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Showing 1–24 of 199 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Positive affect Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Seeing the World Through Assorted Glasses

NCT02483559
View directory record Official record
Conditions
Sleep
Interventions
Amber Lenses, Placebo Lenses
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 50 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 7, 2017 · Synced Sep 2, 2026, 4:22 PM EDT
Suspended Not applicable Interventional

ORCHID: An Online Intervention for Persons With HIV (Miami)

NCT05935644
View directory record Official record
Conditions
HIV/AIDS, HPV Infection
Interventions
ORCHID
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 90 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 2, 2026, 4:22 PM EDT
Completed Not applicable Interventional Results available

Effects of a Wellbeing Intervention on Inflammation Through Reward and Threat Processes

NCT06294145
View directory record Official record
Conditions
Low Positive Affect
Interventions
Savoring Intervention
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 25 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 2, 2026, 4:22 PM EDT
Completed Not applicable Interventional

A Pilot Study of Positive Affect Training

NCT01853098
View directory record Official record
Conditions
Affect (Mental Function), Compassion
Interventions
Positive Affect Training (PAT)
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 17, 2018 · Synced Sep 2, 2026, 4:22 PM EDT
Completed Not applicable Interventional

A Pilot Study of Changing Medication Adherence In Hypertensive African-American Patients

NCT00248937
View directory record Official record
Conditions
Hypertension
Interventions
Positive affect and self-affect induction
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 2, 2008 · Synced Sep 2, 2026, 4:22 PM EDT
Not listed Not applicable Interventional

Internet-based Positive Psychological Intervention for Hispanic/Latino Adult With Hypertension in a Primary Care Setting

NCT03892057
View directory record Official record
Conditions
Uncontrolled Hypertension, Cardiovascular Risk Factor
Interventions
Internet-based Positive Psychological Intervention
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 4, 2019 · Synced Sep 2, 2026, 4:22 PM EDT
Not listed Not applicable Interventional

Intervention to Support Participation in Regular Exercise in the Elderly (INSPIRE)

NCT02464254
View directory record Official record
Conditions
Chronic Illnesses
Interventions
Physical activity plus positive affect, Physical activity plus education
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
60 Years to 110 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 20, 2019 · Synced Sep 2, 2026, 4:22 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Parent Encouragement And Coaching of Happiness in Youth

NCT06725160
View directory record Official record
Conditions
Depression, Parent-Child Relations
Interventions
Parent Coaching, Active Control
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
4 Years to 99 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Sep 2, 2026, 4:22 PM EDT
Completed Not applicable Interventional Results available

A Positive Psychology Intervention for Patients With Multiple Sclerosis

NCT03637699
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Positive Psychology
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 15, 2021 · Synced Sep 2, 2026, 4:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Life Enhancing Activities for Family Caregivers

NCT01825681
View directory record Official record
Conditions
Stress, Dementia, Affect
Interventions
Positive Affect
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 4, 2019 · Synced Sep 2, 2026, 4:22 PM EDT
Recruiting Not applicable Interventional

Increasing Resiliency Among Early Post-Treatment Lymphoma Survivors

NCT07014293
View directory record Official record
Conditions
Lymphoma
Interventions
Enhanced Usual Care, SMART3RP-Lymphoma
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
254 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 2, 2026, 4:22 PM EDT
Completed Not applicable Interventional Results available

Treatment for Affect Dimensions

NCT03439748
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Positive Affect Treatment, Negative Affect Treatment
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
2
States / cities
Los Angeles, California • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 11, 2024 · Synced Sep 2, 2026, 4:22 PM EDT
Recruiting Not applicable Interventional

Teen Brain Online II: Understanding How Social Media Affects the Teen Brain

NCT06817993
View directory record Official record
Conditions
Depression
Interventions
Rejection and Acceptance Feedback
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
13 Years to 17 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 2, 2026, 4:22 PM EDT
Completed Phase 1Phase 2 Interventional

The MHERO Study (Michigan's Hypertension, Diabetes, and Obesity Education Research Online)

NCT03729479
View directory record Official record
Conditions
Type2 Diabetes Mellitus, Hypertension, PreDiabetes, Overweight and Obesity
Interventions
DASH diet, Very low carbohydrate, ketogenic diet, Extras
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
21 Years to 70 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 28, 2020 · Synced Sep 2, 2026, 4:22 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Stress and Anxiety Effects on Valuation

NCT07252947
View directory record Official record
Conditions
Reward Value Level
Interventions
Socially Evaluated Cold Pressor Task (SECPT), Non-Stressful Control Task
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Sep 2, 2026, 4:22 PM EDT
Completed Not applicable Interventional Results available

Trial on the Effect of E-cigarette Advertising on Cigarette Perceptions in Adolescents

NCT03786042
View directory record Official record
Conditions
Attentional Bias, Smoking Cues, Positive Perceptions About Cigarette Smoking, Social Norms, Smoking Susceptibility
Interventions
E-cigarette ad exposure, non e-cigarette TV commercials
Behavioral · Other
Lead sponsor
Trustees of Dartmouth College
Other
Eligibility
14 Years to 17 Years
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Sep 2, 2026, 4:22 PM EDT
Completed Not applicable Interventional Results available

Positive Psychology for Physical Activity Promotion

NCT03826173
View directory record Official record
Conditions
Obesity, Physical Activity
Interventions
PPPA, PA
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 3, 2023 · Synced Sep 2, 2026, 4:22 PM EDT
Completed Phase 1 Interventional

Positive Affect Promotion to Empower Optimal Adherence to HIV Therapy

NCT04035759
View directory record Official record
Conditions
HIV/AIDS
Interventions
APPEAL
Behavioral
Lead sponsor
State University of New York - Downstate Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Oct 31, 2021 · Synced Sep 2, 2026, 4:22 PM EDT
Active, not recruiting Not applicable Interventional

Trauma Intervention to Optimize PrEP Among Women Who Inject Drugs

NCT05192434
View directory record Official record
Conditions
HIV Infections, Opioid Use, Trauma, Psychological
Interventions
Expressive Writing, Contingency Management
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
18 Years and older · Female only
Enrollment
219 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Sep 2, 2026, 4:22 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Emotional Well-being and Measures of Healthy Aging

NCT07334106
View directory record Official record
Conditions
Aging, Aging, Healthy, Aging Well, Aging, Biological
Interventions
Positive Emotion Skills Intervention
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
40 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced Sep 2, 2026, 4:22 PM EDT
Recruiting Not applicable Interventional

Integrated Health Care for PTSD

NCT07220681
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD)
Interventions
Yoga and meditation, Wellness, Positive affect, Information
Behavioral · Other
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
5
States / cities
Little Rock, Arkansas • San Diego, California • Durham, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Sep 2, 2026, 4:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Positive Affect as a Source of Resilience for Adults in Chronic Pain

NCT04869345
View directory record Official record
Conditions
Geriatric, Chronic Pain
Interventions
LARKSPUR
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
50 Years and older
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 30, 2023 · Synced Sep 2, 2026, 4:22 PM EDT
Completed Not applicable Interventional Results available

A Single Arm Pilot Study to Refine a Novel Approach to Exercise Promotion Based on Affect-regulation

NCT04903249
View directory record Official record
Conditions
Breast Cancer
Interventions
Core Exercise Promotion Intervention
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Sep 2, 2026, 4:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Improving Resiliency in Air Force Personnel

NCT05460663
View directory record Official record
Conditions
Military Personnel, Health Promotion
Interventions
Stress Management and Resilience Training (SMART)
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Dayton, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 7, 2024 · Synced Sep 2, 2026, 4:22 PM EDT