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Showing 1–24 of 32 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Per-oral Endoscopic Myotomy Clear all
Recruiting No phase listed Observational

Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure

NCT05711758
View directory record Official record
Conditions
Obesity, Obesity, Morbid, Obesity, Primary, Metabolic Disease, Delayed Gastric Emptying Following Procedure
Interventions
PSAM Treatment Patients
Procedure
Lead sponsor
Christopher C. Thompson, MD, MSc
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Sep 13, 2026, 7:24 PM EDT
Completed Not applicable Interventional

Monopolar and Bipolar Current RFA Knife in POEM

NCT05272046
View directory record Official record
Conditions
Esophageal Motility Disorders
Interventions
Per-oral Endoscopic Myotomy, Speedboat (Bipolar electrocautery knife)
Procedure · Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 13, 2026, 7:24 PM EDT
Recruiting Not applicable Interventional

POEM-F for Achalasia International Study

NCT06042127
View directory record Official record
Conditions
Achalasia
Interventions
POEM-F, Conventional POEM
Procedure
Lead sponsor
Chinese University of Hong Kong
Other
Eligibility
18 Years to 65 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 2, 2024 · Synced Sep 13, 2026, 7:24 PM EDT
Active, not recruiting Not applicable Interventional

Endoscopic Myotomy of the Pylorus To Improve Emptying and Symptoms Trial

NCT05039424
View directory record Official record
Conditions
Gastroparesis
Interventions
Endoscopic per-oral pyloromyotomy (POP), Diagnostic esophagogastroduodenoscopy (EGD) without pyloric disruption
Procedure
Lead sponsor
Matthew Allemang
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 13, 2026, 7:24 PM EDT
Completed Not applicable Interventional

POEM Anterior Versus Posterior Approach

NCT02454335
View directory record Official record
Conditions
Achalasia
Interventions
Peroral Endoscopic Myotomy
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 1, 2018 · Synced Sep 13, 2026, 7:24 PM EDT
Completed No phase listed Observational

ConMed Beamer Study

NCT04752670
View directory record Official record
Conditions
Gastrointestinal Neoplasms, Achalasia, Gastroparesis
Interventions
Not listed
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 26, 2022 · Synced Sep 13, 2026, 7:24 PM EDT
Completed No phase listed Observational

Per-Oral Endoscopic Myotomy

NCT01402518
View directory record Official record
Conditions
Achalasia
Interventions
Per-oral enodscopic myotomy
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2019
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Sep 13, 2026, 7:24 PM EDT
Withdrawn Not applicable Interventional

Management of Symptomatic Gastric Sleeve Stenosis After Laparoscopic Sleeve Gastrectomy

NCT04781946
View directory record Official record
Conditions
Gastric Stenosis
Interventions
Endoscopic pneumatic balloon dilation, Gastric peroral endoscopic myotomy (G-POEM), Roux-en-Y gastric bypass (RYGB)
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 12, 2023 · Synced Sep 13, 2026, 7:24 PM EDT
Completed No phase listed Observational

G-POEM for Treatment of Refractory Gastroparesis

NCT02732821
View directory record Official record
Conditions
Diabetic Gastroparesis, Idiopathic Gastroparesis, Gastroparesis Postoperative
Interventions
Gastric Per Oral Endoscopic Myotomy
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 20, 2020 · Synced Sep 13, 2026, 7:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Short Vs Standard Length Myotomy in Achalasia

NCT04798547
View directory record Official record
Conditions
Achalasia
Interventions
Short Myotomy, Standard Length Myotomy
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 14, 2024 · Synced Sep 13, 2026, 7:24 PM EDT
Not listed Phase 2 Interventional

Endolumenal Partial Myotomy for Esophageal Motility Disorders

NCT01302301
View directory record Official record
Conditions
Esophageal Motility Disorders
Interventions
Per oral endolumenal myotomy
Procedure
Lead sponsor
The Oregon Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 27, 2011 · Synced Sep 13, 2026, 7:24 PM EDT
Active, not recruiting Not applicable Interventional

Impact of Per Oral Pyloromyotomy (POP) on Glycemic Control in Diabetes

NCT04696159
View directory record Official record
Conditions
Diabetes Mellitus, Gastroparesis With Diabetes Mellitus, Gastroparesis
Interventions
Pyloromyotomy
Procedure
Lead sponsor
Matthew Allemang
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 13, 2026, 7:24 PM EDT
Completed Not applicable Interventional

Anterior Orientation vs Posterior Orientation in Per Oral Endoscopic Myotomy POEM for the Treatment of Achalasia

NCT03228758
View directory record Official record
Conditions
Achalasia
Interventions
Per Oral Endoscopic Myotomy
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Mineola, New York
Source: ClinicalTrials.gov public record
Updated May 4, 2020 · Synced Sep 13, 2026, 7:24 PM EDT
Not yet recruiting No phase listed Observational

Disposable Endoscope Platform in Third Space Endoscopic Procedures

NCT06738628
View directory record Official record
Conditions
Achalasia, Gastroparesis
Interventions
(Esophageal or Gastric) Per-Oral Endoscopic Myotomy
Procedure
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Sep 13, 2026, 7:24 PM EDT
Not listed Phase 2 Interventional

Endolumenal Partial Myotomy for the Treatment of Esophageal Achalasia

NCT01302288
View directory record Official record
Conditions
Achalasia
Interventions
Per oral endolumenal myotomy
Procedure
Lead sponsor
The Oregon Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 27, 2011 · Synced Sep 13, 2026, 7:24 PM EDT
Completed Phase 1Phase 2 Interventional

Endoscopic Myotomy for the Treatment of Achalasia (Motility Disorder) of the Esophagus - POEM Procedure

NCT01873300
View directory record Official record
Conditions
Achalasia
Interventions
Endoscopic Esophageal Myotomy
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 8, 2015 · Synced Sep 13, 2026, 7:24 PM EDT
Recruiting Phase 4 Interventional

Comprehensive Esophageal Diagnostics Study

NCT04641702
View directory record Official record
Conditions
Achalasia
Interventions
Atropine challenge, Esophageal muscle biopsy
Drug · Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Sep 13, 2026, 7:24 PM EDT
Enrolling by invitation No phase listed Observational

Endoscopic Metabolic and Bariatric Therapies

NCT05725967
View directory record Official record
Conditions
Obesity, Obesity, Morbid, Obesity Associated Disorder, Bariatric Surgery Candidate, Fistula, Gastric, Roux-en-y Anastomosis Site, Ulcer, Gastric, Abdominal Pain, Abdominal Obesity, Complication of Surgical Procedure, Complication of Treatment, Complication,Postoperative, Weight Gain, Weight Loss, Leak, Anastomotic, Delayed Gastric Emptying Following Procedure
Interventions
Primary Obesity Endoscopic Procedures, Endoscopic Revision of Bariatric Surgical Procedures, Bariatric Surgery Procedures, Endoscopic Sleeve Gastroplasty, Trans-oral Outlet Reduction, Intragastric Balloon, Primary obesity surgery endoluminal, Restorative obesity surgery endoluminal, Argon Plasma Coagulation, Gastroplasty with Endoscopic Myotomy, Bariatric Endoscopic Antral Myotomy, Pylorus Sparing Antral Myotomy, Aspiration Therapy
Procedure · Device
Lead sponsor
Christopher C. Thompson, MD, MSc
Other
Eligibility
18 Years to 80 Years
Enrollment
5,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Sep 13, 2026, 7:24 PM EDT
Withdrawn Not applicable Interventional

Peroral Endoscopic Myotomy Versus Botulinum Toxin Injection in Spastic Esophageal Disorders

NCT02663206
View directory record Official record
Conditions
Esophageal Achalasia, Esophageal Spasm, Diffuse, Esophageal Motility Disorders
Interventions
peroral endoscopic myotomy, Botulinum toxin injection
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 11, 2018 · Synced Sep 13, 2026, 7:24 PM EDT
Completed Not applicable Interventional

Peroral Endoscopic Myotomy (POEM) for Esophageal Motility

NCT02314741
View directory record Official record
Conditions
Achalasia
Interventions
POEM Procedure
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 18, 2018 · Synced Sep 13, 2026, 7:24 PM EDT
Not listed No phase listed Observational

Peroral Endoscopic Myotomy (POEM) For The Treatment Of Achalasia: A Registry

NCT02162589
View directory record Official record
Conditions
Achalasia
Interventions
POEM
Procedure
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 90 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 19, 2017 · Synced Sep 13, 2026, 7:24 PM EDT
Completed Not applicable Interventional

Endoscopic Pyloromyotomy for Refractory Gastroparesis

NCT03356067
View directory record Official record
Conditions
Gastroparesis
Interventions
Gastric endoscopic peroral pyloromyotomy, Esophago-gastro-duodenoscopy
Procedure
Lead sponsor
Institute for Clinical and Experimental Medicine
Government
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 26, 2021 · Synced Sep 13, 2026, 7:24 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Per-Oral Endoscopic Myotomy (POEM) for the Treatment of Achalasia, Database Repository

NCT02770859
View directory record Official record
Conditions
Achalasia
Interventions
POEM (Per Oral Endoscopic Myotomy)
Procedure
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2040
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 13, 2026, 7:24 PM EDT
Completed Not applicable Interventional

Per Oral Endoscopic Myotomy (POEM) for Esophagogastric Junction Outflow Obstruction (EGOO)

NCT01942018
View directory record Official record
Conditions
Esophagogastric Junction Outflow Obstruction
Interventions
POEM
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 27, 2020 · Synced Sep 13, 2026, 7:24 PM EDT