Search | Clinical Trials Finder

Independent directory Public ClinicalTrials.gov records United States

ClinicalTrials.gov public records Last synced Sep 23, 2026, 12:36 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.

Local D1 index available.

Filters: Intervention: Phenoptin Clear all

Conditions: Phenylketonurias
Interventions: sapropterin dihydrochloride; Drug
Lead sponsor: BioMarin Pharmaceutical; Industry
Eligibility: 8 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2006
U.S. locations: 14
States / cities: Los Angeles, California • Oakland, California • Sacramento, California + 11 more

Conditions: Phenylketonuria, Hyperphenylalaninaemia
Interventions: Kuvan; Drug
Lead sponsor: BioMarin Pharmaceutical; Industry
Eligibility: Not listed
Enrollment: 1,887 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2021
U.S. locations: 45
States / cities: Los Angeles, California • Orange, California • San Diego, California + 38 more

Conditions: Phenylketonuria
Interventions: tetrahydrobiopterin (BH4); Drug
Lead sponsor: The University of Texas Medical Branch, Galveston; Other
Eligibility: 10 Years and older
Enrollment: 57 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2015
U.S. locations: 1
States / cities: Galveston, Texas

Conditions: Gastroparesis
Interventions: sapropterin dihydrochloride; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Stanford, California

Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: Antioxidant, Tetrahydrobiopterin (BH4), Exercise training; Dietary Supplement · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2025
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Intermittent Claudication
Interventions: Placebo, Sapropterin Dihydrochloride; Other · Drug
Lead sponsor: BioMarin Pharmaceutical; Industry
Eligibility: 40 Years to 80 Years
Enrollment: 190 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 17
States / cities: Scottsdale, Arizona • Sacramento, California • San Diego, California + 14 more

Conditions: Phenylketonuria
Interventions: Sapropterin; Drug
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 18 Years to 50 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cystic Fibrosis
Interventions: BH4 5mg, BH4 20mg, Antioxidant Cocktail; Drug · Dietary Supplement
Lead sponsor: Augusta University; Other
Eligibility: 7 Years and older
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Augusta, Georgia

Conditions: PKU
Interventions: diet, sapropterin dihydrochloride; Dietary Supplement · Drug
Lead sponsor: Children's National Research Institute; Other
Eligibility: 18 Years to 40 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Menopause, Aging
Interventions: KUVAN, Placebo, Cetrotide, Climara, Placebo transdermal patch; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 70 Years · Female only
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Autistic Disorder
Interventions: sapropterin, Placebo; Drug
Lead sponsor: The Children's Health Council; Other
Eligibility: 3 Years to 6 Years
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Phenylketonuria
Interventions: Kuvan, Meal Challenge; Drug · Other
Lead sponsor: Emory University; Other
Eligibility: 10 Years to 45 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Decatur, Georgia

Conditions: Autism Spectrum Disorder
Interventions: sapropterin dihydrochloride; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 2 Years to 6 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Schizo Affective Disorder, Schizophrenia
Interventions: L-arginine, Sapropterin Dihydrochloride; Drug
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Pulmonary Arterial Hypertension
Interventions: sapropterin dihydrochloride (6R-BH4); Drug
Lead sponsor: Vanderbilt University; Other
Eligibility: 18 Years and older
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Phenylketonuria
Interventions: Not listed
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 18 Years to 55 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Hypertension
Interventions: Tetrahydrobiopterin; Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2005
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Phenylketonuria
Interventions: Sapropterin (Kuvan); Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 6 Years to 50 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2018
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: GTP Cyclohydrolase Deficiency
Interventions: Sapropterin; Drug
Lead sponsor: University of Utah; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Rheumatologic Disease
Interventions: BH4, Vasculopathy assessment, Placebo; Drug · Diagnostic Test
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 95 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Phenylketonuria
Interventions: sapropterin dihydrochloride; Drug
Lead sponsor: BioMarin Pharmaceutical; Industry
Eligibility: 4 Years and older
Enrollment: 111 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 14
States / cities: Los Angeles, California • Sacramento, California • San Jose, California + 11 more

Conditions: Heart Failure, Cardiovascular Disease
Interventions: Kuvan; Drug
Lead sponsor: Providence VA Medical Center; Federal
Eligibility: 18 Years and older
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Schizophrenia, Schizoaffective Disorder
Interventions: Kuvan, Multivitamin; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 64 Years
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: Phenylketonuria
Interventions: Kuvan, Diet; Drug · Other
Lead sponsor: University of Miami; Other
Eligibility: 4 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Miami, Florida