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Showing 1–24 of 30 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Patients with acute appendicitis Clear all
Completed Phase 2 Interventional Results available

The Role of Contrast Enhanced Ultrasound in Appendicitis

NCT03687502
View directory record Official record
Conditions
Acute Appendicitis
Interventions
Sulfur hexafluoride lipid-type A microspheres
Drug
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
8 Years to 17 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 7, 2023 · Synced Sep 18, 2026, 6:04 PM EDT
Withdrawn Not applicable Interventional

The Effect of Gum Chewing on Postoperative Ileus

NCT00879294
View directory record Official record
Conditions
Perforated Appendicitis
Interventions
Motion sickness wristband, Chewing Gum
Device · Dietary Supplement
Lead sponsor
Wake Forest University
Other
Eligibility
6 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 5, 2017 · Synced Sep 18, 2026, 6:04 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Appendicitis Choice of Treatment Study

NCT04968782
View directory record Official record
Conditions
Acute Appendicitis
Interventions
Patients with acute appendicitis
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 22, 2022 · Synced Sep 18, 2026, 6:04 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Comparison of UGBRS Block and Local Infiltration

NCT02352519
View directory record Official record
Conditions
Appendicitis
Interventions
UGBRSB, Local Infiltration
Procedure
Lead sponsor
Baylor College of Medicine
Other
Eligibility
6 Years to 17 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 20, 2015 · Synced Sep 18, 2026, 6:04 PM EDT
Recruiting Phase 4 Interventional

APPI-Cost Trial for Perforated Appendicitis

NCT06705842
View directory record Official record
Conditions
Perforated Appendicitis
Interventions
PVI, Usual Care
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
346 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 10, 2025 · Synced Sep 18, 2026, 6:04 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study

NCT07579312
View directory record Official record
Conditions
Intra Abdominal Infections, Appendicitis Acute, Pyelonephritis, Diverticulitis, Epiploic Appendagitis
Interventions
TruNAV, an RNA-based blood test for host immune activation by infections
Diagnostic Test
Lead sponsor
True Bearing Diagnostics, Inc.
Industry
Eligibility
7 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 18, 2026, 6:04 PM EDT
Completed Not applicable Interventional Results available

Randomized Controlled Trial of a Patient Activation Tool in Pediatric Appendicitis (Antibiotics Alone vs. Appendectomy)

NCT02110485
View directory record Official record
Conditions
Appendicitis, Children
Interventions
Patient Activation Tool
Other
Lead sponsor
Peter Minneci
Other
Eligibility
7 Years to 17 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 18, 2019 · Synced Sep 18, 2026, 6:04 PM EDT
Terminated Not applicable Interventional Results available

Single-incision Laparoscopic (SILS) Versus Conventional Laparoscopic Appendectomy for the Treatment of Acute Appendicitis

NCT00997516
View directory record Official record
Conditions
Appendicitis
Interventions
SILS appendectomy, conventional laparoscopic appendectomy
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 21, 2014 · Synced Sep 18, 2026, 6:04 PM EDT
Terminated Not applicable Interventional Results available

Operative vs Non-Operative Management of Acute Appendicitis and Acute Cholecystitis in COVID-19 Positive Patients

NCT04748120
View directory record Official record
Conditions
Covid19, Appendicitis, Cholecystitis, Acute, Cholecystitis; Gallstone, Cholecystitis
Interventions
Operative management, Non-operative management
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 13, 2022 · Synced Sep 18, 2026, 6:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Physician Race and Gender on Simulated Patients' Ratings

NCT04190901
View directory record Official record
Conditions
Bias, Racial, Bias, Sex, Patient Satisfaction, Physician-Patient Relations
Interventions
Simulated Black Male Physician, Simulated Black Female Physician, Simulated White Male Physician, Simulated White Female Physician
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
3,592 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 20, 2020 · Synced Sep 18, 2026, 6:04 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of Local Anesthetic at Incision Site

NCT02483689
View directory record Official record
Conditions
Post Operative Pain, Appendicitis
Interventions
Pre Incisional Local Anesthetic, Pre-Incisional Saline, Post-Closure Local Anesthetic, Post-Closure Saline
Drug · Other
Lead sponsor
Valley Anesthesiology Consultants
Other
Eligibility
9 Years to 17 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated May 1, 2018 · Synced Sep 18, 2026, 6:04 PM EDT
Recruiting Not applicable Interventional

Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon

NCT04168866
View directory record Official record
Conditions
Appendicitis
Interventions
Operative management, Drainage or antibiotics
Procedure · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2029
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Sep 18, 2026, 6:04 PM EDT
Completed Not applicable Interventional Results available

Probiotics and Antibiotic Associated Diarrhea in Pediatric Complicated Appendicitis

NCT04529980
View directory record Official record
Conditions
Appendicitis, Appendicitis; Perforation
Interventions
Lactobacillus rhamnosus GG (LGG) Probiotic, Placebo
Dietary Supplement
Lead sponsor
Children's Health
Other
Eligibility
4 Years to 18 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 12, 2024 · Synced Sep 18, 2026, 6:04 PM EDT
Completed Not applicable Interventional Results available

Magnetic Resonance Imaging (MRI) of Appendicitis in Children

NCT00723788
View directory record Official record
Conditions
Appendicitis
Interventions
MRI of the abdomen
Device
Lead sponsor
Children's National Research Institute
Other
Eligibility
8 Years to 18 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2014 · Synced Sep 18, 2026, 6:04 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Pilot Study to Identify the Influence of Genetic Profile Aberrations on Patients With Recurrent Hernias

NCT00527670
View directory record Official record
Conditions
Pathological Processes
Interventions
Normal Controls, Recurrent Hernia
Procedure
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 7, 2016 · Synced Sep 18, 2026, 6:04 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Comparison of Medical and Surgical Treatment of Uncomplicated Acute Appendicitis in Children

NCT02991937
View directory record Official record
Conditions
Appendicitis
Interventions
Piperacillin/Tazobactam, Surgical Treatment
Drug · Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
6 Years to 17 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 20, 2022 · Synced Sep 18, 2026, 6:04 PM EDT
Completed Not applicable Interventional Results available

Fast Track Appendectomy for Suppurative Appendicitis

NCT02137603
View directory record Official record
Conditions
Suppurative Appendicitis
Interventions
Patients discharged home the same day following appendectomy
Other
Lead sponsor
Johns Hopkins All Children's Hospital
Other
Eligibility
5 Years to 18 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Jul 2, 2023 · Synced Sep 18, 2026, 6:04 PM EDT
Recruiting Not applicable Interventional

PAINED: Project Addressing INequities in the Emergency Department

NCT05488080
View directory record Official record
Conditions
Pain, Appendicitis, Bias, Racial, Fractures, Bone
Interventions
Department-level audit and feedback and electronic health record-embedded clinical decision support
Behavioral
Lead sponsor
Children's National Research Institute
Other
Eligibility
0 Years and older
Enrollment
22,032 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Sep 18, 2026, 6:04 PM EDT
Completed Not applicable Interventional Results available

The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis

NCT02881996
View directory record Official record
Conditions
Perforated Appendicitis
Interventions
IV tylenol, No IV tylenol, Ketorolac
Drug
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
2 Years to 17 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 11, 2021 · Synced Sep 18, 2026, 6:04 PM EDT
Not listed No phase listed Observational

Non-operative Management of Early Appendicitis in Children

NCT01718275
View directory record Official record
Conditions
Appendicitis
Interventions
Not listed
Lead sponsor
Peter Minneci
Other
Eligibility
7 Years to 17 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Sep 18, 2026, 6:04 PM EDT
Completed Not applicable Interventional Results available

The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial

NCT02800785
View directory record Official record
Conditions
Appendicitis
Interventions
Cefoxitin, Ertapenem, Moxifloxacin, Tigecycline, Ticarcillin-Clavulanic Acid; Metronidazole plus Cefazolin, Cefuroxime, Ceftriaxone, Cefotaxime, Ciprofloxacin, or Levofloxacin, Appendectomy
Drug · Procedure
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
1,552 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
25
States / cities
Sylmar, California • Torrance, California • Aurora, Colorado + 14 more
Source: ClinicalTrials.gov public record
Updated May 5, 2023 · Synced Sep 18, 2026, 6:04 PM EDT
Withdrawn Phase 1Phase 2 Interventional

Narcotic vs. Non-narcotic Pain Regimens After Pediatric Appendectomy

NCT03528343
View directory record Official record
Conditions
Appendicitis, Pain, Postoperative
Interventions
Non-narcotic pain control
Drug
Lead sponsor
University of Utah
Other
Eligibility
Up to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 6, 2020 · Synced Sep 18, 2026, 6:04 PM EDT
Completed Not applicable Interventional

CT Scan Using IV Contrast Alone for Pediatric Appendicitis

NCT00716703
View directory record Official record
Conditions
Appendicitis, Child, Contrast Media
Interventions
CT Scan using IV contrast alone
Other
Lead sponsor
University of Rochester
Other
Eligibility
3 Years to 18 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 15, 2008 · Synced Sep 18, 2026, 6:04 PM EDT
Completed Phase 2 Interventional Results available

Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis

NCT02664220
View directory record Official record
Conditions
Acute, Perforated Appendicitis
Interventions
Povidone-iodine irrigation, No irrigation
Drug · Procedure
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
2 Years to 17 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 16, 2019 · Synced Sep 18, 2026, 6:04 PM EDT