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Showing 1–20 of 20 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Phonation Clear all
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor

NCT05216770
View directory record Official record
Conditions
Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
Interventions
Brain imaging, Laryngeal sensory block with topical bupivacaine
Other · Drug
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
18 Years to 80 Years
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Sep 2, 2026, 6:31 AM EDT
Not yet recruiting Not applicable Interventional

PhoRTE® Therapy Efficacy: In-Person Versus Telehealth

NCT06934265
View directory record Official record
Conditions
Atrophy of Vocal Cord, Presbyphonia, Dysphonia, Glottic Insufficiency, Voice Change, Voice Disorder, Adults, Aging, Speech Therapy, Voice Alteration
Interventions
exuberant voice therapy
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
54 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
4
States / cities
Arcadia, California • Beverly Hills, California • Glendale, California + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 2, 2026, 6:31 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Straw Phonation Exercise Program for Pitch Extension

NCT05357222
View directory record Official record
Conditions
Voice Fatigue, Voice Disorders, Voice Hoarseness
Interventions
Straw phontion
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 2, 2026, 6:31 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Mobile Parkinson Observatory for Worldwide, Evidence-based Research (mPower)

NCT02696603
View directory record Official record
Conditions
Parkinson Disease, Neurodegenerative Diseases, Movement Disorders, Central Nervous System Diseases, Brain Diseases, Basal Ganglia Diseases, Parkinsonian Disorders
Interventions
Participant self-assessment surveys, Phonation, Gait and balance, Memory, Dexterity, Participant open-response writing, Parkinson mPower mobile application
Behavioral · Other
Lead sponsor
Sage Bionetworks
Other
Eligibility
18 Years and older
Enrollment
20,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 10, 2025 · Synced Sep 2, 2026, 6:31 AM EDT
Terminated Not applicable Interventional Results available

Rhythm-based Intervention in Aphasia

NCT04581564
View directory record Official record
Conditions
Aphasia
Interventions
Rhythm-based speech therapy app (i.e., Speech Hero), Non-rhythm based (singing) application (conventional speech therapy)
Behavioral
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
18 Years to 90 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Jul 13, 2025 · Synced Sep 2, 2026, 6:31 AM EDT
Withdrawn Not applicable Interventional

Phonation Therapy to Improve Symptoms and Lung Physiology in Patients Referred for Pulmonary Rehabilitation

NCT05621967
View directory record Official record
Conditions
COVID-19
Interventions
Tonation Breathing Techniques, Music Driven Vocal Exercises, Silent Breathing
Behavioral
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 22, 2023 · Synced Sep 2, 2026, 6:31 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Voice Rest and Injection Laryngoplasty

NCT05542550
View directory record Official record
Conditions
Vocal Cord Paralysis
Interventions
Voice Rest, No Voice Rest
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 89 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 18, 2024 · Synced Sep 2, 2026, 6:31 AM EDT
Recruiting Not applicable Interventional

Characterizing the Impact of Presbyphonia on Social Interaction

NCT06441136
View directory record Official record
Conditions
Presbyphonia
Interventions
PhoRTE Program, University of California Los Angeles (UCLA) Loneliness Scale, Social Disconnectedness Scale, Patient Health Questionnaire 9, Aging Voice Index, The Edmonton Frail Scale, Vocal Effort Scale, Montreal Cognitive Assessment, Voice Handicap Index-10, Voice Problem Impact Scales, Cough Severity Index, Laryngoscopy, Acoustic, perceptual, and aerodynamic assessments
Other · Procedure
Lead sponsor
Matthew R. Hoffman
Other
Eligibility
65 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Sep 2, 2026, 6:31 AM EDT
Completed Not applicable Interventional

Correlation of Phonation With Deglutition and Aspiration Risk in the ICU Patients - an Exploratory Study

NCT01011803
View directory record Official record
Conditions
Aspiration
Interventions
Combined speech therapy tools, measures of swallowing function
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 10, 2013 · Synced Sep 2, 2026, 6:31 AM EDT
Completed Not applicable Interventional Results available

Singing and Cardiovascular Health in Older Adults

NCT04121741
View directory record Official record
Conditions
Cardiovascular Diseases, Cardiovascular Risk Factor, Cardiovascular Health
Interventions
Singing with Music Therapist, Singing with Guided Video, Control Arm
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
55 Years to 79 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 4, 2025 · Synced Sep 2, 2026, 6:31 AM EDT
Recruiting Phase 1Phase 2 Interventional

A Phase 1/2 Study of Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis

NCT03952637
View directory record Official record
Conditions
Lysosomal Diseases, Gangliosidosis, GM1
Interventions
AAV9-GLB1, Abdominal ultrasound, Rituximab, Sirolimus, Methylprednisolone, Prednisone, Audiology assessment with ABR, Bone density scan (DEXA), Electrocardiogram (EKG), Echocardiogram, Electroencephalogram (EEG) awake and extended overnight, Laboratory tests, Lumbar puncture, Brain MRI/MRS/fMRI, Neurocognitive testing, Neurology exam, PICC or other Central line placement, Skeletal survey, Skin biopsy, Speech and modified barium swallow study, Ophthalmology exam
Biological · Procedure · Drug + 3 more
Lead sponsor
National Human Genome Research Institute (NHGRI)
NIH
Eligibility
6 Months to 12 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 10, 2025 · Synced Sep 2, 2026, 6:31 AM EDT
Completed Not applicable Interventional

Intensive Versus Traditional Voice Therapy

NCT03129880
View directory record Official record
Conditions
Dysphonia
Interventions
Weekly Voice Therapy, Intensive Voice Therapy
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2024
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Sep 2, 2026, 6:31 AM EDT
Completed No phase listed Observational

Cough in Reduced True Vocal Fold Mobility

NCT02407301
View directory record Official record
Conditions
Unilateral Vocal Cord Paresis, Unilateral Vocal Cord Paralysis
Interventions
cough airflow measure, vocal tasks, true vocal fold movement, spirometry test, maximum expiratory pressure (MEP)
Other
Lead sponsor
University of Florida
Other
Eligibility
40 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 12, 2016 · Synced Sep 2, 2026, 6:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Technology-assisted Vocal Exercise for Older Adults

NCT03015870
View directory record Official record
Conditions
Aging
Interventions
Vocal exercise with real-time feedback, Vocal exercise with recording
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
65 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Champaign, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Sep 2, 2026, 6:31 AM EDT
Terminated Not applicable Interventional Results available

Expiratory Muscle Strength Training and Phonation Resistance Training Exercises For Elderly Patients With Vocal Fold Atrophy

NCT03696576
View directory record Official record
Conditions
Voice Disorder, Vocal Cord Atrophy, Presbyphonia
Interventions
EMST, PhoRTE
Device · Behavioral
Lead sponsor
Emory University
Other
Eligibility
65 Years to 95 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Atlanta, Georgia • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 29, 2021 · Synced Sep 2, 2026, 6:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate Effects of Gargle Phonation in Voice

NCT04766658
View directory record Official record
Conditions
Voice Disorders, Muscle Tension Dysphonia, Speech Therapy
Interventions
Gargle Phonation, Water swallow
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 89 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
2
States / cities
Scottsdale, Arizona • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 18, 2022 · Synced Sep 2, 2026, 6:31 AM EDT
Not listed Not applicable Interventional

Treating Laryngeal Hyperfunction With Flow Phonation

NCT01988207
View directory record Official record
Conditions
Muscle Tension Dysphonia
Interventions
Vocal Hygiene Training, Flow Phonation Exercises
Behavioral
Lead sponsor
University of Central Arkansas
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Conway, Arkansas
Source: ClinicalTrials.gov public record
Updated Nov 19, 2013 · Synced Sep 2, 2026, 6:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Controlled Phonation and Vocal Rest Programs After Acute Vocal Exertion in Healthy Adults

NCT03762993
View directory record Official record
Conditions
Healthy
Interventions
Vocal rest and Controlled Phonation
Behavioral
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 50 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 4, 2021 · Synced Sep 2, 2026, 6:31 AM EDT
Completed Not applicable Interventional

Speech Rehabilitation Based on Mobile Applications

NCT06592183
View directory record Official record
Conditions
Stroke, Motor Speech Disorder
Interventions
Smart-phone based, self-driven speech rehabilitation
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Jan 5, 2026 · Synced Sep 2, 2026, 6:31 AM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

Translaryngeal Vibration for Hyperfunctional Voice Disorders

NCT07145086
View directory record Official record
Conditions
Dysphonia, Muscle Tension Dysphonia
Interventions
Voice therapy with vibration
Behavioral
Lead sponsor
Texas Christian University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Sep 2, 2026, 6:31 AM EDT