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ClinicalTrials.gov public records Last synced Oct 1, 2026, 6:55 AM EDT

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Showing 25–48 of 48 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Photobiomodulation (PBM) Clear all
Recruiting Not applicable Interventional

Transcranial Photobiomodulation (tPBM) in Alzheimer's Disease Study

NCT07224607
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
Photobiomodulation
Device
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
55 Years to 89 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Oct 1, 2026, 6:55 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

The Revitalize Study in Older Adults at Risk for Alzheimer's Disease

NCT04018092
View directory record Official record
Conditions
Cognitive Aging, Alzheimer Disease, Protection Against
Interventions
Active NIR-PBM, Sham NIR-PBM
Device
Lead sponsor
University of Florida
Other
Eligibility
65 Years to 89 Years
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
2
States / cities
Tucson, Arizona • Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 1, 2026, 6:55 AM EDT
Completed Not applicable Interventional Results available

Prevention of Oral Mucositis Using Photobiomodulation Therapy

NCT04227340
View directory record Official record
Conditions
Oral Mucositis
Interventions
Photobiomodulation Therapy (PBM), Pain and Oral Function Assessment, Parent-Reported Satisfaction Survey
Device · Other
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
Not listed
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 4, 2022 · Synced Oct 1, 2026, 6:55 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

On the BRINK: PhotoBiomodulation (PBM) for Mucositis in Patients Undergoing Allogeneic Hematopoietic Stem Cell TRansplant (HSCT) - Implementing the Evidence & Discovering New Knowledge

NCT06625619
View directory record Official record
Conditions
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Interventions
Non-Interventional Study
Other
Lead sponsor
City of Hope Medical Center
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Oct 1, 2026, 6:55 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Luminance RED for Canker Sores

NCT04914533
View directory record Official record
Conditions
Canker Sore
Interventions
Luminance RED Low Level Laser Therapy Device
Device
Lead sponsor
ProofPilot
Industry
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 1, 2026, 6:55 AM EDT
Completed Phase 1 Interventional

Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depression

NCT00961454
View directory record Official record
Conditions
Major Depression, Anxiety Disorder, Post-Traumatic Stress Disorder, Substance Abuse Disorder
Interventions
Photobiomodulation with a super-luminous light emitting diode
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 19, 2009 · Synced Oct 1, 2026, 6:55 AM EDT
Recruiting Not applicable Interventional

Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery

NCT06574152
View directory record Official record
Conditions
Apical Periodontitis, Endodontically Treated Teeth, Endodontic Disease, Apical Cyst, Apical Granuloma, Periradicular Disease, Previous Endodontic Treatment
Interventions
PBM treatment, PBM sham treatment, EMS
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 1, 2026, 6:55 AM EDT
Completed Not applicable Interventional Results available

Revitalize Cognition: Near Infrared Stimulation in Parkinson Patients

NCT06688357
View directory record Official record
Conditions
Parkinson Disease
Interventions
Active NIR-PBM (MedX 1116, MCT502), Sham NIR-PBM (MedX 1116, MCT502)
Device
Lead sponsor
University of Florida
Other
Eligibility
62 Years to 89 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 17, 2025 · Synced Oct 1, 2026, 6:55 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Photobiomodulation and Tooth Analgesia

NCT06691269
View directory record Official record
Conditions
Dental Anaesthesia, Dental Pain, Dental Analgesia
Interventions
Photobiomodulation, Topical Benzocaine, Local Anesthesia
Device · Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
6 Years to 12 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Oct 1, 2026, 6:55 AM EDT
Recruiting Not applicable Interventional

Photobiomodulation for Management of Temporomandibular Disorder Pain

NCT05916235
View directory record Official record
Conditions
Pain Related to TMD
Interventions
THOR® laser system
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 99 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 24, 2025 · Synced Oct 1, 2026, 6:55 AM EDT
Completed Not applicable Interventional Results available

Photobiomodulation for Improving Brain Function in Dementia (PBM Dementia)

NCT03160027
View directory record Official record
Conditions
Dementia, Alzheimer Type
Interventions
Vielight Neuro Gamma
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
50 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 6, 2020 · Synced Oct 1, 2026, 6:55 AM EDT
Completed Phase 1 Interventional

A Study Evaluating the Efficacy of the Vielight Neuro RX Gamma in the Treatment of Post COVID-19 Cognitive Impairment

NCT05857124
View directory record Official record
Conditions
Post COVID-19 Cognitive Impairment
Interventions
Vielight Neuro RX Gamma active device, Vielight Neuro RX Gamma sham device
Device
Lead sponsor
Vielight Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Fullerton, California
Source: ClinicalTrials.gov public record
Updated Jun 15, 2025 · Synced Oct 1, 2026, 6:55 AM EDT
Completed Not applicable Interventional

Bioactive Knee Sleeves After ACL Reconstruction

NCT07707128
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Reconstruction Surgery
Interventions
Bioactive Knee Sleeve
Device
Lead sponsor
Western Kentucky Heart and Lung Research Foundation and Educational Trust
Other
Eligibility
16 Years to 40 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Bowling Green, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 1, 2026, 6:55 AM EDT
Recruiting Not applicable Interventional

tPBM in Older Adults With Traumatic Brain Injury

NCT06956404
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Transcranial photobiomodulator (tPBM), Transcranial photobiomodulator (tPBM) in sham mode
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
55 Years to 85 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Oct 1, 2026, 6:55 AM EDT
Active, not recruiting Phase 2 Interventional

Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD)

NCT04784416
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer Disease
Interventions
Active tPBM-2.0, Sham tPBM-2.0, 18F-MK-6240
Device · Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
65 Years to 85 Years
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
3
States / cities
Boston, Massachusetts • New York, New York • Orangeburg, New York
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Oct 1, 2026, 6:55 AM EDT
Terminated Not applicable Interventional Results available

Photobiomodulation for the Management of Temporomandibular Disorder Pain

NCT04415281
View directory record Official record
Conditions
Pain Related to TMD
Interventions
THOR® laser system, sham THOR® laser system
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 12, 2023 · Synced Oct 1, 2026, 6:55 AM EDT
Not listed Not applicable Interventional

Vielight RX Plus for the Treatment of COVID-19 Respiratory Symptoms

NCT04418505
View directory record Official record
Conditions
COVID-19
Interventions
Vielight RX Plus
Device
Lead sponsor
Vielight Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
295 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Port Orange, Florida
Source: ClinicalTrials.gov public record
Updated Jun 14, 2021 · Synced Oct 1, 2026, 6:55 AM EDT
Recruiting Phase 2 Interventional

A Study of Photobiomodulation (PBM) Therapy in People With Oral Graft-Versus-Host Disease (GVHD) After Stem Cell Transplant

NCT05675930
View directory record Official record
Conditions
Graft-Versus-Host Disease, GVHD, Undefined
Interventions
Photobiomodulation Therapy, Placebo sham device
Device · Other
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
4 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
9
States / cities
Bethesda, Maryland • Basking Ridge, New Jersey • Middletown, New Jersey + 6 more
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 1, 2026, 6:55 AM EDT
Completed Early Phase 1 Interventional

Photobiomodulation for the Treatment of Diabetic Macular Edema

NCT02457975
View directory record Official record
Conditions
Diabetic Retinopathy
Interventions
670nm PBM, intravitreous VEGF-inhibitors
Device · Drug
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 10, 2019 · Synced Oct 1, 2026, 6:55 AM EDT
Recruiting Phase 4 Interventional

Effects of Photobiomodulation (PBM) on Pain After Presentation of Aphthous Ulcers in Pediatric Dental Patients

NCT06819033
View directory record Official record
Conditions
Aphthous Ulcer
Interventions
PBM Therapy, Maalox plus Benadryl
Device · Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
5 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 25, 2025 · Synced Oct 1, 2026, 6:55 AM EDT
Withdrawn Not applicable Interventional

Photobiomodulation on Neuropathic Pain and Sensation Post-mastectomy

NCT06194136
View directory record Official record
Conditions
Neuropathic Pain, Sensation Disorders
Interventions
PBM light therapy
Device
Lead sponsor
Tufts University
Other
Eligibility
18 Years to 65 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 9, 2025 · Synced Oct 1, 2026, 6:55 AM EDT
Completed Not applicable Interventional Results available

Shockwave, Photobiomodulation, and Physical Therapy for Achilles Tendinopathy

NCT05751785
View directory record Official record
Conditions
Achilles Tendinopathy
Interventions
Physical Therapy, Shockwave Therapy, Photobiomodulation Therapy
Other · Device
Lead sponsor
Musculoskeletal Injury Rehabilitation Research for Operational Readiness
Federal
Eligibility
18 Years to 64 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jul 22, 2025 · Synced Oct 1, 2026, 6:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Examining the Differential Effects of Photobiomodulation on Sleep and Performance

NCT05116605
View directory record Official record
Conditions
Sleep Quality
Interventions
Photobiomodulation (PBM)
Other
Lead sponsor
West Virginia University
Other
Eligibility
18 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Apr 25, 2025 · Synced Oct 1, 2026, 6:55 AM EDT
Completed Not applicable Interventional Results available

A Pilot Study Evaluating Photobiomodulation Therapy for Diabetic Macular Edema

NCT03866473
View directory record Official record
Conditions
Diabetic Macular Edema
Interventions
Retilux, Sham Light Device
Device
Lead sponsor
Jaeb Center for Health Research
Other
Eligibility
18 Years and older
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
20
States / cities
Huntington Beach, California • Oakland, California • Santa Barbara, California + 16 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2022 · Synced Oct 1, 2026, 6:55 AM EDT