phase 3 Interventional Results available

An Open-label, 8-week Safety, Efficacy, and Assessment of Cooling Methods for Administration of CNTX-4975-05 for Knee OA

NCT03661996
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
CNTX-4975-05, Lidocaine without epinephrine, ElastoGel, Breg Ice Water Pump
Drug · Device
Lead sponsor
Centrexion Therapeutics
Industry
Eligibility
40 Years to 95 Years
Enrollment
854 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
28
States / cities
Birmingham, Alabama • Peoria, Arizona • Tucson, Arizona + 24 more
Source: ClinicalTrials.gov public record
Updated Mar 8, 2022 · Synced Sep 13, 2026, 10:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Professional Objective Bike Fit on Power Output and Comfort

NCT06988384
View directory record Official record
Conditions
Healthy Population
Interventions
Bike fitting
Other
Lead sponsor
University of Wisconsin, River Falls
Other
Eligibility
18 Years to 64 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
River Falls, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Sep 13, 2026, 10:15 AM EDT
Completed No phase listed Observational

Iodine Content for Diagnostic AccuRacy and Patient Comfort For Individuals Undergoing Cardiac Computed Tomography (CT) Scanning

NCT01052441
View directory record Official record
Conditions
Coronary Arteriosclerosis
Interventions
Not listed
Lead sponsor
MDDX LLC
Industry
Eligibility
18 Years to 80 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
2
States / cities
Albany, New York • Poughkeepsie, New York
Source: ClinicalTrials.gov public record
Updated Dec 10, 2012 · Synced Sep 13, 2026, 10:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Mindfulness Programs on Postoperative Pain

NCT04788329
View directory record Official record
Conditions
Post Operative Pain
Interventions
"Prepare for Surgery, Heal Faster" Program, Wim Hof Method
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 100 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 20, 2022 · Synced Sep 13, 2026, 10:15 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Vapocoolant Spray to Reduce Pain With Nexplanon Insertion

NCT06933381
View directory record Official record
Conditions
Reducing Pain With Nexplanon Implant Insertion
Interventions
Vapocoolant spray, Placebo
Device · Other
Lead sponsor
Queen's Medical Center
Other
Eligibility
14 Years and older · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
3
States / cities
Honolulu, Hawaii • Waimea, Hawaii
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Sep 13, 2026, 10:15 AM EDT
Terminated Phase 4 Interventional Results available

Vapocoolant Spray for Numbing Small Boils Before Incision and Drainage

NCT01673061
View directory record Official record
Conditions
Abscess
Interventions
Lidocaine, Vapocoolant
Drug
Lead sponsor
Albert Einstein Healthcare Network
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 18, 2020 · Synced Sep 13, 2026, 10:15 AM EDT
Completed Not applicable Interventional Results available

Cooling to Alleviate Migraine #3

NCT06874361
View directory record Official record
Conditions
Migraine With or Without Aura, Migraine, Migraine Headache
Interventions
Mi-Helper
Device
Lead sponsor
Mi-Helper, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Indian Harbour Beach, Florida
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 13, 2026, 10:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Spencer's Technique on Shoulder Function

NCT06447493
View directory record Official record
Conditions
Shoulder
Interventions
Osteopathic Manipulative Treatment-Spencer's Technique (Modified), Rest
Other
Lead sponsor
Edward Via Virginia College of Osteopathic Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Sep 13, 2026, 10:15 AM EDT
Completed No phase listed Observational

The Impact of a Physical Activity Program on Biomarkers of Aging During Chemotherapy for Breast Cancer

NCT02167932
View directory record Official record
Conditions
Breast Cancer, Aging
Interventions
Walk With Ease
Behavioral
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
21 Years to 59 Years · Female only
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 5, 2018 · Synced Sep 13, 2026, 10:15 AM EDT
Active, not recruiting Not applicable Interventional

Perineal Massage for Pessary Examinations

NCT06416982
View directory record Official record
Conditions
Prolapse, Vaginal, Stress Urinary Incontinence, Pessaries, Pain
Interventions
Perineal massage
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older · Female only
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Sep 13, 2026, 10:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neuroendocrine Changes in Cervical Spinal Manipulation and Mobilization Non-specific Mechanical Neck Pain

NCT04911608
View directory record Official record
Conditions
Neck Pain
Interventions
cervical spinal manipulation, cervical spinal mobilization
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 19, 2023 · Synced Sep 13, 2026, 10:15 AM EDT
Completed No phase listed Observational

Comfortability Workshop

NCT04081454
View directory record Official record
Conditions
Chronic Pain
Interventions
Workshop, Education
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
11 Years to 17 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Sep 13, 2026, 10:15 AM EDT
Completed Not applicable Interventional Results available

Transcutaneous Electrical Nerve Stimulation (TENS) for IUD Insertion Pain

NCT06245655
View directory record Official record
Conditions
Pain
Interventions
Transcutaneous Electrical Nerve Stimulation (TENS)
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
5
States / cities
New Haven, Connecticut • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 13, 2026, 10:15 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Quadratus Lumborum Block Versus Control for Total Hip Arthroplasty

NCT03408483
View directory record Official record
Conditions
Total Hip Arthroplasty
Interventions
Quadratus Lumborum Block (QLB), Standard of Care
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 8, 2021 · Synced Sep 13, 2026, 10:15 AM EDT
Terminated Not applicable Interventional Results available

Virtual Reality Decreases Child Anxiety and Pain as Well as Caregiver Anxiety and Pain Perception During Orthopaedic Clinic Office Procedures

NCT05708586
View directory record Official record
Conditions
Anxiety, Pain
Interventions
Control, Virtual Reality (VR)
Behavioral · Device
Lead sponsor
University of Michigan
Other
Eligibility
4 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 26, 2024 · Synced Sep 13, 2026, 10:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving Community Ambulation After Hip Fracture

NCT01783704
View directory record Official record
Conditions
Hip Fracture
Interventions
Nutrition, PUSH, PULSE
Dietary Supplement · Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
60 Years and older
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
4
States / cities
Farmington, Connecticut • Baltimore, Maryland • Lebanon, New Hampshire + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2022 · Synced Sep 13, 2026, 10:15 AM EDT
Completed Not applicable Interventional Results available

Abdominal Ice Packs for Pain Control and Reduction of Narcotic Use Following Laparoscopic Hysterectomy

NCT03341533
View directory record Official record
Conditions
Pain, Postoperative, Hysterectomy, Narcotic Use, Cryotherapy Effect
Interventions
Ice packs plus usual post-op analgesia, Usual post-op analgesia
Procedure · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 13, 2020 · Synced Sep 13, 2026, 10:15 AM EDT
Recruiting Not applicable Interventional

Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response

NCT04142177
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Pain EASE, Tailored exercise, Continued Care and Active Monitoring, Cognitive Behavioral Therapy (CBT), Spinal Manipulation Therapy (SMT), Yoga
Other · Procedure · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
2,529 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
19
States / cities
Phoenix, Arizona • Loma Linda, California • Long Beach, California + 16 more
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 13, 2026, 10:15 AM EDT
Recruiting No phase listed Observational

3D Printed Orthosis for Wrist Instability for Ehlers-Danlos Syndrome Patient

NCT07565636
View directory record Official record
Conditions
Ehlers-Danlos Syndrome Hypermobility Type (hEDS)
Interventions
3D scanned and 3D printed wrist hand orthosis
Device
Lead sponsor
ELewis
Other
Eligibility
21 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Lowell, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 13, 2026, 10:15 AM EDT
Recruiting Not applicable Interventional

TENS Analgesia During Outpatient Urethral Bulking for Stress Urinary Incontinence.

NCT06369922
View directory record Official record
Conditions
Stress Incontinence Female, Urinary Incontinence, Urinary Incontinence,Stress, Pain, Pain Acute
Interventions
TENS, Control TENS
Procedure
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Sep 13, 2026, 10:15 AM EDT
Recruiting Not applicable Interventional

Weighted Blanket Use for Adults With Chronic Pain

NCT07498491
View directory record Official record
Conditions
Chronic Pain, Musculoskeletal Pain, Sleep Disturbance, Pain Disorders
Interventions
Weighted Blanket
Device
Lead sponsor
National University of Natural Medicine
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Sep 13, 2026, 10:15 AM EDT
Completed Not applicable Interventional

Comparing Acupuncture, BioModulator, and Transcutaneous Electrical Nerve Stimulation for Symptomatic Treatment of Chronic Pain.

NCT01752010
View directory record Official record
Conditions
Chronic Pain, Depression, PTSD Symptoms, Sleep
Interventions
Traditional Chinese Acupuncture, Tennant™ Biomodulator Treatment, Transcutaneous electrical nerve stimulation (TENS) Treatment
Other · Device
Lead sponsor
Samueli Institute for Information Biology
Other
Eligibility
18 Years to 60 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 18, 2015 · Synced Sep 13, 2026, 10:15 AM EDT