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Conditions: Graves Disease, Hyperthyroidism/Thyrotoxicosis
Interventions: Heart rate-based AI software for detecting thyrotoxicosis; Device
Lead sponsor: THYROSCOPE INC.; Industry
Eligibility: 22 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Geriatrics, Aged, Geriatric Syndromes, Cardiovascular Diseases
Interventions: Cognitive Assessment, Activities of Daily Living Questionnaire, Instrumental Activities of Daily Living, subscale of the OARS, Karnofsky Self-reported Performance Rating Scale, Number of Falls, Physical Health Section, subscale of the OARS, MOS Social Activity Survey, Unintentional Weight Loss, Peripheral Blood Draw, Buccal Swab, Heart Health and Smoking History from BRFSS questionnaire, Gait Speed, Grip Strength, Height and Weight measurements, Blood pressure measurement, Optional bone marrow biopsy, Blood draw for trauma measurements, Femur head donation, Knee bone fragments, Bone marrow aspirate; Other · Genetic · Procedure
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 50 Years and older
Enrollment: 2,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2030
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Glaucoma, GLAUCOMA 1, OPEN ANGLE, D (Disorder), Ocular Hypertension, Ocular Hypertension (OH), Ocular Hypertension Glaucoma, IOP, Intraocular Pressure, Glaucoma Open-Angle, Glaucoma and Ocular Hypertension, Glaucoma Patients and Healthy Controls, Normal Tension Glaucoma (NTG)
Interventions: miLens system; Device
Lead sponsor: Smartlens, Inc.; Industry
Eligibility: 22 Years to 80 Years
Enrollment: 86 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 3
States / cities: Fullerton, California • Petaluma, California • Torrance, California

Conditions: Healthy
Interventions: Masimo INVSENSOR00057; Device
Lead sponsor: Masimo Corporation; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 86 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: Irvine, California

Conditions: Healthy
Interventions: AMATEA™, Caffeine, Placebo; Dietary Supplement · Other
Lead sponsor: University of Memphis; Other
Eligibility: 18 Years to 40 Years
Enrollment: 59 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Prostate Cancer, Urology, Prostate Cancer (Diagnosis)
Interventions: PROSTEST; Diagnostic Test
Lead sponsor: Wren Laboratories LLC; Industry
Eligibility: 45 Years to 80 Years · Male only
Enrollment: 1,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Branford, Connecticut

Conditions: Multiple Chronic Conditions, Disability Physical
Interventions: Behavioral Activation + Occupational Therapy, Enhanced Usual Care; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 60 Years and older
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Older, Adults, Older Adults, Balance
Interventions: restricted vision (no-V), full vision (full-V); Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 65 Years to 80 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Normal
Interventions: Kerato-Refracto Tonometer; Device
Lead sponsor: Topcon Corporation; Industry
Eligibility: 22 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Insufficient Sleep, Obesity
Interventions: Fixed sleep goal, Personalized sleep goal, Digital sleep health messaging without virtual study visit, Digital sleep health messaging with virtual study visit, Inactive Parent-Directed Loss-Framed Incentive, Active Parent-Directed Loss-Framed Incentive, Inactive Supportive Feedback, Active Supportive Feedback; Behavioral
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 8 Years to 12 Years
Enrollment: 5,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: PrEP Uptake
Interventions: PrEP Education, Provider training, EMR Optimization, PrEP Navigation, Provider Audit and Feedback; Behavioral · Other
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older
Enrollment: 724 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Head and Neck Cancer
Interventions: Neurocognitive Tests, Questionnaires; Other
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years to 89 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 7
States / cities: Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more

Conditions: Amputation Stump
Interventions: Static socket, User adjusted socket, Microprocessor-adjusting sockets; Device
Lead sponsor: Brooke Army Medical Center; Federal
Eligibility: 18 Years to 55 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Fort Sam Houston, Texas

Conditions: Major Depressive Disorder
Interventions: Pathway Platform mobile app; Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 89 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Oak Lawn, Illinois

Conditions: Breast Cancer, Cancer Survivor
Interventions: white button mushroom extract, flow cytometry, high performance liquid chromatography, laboratory biomarker analysis, mass spectrometry, pharmacogenomic studies, pharmacological study; Drug · Other
Lead sponsor: City of Hope Medical Center; Other
Eligibility: 21 Years and older · Female only
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 2
States / cities: Duarte, California • Pasadena, California

Conditions: Pulmonary Hypertension
Interventions: blood draw, Short Performance Physical Battery, Grip strength test, Six minute walk test, Chest CT scan, Dual-Energy X-ray Absorptiometry Scan, Activity monitoring, 24 hour diet recall, Echocardiogram, Quality of Life Questionnaire (emPHasis 10), International Physical Activity Questionnaire Short Form (IPAQ-SF); Diagnostic Test · Radiation · Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania • Providence, Rhode Island

Conditions: Latent Tuberculosis
Interventions: TB Infection ECHO; Other
Lead sponsor: Kent Hospital, Rhode Island; Other
Eligibility: 18 Years and older
Enrollment: 84 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Pawtucket, Rhode Island

Conditions: Compartment Syndrome of Leg
Interventions: Near Infrared Spectroscopy; Device
Lead sponsor: Nonin Medical, Inc; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Healthy
Interventions: 2 mg hydromorphone, 1000 mg Acetaminophen, 4 mg hydromorphone, dextrose; Drug
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years to 40 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Healthy Volunteers
Interventions: armodafinil, Placebo (for armodafinil); Drug
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 35 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Preterm Birth
Interventions: Not listed
Lead sponsor: KC BioMediX, Inc; Industry
Eligibility: 30 Weeks to 36 Weeks
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Raleigh, North Carolina

Conditions: Fear Pain
Interventions: Skin conductance levels and slopes over time in conditioned fear as metrics.as metrics for anxiety; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 16 Years to 88 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Down Syndrome, Congenital Heart Disease
Interventions: Stanford Binet Intelligence Scales, Fifth Edition, Vineland Adaptive Behavior Scales Third Edition, Peabody Picture Vocabulary Test, Fifth Edition, Expressive Vocabulary Test, Third Edition, Leiter International Performance Scale, Third Edition, Social Communication Questionnaire, Current Form, Aberrant Behavior Checklist, Repetitive Behavior Scale, Revised; Other
Lead sponsor: Carelon Research; Other
Eligibility: 60 Months to 155 Months
Enrollment: 273 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 13
States / cities: Wilmington, Delaware • Washington D.C., District of Columbia • Atlanta, Georgia + 10 more

Conditions: Mild Traumatic Brain Injury, Post-Concussive Symptoms
Interventions: Not listed
Lead sponsor: VA Eastern Colorado Health Care System; Federal
Eligibility: 18 Years to 45 Years
Enrollment: 3 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Denver, Colorado

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Evaluating an AI Tool for Detecting Thyrotoxic States

Aging, Geriatric Syndromes and Clonal Hematopoiesis

24-hour Wear Performance and Safety Study of Smartlens miLens Contact Lens for IOP Monitoring

Clinical Performance of Masimo INVSENSOR00057 for Heart Rate Measurements

Impact of AMATEA™️ on Physiological Measures and Gaming Performance in Active Gamers: a Placebo Controlled, Double-blind, Randomized Study

A Single-arm, Multicenter Prospective Study to Evaluate the Diagnostic Performance of PROSTest in Men With PSA ≥ 3ng/ml Using Biopsy as the Sole Ground Truth

Behavioral Activation + Occupational Therapy

Postural Control in Adults

TRK-3 Performance of Pachymetry

Optimizing a Mobile Health Platform for Sleep Promotion and Obesity Prevention in Children

PrEP Optimization Among Women to Enhance Retention and Uptake

A Study of Neurocognitive Tests and Questionnaires for People With Head and Neck Cancer Who Are Undergoing Radiation Therapy

Do Adaptable Sockets Improve Military Performance?

Use of a Digitally Enabled App With Clinical Team Interface in the Management of Depression

White Button Mushroom Extract in Preventing the Recurrence of Breast Cancer in Postmenopausal Breast Cancer Survivors

Understanding the Effects of Pulmonary Arterial Hypertension on Lean Muscle Mass

Improving Rhode Island's Tuberculosis Preventive Services in Primary Care

Evaluating the Diagnostic Performance of ACS Using NIRS in Traumatized Lower Extremities

The Effects of Hydromorphone on Responses to Verbal Tasks

Effect of Armodafinil on Simulated Driving

Comparison of Non-nutritive Suck (NNS) Measures to Clinical Estimates of Suck and Feeding Readiness in Preterm Infants

Human Behaviors Related to the Expectation of Pain

Congenital Heart Disease: Impact on Learning and Development in Down Syndrome (CHILD-DS)

Consistency of Automated Neuropsychological Assessment Metrics (ANAM) Performance in Those With Deployment Acquired Mild Traumatic Brain Injury (TBI)