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ClinicalTrials.gov public records Last synced Nov 12, 2026, 12:55 AM EST

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Showing 1–24 of 228 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Placebo + Cocaine Clear all

Conditions: Alcoholism, Cocaine Dependence
Interventions: Vigabatrin, Placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cocaine Use Disorder, Substance Use Disorders, Healthy Volunteers
Interventions: Cohort 1 - TMP-301, Placebo, Cohort 2 - TMP-301, Cohort 3 - TMP-301, Cohort 4 - TMP-301; Drug
Lead sponsor: Tempero Bio, Inc.; Industry
Eligibility: 18 Years to 59 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Cocaine Use Disorder (CUD)
Interventions: Cobenfy, Placebo; Drug
Lead sponsor: Joshua A. Lile, Ph.D.; Other
Eligibility: 18 Years to 60 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2032
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Cocaine Dependence
Interventions: varenicline, placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Substance Abuse
Interventions: Placebo, Rivastigmine 3 mg, Huperzine A 0.4 mg, Rivastigmine 6 mg, Huperzine A 0.8 mg; Drug
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 55 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cocaine Related Disorders
Interventions: Lofexidine, Placebo; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 50 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 2
States / cities: San Francisco, California • Houston, Texas

Conditions: Cocaine Use Disorder, Anxiety
Interventions: suvorexant, Placebo (for suvorexant); Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 19 Years to 55 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cocaine-Related Disorders, Substance-Related Disorders
Interventions: Reserpine; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 99 Years
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2003
U.S. locations: 3
States / cities: Boston, Massachusetts • Cincinnati, Ohio • Dayton, Ohio

Conditions: Cocaine Dependence, Alcoholism
Interventions: Naltrexone; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 65 Years
Enrollment: 164 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1998 – 2003
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cocaine Dependence
Interventions: levodopa/carbidopa, Ropinirole 2 mg/d, Placebo, Ropinirole 4 mg/d; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 55 Years
Enrollment: 119 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cocaine Dependence, Depressive Symptoms
Interventions: sertraline, Placebo, gabapentin; Drug
Lead sponsor: University of Arkansas; Other
Eligibility: 18 Years to 65 Years
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Cocaine Dependence, Cocaine Addiction
Interventions: Metyrapone, Oxazepam, Placebo; Drug
Lead sponsor: Embera NeuroTherapeutics, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Shreveport, Louisiana

Conditions: Cocaine Dependence
Interventions: Clavulanic Acid Only Product, Placebo; Drug
Lead sponsor: Temple University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania • Charleston, South Carolina

Conditions: Cocaine Use Disorder, Alcohol Use Disorder
Interventions: Pioglitazone, Placebo, Therapy, Contingency Management; Drug · Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 60 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cocaine Use Disorders
Interventions: Bupropion; Drug
Lead sponsor: Craig Rush; Other
Eligibility: 18 Years to 55 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Cocaine-Related Disorders
Interventions: Low Dose Modafinil, High Dose Modafinil, Placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 60 Years
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Cocaine Use, Unspecified
Interventions: Craving Manipulation, Cocaine, Placebo; Behavioral · Drug
Lead sponsor: William Stoops; Other
Eligibility: 18 Years to 55 Years
Enrollment: 5 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Cocaine Use Disorder, HIV
Interventions: Semaglutide, Placebo; Drug
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Baltimore, Maryland

Conditions: Cocaine Dependence, Opioid Dependence
Interventions: Disulfiram, Methadone, CBT, Lactose; Drug · Behavioral · Other
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 64 Years
Enrollment: 93 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cocaine Abuse, Cocaine Dependence
Interventions: Progesterone, Placebo; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cocaine Use
Interventions: l-tetrahydropalmatine (l-THP), Placebo; Drug
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 50 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Catonsville, Maryland

Conditions: Cocaine Use Disorder
Interventions: Suvorexant, Cocaine, Placebo oral capsule; Drug
Lead sponsor: William Stoops; Other
Eligibility: 18 Years to 55 Years
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Cocaine Abuse
Interventions: Aripiprazole + Cocaine, Placebo + Cocaine; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 21 Years to 45 Years
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: New York, New York

Conditions: Cocaine Dependence
Interventions: Citalopram, Placebo; Drug
Lead sponsor: Joy Schmitz; Other
Eligibility: 18 Years to 60 Years
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2016
U.S. locations: 1
States / cities: Houston, Texas

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Vigabatrin for Cocaine and Alcohol Dependence

Multiple Ascending Dose Study of TMP-301 in Healthy Subjects

The Impact of Cobenfy Maintenance on Cocaine's Effects

Chantix for Treating Cocaine Dependence

Rivastigmine and Huperzine A as Treatments for Cocaine Dependence

Interactions Between Intravenous (IV) Cocaine and Lofexidine

Role of the Orexin Receptor System in Stress, Sleep and Cocaine Use

Reserpine for the Treatment of Cocaine Dependence - 1

Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence

Cognitive Remediation for Cocaine Dependence

Clinical Efficacy of Sertraline Augmented With Gabapentin in Depressed, Recently Abstinent Cocaine-dependent Humans

A Placebo-Controlled Study of a Combination of Metyrapone and Oxazepam in Cocaine Addiction

Clavulanic Acid for the Treatment of Cocaine Use Disorder

PPARγ Agonist Treatment for Cocaine Dependence

A Novel Anti-Obesity Drug Combination as a Pharmacotherapy for Cocaine Dependence

Modafinil Treatment for Cocaine-Dependent Individuals

Behavioral Effects of Drugs (Inpatient): 38

Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV

Pharmacogenetics of Disulfiram for Cocaine

Progesterone for Postpartum Cocaine Relapse

L-tetrahydropalmatine (l-THP) Treatment for Cocaine Use Disorder

Suvorexant and Cocaine

Effects of Aripiprazole on Cocaine Craving and Self-Administration

Citalopram for Cocaine Dependence