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Showing 1–24 of 102 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Positive Affect Treatment Clear all
Completed Not applicable Interventional Results available

Effects of a Wellbeing Intervention on Inflammation Through Reward and Threat Processes

NCT06294145
View directory record Official record
Conditions
Low Positive Affect
Interventions
Savoring Intervention
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 25 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 3, 2026, 5:52 AM EDT
Completed Not applicable Interventional

A Pilot Study of Positive Affect Training

NCT01853098
View directory record Official record
Conditions
Affect (Mental Function), Compassion
Interventions
Positive Affect Training (PAT)
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 17, 2018 · Synced Sep 3, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional

Increasing Resiliency Among Early Post-Treatment Lymphoma Survivors

NCT07014293
View directory record Official record
Conditions
Lymphoma
Interventions
Enhanced Usual Care, SMART3RP-Lymphoma
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
254 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 3, 2026, 5:52 AM EDT
Completed Not applicable Interventional Results available

Treatment for Affect Dimensions

NCT03439748
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Positive Affect Treatment, Negative Affect Treatment
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
2
States / cities
Los Angeles, California • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 11, 2024 · Synced Sep 3, 2026, 5:52 AM EDT
Completed Phase 1Phase 2 Interventional

The MHERO Study (Michigan's Hypertension, Diabetes, and Obesity Education Research Online)

NCT03729479
View directory record Official record
Conditions
Type2 Diabetes Mellitus, Hypertension, PreDiabetes, Overweight and Obesity
Interventions
DASH diet, Very low carbohydrate, ketogenic diet, Extras
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
21 Years to 70 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 28, 2020 · Synced Sep 3, 2026, 5:52 AM EDT
Completed Phase 1 Interventional

Positive Affect Promotion to Empower Optimal Adherence to HIV Therapy

NCT04035759
View directory record Official record
Conditions
HIV/AIDS
Interventions
APPEAL
Behavioral
Lead sponsor
State University of New York - Downstate Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Oct 31, 2021 · Synced Sep 3, 2026, 5:52 AM EDT
Active, not recruiting Not applicable Interventional

Trauma Intervention to Optimize PrEP Among Women Who Inject Drugs

NCT05192434
View directory record Official record
Conditions
HIV Infections, Opioid Use, Trauma, Psychological
Interventions
Expressive Writing, Contingency Management
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
18 Years and older · Female only
Enrollment
219 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Sep 3, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional

Integrated Health Care for PTSD

NCT07220681
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD)
Interventions
Yoga and meditation, Wellness, Positive affect, Information
Behavioral · Other
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
5
States / cities
Little Rock, Arkansas • San Diego, California • Durham, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Sep 3, 2026, 5:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

NEPAL (Neuromodulatory Examination of Pain and Mobility Across the Lifespan)

NCT02488863
View directory record Official record
Conditions
Musculoskeletal Pain, Pain, Chronic
Interventions
MRI Neuroimaging, Quantitative Sensory Testing, Questionnaires, Physical and Cognitive Function Testing
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2024
U.S. locations
4
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 17, 2025 · Synced Sep 3, 2026, 5:52 AM EDT
Completed Not applicable Interventional Results available

A Novel Cognitive Reappraisal Intervention for Suicide Prevention

NCT03026127
View directory record Official record
Conditions
Suicide Prevention
Interventions
Cognitive Reappraisal Intervention for Suicide Prevention, Supportive Therapy
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
50 Years to 90 Years
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Sep 3, 2026, 5:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Optimizing Mindfulness Based Cognitive Therapy (MBCT) Maintenance

NCT05859386
View directory record Official record
Conditions
Depression
Interventions
Mindfulness maintenance program
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 2, 2024 · Synced Sep 3, 2026, 5:52 AM EDT
Completed Not applicable Interventional Results available

Compassion Meditation for PTSD

NCT02372396
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Compassion Meditation (CM), Relaxation
Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2018 · Synced Sep 3, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional

Psychological Options for Wellness and Recovery (POWeR) Trial for Veterans With Chronic Back/Neck Pain

NCT07137715
View directory record Official record
Conditions
Chronic Pain, Back Pain, Back Pain Lower Back Chronic, Neck Pain
Interventions
Pain reprocessing therapy (PRT), Cognitive Behavioral Therapy for Chronic Pain (CBT-CP), Usual Care
Behavioral · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Sep 3, 2026, 5:52 AM EDT
Completed Not applicable Interventional

THRIVE Study: Positive Affect Training for Endocrine Therapy Medication Adherence

NCT06388304
View directory record Official record
Conditions
Breast Cancer, DCIS
Interventions
THRIVE Online PAT Program
Behavioral
Lead sponsor
Joanna Arch
Other
Eligibility
21 Years and older · Female only
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Sep 3, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional

Neuroscience-informed Treatment to Remotely Target Reward Mechanisms in Post-acute Anorexia Nervosa

NCT05799872
View directory record Official record
Conditions
Anorexia Nervosa
Interventions
Positive Affect Treatment for Anorexia Nervosa (PAT-AN):, Psychoeducational and Behavioral Therapy (PBT)
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 3, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Restorative Neurophysiology: Backing up and Restoring the Brain (BandR)

NCT07252011
View directory record Official record
Conditions
Adults With Variability in Their Mood
Interventions
Transcranial alternating current stimulation (tACS), Neuro/biofeedback, Recall, Physiological stimulation
Device · Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Sep 3, 2026, 5:52 AM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers

A Cognitive- Behavioral Play Intervention for Siblings of Children Diagnosed With Cancer

NCT01704885
View directory record Official record
Conditions
Any Cancer Diagnosis
Interventions
Play Intervention, Questionnaires
Behavioral · Other
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
4 Years to 10 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 2, 2015 · Synced Sep 3, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional

Reward Processing and Exposure Therapy for Social Anxiety Disorder

NCT06776991
View directory record Official record
Conditions
Social Anxiety Disorder (Social Phobia), Public Speaking Anxiety, Anhedonia, ANXIETY DISORDERS (or Anxiety and Phobic Neuroses), Phobic Disorders
Interventions
Positive Affect Treatment - Behavioral (PAT-B), Relaxation Treatment, Exposure Therapy
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 60 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Sep 3, 2026, 5:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Factorial Trial Testing Guided Thinking Tasks to Optimize a Physical Activity Intervention

NCT05235360
View directory record Official record
Conditions
Physical Inactivity
Interventions
Episodic future thinking, Positive affect imagery, Action planning, High dose, Recent thinking, Neutral imagery, Low dose
Behavioral
Lead sponsor
Southern Methodist University
Other
Eligibility
18 Years to 64 Years
Enrollment
184 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 3, 2026, 5:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Resurgence as Choice: Basic and Clinical Studies

NCT03423940
View directory record Official record
Conditions
Problem Behavior, Self-injury, Communication
Interventions
Functional communication training
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
3 Years to 19 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Somerset, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 2, 2024 · Synced Sep 3, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Positive Affect Treatment for Adolescents With Early Life Adversity

NCT06273137
View directory record Official record
Conditions
Depression
Interventions
Positive affect treatment, Supportive psychotherapy (SUP)
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
12 Years to 16 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2030
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 3, 2026, 5:52 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Evaluation of Whether Deferiprone Affects QT Interval in Healthy Subjects

NCT01860703
View directory record Official record
Conditions
Prolonged QTc Interval
Interventions
Deferiprone, deferiprone matching placebo tablets, moxifloxacin, placebo
Drug
Lead sponsor
ApoPharma
Industry
Eligibility
18 Years to 45 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Tempe, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 11, 2014 · Synced Sep 3, 2026, 5:52 AM EDT
Completed Not applicable Interventional

Affect Treatment for Depression and Anxiety (TAD Pilot)

NCT06488859
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Positive Affect Treatment, Positive Affect Treatment and Negative Affect Treatment
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Los Angeles, California • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 10, 2025 · Synced Sep 3, 2026, 5:52 AM EDT
Completed Not applicable Interventional Results available

Pilot of Mindfulness Oriented Recovery Enhancement in MethadoneTreatment

NCT03894501
View directory record Official record
Conditions
Opioid Use, Chronic Pain
Interventions
Mindfulness Oriented Recovery Enhancement, Methadone program behavioral treatment as usual
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced Sep 3, 2026, 5:52 AM EDT