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ClinicalTrials.gov public records Last synced Sep 10, 2026, 7:37 AM EDT

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Showing 1–24 of 61 matching trials from the live ClinicalTrials.gov search.
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Recruiting Phase 2 Interventional

NSAID Use After Robotic Partial Nephrectomy

NCT05842044
View directory record Official record
Conditions
Kidney Cancer, Renal Cancer, Renal Neoplasm
Interventions
Ketorolac, Acetaminophen, Oxycodone, Hydromorphone, Ibuprofen
Drug
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 99 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Sep 10, 2026, 7:37 AM EDT
Terminated Phase 4 Interventional Results available

Steroids in Total Knee Arthroplasty

NCT02219581
View directory record Official record
Conditions
Postoperative Pain, Inflammation, Osteoarthritis
Interventions
Dexamethasone 10 mg, Dexamethasone 20 mg, Standard multimodal pain management regimen, Placebo
Drug
Lead sponsor
Thomas L Bradbury
Other
Eligibility
18 Years to 100 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Tucker, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 3, 2022 · Synced Sep 10, 2026, 7:37 AM EDT
Not yet recruiting Phase 4 Interventional

Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery

NCT07600697
View directory record Official record
Conditions
Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI), Postoperative Pain
Interventions
Suzetrigine, Opioid Analgesics (Tramadol or Oxycodone), Scheduled Acetaminophen and Ibuprofen
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Sep 10, 2026, 7:37 AM EDT
Terminated Phase 3 Interventional Results available

Ibuprofen to Decrease Opioid Use and Post-operative Pain Following Unilateral Inguinal Herniorrhaphy

NCT02929589
View directory record Official record
Conditions
Pain, Hernia
Interventions
Ibuprofen, Opioid Medication, Placebo, Ibuprofen + Opioid medication
Drug
Lead sponsor
Mike O'Callaghan Military Hospital
Federal
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Nellis Air Force Base, Nevada
Source: ClinicalTrials.gov public record
Updated Mar 25, 2024 · Synced Sep 10, 2026, 7:37 AM EDT
Recruiting Phase 4 Interventional

Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

NCT05722002
View directory record Official record
Conditions
Surgery, Pain, Postoperative
Interventions
NSAID, Opioid, Acetaminophen
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
6
States / cities
Ann Arbor, Michigan • Detroit, Michigan • St Louis, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 10, 2026, 7:37 AM EDT
Completed Phase 4 Interventional

An Open Label, Prospective Study of the Analgesic Efficacy of Oral Xartemis Compared to Generic Oxycodone/APAP( Acetaminophen) in the Treatment of Moderate to Severe Post Operative Pain.

NCT02101476
View directory record Official record
Conditions
Post Operative Pain
Interventions
Percocet, Xartemis
Drug
Lead sponsor
Lotus Clinical Research, LLC
Other
Eligibility
18 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2018 · Synced Sep 10, 2026, 7:37 AM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers Results available

Opioid-Free Pain Protocol After Shoulder Arthroplasty

NCT05488847
View directory record Official record
Conditions
Shoulder Arthropathy, Shoulder Pain
Interventions
Celecoxib, Pregabalin, Tramadol, Dexamethasone, Acetaminophen, Ropivicaine, Epinephrine, Ketorolac, Tizanidine, Magnesium, Ibuprofen, Oxycodone Hydrochloride 5 Mg
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 10, 2026, 7:37 AM EDT
Recruiting Phase 4 Interventional

Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial

NCT06671002
View directory record Official record
Conditions
Surgery, Pain, Post Operative
Interventions
NSAID, Opioid, Acetaminophen, Ibuprofen
Drug
Lead sponsor
University of Michigan
Other
Eligibility
12 Years to 20 Years
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
4
States / cities
Los Angeles, California • Palo Alto, California • Ann Arbor, Michigan + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Sep 10, 2026, 7:37 AM EDT
Terminated Phase 3 Interventional

A Randomized, Open Label, Prospective Study to Explore the Clinical Characteristics of Oral MNK155 and Norco 7.5mg/325 When Used for the Treatment of Moderate to Severe Post Operative Pain

NCT02381132
View directory record Official record
Conditions
Post Operative Pain
Interventions
Norco 7.5mg/325, MNK155
Drug
Lead sponsor
Neil Singla
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Mar 24, 2016 · Synced Sep 10, 2026, 7:37 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Prospective Randomized Controlled Trial of an Enhanced Recovery Protocol for Anorectal Surgery

NCT03738904
View directory record Official record
Conditions
Anorectal Disorder
Interventions
ERAS, Standard of care
Combination Product
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 17, 2023 · Synced Sep 10, 2026, 7:37 AM EDT
Completed Phase 2 Interventional Results available

Postoperative Pain Management in Rhinoplasty

NCT03584152
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Norco 5Mg-325Mg Tablet, Tylenol 325Mg Caplet, Ibuprofen 200 mg
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Sep 10, 2026, 7:37 AM EDT
Completed Phase 4 Interventional Results available

Study of EXPAREL in Patients Undergoing Breast Augmentation

NCT01582490
View directory record Official record
Conditions
Mammoplasty, Postoperative Pain
Interventions
Instillation - EXPAREL, Infiltration - EXPAREL
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years to 75 Years · Female only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Brighton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 1, 2014 · Synced Sep 10, 2026, 7:37 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

A Prospective Pilot Study of a Non-Narcotic Post-Operative Course After Colectomy

NCT05200806
View directory record Official record
Conditions
Analgesia, Post-Operative Pain, Breakthrough Pain, Colectomy
Interventions
Non-Narcotic ERAS Post-Operative Pain Management
Other
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Oct 13, 2022 · Synced Sep 10, 2026, 7:37 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Decreasing Narcotics in Advanced Pelvic Surgery

NCT02110719
View directory record Official record
Conditions
Narcotic Use, Pain, Constipation, Nausea
Interventions
Celebrex, Gabapentin, IV acetaminophen, oral acetaminophen, oral ibuprofen, percocet, vicodin, Oxycodone, dilaudid, Dexamethasone, zofran
Drug
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years to 100 Years · Female only
Enrollment
138 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 16, 2016 · Synced Sep 10, 2026, 7:37 AM EDT
Completed Not applicable Interventional Results available

The Post-Operative Pain Management of Pediatric Supracondylar Elbow Fractures

NCT01328782
View directory record Official record
Conditions
Elbow Fracture
Interventions
Oxycodone with Acetaminophen, Bupivacaine 0.25%, Ropivacaine 0.20%
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
4 Years to 12 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 22, 2015 · Synced Sep 10, 2026, 7:37 AM EDT
Completed Phase 3 Interventional

CPL-01 in the Management of Postoperative Pain After Bunionectomy

NCT05831449
View directory record Official record
Conditions
Bunion, Post-operative Pain
Interventions
Local anesthetic injection of CPL-01, Naropin, 0.5% Injectable Solution, Placebo, Morphine rescue medication, Acetaminophen rescue medication, Oxycodone rescue medication, Bunionectomy
Drug · Procedure
Lead sponsor
Cali Pharmaceuticals LLC
Industry
Eligibility
18 Years to 75 Years
Enrollment
616 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Sep 10, 2026, 7:37 AM EDT
Not yet recruiting Not applicable Interventional

Use of a Vibration Tool for Postoperative Pain Control in Distal Radius Fractures

NCT05318729
View directory record Official record
Conditions
Distal Radius Fracture, Radius Fracture Distal, Radius; Fracture, Lower or Distal End, Postoperative Pain
Interventions
Vibration tool
Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Sep 10, 2026, 7:37 AM EDT
Completed Not applicable Interventional Results available

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

NCT05279898
View directory record Official record
Conditions
Postoperative Delirium, Hemodynamic Instability, Pain, Neurocognitive Dysfunction
Interventions
EEG Monitoring, Ropivacaine, Ketamine, Remifentanil, Dexmedetomidine, Rocuronium, Propofol
Device · Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Sep 10, 2026, 7:37 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Reduced Opioid Prescription After Laparoscopic Hysterectomy

NCT05548582
View directory record Official record
Conditions
Pain, Postoperative, Opioid Misuse, Opioid Use, Pain
Interventions
OxyCODONE 5 mg Oral Tablet, Acetaminophen 500 mg Tab, Ibuprofen 600 mg
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced Sep 10, 2026, 7:37 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

IV vs Oral Acetaminophen in Spine Fusion Perioperative Care

NCT03020875
View directory record Official record
Conditions
Multimodal Analgesic Approach
Interventions
Ofirmev, Per Os Acetaminophen
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 85 Years
Enrollment
166 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Sep 10, 2026, 7:37 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

TAP Block With Plain Bupivacaine Versus Wound Infiltration With Exparel for Postoperative Pain Management

NCT02074709
View directory record Official record
Conditions
Postoperative Pain
Interventions
Plain bupivacaine, Liposomal bupivacaine
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 3, 2018 · Synced Sep 10, 2026, 7:37 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery

NCT04246554
View directory record Official record
Conditions
ACL Injury, Postoperative Pain
Interventions
Ketorolac, Oxycodone-Acetaminophen
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 20, 2021 · Synced Sep 10, 2026, 7:37 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee

NCT02449369
View directory record Official record
Conditions
Unilateral Knee Arthroplasty
Interventions
Preop acetaminophen IV, Preop orphenadrine IV, Postop oral oxycodone & acetaminophen, Postop hydromorphone IV, Postop oral orphenadrine, Postop oral oxycodone, Postop acetaminophen IV, Postop orphenadrine IV
Drug
Lead sponsor
AdventHealth
Other
Eligibility
18 Years to 85 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Winter Park, Florida
Source: ClinicalTrials.gov public record
Updated Aug 30, 2017 · Synced Sep 10, 2026, 7:37 AM EDT
Not listed Phase 4 Interventional

Pain Relief After Hiatal Hernia Repair Surgery

NCT04936711
View directory record Official record
Conditions
Shoulder Pain, Hiatal Hernia
Interventions
Resteck Shiatsu Neck and Back Massager, Marcaine
Device · Drug
Lead sponsor
Norton Thoracic Institute
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 22, 2021 · Synced Sep 10, 2026, 7:37 AM EDT