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ClinicalTrials.gov public records Last synced Oct 7, 2026, 10:47 AM EDT

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Showing 169–192 of 850 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Patient-controlled analgesia Clear all
Completed Phase 3 Interventional Results available

Four Quadrants Transverse Abdominus Plane (4Q-TAP) Block With Plain and Liposomal Bupivacaine vs. Thoracic Epidermal Analgesia (TEA) in Patients Undergoing Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) on an Enhanced Recovery Pathway

NCT03359811
View directory record Official record
Conditions
Peritoneal Cancer
Interventions
Local Anesthetic Solution, Bupivacaine HCl, Liposomal Bupivacaine
Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 18, 2022 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Phase 4 Interventional

Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty

NCT05980546
View directory record Official record
Conditions
Total Knee Replacement, Genicular Nerve Block, Opioid Use
Interventions
Bupivacaine Injection, Dexamethasone injection, Fentanyl, Mepivacaine
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
244 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Oct 7, 2026, 10:47 AM EDT
Terminated Not applicable Interventional Results available

Building Strength Through Rehabilitation for Heart Failure Patients (BISTRO-STUDY)

NCT03615469
View directory record Official record
Conditions
Heart Failure
Interventions
Transcutaneous electrical stimulation, Neuromuscular electrical stimulation
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 31, 2023 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Phase 4 Interventional

Patient-Titrated Automated Intermittent Boluses of Local Anesthetic vs. a Continuous Infusion Via a Perineural Catheter for Postoperative Analgesia

NCT05091905
View directory record Official record
Conditions
Pain, Acute Postoperative, Trauma Injury
Interventions
Continuous Infusion of ropivacaine 0.2%, Titratable Automated Intermittent Boluses of ropivacaine 0.2%
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 7, 2026, 10:47 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Opioid Consumption After Orthopaedic Surgery

NCT03173131
View directory record Official record
Conditions
Orthopedic Disorder
Interventions
Pre-operative opioid counseling
Behavioral
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
280 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 1, 2017 · Synced Oct 7, 2026, 10:47 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Continuous Cryotherapy in Shoulder Arthroplasty Patients

NCT04861441
View directory record Official record
Conditions
Pain, Shoulder
Interventions
Aircast Cryo Cuff (Shoulder) and Aircast Cryo Cuff I/C Motorized Cooler, Icepacks
Device
Lead sponsor
D. Patrick Williams
Other
Eligibility
55 Years to 80 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Erie, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 23, 2023 · Synced Oct 7, 2026, 10:47 AM EDT
Not listed Phase 4 Interventional

Study to Examine Pain Relief With Supplemental Intrathecal Morphine in TKA Patients

NCT02620631
View directory record Official record
Conditions
Acute Pain
Interventions
Morphine, Placebo
Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 80 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Dec 3, 2015 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality Experiences for Anxiety and Pain Control

NCT04759183
View directory record Official record
Conditions
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Interventions
Survey Administration, Virtual Reality Game, Virtual Reality Meditation
Other · Procedure
Lead sponsor
OHSU Knight Cancer Institute
Other
Eligibility
18 Years to 89 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 7, 2022 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Not applicable Interventional

The Effectiveness of Immersive Virtual Reality as a Pain Control Modality After Hip Arthroscopy

NCT05868369
View directory record Official record
Conditions
Hip Pain Chronic
Interventions
iVR Group, Standard pain management regimen
Device · Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Not applicable Interventional

Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation

NCT00060021
View directory record Official record
Conditions
Cancer
Interventions
acupuncture therapy, management of therapy complications, pain therapy
Procedure
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2003
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 30, 2015 · Synced Oct 7, 2026, 10:47 AM EDT
Not yet recruiting Not applicable Interventional

Light Bulb Stimuli to Reduce Chronic Pain

NCT07825792
View directory record Official record
Conditions
Fibromyalgia, Musculoskeletal Pain
Interventions
S-Cone Stimulating Chromatic Light, Equal-Energy White Light
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intervention to Improve Quality of Life in African American Lupus Patients

NCT01837875
View directory record Official record
Conditions
Depression, Systemic Lupus Erythematosus
Interventions
Chronic Disease Self-Management Program (CDSMP), Mail-delivered arthritis kit, Support group, Listserv
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 15, 2018 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Not applicable Interventional Results available

Bioness® StimRouter™ Neuromodulation System for Chronic Pain Therapy

NCT01592344
View directory record Official record
Conditions
Chronic Pain
Interventions
StimRouter - active stimulation, StimRouter - Control
Device
Lead sponsor
Bioness Inc
Industry
Eligibility
22 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
13
States / cities
Scottsdale, Arizona • Napa, California • Pasadena, California + 10 more
Source: ClinicalTrials.gov public record
Updated Apr 11, 2016 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Not applicable Interventional Results available

Adaptation of Ca-HELP Intervention in Rural Geriatric Cancer Patient Population

NCT04262232
View directory record Official record
Conditions
Pain
Interventions
Adapted Ca-HELP for Geriatric Cancer Patients
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
65 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Columbia, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Oct 7, 2026, 10:47 AM EDT
Recruiting Phase 2 Interventional

Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy

NCT06411795
View directory record Official record
Conditions
Duodenal Neoplasm, Pancreatic Neoplasm
Interventions
Bupivacaine, Hydromorphone, Iopamidol, Liposomal Bupivacaine, Medical Chart Review, Questionnaire Administration, Thoracic Epidural Analgesia, Ultrasound Imaging, X-Ray Imaging
Drug · Other · Procedure
Lead sponsor
Masonic Cancer Center, University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Not applicable Interventional

Postoperative Pain Control Results Using Periarticular Versus Intra-capsular Injection of Bupivacaine Liposome Injectable Suspension in Total Knee Arthroplasty

NCT02166632
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Intracapsular Injection, Periarticular Injection
Procedure
Lead sponsor
Broward Health
Other
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Feb 10, 2016 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Phase 4 Interventional Results available

Ultrasound Guided Pain Control Versus Standard Treatment in Emergency Department HIP Fracture Patients

NCT01904071
View directory record Official record
Conditions
Hip Fracture
Interventions
UFNB (Ultrasound guided femoral nerve block), UFIB (Ultrasound Guided Fascia Iliaca Compartment Block), IVMS (IV Morphine)
Procedure · Drug
Lead sponsor
Antonios Likourezos
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jun 6, 2018 · Synced Oct 7, 2026, 10:47 AM EDT
Terminated Not applicable Interventional Results available

Prospective Trial: Pain Management After Pectus Excavatum Repair, Epidural Versus PCA

NCT01863498
View directory record Official record
Conditions
Pectus Excavatum
Interventions
Epidural, PCA
Other
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
12 Years to 17 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Post-Operative Quality of Life Evaluation for Different Anesthesia Techniques for Arthroscopic Shoulder Surgery

NCT01355757
View directory record Official record
Conditions
Rotator Cuff Injury
Interventions
Baxter INFUSOR System, Single Injection of Local Anesthetic
Device · Drug
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years to 75 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 19, 2014 · Synced Oct 7, 2026, 10:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brain Mechanisms of Psychosocial Aspects of Acupuncture Therapy

NCT02908022
View directory record Official record
Conditions
Physician-patient Relationship, Fibromyalgia, Acupuncture Therapy
Interventions
Electroacupuncture Analgesia, Hokanson Rapid Cuff Inflator
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2024
U.S. locations
2
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 16, 2025 · Synced Oct 7, 2026, 10:47 AM EDT
Recruiting Not applicable Interventional

POP SINGER Randomized Clinical Trial

NCT07756541
View directory record Official record
Conditions
Chronic Pain
Interventions
Yoga, Music Therapy
Behavioral
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Oct 7, 2026, 10:47 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Valacyclovir in Pain Management of Acute Apical Abscesses

NCT05266040
View directory record Official record
Conditions
Acute Apical Abscess, Pain, Acute
Interventions
Valacyclovir 500 MG, Placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Oct 7, 2026, 10:47 AM EDT
Withdrawn Phase 4 Interventional

Suboxone User Perioperative Early Referral and Enhanced Recovery After Surgery- Orthopaedic Trauma Surgery Population

NCT04464512
View directory record Official record
Conditions
Addiction Opiate, Chronic Pain, Fractures, Bone, Buprenorphine Dependence
Interventions
Sufentanil
Drug
Lead sponsor
West Virginia University
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Dec 12, 2022 · Synced Oct 7, 2026, 10:47 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Techniques to Reduce the Severity and Frequency of Emergent Reactions

NCT03832309
View directory record Official record
Conditions
Analgesia
Interventions
Do we speak to them in a way that convinces them to have the dream, Speaking to them as a regualar person
Behavioral
Lead sponsor
CHRISTUS Health
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Corpus Christi, Texas
Source: ClinicalTrials.gov public record
Updated Apr 6, 2022 · Synced Oct 7, 2026, 10:47 AM EDT