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Showing 1–24 of 49 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Pain Neuroscience Education Clear all
Recruiting Not applicable Interventional

Virtual 1-Session Spanish "Empowered Relief" Group Intervention for Chronic Pain

NCT04546685
View directory record Official record
Conditions
Chronic Pain
Interventions
Usual Care, Empowered Relief
Other · Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Sep 20, 2026, 5:42 AM EDT
Completed Not applicable Interventional

Pain Neuroscience Education for Acute and Sub-Acute Low Back Pain

NCT03722394
View directory record Official record
Conditions
Low Back Pain, Pain, Chronic, Pain, Back
Interventions
Pain Neuroscience Education
Behavioral
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 25, 2018 · Synced Sep 20, 2026, 5:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Heartache and Backache- An Online Intervention Addressing Emotional and Physical Pain

NCT05513274
View directory record Official record
Conditions
Chronic Pain (Back / Neck)
Interventions
Pain Psychology Neuroscience + Written Emotional Disclosure, Pain Psychology Neuroscience + Healthy Habits Disclosure, Health Behavior Control + Written Emotional Disclosure, Health Behavior Control + Healthy Habits Disclosure
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 75 Years
Enrollment
107 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Sep 20, 2026, 5:42 AM EDT
Completed Not applicable Interventional Results available

Virtual Reality for Pain in Acute Orthopedic Injuries

NCT05552430
View directory record Official record
Conditions
Injuries, Injury Arm, Injury;Sports, Injury, Knee, Injury Wrist, Injury, Ankle, Injury Foot, Injury, Hand, Injury Finger, Injury Leg
Interventions
RelieveVRx
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Sep 20, 2026, 5:42 AM EDT
Recruiting Not applicable Interventional

Brief Pain Exposure Therapy (BPET) For Nociplastic Pain

NCT06208514
View directory record Official record
Conditions
Fibromyalgia, Lupus Erythematosus, Systemic, Chronic Pelvic Pain, Chronic Low Back Pain (CLBP)
Interventions
Brief pain exposure therapy (BPET)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 20, 2026, 5:42 AM EDT
Completed Not applicable Interventional

Type of Exercise and Education in Patients With SubAcromial Pain Syndrome

NCT03127839
View directory record Official record
Conditions
Shoulder Pain
Interventions
Eccentric Strengthening, Traditional Strengthening, Pain education
Procedure · Behavioral
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Sep 20, 2026, 5:42 AM EDT
Recruiting Not applicable Interventional

VCOM Pain Free Research Collaborative

NCT06533345
View directory record Official record
Conditions
Chronic Pain
Interventions
Behavior Change Coaching, Nutrition, Autonomic Recalibration, Dry Needling, Osteopathic Manipulative Treatment, Counseling Psychology, Multiple Treatments
Behavioral · Other · Procedure
Lead sponsor
Edward Via Virginia College of Osteopathic Medicine
Other
Eligibility
21 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 20, 2026, 5:42 AM EDT
Not yet recruiting Not applicable Interventional

Differences in Mechanistic Measures (Oxytocin and Cortisol) of Therapeutic Alliance Between A Talk-Based Therapy and Soft-Tissue Mobilization in Individuals With Chronic Spinal Pain

NCT06987786
View directory record Official record
Conditions
Spine, Low Back Pain, Neck Pain
Interventions
Massage, Talk-based therapy
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 20, 2026, 5:42 AM EDT
Recruiting Not applicable Interventional

Impact of Manual Therapy on Laryngeal Function Following Total Thyroidectomy

NCT06383091
View directory record Official record
Conditions
Total Thyroidectomy
Interventions
Anterior Neck Manual Therapy, Pain Neuroscience Education, Neck Stretches, Scar massage, Voice Exercises, Placebo Anterior Neck Manual Therapy, Placebo Pain Neuroscience Education, Placebo Neck Stretches
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Baltimore, Maryland • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 20, 2026, 5:42 AM EDT
Active, not recruiting Not applicable Interventional

Examining the Effectiveness of Asynchronous Versus Synchronous Yoga for Veterans With Chronic Pain

NCT06973876
View directory record Official record
Conditions
Chronic Pain, Yoga
Interventions
Pain-Sensitive Teleyoga Primer, Synchronous Teleyoga, Asynchronous Teleyoga
Behavioral
Lead sponsor
Portland VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Sep 20, 2026, 5:42 AM EDT
Completed Not applicable Interventional

Single-Session "Empowered Relief" Class for Marfan Syndrome and Related Conditions

NCT05980104
View directory record Official record
Conditions
Chronic Pain, Marfan Syndrome, Vascular Ehlers-Danlos Syndrome, Loeys-Dietz Syndrome
Interventions
Empowered Relief
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Oct 25, 2024 · Synced Sep 20, 2026, 5:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Pain Neuroscience Education in a Spanish-Speaking Population

NCT03785353
View directory record Official record
Conditions
Pain, Educational Problems
Interventions
PNE lecture
Behavioral
Lead sponsor
Shenandoah University
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 15, 2021 · Synced Sep 20, 2026, 5:42 AM EDT
Enrolling by invitation Not applicable Interventional

Using Empowered Relief and Education To Help Postpartum Women Recover After Cesarean Delivery

NCT07192718
View directory record Official record
Conditions
Cesarean Section Complications, Postpartum Care
Interventions
Empowered Relief, Education
Behavioral · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 20, 2026, 5:42 AM EDT
Completed Not applicable Interventional Results available

Virtual Reality for Chronic Pain and Opioid Use Disorder Pilot

NCT05546749
View directory record Official record
Conditions
Chronic Pain, Opioid Use Disorder
Interventions
RelieVRx, Sham VR
Device
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Sep 20, 2026, 5:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Virtual Reality Pain Neuroscience Education for Middle School Students

NCT04470375
View directory record Official record
Conditions
Pain, Education, Virtual Reality
Interventions
Virtual Reality Pain Neuroscience Education
Behavioral
Lead sponsor
University of South Dakota
Other
Eligibility
10 Years to 15 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 4, 2021 · Synced Sep 20, 2026, 5:42 AM EDT
Terminated Not applicable Interventional

Does Prehabilitation Improve Outcomes in Patients Undergoing Complex Spine Fusion Surgery?

NCT05034341
View directory record Official record
Conditions
Lumbar Spine Injury, Spinal Fusion, Frailty, Prehabilitation, Nutritional Supplementation, Functional Outcome
Interventions
Multimodal Prehabilitation, Standard Pre-Surgical Clinical Care
Other
Lead sponsor
University of Florida
Other
Eligibility
55 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 12, 2024 · Synced Sep 20, 2026, 5:42 AM EDT
Completed Not applicable Interventional

Effectiveness of Pain Neuroscience Education (PNE) to Veterans With Post-Traumatic Stress and Low Back Pain

NCT05086159
View directory record Official record
Conditions
Chronic Low Back Pain, Post-traumatic Stress
Interventions
Pain Neuroscience Education, Exercise, Traditional Education
Behavioral
Lead sponsor
Keller Army Community Hospital
Federal
Eligibility
18 Years to 65 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 26, 2021 · Synced Sep 20, 2026, 5:42 AM EDT
Completed Not applicable Interventional

Goal Oriented Activity for Latinos With Spine Pain

NCT05005416
View directory record Official record
Conditions
Low Back Pain, Neck Pain, Chronic Pain, Chronic Low-back Pain
Interventions
GOALS Intervention, Usual Care Physical Therapy
Behavioral
Lead sponsor
San Diego State University
Other
Eligibility
18 Years to 66 Years
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 9, 2025 · Synced Sep 20, 2026, 5:42 AM EDT
Completed Not applicable Interventional Results available

Virtual Empowered Relief for Chronic Pain

NCT05057988
View directory record Official record
Conditions
Chronic Pain, Pain
Interventions
Empowered Relief class
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 15, 2025 · Synced Sep 20, 2026, 5:42 AM EDT
Active, not recruiting Not applicable Interventional

Virtual Reality Treatment for Adults With Chronic Back Pain (VRNT)

NCT07033195
View directory record Official record
Conditions
Chronic Pain, Chronic Back Pain, Chronic Lower Back Pain (CLBP)
Interventions
Skills-based Virtual Reality Therapy, Distraction-based Virtual Reality Therapy
Device
Lead sponsor
CognifiSense Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 20, 2026, 5:42 AM EDT
Enrolling by invitation Not applicable Interventional

Empowered Relief: A One-Time Session to Help Postpartum Women Manage Ongoing Pain After Cesarean Delivery

NCT07090018
View directory record Official record
Conditions
Chronic Pain, Cesarean Section Complications
Interventions
Empowered Relief
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Sep 20, 2026, 5:42 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neural and Psychological Mechanisms of Pain Perception

NCT02446262
View directory record Official record
Conditions
Pain, Normal Physiology, Healthy Volunteers
Interventions
Instructions, Attention, Thermal Pain, Placebo instructions
Behavioral
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years to 50 Years
Enrollment
550 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Sep 20, 2026, 5:42 AM EDT
Completed Not applicable Interventional

PNE Effectiveness Cluster Trial

NCT03168165
View directory record Official record
Conditions
Neck Pain, Low Back Pain, Chronic Pain
Interventions
Pain neuroscience education training
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 75 Years
Enrollment
316 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
41
States / cities
Birmingham, Alabama • Helena, Alabama • Hoover, Alabama + 24 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Sep 20, 2026, 5:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain Neuroscience Education for Depression

NCT04023435
View directory record Official record
Conditions
Chronic Low-back Pain, Depression
Interventions
PNE edcuation
Other
Lead sponsor
St. Ambrose University
Other
Eligibility
18 Years to 90 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 16, 2023 · Synced Sep 20, 2026, 5:42 AM EDT