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Showing 1–24 of 34 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Placebo rectal suppository Clear all
Completed Phase 2 Interventional

Safety and Efficacy Study of Anucort HC TM 25mg Rectal Suppositories to Treat Symptomatic Internal Hemorrhoids

NCT01913158
View directory record Official record
Conditions
Internal Hemorrhoids
Interventions
Anucort-HC, 25 Mg Rectal Suppository, Placebo suppository
Drug
Lead sponsor
G & W Laboratories Inc.
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
3
States / cities
Huntsville, Alabama • Sanford, Florida • Wyoming, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 2, 2016 · Synced Sep 3, 2026, 6:54 PM EDT
Completed Phase 3 Interventional Results available

A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis

NCT02692391
View directory record Official record
Conditions
Acute Pancreatitis
Interventions
Indomethacin, Placebo
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 21, 2021 · Synced Sep 3, 2026, 6:54 PM EDT
Terminated Phase 3 Interventional Results available

Efficacy and Safety Study of MAX-002 Suppository Versus Placebo and Active Medicine in Mild to Moderate Ulcerative Proctitis

NCT01016262
View directory record Official record
Conditions
Proctitis, Ulcerative
Interventions
MAX-002, Placebo, Canasa®
Drug
Lead sponsor
Forest Laboratories
Industry
Eligibility
18 Years and older
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
22
States / cities
Birmingham, Alabama • Dothan, Alabama • Tucson, Arizona + 19 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Sep 3, 2026, 6:54 PM EDT
Completed Phase 2 Interventional Results available

Topical Metronidazole and Miconazole Co-formulated Vaginal Suppositories for Preventing Vaginal Infections in HIV-seronegative Women

NCT01230814
View directory record Official record
Conditions
Bacterial Vaginosis, Candidiasis, Trichomoniasis
Interventions
Neo-Penotran® Forte (active ingredient Metronidazole & Miconazole Nitrate), Placebo
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 45 Years · Female only
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 5, 2014 · Synced Sep 3, 2026, 6:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Randomized, Double-blind, Placebo-controlled Trial Investigating the Role of a Personal Care Product on Vaginal Health

NCT05659745
View directory record Official record
Conditions
Vaginal Personal Care
Interventions
VM-02, Commercial Oral Probiotic Competitor, VM-02 Placebo
Other · Dietary Supplement
Lead sponsor
Seed Health
Industry
Eligibility
18 Years and older · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Venice, California
Source: ClinicalTrials.gov public record
Updated May 30, 2023 · Synced Sep 3, 2026, 6:54 PM EDT
Terminated Phase 4 Interventional Results available

Rectal Indomethacin in the Prevention of Post-endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis in High Risk Patients

NCT00820612
View directory record Official record
Conditions
Post-ERCP Pancreatitis
Interventions
Indomethacin, Placebo suppositories
Drug · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
602 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
4
States / cities
Indianapolis, Indiana • Lexington, Kentucky • Ann Arbor, Michigan + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2013 · Synced Sep 3, 2026, 6:54 PM EDT
Not listed Not applicable Interventional

Rectal Indomethacin to Prevent Acute Pancreatitis in EUS-FNA of Pancreatic Cysts

NCT05572788
View directory record Official record
Conditions
Pancreatic Cyst, Pancreatitis, Acute
Interventions
EUS-guided fine needle aspiration of pancreatic cysts
Procedure
Lead sponsor
Orlando Health, Inc.
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jan 30, 2024 · Synced Sep 3, 2026, 6:54 PM EDT
Not yet recruiting Phase 1 Interventional

Vaginal Sildenafil for Primary Dysmenorrhea

NCT07508358
View directory record Official record
Conditions
Dysmenorrhea, Menstrual Pain
Interventions
Sildenafil citrate vaginal suppository, Placebo vaginal suppository
Drug
Lead sponsor
Kevin Hellman
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Sep 3, 2026, 6:54 PM EDT
Completed Phase 3 Interventional Results available

Dehydroepiandrosterone (DHEA) Against Vaginal Atrophy

NCT01358760
View directory record Official record
Conditions
Vaginal Atrophy
Interventions
Placebo, DHEA
Drug
Lead sponsor
EndoCeutics Inc.
Industry
Eligibility
40 Years to 75 Years · Female only
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
32
States / cities
Montgomery, Alabama • Tucson, Arizona • Little Rock, Arkansas + 27 more
Source: ClinicalTrials.gov public record
Updated Jun 11, 2017 · Synced Sep 3, 2026, 6:54 PM EDT
Completed Phase 4 Interventional Results available

Reduction of Bladder Injection Pain With Belladonna Opiate Suppository

NCT02600715
View directory record Official record
Conditions
Overactive Bladder, Urinary Urge Incontinence, Urinary Bladder, Neurogenic, Painful Bladder Syndrome
Interventions
Onabotulinumtoxin A (BoNT), belladonna, Morphine, Placebo, Active B&O suppository of belladonna
Drug
Lead sponsor
Edgar LeClaire, MD
Other
Eligibility
18 Years and older · Female only
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
2
States / cities
Wichita, Kansas
Source: ClinicalTrials.gov public record
Updated Sep 19, 2018 · Synced Sep 3, 2026, 6:54 PM EDT
Withdrawn Phase 1 Interventional Accepts healthy volunteers

The CBD-IC Randomized Controlled Trial: Evaluation of Hemp Cannabidiol SuppositoRies for Pain and Urinary SymptOms in INterstitial Cystitis (CHRONIC)

NCT04349930
View directory record Official record
Conditions
Interstitial Cystitis, Bladder Pain Syndrome
Interventions
Cannabidiol vaginal suppository, Placebo vaginal suppository
Drug
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jan 14, 2021 · Synced Sep 3, 2026, 6:54 PM EDT
Not listed Phase 4 Interventional

Impact of Placement of a Diazepam Suppository on Early Postoperative Pain Following Pelvic Reconstructive Surgery

NCT04198233
View directory record Official record
Conditions
Postoperative Pain
Interventions
Diazepam, Placebos
Drug
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 22, 2020 · Synced Sep 3, 2026, 6:54 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Lactated Ringers With or Without Rectal Indomethacin to Prevent Post-ERCP Pancreatitis

NCT02641561
View directory record Official record
Conditions
Post-ERCP Acute Pancreatitis
Interventions
Indomethacin, Lactated Ringer's Solution, Normal Saline, Placebo
Drug
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older
Enrollment
192 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 26, 2018 · Synced Sep 3, 2026, 6:54 PM EDT
Completed Phase 4 Interventional Results available

Assessing Maternal Post-partum Pain With Suppositories

NCT01271855
View directory record Official record
Conditions
Pain
Interventions
Belladonna and opioid suppository, Glycerin Suppository
Drug
Lead sponsor
Loyola University
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
2
States / cities
Maywood, Illinois • Melrose Park, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 6, 2018 · Synced Sep 3, 2026, 6:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Rectal Microbicide Acceptability, Tolerability and Adherence

NCT03671239
View directory record Official record
Conditions
HIV Prevention
Interventions
Placebo rectal insert, Placebo rectal suppository, Placebo rectal douche
Behavioral
Lead sponsor
Microbicide Trials Network
Network
Eligibility
18 Years to 35 Years
Enrollment
217 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
3
States / cities
Birmingham, Alabama • San Francisco, California • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 19, 2023 · Synced Sep 3, 2026, 6:54 PM EDT
Completed Not applicable Interventional

Diazepam Vaginal Suppositories for High Tone Pelvic Floor Dysfunction.

NCT01233791
View directory record Official record
Conditions
Female Patients With High Tone Pelvic Floor Dysfunction
Interventions
Vaginal Diazepam Suppository, Placebo Suppository
Drug
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 9, 2015 · Synced Sep 3, 2026, 6:54 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

B&O for TLH Post-operative Pain and Nausea

NCT03657407
View directory record Official record
Conditions
Hysterectomy, Pain, Postoperative
Interventions
Belladonna Opium, Glycerin Suppository
Drug
Lead sponsor
Anna Reinert
Other
Eligibility
18 Years to 75 Years · Female only
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 1, 2019 · Synced Sep 3, 2026, 6:54 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Vaginal Progesterone for the Prevention of Preterm Birth in Women With Arrested Preterm Labor

NCT01840228
View directory record Official record
Conditions
Premature Birth, Obstetric Labor, Premature
Interventions
Micronized progesterone suppository
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 17, 2019 · Synced Sep 3, 2026, 6:54 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

24-hour Mifepristone and Buccal Versus Mifepristone and Vaginal Misoprostol for Cervical Preparation for D&E

NCT03134183
View directory record Official record
Conditions
Abortion, Second Trimester
Interventions
Vaginal Misoprostol, Buccal Misoprostol
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 17, 2018 · Synced Sep 3, 2026, 6:54 PM EDT
Completed Not applicable Interventional

Randomized, Double-Blind Placebo-Controlled Trial to Assess Overall User Experience of a Synbiotic Vaginal Suppository

NCT06236893
View directory record Official record
Conditions
Vaginal Personal Care
Interventions
VH-01 vaginal suppository tablet, Placebo vaginal suppository tablet
Other
Lead sponsor
Seed Health
Industry
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Sep 3, 2026, 6:54 PM EDT
Completed Phase 3 Interventional Results available

DHEA Against Vaginal Atrophy - 3-Month Efficacy Study

NCT01256684
View directory record Official record
Conditions
Vaginal Atrophy
Interventions
Placebo, DHEA
Drug
Lead sponsor
EndoCeutics Inc.
Industry
Eligibility
40 Years to 75 Years · Female only
Enrollment
255 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
24
States / cities
Montgomery, Alabama • Tucson, Arizona • Sacramento, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jun 25, 2017 · Synced Sep 3, 2026, 6:54 PM EDT
Completed Phase 2 Interventional Results available

Effects of Inhibiting Early Inflammation in Kidney Transplant Patients

NCT02495077
View directory record Official record
Conditions
Kidney Transplant
Interventions
Infliximab, Methylprednisolone, Mycophenolate Mofetil, Tacrolimus, Thymoglobulin®, Acetaminophen, Loratadine, Placebo for Infliximab, Prednisone, Diphenhydramine
Biological · Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years and older
Enrollment
290 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
13
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 15, 2022 · Synced Sep 3, 2026, 6:54 PM EDT
Completed Phase 3 Interventional Results available

Topical DHEA Against Vaginal Atrophy

NCT01846442
View directory record Official record
Conditions
Vaginal Atrophy
Interventions
Placebo, DHEA (0.25%), DHEA (0.5%), DHEA (1.0%)
Drug
Lead sponsor
EndoCeutics Inc.
Industry
Eligibility
40 Years to 75 Years · Female only
Enrollment
218 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
2
States / cities
Cleveland, Ohio • Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 28, 2017 · Synced Sep 3, 2026, 6:54 PM EDT
Terminated Phase 2 Interventional Results available

Treating Anorectal Dysfunction in MS

NCT02609607
View directory record Official record
Conditions
Constipation, Fecal Incontinence, Multiple Sclerosis
Interventions
Bisacodyl, Placebo
Drug · Other
Lead sponsor
David Levinthal
Other
Eligibility
18 Years to 80 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 21, 2020 · Synced Sep 3, 2026, 6:54 PM EDT