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ClinicalTrials.gov public records Last synced Oct 2, 2026, 2:33 AM EDT

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Showing 97–120 of 170 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Placebo oxytocin Clear all
Terminated Phase 3 Interventional Results available

High Dose Oxytocin Nasal Spray for Treatment of Tinnitus

NCT04210310
View directory record Official record
Conditions
Tinnitus
Interventions
Oxytocin, Placebo nasal spray
Drug · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 75 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 5, 2022 · Synced Oct 2, 2026, 2:33 AM EDT
Completed Phase 2 Interventional Results available

Intranasal Oxytocin for the Treatment of Children and Adolescents With Autism Spectrum Disorders (ASD)

NCT01908205
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
Intranasal Oxytocin, Placebo
Drug
Lead sponsor
Holland Bloorview Kids Rehabilitation Hospital
Other
Eligibility
10 Years to 17 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Oct 2, 2026, 2:33 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Oxytocin Aging Study

NCT02069431
View directory record Official record
Conditions
Inflammation
Interventions
Intranasal Oxytocin spray, Intranasal Placebo spray
Drug · Other
Lead sponsor
University of Florida
Other
Eligibility
55 Years to 100 Years
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 19, 2020 · Synced Oct 2, 2026, 2:33 AM EDT
Terminated Not applicable Interventional Results available

Oxytocin Add-on Study for Stable Anxiety Patients

NCT00989937
View directory record Official record
Conditions
Anxiety Disorders
Interventions
Oxytocin, Placebo
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 25, 2019 · Synced Oct 2, 2026, 2:33 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Examining Dose-Related Effects of Oxytocin on Social Cognition Across Populations

NCT02149823
View directory record Official record
Conditions
Borderline Personality Disorder, BPD, Schizotypal Personality Disorder, SPD, Autism Spectrum Disorder, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
Interventions
Syntocinon 24 Intranasal Units (IU), Syntocinon 40 Intranasal Units (IU), Intranasal Placebo
Drug
Lead sponsor
Maria de las Mercedes Perez Rodriguez
Other
Eligibility
18 Years to 65 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2022
U.S. locations
2
States / cities
New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 10, 2022 · Synced Oct 2, 2026, 2:33 AM EDT
Completed Phase 1 Interventional

An fMRI Study of the Effect of Intravenous Oxytocin vs. Placebo on Response Inhibition and Face Processing in Autism

NCT00263796
View directory record Official record
Conditions
Autism
Interventions
Oxytocin, Placebo
Drug
Lead sponsor
Anagnostou, Evdokia, M.D.
Individual
Eligibility
18 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 30, 2014 · Synced Oct 2, 2026, 2:33 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Oxytocin Treatment of Opioid Dependence

NCT02548728
View directory record Official record
Conditions
Opioid Dependence, Opioid Withdrawal
Interventions
Intranasal Oxytocin Spray, Placebo
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
21 Years to 45 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 7, 2019 · Synced Oct 2, 2026, 2:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Postpartum Oxytocin Administration in the Era of Delayed Cord Clamping

NCT04632264
View directory record Official record
Conditions
Postpartum Hemorrhage
Interventions
Initiation of standard postpartum oxytocin immediately following fetal shoulder delivery, Initiation of standard postpartum oxytocin immediately following placenta delivery, Saline Placebo
Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 29, 2021 · Synced Oct 2, 2026, 2:33 AM EDT
Completed Phase 2 Interventional Results available

Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress

NCT02742532
View directory record Official record
Conditions
Alcohol Use Disorder, Stress Disorders, Post-Traumatic, Anxiety Disorders, Substance Use Disorders
Interventions
Oxytocin, Placebo
Drug
Lead sponsor
Jennifer Mitchell
Other
Eligibility
18 Years to 65 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 2, 2026, 2:33 AM EDT
Completed Phase 4 Interventional

Target Engagement and Response to Oxytocin

NCT03245437
View directory record Official record
Conditions
Schizophrenia
Interventions
Oxytocin nasal spray, Social Cognition Skills Training, Health Management, Placebo nasal spray
Drug · Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 21, 2025 · Synced Oct 2, 2026, 2:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Intranasal Neuropeptide on Emotion Perception in Trait Anxiety

NCT01551303
View directory record Official record
Conditions
Social Intelligence
Interventions
Oxytocin, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 30, 2014 · Synced Oct 2, 2026, 2:33 AM EDT
Withdrawn Phase 2Phase 3 Interventional Accepts healthy volunteers

Faces: Choices Study

NCT02409862
View directory record Official record
Conditions
Socioemotional Aging
Interventions
Oxytocin Spray, Placebo Spray
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 85 Years · Male only
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 26, 2018 · Synced Oct 2, 2026, 2:33 AM EDT
Not listed Phase 1 Interventional

Treating Stress and Anxiety in Individuals With Alcohol Use Disorder (AUD)

NCT06224127
View directory record Official record
Conditions
Anxiety Disorders, Alcohol Use Disorder, Stress, Psychological
Interventions
active heat, Active c tactile fiber stimulation, sham heat, Sham c tactile fiber stimulation
Device · Drug
Lead sponsor
Soovu Labs Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 25, 2024 · Synced Oct 2, 2026, 2:33 AM EDT
Withdrawn Phase 2 Interventional

Oxytocin on Approach Bias and Craving

NCT03865615
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Oxytocin, Placebo
Drug
Lead sponsor
Jennifer Mitchell
Other
Eligibility
21 Years to 40 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Jun 6, 2022 · Synced Oct 2, 2026, 2:33 AM EDT
Completed Not applicable Interventional Results available

The Gender-Sex Hormone Interface With Craving & Stress-Related Changes in Smoking

NCT01576874
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Oxytocin, placebo
Drug
Lead sponsor
Kevin Gray, MD
Other
Eligibility
18 Years to 45 Years
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 1, 2020 · Synced Oct 2, 2026, 2:33 AM EDT
Completed Phase 3 Interventional Results available

Calcium Chloride for Prevention of Blood Loss During Intrapartum Cesarean Delivery

NCT05027048
View directory record Official record
Conditions
Uterine Atony, Uterine Atony With Hemorrhage, Postpartum Hemorrhage, Cesarean Section Complications
Interventions
Calcium chloride, Saline placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pacifica, California
Source: ClinicalTrials.gov public record
Updated Jun 11, 2024 · Synced Oct 2, 2026, 2:33 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Prenatal Cocaine, Nasal Oxytocin, and Maternal Psychophysiology

NCT02872467
View directory record Official record
Conditions
Substance Abuse Problem, Pregnancy
Interventions
Syntocinon treatment, Placebo
Drug · Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 42 Years · Female only
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 18, 2023 · Synced Oct 2, 2026, 2:33 AM EDT
Terminated Not applicable Interventional Results available

Oxytocin Add-on for Stable Depressed Patients

NCT01211756
View directory record Official record
Conditions
Major Depressive Disorder, Dysthymia Disorder
Interventions
Oxytocin, Placebo
Drug
Lead sponsor
David Feifel
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 25, 2019 · Synced Oct 2, 2026, 2:33 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy

NCT06483659
View directory record Official record
Conditions
Postoperative Pain
Interventions
Oxytocin, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
152 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 2, 2026, 2:33 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Brain Blood Flow Changes Elicited by Oxytocin in Volunteers With and Without Schizophrenia

NCT01123317
View directory record Official record
Conditions
Schizophrenia
Interventions
Oxytocin
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 55 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Oct 2, 2026, 2:33 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

A Randomized Controlled Trial to Test the Effects Oxytocin and Vibration Have on Heat Pain Threshold After UV-B Burn

NCT06651476
View directory record Official record
Conditions
Sunburn
Interventions
oxytocin, placebo
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 55 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Oct 2, 2026, 2:33 AM EDT
Completed Phase 2 Interventional Results available

A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine

NCT05679908
View directory record Official record
Conditions
Chronic Migraine, Chronic Migraine, Headache, Chronic Migraine Without Aura, Aura Migraine
Interventions
TNX-1900, Placebo Nasal Spray
Drug
Lead sponsor
Tonix Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
26
States / cities
Little Rock, Arkansas • Lemon Grove, California • Oceanside, California + 23 more
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Oct 2, 2026, 2:33 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

A Study to Evaluate Pharmacokinetics, Pharmacodynamics and Tissue Concentrations of Epelsiban

NCT02213029
View directory record Official record
Conditions
Embryo Transfer
Interventions
Epelsiban, Placebo, Oxytocin, Ortho-Cylcen (21)® tablet
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 35 Years · Female only
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
Glendale, California • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 8, 2017 · Synced Oct 2, 2026, 2:33 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

The Impact of Oxytocin on the Neurobiology of Anorexia Nervosa

NCT03414112
View directory record Official record
Conditions
Anorexia Nervosa
Interventions
Intranasal oxytocin
Biological
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older · Female only
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 11, 2022 · Synced Oct 2, 2026, 2:33 AM EDT