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ClinicalTrials.gov public records Last synced Sep 10, 2026, 6:30 AM EDT

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Showing 1–24 of 64 matching trials from the live ClinicalTrials.gov search.
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Terminated Not applicable Interventional

Measurement of the Partial Pressure of Oxygen in Cutaneous Tumors Using Electron Paramagnetic Resonance (EPR) Oximetry

NCT03716193
View directory record Official record
Conditions
Skin Lesion, Skin Cancer, Skin Melanoma, Tumor Skin
Interventions
Oxygen
Other
Lead sponsor
West Virginia University
Other
Eligibility
18 Years to 90 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 10, 2026, 6:30 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Prolonged Hypoxic Breathing in Healthy Volunteers: a Safety Study

NCT02860975
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Inhaled Nitrogen
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 40 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Sep 10, 2026, 6:30 AM EDT
Completed Not applicable Interventional

Characterization of Rectal Cancer Hypoxia Using pO2 Histography and Immunohistochemistry for Hypoxia-Related Proteins

NCT01189877
View directory record Official record
Conditions
Rectal Cancer
Interventions
Eppendorf hypoximeter
Procedure
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years to 89 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 10, 2012 · Synced Sep 10, 2026, 6:30 AM EDT
Active, not recruiting Not applicable Interventional

Brain Oxygen Optimization in Severe TBI, Phase 3

NCT03754114
View directory record Official record
Conditions
Brain Injuries, Traumatic
Interventions
ICP + PbtO2 guided management strategy, ICP guided management strategy
Other
Lead sponsor
University of Michigan
Other
Eligibility
14 Years and older
Enrollment
1,094 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
48
States / cities
Los Angeles, California • Palo Alto, California • Sacramento, California + 38 more
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 10, 2026, 6:30 AM EDT
Not listed No phase listed Observational

Predictors of Upper Airway Function and Sleep-disordered Breathing in the Critically Ill

NCT02112604
View directory record Official record
Conditions
Critically Ill, Obstructive Sleep Apnea
Interventions
Ventilator, Alice PDx, Pulmonary function test, Muscle strength tests, Grip strength measurement, Sedatives and muscle relaxants given in the ICU
Device · Other · Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2016 · Synced Sep 10, 2026, 6:30 AM EDT
Recruiting Not applicable Interventional

Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)

NCT03963622
View directory record Official record
Conditions
ARDS
Interventions
Respiratory Mechanics, Standard Ventilation Strategy
Other
Lead sponsor
Unity Health Toronto
Other
Eligibility
18 Years and older
Enrollment
740 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 10, 2026, 6:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brain Oximeter Calibration and Validation Study

NCT05397704
View directory record Official record
Conditions
Brain Injuries, Traumatic
Interventions
brain pulse oximeter
Device
Lead sponsor
Cyban Pty Ltd
Industry
Eligibility
18 Years to 45 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 1, 2023 · Synced Sep 10, 2026, 6:30 AM EDT
Terminated No phase listed Observational

Use of Brain Oxygen Tension Level and Cleaved-tau Protein to Detect Vasospasm After SAH

NCT00582868
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Cerebral Vasospasm
Interventions
Licox Brain Oxygen Monitor, CSF, Whole blood
Device · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 1, 2015 · Synced Sep 10, 2026, 6:30 AM EDT
Not listed Not applicable Interventional

Intraoperative Oxygen Concentration and Neurocognition After Cardiac Surgery

NCT02591589
View directory record Official record
Conditions
Hyperoxia, Normoxic, Delirium
Interventions
Normoxic oxygenation, Hyperoxic oxygenation
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 22, 2020 · Synced Sep 10, 2026, 6:30 AM EDT
Completed Not applicable Interventional Results available

Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period

NCT04452188
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome, Total Anomalous Pulmonary Venous Return, Truncus Arteriosus, Pulmonary Atresia With Ventricular Septal Defect, Transposition of the Great Arteries, Double Outlet Right Ventricle, Subpulmonary VSD, Tetralogy of Fallot, Double Outlet Right Ventricle With Subaortic Ventricular Septal Defect and Pulmonary Stenosis, Cardiopulmonary Bypass
Interventions
Normoxia (with controlled re-oxygenation), Standard of care ventilation
Other
Lead sponsor
University of Michigan
Other
Eligibility
Up to 29 Days
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 17, 2024 · Synced Sep 10, 2026, 6:30 AM EDT
Completed Not applicable Interventional

Hyperbaric Oxygen Therapy for Post-Concussion Syndrome

NCT05643482
View directory record Official record
Conditions
Post-Concussion Syndrome
Interventions
Hyperbaric Oxygen Treatment, Placebo gas
Device · Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 10, 2026, 6:30 AM EDT
Terminated Phase 2 Interventional Results available

Study of Oxycyte in Severe Closed Head Injury

NCT00174980
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Oxycyte
Drug
Lead sponsor
Tenax Therapeutics, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Sep 10, 2026, 6:30 AM EDT
Completed Not applicable Interventional

Intermittent Hypoxia Paired with High Intensity Training in Brain Injury

NCT04472442
View directory record Official record
Conditions
Brain Injuries
Interventions
Intermittent hypoxia, Sham hypoxia
Procedure
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 85 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Sep 10, 2026, 6:30 AM EDT
Completed No phase listed Interventional Results available

Correlation of Changes in PaO2 and ORi in Adult Patients

NCT03488238
View directory record Official record
Conditions
Hyperoxia
Interventions
ORi sensor
Device
Lead sponsor
Masimo Corporation
Industry
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Sep 19, 2021 · Synced Sep 10, 2026, 6:30 AM EDT
Completed Phase 1 Interventional

Hyperbaric Oxygen Treatment (HBOT) During Methadone Tapering

NCT05924022
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Hyperbaric Oxygen Treatment Full, Hyperbaric Oxygen Treatment Sham, Hyperbaric Oxygen Treatment Partial Pressure
Combination Product
Lead sponsor
Washington State University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 10, 2026, 6:30 AM EDT
Active, not recruiting Early Phase 1 Interventional

Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder

NCT03748446
View directory record Official record
Conditions
Major Depressive Disorder, Bipolar Depression
Interventions
Xenon, Nitrogen gas
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Sep 10, 2026, 6:30 AM EDT
Completed Phase 3 Interventional

The Effects of Physiologic Oxygen Tension on Clinical In Vitro Fertilization Outcomes

NCT01010386
View directory record Official record
Conditions
Pregnancy, Infertility
Interventions
Atmospheric oxygen tension, Physiologic oxygen tension
Procedure
Lead sponsor
Yale University
Other
Eligibility
18 Years to 42 Years
Enrollment
851 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
4
States / cities
San Francisco, California • New Haven, Connecticut • Storrs, Connecticut + 1 more
Source: ClinicalTrials.gov public record
Updated May 7, 2017 · Synced Sep 10, 2026, 6:30 AM EDT
Active, not recruiting Phase 3 Interventional

Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients

NCT04534959
View directory record Official record
Conditions
Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
Interventions
Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 120 Years
Enrollment
6,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
8
States / cities
Birmingham, Alabama • Denver, Colorado • Cincinnati, Ohio + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Sep 10, 2026, 6:30 AM EDT
Not listed Not applicable Interventional

Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea

NCT03736382
View directory record Official record
Conditions
Obstructive Sleep Apnea, Spinal Cord Injuries
Interventions
Mild intermittent hypoxia, Sham protocol, Continuous positive airway pressure (CPAP)
Other
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
2
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 18, 2024 · Synced Sep 10, 2026, 6:30 AM EDT
Completed No phase listed Observational

Imputation of PaO2 From SaO2

NCT02598492
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
arterial blood gas
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
646 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 7, 2022 · Synced Sep 10, 2026, 6:30 AM EDT
Completed Not applicable Interventional

Effect of CPAP on Fetal pH at Scheduled C-section in Morbidly Obese Women

NCT04993651
View directory record Official record
Conditions
Morbid Obesity, Cesarean Delivery Affecting Fetus
Interventions
CPAP
Device
Lead sponsor
Eastern Virginia Medical School
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 10, 2026, 6:30 AM EDT
Completed Not applicable Interventional

Late Permissive Hypercapnia for Intubated and Ventilated Preterm Infants

NCT02799875
View directory record Official record
Conditions
Premature Neonate
Interventions
Higher permissive hypercapnia, Lower Permissive Hypercapnia
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
7 Days to 14 Days
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 2, 2021 · Synced Sep 10, 2026, 6:30 AM EDT
Recruiting Phase 1Phase 2 Interventional

Intermittent Hypoxia-initiated Plasticity in Humans: A Multi-pronged Therapeutic Approach to Treat Sleep Apnea and Overlapping Co-morbidities

NCT05558501
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Mild Intermittent Hypoxia, Sham MIH
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
30 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 3, 2025 · Synced Sep 10, 2026, 6:30 AM EDT
Terminated Not applicable Interventional

DAMP-Mediated Innate Immune Failure and Pneumonia After Trauma - the Harvard-Longwood (HALO) Campus Area Consortium

NCT03993002
View directory record Official record
Conditions
Respiratory Failure
Interventions
Normoxia with Normocarbia, Normoxia with Hypercarbia, Hyperoxia with Normocarbia, Hyperoxia with Hypercarbia
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 17, 2022 · Synced Sep 10, 2026, 6:30 AM EDT