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Conditions: Lung Cancer
Interventions: Autologous Blood Patch, Standard of Care (per Physician); Procedure
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Abdominal Reconstruction
Interventions: Vacuum-assisted closure (VAC) therapy, Gauze dressing; Procedure
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 70 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Spinal Cord Ischemia
Interventions: Cerebrospinal Fluid Drain Placement; Procedure
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 100 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 2
States / cities: Birmingham, Alabama • Worcester, Massachusetts

Conditions: Hip Dysplasia, Cerebral Palsy
Interventions: Proximal Femoral Resection Arthroplasty, Subtrochanteric Valgus Osteotomy; Procedure
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 7 Years to 21 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 5
States / cities: Phoenix, Arizona • Miami, Florida • Boston, Massachusetts + 2 more

Conditions: Colorectal Cancer
Interventions: xBar™ System; Device
Lead sponsor: Exero Medical Ltd.; Industry
Eligibility: 21 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 6
States / cities: Louisville, Kentucky • Baltimore, Maryland • Lincoln, Nebraska + 2 more

Conditions: Surgical Wound Infection
Interventions: Vacuum-assisted closure, Standard sterile dressing; Device
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 166 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 4
States / cities: Lebanon, New Hampshire • Nashua, New Hampshire

Conditions: Lumbar Spinal Stenosis, Thoracic Spinal Stenosis
Interventions: Tranexamic Acid, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 85 Years
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Infections, Quality of Life
Interventions: Showering 48 hours after surgery; Other
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years to 100 Years · Female only
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Perioperative/Postoperative Complications, Prostate Cancer
Interventions: robot-assisted laparoscopic surgery, questionnaire administration, intraoperative complication management/prevention; Procedure · Other
Lead sponsor: City of Hope Medical Center; Other
Eligibility: 18 Years and older · Male only
Enrollment: 191 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Duarte, California

Conditions: Osteoarthritis
Interventions: Antimicrobial Barrier Dressing, Negative Pressure Wound Therapy (NPWT); Combination Product · Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 100 Years
Enrollment: 230 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Wound Infection
Interventions: Purse string closure, Primary closure; Procedure
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Glioblastoma, Malignant Glioma, Recurrent Glioblastoma, Recurrent Malignant Glioma
Interventions: Biospecimen Collection, Computed Tomography, Dexamethasone, Invasive Procedure, Magnetic Resonance Imaging, RAGE Antagonist FPS-ZM1, Resection; Procedure · Drug
Lead sponsor: City of Hope Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2028
U.S. locations: 1
States / cities: Duarte, California

Conditions: Postoperative Wound Infection, Postoperative Complications, Surgical Site Infection, Drain Site Complication
Interventions: Showering, Restriction of Showering; Other
Lead sponsor: Sean Devitt; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Danville, Pennsylvania

Conditions: End Stage Liver DIsease, Obesity, Acute Kidney Injury
Interventions: Direct Peritoneal Resuscitation; Procedure
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Tissue Expansion, Implant Based Breast Reconstruction
Interventions: Blossom tissue expander, Standard tissue expansion; Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Pelvic Fractures, Acetabular Fractures, Hip Fractures
Interventions: VAC device, Gauze dressing; Device · Other
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years and older
Enrollment: 115 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Post-operative Complications, Surgical Site Infection, Surgical Wound Infection
Interventions: Prevena™ Incision Management System (PIMS), Standard-of-care Dressing; Device
Lead sponsor: KCI USA, Inc; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Post Operative Atrial Fibrillation
Interventions: CardiaMend with the Addition of Amiodarone; Combination Product
Lead sponsor: WakeMed Health and Hospitals; Other
Eligibility: 20 Years to 85 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Raleigh, North Carolina

Conditions: Osteoarthritis
Interventions: Wound drainage, Total Shoulder Arthroplasty; Procedure
Lead sponsor: Columbia University; Other
Eligibility: Not listed
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Total Joint Arthroplasty
Interventions: Hemovac drain, Re-infusion drain, Tranexamic drain; Procedure
Lead sponsor: OrthoCarolina Research Institute, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 204 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Charlotte, North Carolina

Conditions: Peripheral Artery Disease, Critical Limb Ischemia, Claudication
Interventions: standard gauze dressing, Prevena Incision Management system; Other
Lead sponsor: University of Vermont Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 242 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 5
States / cities: Portland, Maine • Boston, Massachusetts • Lebanon, New Hampshire + 1 more

Conditions: Complications, Postoperative
Interventions: Drain; Device
Lead sponsor: Twin Cities Spine Center; Other
Eligibility: 18 Years to 70 Years
Enrollment: 975 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2040
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Mastectomy, Implant Based Breast Reconstruction
Interventions: Interi Manifold Drain System, Jackson Pratt Drain System; Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Thyroglossal Duct Cysts
Interventions: Post-surgical drain, No post-surgical drain; Procedure
Lead sponsor: University of Rochester; Other
Eligibility: 3 Years to 17 Years
Enrollment: 178 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 5
States / cities: Los Angeles, California • Hartford, Connecticut • Chicago, Illinois + 2 more

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Prolonged Air Leak (PAL) Autologous Blood Patch Intervention Trial

A Comparison of Incisional Negative-Pressure Wound Therapy Versus Conventional Dressings Following Abdominal Surgery

Prophylactic vs Therapeutic Cerebrospinal Fluid Drain Placement During Endovascular Thoracoabdominal Aortic Aneurysm Repair

A Randomized Control Trial of Hip Dislocation Techniques for Pediatric Patients With Cerebral Palsy

Anastomotic Safety and Surveillance Using Real-time Enhanced Sensing Using xBar

Vacuum Assisted Closure for Cesarean Section

Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery

Effect of Drain Care on Infection Rate and Quality of Life in Implant-Based Breast Reconstruction.

Robotic Assisted Laparoscopic Prostatectomy With or Without Pelvic Drain Placement in Reducing Adverse Events After Surgery in Patients With Prostate Cancer

Antimicrobial Barrier Dressing Versus Closed-incision Negative Pressure Therapy in the Obese Primary Total Joint Arthroplasty

A Randomized Trial of Ostomy Closure Techniques

FPS-ZM1 With or Without Dexamethasone for Controlling Post Operative Cerebral Edema in Patients With Glioblastoma

Studying How Outpatient Water affEcts Risks With Drains (SHOWER Study)

Use of Direct Peritoneal Resuscitation in High-risk Liver Transplant Recipients

Blossom® Smart Expander Device for Tissue Expander/Implant-Based Breast Reconstruction

Role of Vacuum Assisted Closure (VAC) Device in Postoperative Management of Pelvic and Acetabular Fractures

The Use of the Prevena™ Incision Management System on Post-Surgical Cesarean Section Incisions

Prevention of Post-OP AFib Using Combination of CardiaMend and Amiodarone

Closed Suction Drainage in Shoulder Arthroplasty

Reinfusion Drains vs Tranexamic Acid in Total Joint Arthroplasty

Comparison of Prevena Negative Pressure Incision Management System vs. Standard Dressing After Vascular Surgery

A Prospective, Randomized Comparison Of Drainage Techniques After One- Or Two-Level Open Posterior Lumbar Decompression Or Decompression And Fusion

Assessment of the Interi Manifold in Implant-Based Breast Reconstruction

Assessing Post-operative Outcomes After Children's Sistrunk Procedure With or Without a Drain