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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Positive Affect + Education Clear all
Completed Not applicable Interventional Results available

Effects of a Wellbeing Intervention on Inflammation Through Reward and Threat Processes

NCT06294145
View directory record Official record
Conditions
Low Positive Affect
Interventions
Savoring Intervention
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 25 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 27, 2026, 9:57 AM EDT
Completed Not applicable Interventional

Incorporating Positive Affect Promoting Activities Into Cognitive Behavioral Therapies

NCT06432959
View directory record Official record
Conditions
Depression, Borderline Personality Disorder, Emotion Regulation
Interventions
Psychotherapy, Positive Affect Promoting Activities, Psychotherapy
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 21, 2025 · Synced Sep 27, 2026, 9:57 AM EDT
Not listed Not applicable Interventional

Positive Psychology Intervention for Spanish-speaking Hispanic/Latino Adults at Risk for Cardiovascular Disease

NCT03221114
View directory record Official record
Conditions
Uncontrolled Hypertension, Cardiovascular Risk Factor
Interventions
Positive Psychological Intervention
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 19, 2019 · Synced Sep 27, 2026, 9:57 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Positive Affect Treatment for Adolescents With Early Life Adversity

NCT06273137
View directory record Official record
Conditions
Depression
Interventions
Positive affect treatment, Supportive psychotherapy (SUP)
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
12 Years to 16 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2030
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 27, 2026, 9:57 AM EDT
Recruiting Not applicable Interventional

Neuroscience-informed Treatment to Remotely Target Reward Mechanisms in Post-acute Anorexia Nervosa

NCT05799872
View directory record Official record
Conditions
Anorexia Nervosa
Interventions
Positive Affect Treatment for Anorexia Nervosa (PAT-AN):, Psychoeducational and Behavioral Therapy (PBT)
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 27, 2026, 9:57 AM EDT
Recruiting Not applicable Interventional

Psychological Options for Wellness and Recovery (POWeR) Trial for Veterans With Chronic Back/Neck Pain

NCT07137715
View directory record Official record
Conditions
Chronic Pain, Back Pain, Back Pain Lower Back Chronic, Neck Pain
Interventions
Pain reprocessing therapy (PRT), Cognitive Behavioral Therapy for Chronic Pain (CBT-CP), Usual Care
Behavioral · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Sep 27, 2026, 9:57 AM EDT
Completed Not applicable Interventional

Trial Using Motivational Interviewing Positive Affect and Self-Affirmation in Hypertension (TRIUMPH)

NCT01024933
View directory record Official record
Conditions
Hypertension
Interventions
Positive Affect/Self-Affirmation/Motivational Interviewing, Educational and Behavioral
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
238 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 22, 2017 · Synced Sep 27, 2026, 9:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reducing Sleep Disparities in Minority Children

NCT01301989
View directory record Official record
Conditions
Sleep
Interventions
Sleep Counselor Intervention, Sleep Education Control
Behavioral · Other
Lead sponsor
Columbia University
Other
Eligibility
60 Months to 87 Months
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 3, 2015 · Synced Sep 27, 2026, 9:57 AM EDT
Completed Not applicable Interventional

Web-Delivered Interventions for Blood Sugar Control for Individuals With Type 2 Diabetes

NCT02676648
View directory record Official record
Conditions
Diabetes Mellitus, Type 2
Interventions
Multicomponent online program, Breath meter, Text messages, Diet-appropriate foods and cookbooks
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 8, 2021 · Synced Sep 27, 2026, 9:57 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Randomized Trial of an HIV Prevention and Relationship Education Program for Young Male Couples

NCT03186534
View directory record Official record
Conditions
Hiv, Chlamydia, Gonorrhea, Relation, Interpersonal
Interventions
2GETHER, Positive Affect Enhancement
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Male only
Enrollment
256 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Sep 27, 2026, 9:57 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Researchers At UC San Diego Are Learning About the Benefits of Human Milk and How It Influences Infant and Child Health

NCT05553743
View directory record Official record
Conditions
Breastfeeding, COVID-19 Infection, COVID-19 Vaccine, Remdesivir, Antibiotics
Interventions
COVID-19 Exposure, Antibiotic
Biological · Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2040
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Sep 27, 2026, 9:57 AM EDT
Completed Not applicable Interventional

Affect Treatment for Depression and Anxiety

NCT05203861
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Positive Affect Treatment, Negative Affect Treatment
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Los Angeles, California • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 24, 2025 · Synced Sep 27, 2026, 9:57 AM EDT
Active, not recruiting Not applicable Interventional

Acceptability and Efficacy of Pain Reprocessing Therapy in Racially/ Ethnically Diverse Adults With Chronic Back Pain

NCT05820204
View directory record Official record
Conditions
Pain, Chronic, Back Pain
Interventions
Pain reprocessing therapy (PRT), Cognitive Behavioral Therapy for Chronic Pain (CBT-CP), Usual care
Behavioral · Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 27, 2026, 9:57 AM EDT
Completed Not applicable Interventional

Piloting Text Messages to Promote Positive Affect and Physical Activity

NCT04077229
View directory record Official record
Conditions
Acute Coronary Syndrome
Interventions
Intervention arm: Text Message Intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 20, 2020 · Synced Sep 27, 2026, 9:57 AM EDT
Completed Not applicable Interventional Results available

Adaptability and Resilience in Aging Adults-2

NCT04068922
View directory record Official record
Conditions
Aging, Chronic Low-back Pain
Interventions
Resilience Intervention
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
60 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Sep 27, 2026, 9:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intervention to Improve Quality of Life in African American Lupus Patients

NCT01837875
View directory record Official record
Conditions
Depression, Systemic Lupus Erythematosus
Interventions
Chronic Disease Self-Management Program (CDSMP), Mail-delivered arthritis kit, Support group, Listserv
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 14, 2018 · Synced Sep 27, 2026, 9:57 AM EDT
Not listed Not applicable Interventional

Internet-based Positive Psychological Intervention for Hispanic/Latino Adult With Hypertension in a Primary Care Setting

NCT03892057
View directory record Official record
Conditions
Uncontrolled Hypertension, Cardiovascular Risk Factor
Interventions
Internet-based Positive Psychological Intervention
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 4, 2019 · Synced Sep 27, 2026, 9:57 AM EDT
Not listed Not applicable Interventional

Preventing OUD in Justice-Involved Youth

NCT04901312
View directory record Official record
Conditions
Substance Use Disorders, Recidivism
Interventions
Adolescent Community Reinforcement Approach, Assertive Continuing Care, Trauma Affect Regulation Guide for Education and Therapy, Motivational Interviewing, Opioid Education Workbook
Behavioral · Other
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
15 Years to 25 Years
Enrollment
215 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Olympia, Washington
Source: ClinicalTrials.gov public record
Updated Oct 26, 2022 · Synced Sep 27, 2026, 9:57 AM EDT
Completed Not applicable Interventional

Maladaptive Psychosocial Beliefs and Adolescents With Patellofemoral Pain

NCT04752501
View directory record Official record
Conditions
Patellofemoral Pain Syndrome, Knee Pain Chronic, Patellofemoral Syndrome, Anterior Knee Pain Syndrome
Interventions
Psychologically Informed Education, Biomedical Education (Control)
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
12 Years to 18 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 2, 2023 · Synced Sep 27, 2026, 9:57 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Skin Savvy Study: A Behavioral Skin Cancer Prevention Intervention

NCT00709306
View directory record Official record
Conditions
Skin Cancer Prevention
Interventions
UV-Detect Photos, Motivational Interviewing, Education
Device · Behavioral
Lead sponsor
Fox Chase Cancer Center
Other
Eligibility
18 Years to 24 Years
Enrollment
197 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 30, 2018 · Synced Sep 27, 2026, 9:57 AM EDT
Completed Not applicable Interventional Results available

Cognitive-Behavioral Therapy and Supportive Psychotherapy for Body Dysmorphic Disorder

NCT01453439
View directory record Official record
Conditions
Body Dysmorphic Disorder, Obsessive-Compulsive Spectrum Disorder, Anxiety Disorders, Somatoform Disorders
Interventions
Cognitive Behavioral Therapy, Supportive Psychotherapy
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
2
States / cities
Boston, Massachusetts • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 14, 2020 · Synced Sep 27, 2026, 9:57 AM EDT
Completed Phase 1Phase 2 Interventional Results available

The University of Michigan Wellness for Liver Health Study

NCT05010070
View directory record Official record
Conditions
Nonalcoholic Fatty Liver Disease
Interventions
diet and lifestyle program
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 13, 2023 · Synced Sep 27, 2026, 9:57 AM EDT
Completed Not applicable Interventional Results available

Improving Attentional and Cognitive Control in the Psychological Treatment of Intrusive Thoughts

NCT04225624
View directory record Official record
Conditions
Obsessive-Compulsive Disorder, Generalized Anxiety Disorder, Major Depressive Disorder
Interventions
Emotion Regulation Therapy - Attention Regulation (AR-ERT), Supportive Psychotherapy (SPT)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 27, 2026, 9:57 AM EDT
Not listed Not applicable Interventional

Intervention to Support Participation in Regular Exercise in the Elderly (INSPIRE)

NCT02464254
View directory record Official record
Conditions
Chronic Illnesses
Interventions
Physical activity plus positive affect, Physical activity plus education
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
60 Years to 110 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 20, 2019 · Synced Sep 27, 2026, 9:57 AM EDT