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ClinicalTrials.gov public records Last synced Nov 7, 2026, 8:51 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 42 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Placebo hydromorphone Clear all

Conditions: Postoperative Pain, Inflammation, Osteoarthritis
Interventions: Dexamethasone 10 mg, Dexamethasone 20 mg, Standard multimodal pain management regimen, Placebo; Drug
Lead sponsor: Thomas L Bradbury; Other
Eligibility: 18 Years to 100 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Tucker, Georgia

Conditions: Postsurgical Pain
Interventions: CA-008 5 mg, Placebo, Bupivacaine Hydrochloride, Hydromorphone, Fentanyl, Acetaminophen, Oxycodone, CA-008 10 mg, CA-008 15 mg; Drug
Lead sponsor: Concentric Analgesics; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Pasadena, California

Conditions: Colorectal Surgery, Pain, Postoperative, Analgesic, Opioid
Interventions: Morphine, Hydromorphone; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 75 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Postoperative Pain, Opioid Use
Interventions: Conditioned open-label placebo (COLP), Surveys about pain, opioid use and depression symptoms; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Chronic Lower Back Pain (CLBP)
Interventions: Within-subject test of blinded study medications (Placebo, Hydromorphone, Gabapentin); Drug
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 65 Years
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2032
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Breast - Female
Interventions: Transversus Abdominis Plane (TAP) block, Nimbus Infusion Pump IV Administration, Bupivacaine infusion, Acetominophen, Hydromorphone, Oxycodone, Ondansetron; Procedure · Device · Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: Stanford, California

Conditions: Pain Management, Opioid Consumption
Interventions: Placebo, Oxycodone 5 mg, Multimodal Non-Opioid Analgesia; Drug · Other
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Pain
Interventions: Fentanyl Nasal Spray, Hydromorphone PCA, Placebo Nasal Spray; Drug · Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Opioid Withdrawal, Opioid Use Disorder, Opioid Craving
Interventions: Hydromorphone, Naloxone + lofexidine pretreatment, Naloxone + placebo pretreatment, Lofexidine; Drug
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Pituitary Tumor, Pain
Interventions: IV Caldolor, IV Placebo; Drug
Lead sponsor: St. Joseph's Hospital and Medical Center, Phoenix; Other
Eligibility: 18 Years to 79 Years
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Sickle Cell Disease, Sickle Cell Crisis, Pain, Acute
Interventions: Lidocaine Iv, Placebo; Drug
Lead sponsor: Community Medical Center, Toms River, NJ; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 3
States / cities: Long Branch, New Jersey • New Brunswick, New Jersey • Newark, New Jersey

Conditions: Acute Pain, Pain, Postoperative, Colorectal Surgery
Interventions: Placebo, Ketamine, Acetaminophen, Opioid, Alvimopan; Drug
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Low Back Pain, Recurrent, Healthy
Interventions: Within-Subject test of blinded study medication; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 109 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Analgesic Response
Interventions: morphine sulfate, hydrocodone, hydromorphone HCI, oxycodone, buprenorphine, oral tablet placebo, sublingual tablet placebo; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 20 Years to 50 Years · Male only
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Postoperative Pain
Interventions: Methadone, Saline; Drug
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 75 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Opioid-use Disorder, Pain, Acute
Interventions: HYDROmorphone Injectable Solution, Ketamine, Placebos; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 60 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Opioid-Related Disorders, Chronic Pain
Interventions: Buprenorphine, Hydromorphone, Placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Acute Pain
Interventions: IV acetaminophen + 0.5 mg IV hydromorphone, Normal saline + 0.5 mg IV hydromorphone; Drug
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 65 Years and older
Enrollment: 159 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Analgesia, Obstetrical, Postpartum Hemorrhage, Opioid Use, Nonsteroidals (NSAIDs)Toxicity, Coagulation Defect; Postpartum, Postoperative Pain, Ketorolac Adverse Reaction, Blood Loss, Postoperative
Interventions: Ketorolac, Placebo; Drug
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 70 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Pain, Cannabis, Opioid Use
Interventions: Within-subject test of blinded study medications; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid Abuse, Opioid Addiction, Stimulant Abuse, Stimulant Addiction
Interventions: tramadol, placebo, Hydromorphone, Methylphenidate; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 21 Months to 55 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Healthy
Interventions: 2 mg hydromorphone, 1000 mg Acetaminophen, 4 mg hydromorphone, dextrose; Drug
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years to 40 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Opioid Use Disorder
Interventions: AZD4041, Itraconazole, Buprenorphine, Buprenorphine / Naloxone, Hydromorphone, Placebo; Drug
Lead sponsor: AstraZeneca; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Pain Management
Interventions: Hylenex recombinant , morphine, saline, Saline; Drug · Other
Lead sponsor: HPC Healthcare, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 3
States / cities: Lakeland, Florida • Tampa, Florida • Temple Terrace, Florida

Search by objective public record fields.

Steroids in Total Knee Arthroplasty

Study in Subjects Undergoing Complete Abdominoplasty

Intrathecal Opioids for Colorectal Resection

Conditioned Open-label Placebo (COLP) for Peri-operative Pain Management in Patients With Head and Neck Cancer

Mechanistic Evaluation of Polypharmacy Effects for Pain

Transversus Abdominis Plane Block in Microsurgical Breast Recon w/Abdominal Free Flap in Breast CA

Opioid-Sparing Joint Replacement

Fentanyl for Breakthrough Pain in the Emergency Department

Assessing a Clinically-meaningful Opioid Withdrawal Phenotype

Analgesia Regimens Following Trans-sphenoidal Surgery for Pituitary Tumors

Lidocaine Intravenous in the Emergency Department For Sickle Cell Crisis

Ketamine in Colorectal Surgery

Effects of Sleep Disruption on Drug Response

Analgesic Response to Opioid Analgesics in Buprenorphine-Maintained Individuals

Methadone Versus Placebo in Spine Fusion

Acute Pain Management in Patients on Opioid Replacement Therapy

Study of the Treatment of Experimental Pain in Buprenorphine Maintained Persons With Chronic Musculoskeletal Pain

IV Acetaminophen as an Analgesic Adjunct

Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery

Enhancing Medication-based Analgesia in Humans- STUDY 2

The Discriminative Effects of Tramadol in Humans

The Effects of Hydromorphone on Responses to Verbal Tasks

Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2).

Efficacy of Hylenex in the Treatment of Pain Among Hospice Patients