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Conditions: Cardiovascular Diseases, Diabetes Mellitus, Hyperlipidemia, Hypertension, Obesity
Interventions: Nutritional counseling, Walking program, Simple pedometer, Enhanced pedometer; Behavioral · Device
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years and older · Male only
Enrollment: 254 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Childhood Obesity
Interventions: Family-based behavioral intervention; Behavioral
Lead sponsor: Seattle Children's Hospital; Other
Eligibility: 7 Years to 11 Years
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Diabetes Mellitus, Type 2, PreDiabetes, Obesity
Interventions: DEXCOM G6 RT-CGM; Device
Lead sponsor: Nicole Ehrhardt, MD; Other
Eligibility: 18 Years to 55 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Spinal Cord Injuries
Interventions: Sprint Interval Training (SIT), Usual Care, Home Ergometer (ERGO), Motivational Interviewing (MI); Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 65 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Obesity
Interventions: Fruit and Vegetable Juice Concentrate (FVJC), Placebo; Dietary Supplement
Lead sponsor: Nemours Children's Clinic; Other
Eligibility: 6 Years to 10 Years · Male only
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Alcohol Dependence, Chronic Hepatitis C
Interventions: Motivational Enhancement Therapy (MET), Health education; Behavioral
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years and older
Enrollment: 139 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 2
States / cities: Minneapolis, Minnesota • Portland, Oregon

Conditions: Herniated Disc, Low Back Pain
Interventions: Diskectomy, Non-surgical treatments; Procedure
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 501 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2015
U.S. locations: 13
States / cities: Oakland, California • San Francisco, California • Decatur, Georgia + 9 more

Conditions: Depression - Major Depressive Disorder
Interventions: Behavioral Activation (Action Brings Change Project 10-Minute Version), Mindful Acceptance, Moral Elevation, Mindful Attention Skills, 5 Habits to Beat Depression, Interactive Cognitive Reappraisal, Expressive Writing (AI-supported), Inner Child Healing Walk, Savoring Strategies, Personalized Intervention Recommender, Dialectical Behavioral Therapy Skills, All about Trout, Reframing Negative Thoughts; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 7,505 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Pregnancy, Weight Gain
Interventions: Responses to Brief Video Messages (Facebook), Response to Brief Video Messages (Clinic), Response to Brief Video Messages (Social Network); Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 1,670 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Chronic Pain
Interventions: Shared Decision Making, Motivational Interviewing and Cognitive Behavioral Therapy for Chronic Pain; Behavioral
Lead sponsor: RTI International; Other
Eligibility: 18 Years to 85 Years
Enrollment: 543 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 3
States / cities: Chapel Hill, North Carolina • Durham, North Carolina • Nashville, Tennessee

Conditions: Intentional Self-Harm by Other Specified Means
Interventions: Lethal Means Counseling, Health and Stress Reduction; Behavioral
Lead sponsor: University of Southern Mississippi; Other
Eligibility: 18 Years to 60 Years
Enrollment: 232 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Hattiesburg, Mississippi

Conditions: Childhood Obesity, Overweight, Communication, Weight Loss
Interventions: Communication regarding overweight status, Risk-factor assessment and counseling, Lifestyle behavior assessment and counseling, Interval follow-up to readdress weight, Patient-centered communication; Other
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 6 Years to 12 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Type2 Diabetes
Interventions: Positive Psychology + Motivational Interviewing, MI-based Health Education Intervention; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Obesity
Interventions: Lifestyle counseling; Behavioral
Lead sponsor: Winthrop University Hospital; Other
Eligibility: 8 Years to 16 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 1
States / cities: Mineola, New York

Conditions: Stroke, Hemiplegia
Interventions: Theraband with exercise video, usual care with advice to exercise; Device · Other
Lead sponsor: Kaiser Permanente; Other
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: San Diego, California

Conditions: HIV
Interventions: Reducing Risk Behavior, Support and Guidance; Behavioral
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 24 Years
Enrollment: 2 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 2
States / cities: Atlanta, Georgia

Conditions: Prostate Carcinoma, Recurrent Prostate Carcinoma
Interventions: Antiandrogen Therapy, Behavioral Intervention, Biospecimen Collection, Cardiac Computerized Tomographic Angiography, Computed Tomography, Electronic Health Record Review, Internet-Based Intervention, Lifestyle Counseling, Medical Device Usage and Evaluation, Nutritional Intervention, Questionnaire Administration, Radiation Therapy, Referral, Semaglutide, Short-Term Fasting, Tirzepatide; Drug · Behavioral · Procedure + 2 more
Lead sponsor: City of Hope Medical Center; Other
Eligibility: 30 Years to 79 Years · Male only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Duarte, California

Conditions: Body Weight Changes
Interventions: Videos, Action Plans, Discussion Boards, Health behavior tracking; Behavioral
Lead sponsor: University of Nebraska; Other
Eligibility: 40 Years to 64 Years · Female only
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Auburn, Nebraska

Conditions: Breast Cancer, Obesity
Interventions: Group phone counseling, Newsletter; Behavioral
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: Up to 75 Years · Female only
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Knee Osteoarthritis
Interventions: Decision Aid (DA) Intervention; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 50 Years and older
Enrollment: 340 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2019
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Hepatopancreaticobiliary (HPB) Malignancy, Ovarian Cancer (OvCa), Kidney Cancers, Bladder Cancer
Interventions: Comprehensive multimodal prehabilitation (CMMP); Other
Lead sponsor: The Methodist Hospital Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 148 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Depression, Suicidality, Substance Abuse, HIV, Minority Stress
Interventions: Expressive Writing (EW) Intervention, Self-Affirmation (SA) Intervention, Control; Behavioral · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 29 Years
Enrollment: 108 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 3
States / cities: New Haven, Connecticut • Worcester, Massachusetts • Johnson City, Tennessee

Conditions: Type 2 Diabetes, Obesity, Pediatric Obesity
Interventions: Lifestyle Intervention; Behavioral
Lead sponsor: Arizona State University; Other
Eligibility: 10 Years to 99 Years
Enrollment: 132 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Intolerance of Uncertainty, Anxiety, Intolerance of Uncertainty; Anxiety, Depression, Anxiety
Interventions: Uncertainty-focused single session intervention, Maintaining a healthy lifestyle single session intervention; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 25 Years to 60 Years
Enrollment: 140 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Chicago, Illinois

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Veterans Walk for Health Study

Peer Counseling in Family-Based Treatment for Childhood Obesity

Continuous Glucose Monitoring in Diabetes and Prediabetes

Feasibility of a Sprint Interval Training Program During Inpatient Spinal Cord Injury Rehabilitation

Fruit and Vegetable Juice Concentrate Effects on RBP4 and Antioxidant Capacity in Lean and Overweight 6-10 Year Old Boys

Study of the Effects of Motivational Enhancement Therapy on Alcohol Use in Chronic Hepatitis C Patients

Spine Patient Outcomes Research Trial (SPORT) - Intervertebral Disc Herniation

A Megastudy of Single-Session Interventions for Depression

Effectiveness of Video Messaging About Diet, Exercise and Weight Gain in Pregnancy in Regional and National Samples

Integrated Services for Pain: Interventions to Reduce Pain Effectively

Comparison of Lethal Means Counseling and an Active Control Condition, With and Without Provision of Gun Locks

Primary Care, Communication, and Improving Children's Health

A Psychological-behavioral Intervention for Physical Activity in Type 2 Diabetes

Childhood Obesity-A Study of Intervention

E-Rehabilitation: Aerobic Resistance Training for Stroke Survivors

The Georgia Latino AIDS/HIV Diagnosis and Linkage in Youth (GLADLY) Project

Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial

Weight Maintenance Through Physical Activity and Social Support in Rural Middle-Aged Women

Rural Women Connecting for Better Health

African American Preference for Knee Replacement: A Patient-Centered Intervention

Comprehensive Multimodal Prehabilitation Alone or With Neoadjuvant Therapy Before Major Cancer Surgery

Development and Preliminary Trial of a Brief, Portable Health Intervention for Rural Sexual Minority Emerging Adults

Preventing Diabetes in Latino Families

Test of Target Engagement of Ambiguity Aversion