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Showing 25–47 of 23 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Placebo Lozenge Clear all
Completed Phase 4 Interventional Results available

Smoking Cessation Medications: Efficacy, Mechanisms and Algorithms

NCT00332644
View directory record Official record
Conditions
Nicotine Dependence
Interventions
nicotine patch, nicotine lozenge, nicotine patch + nicotine lozenge, bupropion, bupropion + lozenge, placebo
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
1,504 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
2
States / cities
Madison, Wisconsin • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 29, 2011 · Synced Sep 25, 2026, 10:20 PM EDT
Completed Phase 3 Interventional

Xylitol Adult Caries Trial (X-ACT)

NCT00393055
View directory record Official record
Conditions
Dental Caries
Interventions
xylitol, inactive lozenge
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
25 Years to 80 Years
Enrollment
709 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
3
States / cities
Birmingham, Alabama • Chapel Hill, North Carolina • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 11, 2011 · Synced Sep 25, 2026, 10:20 PM EDT
Active, not recruiting Not applicable Interventional

SLeep and OPioid UsE in Patients Undergoing Total Knee Arthroplasty

NCT04247646
View directory record Official record
Conditions
Opioid Use, Pain, Postoperative, Sleep, Delirium
Interventions
Melatonin, Placebo
Dietary Supplement
Lead sponsor
Scripps Health
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Sep 25, 2026, 10:20 PM EDT
Completed Phase 2 Interventional

Evaluating the Dietary Supplement Anatabloc in Thyroid Health-ASAP (Antabloc Supplementation Autoimmune Prevention)

NCT01551498
View directory record Official record
Conditions
Thyroiditis, Autoimmune
Interventions
Anatabloc Supplement, Placebo
Dietary Supplement
Lead sponsor
Rock Creek Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
9
States / cities
West Palm Beach, Florida • Zephyrhills, Florida • La Grange, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Nov 1, 2015 · Synced Sep 25, 2026, 10:20 PM EDT
Completed Phase 3 Interventional

Capsaicin Lozenges in Treating Patients With Mucositis Caused by Radiation Therapy

NCT00003610
View directory record Official record
Conditions
Head and Neck Cancer, Radiation Toxicity
Interventions
capsaicin, placebo, radiation therapy
Dietary Supplement · Other · Radiation
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2006
U.S. locations
17
States / cities
Scottsdale, Arizona • Peoria, Illinois • Urbana, Illinois + 14 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2016 · Synced Sep 25, 2026, 10:20 PM EDT
Completed Not applicable Interventional Results available

A Clinical Trial to Evaluate Long-term Efficacy and Safety of Lozenges Containing Lactobacilli Reuteri (Prodentis™) on Gingivitis

NCT01811316
View directory record Official record
Conditions
Gingivitis
Interventions
Probiotics
Other
Lead sponsor
Sunstar Americas
Industry
Eligibility
18 Years to 65 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 6, 2017 · Synced Sep 25, 2026, 10:20 PM EDT
Completed Early Phase 1 Interventional Results available

Treatment of HFpEF With Nitrate Supplement

NCT03289481
View directory record Official record
Conditions
Heart Failure With Normal Ejection Fraction
Interventions
Active lozenge, Placebo
Dietary Supplement · Drug
Lead sponsor
MaineHealth
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Rockport, Maine
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Sep 25, 2026, 10:20 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Probiotic Effect on Dietary Nitrate to Plasma Nitrite Production ( OPEDNPN )

NCT06375694
View directory record Official record
Conditions
Hypertension, Cardiovascular Diseases, Diabetes
Interventions
Herbiotics Oral + Ent Probiotic, Placebo
Dietary Supplement
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 18, 2024 · Synced Sep 25, 2026, 10:20 PM EDT
Completed Phase 4 Interventional Results available

Stress Neuroadaptation in Tobacco Dependence

NCT03262233
View directory record Official record
Conditions
Nicotine Dependence
Interventions
nicotine, placebo
Combination Product · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 60 Years
Enrollment
226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 22, 2019 · Synced Sep 25, 2026, 10:20 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Smoking Relapse Prevention in Schizophrenia

NCT00320697
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder, Smokers
Interventions
bupropion + nicotine patch + nicotine gum or lozenges, Placebo pill + placebo patch
Drug
Lead sponsor
North Suffolk Mental Health Association
Other
Eligibility
18 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 26, 2016 · Synced Sep 25, 2026, 10:20 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of a Daily Oral Care Lozenge on Oral Health and Quality of Life in Older Adults

NCT03693027
View directory record Official record
Conditions
Oral Health
Interventions
PTx800 lozenges, Placebo control
Dietary Supplement
Lead sponsor
Primal Therapies Inc.
Industry
Eligibility
60 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 8, 2018 · Synced Sep 25, 2026, 10:20 PM EDT
Completed Not applicable Interventional

The Oral Microbiome in OSCC

NCT04925700
View directory record Official record
Conditions
Oral Cancer
Interventions
ProDentis Lozenge, Placebo Lozenge
Dietary Supplement · Other
Lead sponsor
University of Iowa
Other
Eligibility
21 Years to 89 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 25, 2026, 10:20 PM EDT
Terminated Phase 2 Interventional

An Outpatient Study Investigating Non-prescription Treatments for COVID-19

NCT04621149
View directory record Official record
Conditions
COVID-19
Interventions
chlorine dioxide, zinc acetate, Famotidine, placebo, lactoferrin, green tea extract
Other · Dietary Supplement · Drug
Lead sponsor
Profact, Inc.
Other
Eligibility
20 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Tempe, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 29, 2022 · Synced Sep 25, 2026, 10:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of an Investigational Lozenge (Biofresh® 4plus) Versus Placebo Control on Oral Malodor (Intra-Oral Halitosis)

NCT05413382
View directory record Official record
Conditions
Halitosis
Interventions
Biofresh® 4plus, Placebo
Dietary Supplement
Lead sponsor
Novozymes A/S
Industry
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 9, 2022 · Synced Sep 25, 2026, 10:20 PM EDT
Terminated Phase 2 Interventional

Study to Evaluate Dietary Supplementation With a Version of Anatabloc(R) in Subjects With Alzheimer's Disease

NCT01669876
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Anatabloc(R), Placebo
Dietary Supplement
Lead sponsor
Rock Creek Pharmaceuticals, Inc.
Industry
Eligibility
65 Years to 90 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Sarasota, Florida
Source: ClinicalTrials.gov public record
Updated Apr 29, 2015 · Synced Sep 25, 2026, 10:20 PM EDT
Completed Phase 3 Interventional Results available

Progesterone vs Placebo Therapy for Women With Epilepsy

NCT00029536
View directory record Official record
Conditions
Epilepsy
Interventions
Progesterone Lozenges, Matched Placebo Lozenges
Biological · Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
13 Years to 45 Years · Female only
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2010
U.S. locations
14
States / cities
Los Angeles, California • Atlanta, Georgia • Baltimore, Maryland + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2017 · Synced Sep 25, 2026, 10:20 PM EDT
Completed Not applicable Interventional

Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD

NCT03064048
View directory record Official record
Conditions
Argininosuccinate Lyase Deficiency, Urea Cycle Disorder, Urea Cycle Disorders, Inborn, Argininosuccinic Aciduria
Interventions
Neo-ASA, Placebo
Dietary Supplement
Lead sponsor
Baylor College of Medicine
Other
Eligibility
6 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 26, 2023 · Synced Sep 25, 2026, 10:20 PM EDT
Terminated Phase 1Phase 2 Interventional

The Evaluation of Nitric Oxide Generating Lozenges on Outcome in Newly Diagnosed COVID-19 Patient of African American and Hispanic Origin

NCT04601077
View directory record Official record
Conditions
COVID-19
Interventions
Nitric Oxide lozenges, 30 mg, Placebo
Drug
Lead sponsor
Nitric Oxide Innovations LLC
Industry
Eligibility
50 Years to 85 Years
Enrollment
524 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Lake Bluff, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 5, 2022 · Synced Sep 25, 2026, 10:20 PM EDT
Completed Not applicable Interventional

Nitric Oxide Supplementation in Argininosuccinic Aciduria

NCT02252770
View directory record Official record
Conditions
Argininosuccinic Aciduria, Argininosuccinate Lyase Deficiency, Urea Cycle Disorders
Interventions
Nitric oxide supplement, Placebo
Dietary Supplement
Lead sponsor
Baylor College of Medicine
Other
Eligibility
8 Years to 64 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Sep 25, 2026, 10:20 PM EDT
Terminated Phase 2 Interventional

Interferon-alpha Treatment of Chronic Cough in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

NCT00690885
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive, Pulmonary Fibrosis, Cough
Interventions
interferon-alpha lozenges, placebo lozenges
Drug
Lead sponsor
Ainos, Inc. (f/k/a Amarillo Biosciences Inc.
Industry
Eligibility
40 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Apr 23, 2012 · Synced Sep 25, 2026, 10:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of an Oral Probiotic Intervention With or Without a Novel ADP-1 Toothpaste

NCT05330793
View directory record Official record
Conditions
Oral Health
Interventions
Oral probiotic, Placebo
Dietary Supplement
Lead sponsor
USANA Health Sciences
Industry
Eligibility
18 Years to 65 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
South Jordan, Utah
Source: ClinicalTrials.gov public record
Updated Apr 20, 2023 · Synced Sep 25, 2026, 10:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Clinical Study of the Effect of Two Experimental Lozenges on Oral Malodor After Single Use

NCT05950529
View directory record Official record
Conditions
Oral Malodor
Interventions
Experimental lozenge with the enzyme Polyphenol oxidase and green coffee extract, Experimental lozenge with the enzyme Polyphenol oxidase, green coffee extract and flavor, Placebo lozenge control (sorbitol only), No product
Other
Lead sponsor
Novozymes A/S
Industry
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 17, 2023 · Synced Sep 25, 2026, 10:20 PM EDT
Terminated Phase 2 Interventional

A Phase II Trial to Assess the Effects of Green Tea in Oral Leukoplakia

NCT00176566
View directory record Official record
Conditions
Oral Leukoplakia
Interventions
Lozenge Intake
Drug
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 10, 2009 · Synced Sep 25, 2026, 10:20 PM EDT