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ClinicalTrials.gov public records Last synced Oct 19, 2026, 3:46 PM EDT

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Showing 1–24 of 159 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Painful Stimuli Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Microneedle Pretreatment on Topical Anesthesia

NCT02596750
View directory record Official record
Conditions
Pain
Interventions
Microneedle Roller, Sham microneedle Roller
Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Nov 27, 2018 · Synced Oct 19, 2026, 3:46 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Sevoflurane's Effect on Neurocognition Study

NCT06044740
View directory record Official record
Conditions
Anesthesia, Pain, Amnesia
Interventions
Sevoflurane, Peripheral Nerve Stimulation
Drug · Device
Lead sponsor
Keith M Vogt
Other
Eligibility
18 Years to 59 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 19, 2026, 3:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brain Mechanisms of Juvenile Fibromyalgia

NCT03612258
View directory record Official record
Conditions
Fibromyalgia
Interventions
Functional Magnetic Resonance Imaging
Diagnostic Test
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
13 Years to 17 Years · Female only
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 6, 2025 · Synced Oct 19, 2026, 3:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Exercise-induced Hypoalgesia After Comparative Forms of Exercise

NCT01883895
View directory record Official record
Conditions
Pain
Interventions
Forgionei-Barber pressure-pain stimulator, Concentric Exercise, isometric exercise
Device · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 40 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 24, 2017 · Synced Oct 19, 2026, 3:46 PM EDT
Completed Not applicable Interventional Results available

A New Method for Identifying Sensory Changes in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN)

NCT03687970
View directory record Official record
Conditions
Chemotherapy-induced Peripheral Neuropathy
Interventions
Brief Pain Inventory, Hospital Anxiety and Depression Scale, Neuropathic Pain Symptom Inventory, Diode Laser fiber type Selective Stimulator, Quantitative sensory testing, Conditioned pain modulation efficiency, Spontaneous pain at baseline on 0-10 Numerical Rating Scale (NRS)
Other · Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 19, 2021 · Synced Oct 19, 2026, 3:46 PM EDT
Recruiting Not applicable Interventional

Active Music-Based Intervention in Patients With Chronic Low Back Pain

NCT06940063
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Active music-based intervention
Procedure
Lead sponsor
Sharon Wang-Price
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Denton, Texas
Source: ClinicalTrials.gov public record
Updated Jan 9, 2026 · Synced Oct 19, 2026, 3:46 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effects of Pain and the Memory of Pain on Autonomic and Neuromuscular Function

NCT02269384
View directory record Official record
Conditions
Pain
Interventions
Experimental Noxious Stimulus, Memory of Experimental Noxious Stimulus, Memory of Prior Significant Injury, Mental Challenge Test
Procedure · Behavioral
Lead sponsor
Mount St. Mary's College, Los Angeles, CA
Other
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 18, 2015 · Synced Oct 19, 2026, 3:46 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Endogenous Pain Facilitation and Inhibition in Postpartum Women

NCT01843517
View directory record Official record
Conditions
Pain Inhibition and Facilitation in Post Partum Women
Interventions
Not listed
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 19, 2017 · Synced Oct 19, 2026, 3:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Alpha as a Predictive Biomarker

NCT02796625
View directory record Official record
Conditions
Pain
Interventions
Painful Stimuli
Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
21 Years to 44 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 11, 2021 · Synced Oct 19, 2026, 3:46 PM EDT
Completed Not applicable Interventional Results available

Investigating Fear Of Recurrence as a Modifiable Mechanism of Behavior Change

NCT03853213
View directory record Official record
Conditions
Acute Coronary Syndrome, Fear, Medication Adherence
Interventions
Cognitive Bias Modification Training, Attention Control Training
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 17, 2021 · Synced Oct 19, 2026, 3:46 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Study of Pain Processing in Subjects Suffering From Obstructive Sleep Apnea

NCT00672737
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Remifentanil, Cold pain threshold and tolerance, Heat pain threshold and tolerance, Polysomnography
Drug · Procedure · Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 55 Years · Male only
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Aug 7, 2017 · Synced Oct 19, 2026, 3:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain Sensitivity During Puberty

NCT05145595
View directory record Official record
Conditions
Pain
Interventions
Thermal Sensory Analyzer, Pressure Stimuli, Mechanical Stimuli, Pain Ratings, Thermal pain thresholds, Pressure pain thresholds (PPT), Mechanical temporal summation, Conditioned pain modulation (CPM) efficiency, Offset analgesia efficiency, Cold pain tolerance
Device · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
9 Years to 16 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 9, 2026 · Synced Oct 19, 2026, 3:46 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Non-Invasive Bioelectronic Analytics

NCT04100486
View directory record Official record
Conditions
Autonomic Dysfunction, Autonomic Imbalance, Autonomic Nervous System Diseases, Vagus Nerve Autonomic Disorder
Interventions
Standing-Squatting-Standing Test, Deep Breathing Test, Cold Pressor Test, Cold Face Test, Valsalva Maneuver, Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
Other · Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 60 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 19, 2026, 3:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain Modulation Effectiveness (PME)

NCT05783362
View directory record Official record
Conditions
Healthy People
Interventions
Conditioned Pain Modulation (CPM)
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 31, 2023 · Synced Oct 19, 2026, 3:46 PM EDT
Not listed Not applicable Interventional

Simultaneously Targeting Obesity and Pain: The STOP Trial

NCT02100995
View directory record Official record
Conditions
Obesity, Chronic Pain
Interventions
Intervention Simultaneously Targeting Obesity and Pain, Weight Loss/Weight Self-Management, Chronic Pain Self-Management
Behavioral
Lead sponsor
University of the Sciences in Philadelphia
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 15, 2016 · Synced Oct 19, 2026, 3:46 PM EDT
Completed Not applicable Interventional Results available

Effectiveness of Healthy Habits for Hospitalized Older Adults to Optimize Rehabilitation

NCT04269239
View directory record Official record
Conditions
Insomnia, Pain, Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions
Healthy Habits, Sleep Habits
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
40 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
3
States / cities
Galveston, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 19, 2026, 3:46 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Memory Modulation by Pain During Anesthesia

NCT02515890
View directory record Official record
Conditions
Amnesia, Pain, Anesthesia
Interventions
Dexmedetomidine, Midazolam, Peripheral nerve stimulation, Ketamine
Drug · Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 39 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 1, 2020 · Synced Oct 19, 2026, 3:46 PM EDT
Completed Not applicable Interventional Results available

Peripheral Nerve Stimulation for Shoulder Pain: Dose Response

NCT02928055
View directory record Official record
Conditions
Stroke, Shoulder Pain
Interventions
Peripheral Nerve Stimulation
Device
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
21 Years to 89 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 18, 2021 · Synced Oct 19, 2026, 3:46 PM EDT
Completed Not applicable Interventional Results available

Treatment of Insomnia Secondary to Chronic Pain

NCT00127790
View directory record Official record
Conditions
Insomnia, Pain
Interventions
CBT for Insomnia (CBT-I), CBT for Pain (CBT-P)
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
35 Years to 75 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 17, 2012 · Synced Oct 19, 2026, 3:46 PM EDT
Completed Not applicable Interventional

Respiratory-Gated Vagal Nerve Stimulation for Chronic Pain

NCT04053127
View directory record Official record
Conditions
Chronic Pain
Interventions
RAVANS
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 31, 2022 · Synced Oct 19, 2026, 3:46 PM EDT
Recruiting Phase 2 Interventional

Resilience Enhancement Following Sleep Treatment

NCT07298941
View directory record Official record
Conditions
Chronic Low Back Pain (CLBP), Insomnia
Interventions
Cognitive-behavioral therapy for insomnia (CBTi), CBTi + Savoring Meditation, CBTi + Pain Education
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Oct 19, 2026, 3:46 PM EDT
Completed Phase 1 Interventional

Cognitive Behavioral Therapy for Insomnia in Chronic Pain Patients

NCT00133601
View directory record Official record
Conditions
Insomnia, Chronic Pain
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
National Institute of Nursing Research (NINR)
NIH
Eligibility
25 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 16, 2009 · Synced Oct 19, 2026, 3:46 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Puberty, Sex Hormones and Pain Sensitivity in Adolescents With Migraine

NCT05738213
View directory record Official record
Conditions
Migraine
Interventions
Thermal stimuli, Pressure stimuli, Pain ratings, Pressure pain thresholds (PPT), Conditioned pain modulation (CPM) response, PedMIDAS (Pediatric Migraine Disability Assessment), Hormonal assessment, Pubertal status
Device · Behavioral · Diagnostic Test + 1 more
Lead sponsor
Washington University School of Medicine
Other
Eligibility
11 Years to 15 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 19, 2026, 3:46 PM EDT
Completed Not applicable Interventional Results available

Multimodal Treatment for Hemiplegic Shoulder Pain

NCT02893267
View directory record Official record
Conditions
Stroke, Shoulder Pain
Interventions
Peripheral Nerve Stimulation, Physical Therapy, Sham-PT, Sham-PNS
Device · Other
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
21 Years to 89 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
3
States / cities
Chicago, Illinois • Charlotte, North Carolina • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 19, 2026, 3:46 PM EDT