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ClinicalTrials.gov public records Last synced Oct 14, 2026, 8:37 AM EDT

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Showing 145–168 of 195 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Placebo and Lidocaine Clear all
Completed Not applicable Interventional Results available

Amiodarone for the Prevention of Reperfusion Ventricular Fibrillation

NCT00587483
View directory record Official record
Conditions
Other Intraoperative Cardiac Functional Disturbances During Cardiac Surgery
Interventions
Lidocaine, Amiodarone, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
342 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 11, 2011 · Synced Oct 14, 2026, 8:37 AM EDT
Completed Phase 2 Interventional

PSD502 in Subjects With Premature Ejaculation

NCT03578783
View directory record Official record
Conditions
Premature Ejaculation
Interventions
Placebo, PSD502
Drug
Lead sponsor
Plethora Solutions Ltd
Industry
Eligibility
18 Years and older · Male only
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
21
States / cities
Birmingham, Alabama • Mobile, Alabama • Sherman Oaks, California + 18 more
Source: ClinicalTrials.gov public record
Updated Jul 5, 2022 · Synced Oct 14, 2026, 8:37 AM EDT
Completed Phase 4 Interventional Results available

Evaluation of Oral Midazolam in First-trimester Surgical Abortions

NCT01830881
View directory record Official record
Conditions
Pain, Anxiety, Nausea
Interventions
Midazolam, Ibuprofen, Placebo-Cherry syrup, Lidocaine
Drug · Other
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 25, 2018 · Synced Oct 14, 2026, 8:37 AM EDT
Completed Not applicable Interventional Results available

Evaluation of Spine Surgery Analgesic Pathway

NCT02887404
View directory record Official record
Conditions
Posterior Spine Surgery
Interventions
Spine surgery analgesic pathway, Usual Care
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
299 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 6, 2021 · Synced Oct 14, 2026, 8:37 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Validating a New Non-invasive Approach to Testing Lidocaine Effectiveness

NCT03680885
View directory record Official record
Conditions
ADHD, Controls
Interventions
Lidocaine gel, Placebo, Injected lidocaine
Drug
Lead sponsor
PhenoSolve, LLC
Industry
Eligibility
18 Years to 49 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 15, 2020 · Synced Oct 14, 2026, 8:37 AM EDT
Withdrawn Not applicable Interventional

Lidocaine Patch for Relief of Pain During Epidural Placement in Laboring Patients

NCT01307839
View directory record Official record
Conditions
Pregnant, Labor
Interventions
5% lidocaine patch, placebo patch
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 12, 2012 · Synced Oct 14, 2026, 8:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.

NCT06030297
View directory record Official record
Conditions
Peripheral Neuropathy
Interventions
Diode Laser fiber type Selective Stimulator, ZTlido 1.8 % Topical System, PeriCam PSI NR, Medoc Quantitative Sensory Testing, Inactive Topical System
Procedure · Drug · Diagnostic Test + 1 more
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
2
States / cities
Palo Alto, California • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 14, 2026, 8:37 AM EDT
Withdrawn Not applicable Interventional

Treatment of Postoperative Pain After Total Knee Arthroplasy Using Intravenous Lidocaine Infusion

NCT00616850
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Continuous femoral catheter block, Lidocaine, Preservative free normal saline
Procedure · Drug · Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated May 22, 2014 · Synced Oct 14, 2026, 8:37 AM EDT
Suspended Not applicable Interventional

Insulin Sensitivity in Men With the Metabolic Syndrome

NCT00433173
View directory record Official record
Conditions
Metabolic Syndrome
Interventions
intravenous glucose tolerance test, testosterone, anastrozole, goserelin acetate implant, aerobic capacity (VO2 Max), MRI, muscle biopsy, measurement of resting metabolic rate (energy expenditure), Dual energy x-ray absorptiometry, Fasting oral glucose tolerance test
Procedure · Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
50 Years to 75 Years · Male only
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
2
States / cities
Baltimore, Maryland • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 2, 2010 · Synced Oct 14, 2026, 8:37 AM EDT
Recruiting Phase 2 Interventional

Safety and Efficacy Study of VNX001 Compared to Its Individual Components (Lidocaine and Heparin) or Placebo in Subjects With IC/BPS

NCT05737121
View directory record Official record
Conditions
Interstitial Cystitis, Bladder Pain Syndrome
Interventions
VNX001, Placebo, Lidocaine, Heparin
Drug
Lead sponsor
Vaneltix Pharma, Inc.
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
14
States / cities
Escondido, California • Los Angeles, California • Newport Beach, California + 10 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 14, 2026, 8:37 AM EDT
Completed Phase 1 Interventional

Intrauterine Lidocaine for Laminaria

NCT01541293
View directory record Official record
Conditions
Abortion, Induced, Pain Management
Interventions
Lidocaine, Normal Saline
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older · Female only
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 14, 2014 · Synced Oct 14, 2026, 8:37 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Empathy Through Pain Control: Lidocaine Paracervical Block for IUD Placements

NCT06960317
View directory record Official record
Conditions
Contraception, Pain, Acute, Anesthesia, Local
Interventions
Buffered Lidocaine, Sham Comparator, Unbuffered lidocaine, Xylocaine jelly 2%, Surgilube
Drug · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
204 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 13, 2025 · Synced Oct 14, 2026, 8:37 AM EDT
Completed Phase 4 Interventional

Lidocaine Infusion for Pain Relief in Children Scheduled for Tonsillectomy and Adenoidectomy

NCT03902314
View directory record Official record
Conditions
Children, Only, Tonsillar Hypertrophy, Adenoid Hypertrophy
Interventions
Lidocaine Iv, Saline Solution
Drug
Lead sponsor
Rhode Island Hospital
Other
Eligibility
4 Years to 10 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 11, 2022 · Synced Oct 14, 2026, 8:37 AM EDT
Completed Phase 2 Interventional Results available

Safety and Efficacy of SP-103 in Subjects With Moderate to Severe Acute Lower Back Pain

NCT05096494
View directory record Official record
Conditions
Moderate to Severe Acute Lower Back Pain
Interventions
SP-103, Placebo
Drug
Lead sponsor
Scilex Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
10
States / cities
Phoenix, Arizona • Fernandina Beach, Florida • Jacksonville, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 14, 2026, 8:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Intracervical Lidocaine Gel for IUD Insertional Pain

NCT01214161
View directory record Official record
Conditions
Pain
Interventions
2% lidocaine gel, placebo
Drug · Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 7, 2016 · Synced Oct 14, 2026, 8:37 AM EDT
Terminated Phase 4 Interventional

The Effect of Perioperative Intravenous Lidocaine Infusion on Opioid Consumption After Lumbar Spine Surgery

NCT03624985
View directory record Official record
Conditions
Pain, Postoperative, Opioid Use
Interventions
Intravenous Lidocaine Infusion, Placebo Infusion
Drug
Lead sponsor
University of Vermont Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jan 31, 2023 · Synced Oct 14, 2026, 8:37 AM EDT
Completed Phase 2 Interventional Results available

Safety and Efficacy of Two Vaginal Products Versus Placebo in Patients With Vaginal Discomfort

NCT00590590
View directory record Official record
Conditions
Vulvodynia
Interventions
Lidocaine/Diphenhydramine, lidocaine, placebo
Drug
Lead sponsor
Lumara Health, Inc.
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
41
States / cities
Montgomery, Alabama • Chandler, Arizona • Phoenix, Arizona + 36 more
Source: ClinicalTrials.gov public record
Updated Mar 2, 2012 · Synced Oct 14, 2026, 8:37 AM EDT
Completed Phase 2 Interventional Results available

Efficacy and Safety of the Lidoderm Patch Applied to Patients With Osteoarthritis of the Knee

NCT00589979
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Lidoderm (Lidocaine 5% Patch), Placebo Patch
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
37 Years and older
Enrollment
169 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
20
States / cities
Paradise Valley, Arizona • Phoenix, Arizona • Milford, Connecticut + 16 more
Source: ClinicalTrials.gov public record
Updated Oct 5, 2017 · Synced Oct 14, 2026, 8:37 AM EDT
Completed Phase 2 Interventional

A Study Comparing The Efficacy And Safety Of Lidocaine 5% Patch With Placebo In Patients With Chronic Axial Low Back Pain

NCT00904111
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Lidoderm®, Placebo Topical Patch
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
215 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
18
States / cities
Birmingham, Alabama • Phoenix, Arizona • Carlsbad, California + 15 more
Source: ClinicalTrials.gov public record
Updated Dec 6, 2013 · Synced Oct 14, 2026, 8:37 AM EDT
Completed Phase 2 Interventional

COL-1077 (Lidocaine Bioadhesive Gel, 10%) in Women Undergoing Transvaginal Pipelle-Directed Endometrial Biopsy

NCT02465320
View directory record Official record
Conditions
Endometrial Biopsy
Interventions
COL-1077, Placebo
Drug
Lead sponsor
Juniper Pharmaceuticals, Inc.
Industry
Eligibility
40 Years to 75 Years · Female only
Enrollment
187 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
23
States / cities
Norwalk, California • Colorado Springs, Colorado • Lakewood, Colorado + 19 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2016 · Synced Oct 14, 2026, 8:37 AM EDT
Completed Phase 2 Interventional Results available

Topical Anesthetic Use In Pessary Management

NCT02380742
View directory record Official record
Conditions
Pain
Interventions
lidocaine-prilocaine cream, Placebo cream
Drug
Lead sponsor
Loyola University
Other
Eligibility
18 Years and older · Female only
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 23, 2017 · Synced Oct 14, 2026, 8:37 AM EDT
Completed Phase 3 Interventional

S-Caine™ Peel (Skin Numbing Cream) to Treat Pain During Skin Filler Injection in the Face

NCT00110760
View directory record Official record
Conditions
Pain
Interventions
S-Caine™ Peel (lidocaine and tetracaine cream 7%/7%), Placebo Peel
Drug
Lead sponsor
ZARS Pharma Inc.
Industry
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005
U.S. locations
3
States / cities
Englewood, Colorado • Nashville, Tennessee • Bryan, Texas
Source: ClinicalTrials.gov public record
Updated Jun 5, 2012 · Synced Oct 14, 2026, 8:37 AM EDT
Terminated Phase 2 Interventional Results available

Double-Blind Placebo Controlled Study of Safety,Tolerability, and Efficacy of LiRIS® in Women With Interstitial Cystitis

NCT01475253
View directory record Official record
Conditions
Interstitial Cystitis
Interventions
Lidocaine Releasing Intravesical System - LiRIS®, LiRIS Placebo, Sham Cystoscopy Procedure
Drug · Other · Procedure
Lead sponsor
Allergan
Industry
Eligibility
18 Years and older · Female only
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
27
States / cities
Glendale, Arizona • Glendora, California • Stanford, California + 24 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2015 · Synced Oct 14, 2026, 8:37 AM EDT
Completed Phase 2 Interventional Results available

Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments

NCT03844412
View directory record Official record
Conditions
Vestibulodynia, Temporomandibular Disorder, Fibromyalgia Syndrome, Irritable Bowel Syndrome, Migraines, Tension Headache, Endometriosis, Interstitial Cystitis, Back Pain, Chronic Fatigue Syndrome
Interventions
5% lidocaine/5 mg/ml 0.02% estradiol compound cream, Nortriptyline, Placebo cream, Placebo pill
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
2
States / cities
Los Angeles, California • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Oct 14, 2026, 8:37 AM EDT