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Showing 1–24 of 63 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Power Knee Clear all
Completed Not applicable Interventional

Impact of Exercise in Parkinson's Disease

NCT03495193
View directory record Official record
Conditions
Parkinson Disease
Interventions
Exercise training, Sleep hygiene
Other · Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
45 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 25, 2019 · Synced Sep 5, 2026, 5:06 PM EDT
Recruiting Not applicable Interventional

Postpartum Exercise Intervention

NCT07613333
View directory record Official record
Conditions
Postpartum, Neuromuscular Adaptations, Abdominal Muscles, Pelvic Floor Dysfunctions, Physical Activity
Interventions
Progressive exercise, Active Straight Leg Raise Test, Active Straight Leg Raise Fatigue Task, Lower Extremity Strength Testing, Ultrasound imaging of abdominal wall, Pelvic Floor Muscle Strength Testing, Pelvic Floor Muscle Endurance Testing
Other · Diagnostic Test
Lead sponsor
Carroll University
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Waukesha, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 5, 2026, 5:06 PM EDT
Completed Not applicable Interventional Results available

Lower Limb Prostheses for Individuals Who Carry Infants, Toddlers, and Other Loads

NCT07159490
View directory record Official record
Conditions
Amputation, Prosthesis User
Interventions
Standard-of-care prosthetic foot, Standard-of-care prosthetic foot with heel-stiffening wedge, Standard-of-care prosthetic foot of one category greater stiffness, Dual keel prosthetic foot, Powered ankle-foot
Device
Lead sponsor
VA Puget Sound Health Care System
Federal
Eligibility
18 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Sep 5, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Outcomes With Passive MPKs vs. Powered Prosthetic Knees

NCT05267639
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Above Knee (Injury), Amputation; Traumatic, Leg: Thigh, Between Hip and Knee
Interventions
Power Knee
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
2
States / cities
Holliston, Massachusetts • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 25, 2025 · Synced Sep 5, 2026, 5:06 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Controlling Locomotion Over Continuously Varying Activities for Agile Powered Prosthetic Legs

NCT06138977
View directory record Official record
Conditions
Amputation
Interventions
Powered prosthesis
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 5, 2026, 5:06 PM EDT
Recruiting Not applicable Interventional

Evaluation of a Neural-Controlled Powered Prosthesis Across Diverse Real-World Tasks

NCT07204912
View directory record Official record
Conditions
Transfemoral Amputation
Interventions
MIT Powered Leg
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Sep 5, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Wearing a Powered Ankle-Foot Prosthesis on Amputee Walking

NCT00869947
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Powered ankle-foot prosthesis, No device
Device · Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 60 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 24, 2014 · Synced Sep 5, 2026, 5:06 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Human-Machine System for the H2 Lower Limb Exoskeleton

NCT02114450
View directory record Official record
Conditions
Stroke, Hemiparesis
Interventions
Robot-assisted training with the H2 lower limb powered exoskeleton, Supervised motor practice
Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2029
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 29, 2024 · Synced Sep 5, 2026, 5:06 PM EDT
Active, not recruiting Not applicable Interventional

Impact of Powered Knee-Ankle Prosthesis Leg on Everyday Community Mobility and Social Interaction

NCT03204513
View directory record Official record
Conditions
Transfemoral Amputees
Interventions
Vanderbilt Powered Knee-Ankle Prosthesis, Microprocessor (MP) Knee Prosthesis
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 5, 2026, 5:06 PM EDT
Not listed Not applicable Interventional

Microwave Treatment of Common and Plantar Warts

NCT05371834
View directory record Official record
Conditions
Warts
Interventions
Microwave Treatment (Swift System), Cryotherapy
Device
Lead sponsor
Blackwell Device Consulting
Industry
Eligibility
18 Years to 64 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
6
States / cities
Miami, Florida • Palm Harbor, Florida • Tampa, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated May 20, 2024 · Synced Sep 5, 2026, 5:06 PM EDT
Completed Not applicable Interventional Results available

Mobility Optimization Through Velocity Exercise

NCT00844558
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Gait Training, Control
Other
Lead sponsor
University of Iowa
Other
Eligibility
60 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 5, 2016 · Synced Sep 5, 2026, 5:06 PM EDT
Completed No phase listed Observational

Effects of Frailty, Sarcopenia and Muscle Wasting on Outcomes of Patients in the Surgical Intensive Care Unit

NCT02270502
View directory record Official record
Conditions
Critical Illness, Sarcopenia, Muscle Wasting
Interventions
Ultrasound Philips CX50, Frailty Index Questionnaire, Muscle strength tests
Device · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2016 · Synced Sep 5, 2026, 5:06 PM EDT
Recruiting Not applicable Interventional

Metabolic Cost of Walking With Passive vs. Powered Prosthetic Knees Among Persons With Limb Loss

NCT05831696
View directory record Official record
Conditions
Transfemoral Amputation
Interventions
Powered Microprocessor-controlled Knee (PMPK)
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Sep 5, 2026, 5:06 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Fatigability of Lower Limb Muscle in Older Adults: Protective Effects of Strength Training Exercise in Old Men and Women

NCT03888040
View directory record Official record
Conditions
Aging
Interventions
Exercise
Other
Lead sponsor
Marquette University
Other
Eligibility
18 Years to 100 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Sep 5, 2026, 5:06 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Clinical Trial Comparing Tranexamic Acid (TXA) With Aquamantys Sealer in Total Knee Arthroplasty (TKA)

NCT02374398
View directory record Official record
Conditions
Blood Loss
Interventions
Tranexamic Acid, Aquamantys System, Control
Drug · Device · Other
Lead sponsor
Eastern Maine Medical Center
Other
Eligibility
18 Years and older
Enrollment
127 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Bangor, Maine
Source: ClinicalTrials.gov public record
Updated Jan 15, 2017 · Synced Sep 5, 2026, 5:06 PM EDT
Completed Not applicable Interventional Results available

Adherence and Perspiration While Wearing Lower Limb Prostheses

NCT03900845
View directory record Official record
Conditions
Lower Extremity Amputation
Interventions
Dynamic Air Exchange - Rising Edge Design (DAE-RED), Perforated elastomeric liner, As-prescribed prosthesis
Device
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Sep 5, 2026, 5:06 PM EDT
Recruiting Not applicable Interventional

Powered Prosthesis for Use With TF Osseointegration Recipients

NCT06160882
View directory record Official record
Conditions
Amputation
Interventions
Powered Prosthesis Training and EMG data collection, Perform Osseointegration (OI) surgery and Targeted Muscle Reinnervation (TMR)
Other · Procedure
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 70 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 17, 2025 · Synced Sep 5, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adaptive Recalibration of Prosthetic Leg Neural Control System

NCT02355912
View directory record Official record
Conditions
Amputation
Interventions
Powered knee and ankle prosthesis
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 27, 2020 · Synced Sep 5, 2026, 5:06 PM EDT
Completed Not applicable Interventional

Three Different Approaches for Ultrasound Guided Femoral Nerve Block for Patients Undergoing Total Knee Arthroplasty

NCT01763814
View directory record Official record
Conditions
Knee Arthroplasty
Interventions
Femoral nerve block, Femoral nerve block non stimulating catheter, Femoral nerve block stimulating catheter
Procedure
Lead sponsor
Chicago Anesthesia Pain Specialists
Other
Eligibility
18 Years to 90 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 6, 2019 · Synced Sep 5, 2026, 5:06 PM EDT
Completed Not applicable Interventional

Project 4B: Lower Extremity Strength Training in ICU Patients

NCT02467023
View directory record Official record
Conditions
Sepsis
Interventions
Muscle stimulation with Niveus medical stimulator, measurement of maximal isometric twitch strength, Muscle Biopsy, Muscle Biopsy Medication: Lidocaine, Muscle Biopsy Medication: Versed, Muscle Biopsy Medication: Fentanyl, Blood and Urine Sampling, ineffective muscle stimulation
Device · Procedure · Drug + 1 more
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 18, 2018 · Synced Sep 5, 2026, 5:06 PM EDT
Completed Not applicable Interventional Results available

Powered Orthotic Exoskeleton Training in Stroke

NCT04241848
View directory record Official record
Conditions
Stroke
Interventions
Keeogo, Ambulation training
Device · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jun 9, 2025 · Synced Sep 5, 2026, 5:06 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Modeling, Optimization, and Control Methods for a Personalized Hybrid Walking Exoskeleton

NCT04453943
View directory record Official record
Conditions
Spinal Cord Injuries, Paraplegia, Spinal, Paraplegia, Incomplete
Interventions
Exoskeleton Walking - with or without FES, Exoskeleton Sitting to Standing - with or without FES
Device
Lead sponsor
North Carolina State University
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 30, 2020 · Synced Sep 5, 2026, 5:06 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Posterior Tibial Nerve Stimulation vs. Sham

NCT00534521
View directory record Official record
Conditions
Overactive Bladder
Interventions
Posterior Tibial Nerve Device, Sham
Device
Lead sponsor
Corewell Health East
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 25, 2007 · Synced Sep 5, 2026, 5:06 PM EDT
Recruiting Not applicable Interventional

A Biomechanical Evaluation of the Ossur Power Knee in Persons With Transfemoral Amputation

NCT06218238
View directory record Official record
Conditions
Transfemoral Amputation, Limb Loss, Limb Absence
Interventions
Powered prosthetic knee joint, Conventional prosthetic knee joint
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
45 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Sep 5, 2026, 5:06 PM EDT