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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Placebo for Probiotic Clear all
Not listed Not applicable Interventional Accepts healthy volunteers

Beverage for Immune Support

NCT05566314
View directory record Official record
Conditions
Immune
Interventions
Amunizer, Placebo
Dietary Supplement · Other
Lead sponsor
Nutraceuticals Research Institute
Other
Eligibility
20 Years to 65 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Franklin, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 3, 2022 · Synced Sep 27, 2026, 2:01 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Safety of Lactobacillus Reuteri (L. Reuteri) in Healthy Adults

NCT00922727
View directory record Official record
Conditions
Colic, Gastrointestinal Tract Infections
Interventions
L. reuteri, Sunflower Oil
Biological
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 24, 2018 · Synced Sep 27, 2026, 2:01 AM EDT
Completed Phase 3 Interventional Results available

A Probiotic Intervention to Prevent Relapse Following Hospitalization for Mania

NCT03383874
View directory record Official record
Conditions
Mania (Neurotic)
Interventions
Probio-Tec BG-VCap-6.5, Placebo
Combination Product · Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Sep 27, 2026, 2:01 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Anti-anxiety Biotics for Breast Cancer Survivors

NCT04784182
View directory record Official record
Conditions
Anxiety Generalized, Breast Cancer Female
Interventions
probiotic plus prebiotic supplement, placebo
Dietary Supplement
Lead sponsor
Auburn University
Other
Eligibility
50 Years and older · Female only
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 23, 2023 · Synced Sep 27, 2026, 2:01 AM EDT
Not listed Not applicable Interventional

Assess the Effects of a Limosilactobacillus Supplement on Recurrence of UTI in Healthy Women During a 6-month Period

NCT05793814
View directory record Official record
Conditions
Uncomplicated Symptomatic Urinary Tract Infections
Interventions
Limosilactobacillus reuteri 3613, Placebo
Dietary Supplement
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years to 65 Years · Female only
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Princeton, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 30, 2023 · Synced Sep 27, 2026, 2:01 AM EDT
Completed Phase 3 Interventional Results available

B. Lactis HN019 for Functional Constipation

NCT01463293
View directory record Official record
Conditions
Constipation
Interventions
B. lactis HN019, Placebo
Dietary Supplement
Lead sponsor
Fonterra Research Centre
Industry
Eligibility
18 Years to 70 Years
Enrollment
224 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
12
States / cities
Glendale, Arizona • Encinitas, California • Garden Grove, California + 8 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2014 · Synced Sep 27, 2026, 2:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of a Novel Probiotic on Gastrointestinal Health in Generally Healthy Adults

NCT05595980
View directory record Official record
Conditions
Gastrointestinal Health, Immune Health, Digestive Health
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
BIO-CAT Microbials, LLC
Industry
Eligibility
30 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Addison, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 5, 2023 · Synced Sep 27, 2026, 2:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Probiotics on Stress-associated Gastrointestinal Function in University Students

NCT03056846
View directory record Official record
Conditions
Healthy
Interventions
Placebo, Probiotic Combination, Bifidobacterium bifidum, Bifidobacterium longum
Dietary Supplement
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
634 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 24, 2019 · Synced Sep 27, 2026, 2:01 AM EDT
Recruiting Not applicable Interventional

Study to Investigate Efficacy of a Novel Probiotic on the Bacteriome and Mycobiome of Breast Cancer

NCT04362826
View directory record Official record
Conditions
Breast Cancer
Interventions
Novel probiotic, Placebo
Biological · Other
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 27, 2026, 2:01 AM EDT
Terminated Phase 1Phase 2 Interventional Results available

"CHANGE COVID-19 Severity"

NCT04941703
View directory record Official record
Conditions
COVID-19 Infection
Interventions
Magnesium Citrate plus probiotic
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 99 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 12, 2023 · Synced Sep 27, 2026, 2:01 AM EDT
Completed Phase 2 Interventional

Probiotic (LGG) for Veterans With PTSD

NCT04150380
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Inflammation
Interventions
Lactobacillus rhamnosus GG (LGG; ATCC strain 53103; CRMTS #11272; PTS #3766), Placebo
Biological · Other
Lead sponsor
VA Eastern Colorado Health Care System
Federal
Eligibility
18 Years to 60 Years
Enrollment
383 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Sep 27, 2026, 2:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study of the Effects of Probiotics in Children Grades 1-3

NCT00635388
View directory record Official record
Conditions
Healthy
Interventions
Placebo, Lactobacillus (Probiotic 1), Lactobacillus and Bifidobacterium (Probiotic 2)
Other
Lead sponsor
Procter and Gamble
Industry
Eligibility
5 Years to 9 Years
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 15, 2009 · Synced Sep 27, 2026, 2:01 AM EDT
Active, not recruiting Not applicable Interventional

Impact of Lp299v on Vascular Function in Patients With PASC

NCT05227170
View directory record Official record
Conditions
COVID-19
Interventions
Lactobacillus Plantarum 299v Freeze Dried Capsule, Freeze Dried Potato Starch Capsule
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 89 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 27, 2026, 2:01 AM EDT
Completed Phase 2 Interventional Results available

Asacol Acute Diverticulitis(DIVA)Study

NCT00554099
View directory record Official record
Conditions
Diverticulitis
Interventions
Mesalamine, Probiotic, Placebo, Dietary Advice, Antibiotic for Diverticulitis
Drug · Other
Lead sponsor
Warner Chilcott
Industry
Eligibility
35 Years to 85 Years
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
36
States / cities
Tucson, Arizona • Los Angeles, California • Merced, California + 33 more
Source: ClinicalTrials.gov public record
Updated Apr 21, 2013 · Synced Sep 27, 2026, 2:01 AM EDT
Not yet recruiting Phase 3 Interventional Accepts healthy volunteers

Povidone Iodine for Caries Prevention

NCT07741409
View directory record Official record
Conditions
Dental Caries
Interventions
Povidone Iodine 5% Soln,Top,Kit, Probiotics, Placebo
Drug · Dietary Supplement
Lead sponsor
Jeffrey A. Banas
Other
Eligibility
1 Year to 3 Years
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 27, 2026, 2:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pilot Study of Probiotics in Pre-diabetic Adolescents

NCT03109587
View directory record Official record
Conditions
Obesity, Childhood
Interventions
Vivomixx, Placebo
Dietary Supplement
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
13 Years to 19 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 20, 2020 · Synced Sep 27, 2026, 2:01 AM EDT
Completed Not applicable Interventional

A Study to Evaluate the Effects of a Prebiotic and Probiotic Supplement to Provide Relief From Symptoms Associated With Bacterial Vaginosis and Yeast Infections.

NCT06665126
View directory record Official record
Conditions
Bacterial Vaginosis, Yeast Infection
Interventions
Prebiotic + Probiotic Supplement, Active Placebo Supplement, Excipient Placebo Supplement
Dietary Supplement
Lead sponsor
Happy V
Industry
Eligibility
25 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Sep 27, 2026, 2:01 AM EDT
Completed Phase 1 Interventional

Probiotics and Oxytocin Nasal Spray on Social Behaviors of Autism Spectrum Disorder (ASD) Children

NCT03337035
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
intranasal oxytocin, oral probiotics, oral placebo
Drug · Dietary Supplement
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
3 Years to 25 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Sep 27, 2026, 2:01 AM EDT
Completed Not applicable Interventional

Probiotic in Patients With Bile Acid Malabsorption/Diarrhea

NCT06609148
View directory record Official record
Conditions
Bile Acid Malabsorption, Bile Acid Diarrhea
Interventions
De Simone formulation probiotic, Placebo
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 27, 2026, 2:01 AM EDT
Completed Not applicable Interventional Results available

Double-Blind Trial of a Probiotic Supplement to Reduce the Symptoms of Schizophrenia

NCT01242371
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
Probiotic Supplement, Identical-appearing Placebo
Dietary Supplement
Lead sponsor
Sheppard Pratt Health System
Other
Eligibility
18 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Towson, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 4, 2019 · Synced Sep 27, 2026, 2:01 AM EDT
Recruiting Early Phase 1 Interventional

Probiotic Administration for Adolescent Depression

NCT06898788
View directory record Official record
Conditions
Depression
Interventions
Visbiome, Placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
15 Years to 24 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Sep 27, 2026, 2:01 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

iVS-1 Probiotic Intervention Targeting Biological Aging in Midlife Adults

NCT07407894
View directory record Official record
Conditions
Healthy Aging, Anti Aging
Interventions
Bifidobacterium adolescentis iVS-1, Placebo
Dietary Supplement
Lead sponsor
Synbiotic Health
Industry
Eligibility
40 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Port Richey, Florida
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 27, 2026, 2:01 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Lactobacillus Probiotic for Prevention of UTI

NCT03151967
View directory record Official record
Conditions
Urinary Tract Infections (UTI's)
Interventions
Lactobacillus crispatus CTV-05, Placebo
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 28, 2023 · Synced Sep 27, 2026, 2:01 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Effects of Triphala and VSL#3 Probiotic Supplementation on Stool Microbiome Profiles and Inflammation

NCT03907501
View directory record Official record
Conditions
Human Microbiome
Interventions
Synbiotic, Probiotic, Placebo
Dietary Supplement
Lead sponsor
University of California, San Diego
Other
Eligibility
65 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 5, 2023 · Synced Sep 27, 2026, 2:01 AM EDT