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Showing 1–24 of 58 matching trials from the live ClinicalTrials.gov search.
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Conditions
Amputation, Prosthesis User
Interventions
Standard-of-care prosthetic foot, Standard-of-care prosthetic foot with heel-stiffening wedge, Standard-of-care prosthetic foot of one category greater stiffness, Dual keel prosthetic foot, Powered ankle-foot
Device
Lead sponsor
VA Puget Sound Health Care System
Federal
Eligibility
18 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Outcomes With Passive MPKs vs. Powered Prosthetic Knees

NCT05267639
Conditions
Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Above Knee (Injury), Amputation; Traumatic, Leg: Thigh, Between Hip and Knee
Interventions
Power Knee
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
2
States / cities
Holliston, Massachusetts • Austin, Texas
Conditions
Amputation
Interventions
Powered prosthesis
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Ann Arbor, Michigan
Conditions
Transfemoral Amputation
Interventions
MIT Powered Leg
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Cambridge, Massachusetts
Conditions
Amputation; Traumatic, Hand
Interventions
Point Powered partial hand prosthetic system
Device
Lead sponsor
Point Designs
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Aurora, Colorado • Broomfield, Colorado • Lafayette, Colorado
Conditions
Peripheral Vascular Disease
Interventions
Cryoplasty (PolarCath peripheral balloon catheter), Laser Angioplasty (Spectranetics), SilverHawk Atherectomy, Viabahn Endograft, Angioplasty/Stent (Guidant "Absolute" stent)
Procedure · Device
Lead sponsor
Arizona Heart Institute
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Phoenix, Arizona
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Wearing a Powered Ankle-Foot Prosthesis on Amputee Walking

NCT00869947
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Powered ankle-foot prosthesis, No device
Device · Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 60 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Providence, Rhode Island
Conditions
Amputation
Interventions
Powered Prosthesis, Prescribed Prosthesis
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2031
U.S. locations
1
States / cities
Cambridge, Massachusetts
Conditions
Transfemoral Amputees
Interventions
Vanderbilt Powered Knee-Ankle Prosthesis, Microprocessor (MP) Knee Prosthesis
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Motorized Prostheses for Lower-limb Amputees

NCT07486063
Conditions
Lower-Limb Amputation
Interventions
Powered and passive lower limb prosthesis and control
Device
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2032
U.S. locations
1
States / cities
Salt Lake City, Utah
Conditions
Amputation, Amputation; Traumatic, Hand
Interventions
Myoelectric Implantable Recording Array (MIRA)
Device
Lead sponsor
Boninger, Michael, MD
Other
Eligibility
22 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Conditions
Ventricular Tachycardia (VT)
Interventions
Implantable Cardioverter Defibrillator (ICD), Catheter Ablation
Device · Procedure
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Phoenix, Arizona
Completed Not applicable Interventional Results available

Adherence and Perspiration While Wearing Lower Limb Prostheses

NCT03900845
Conditions
Lower Extremity Amputation
Interventions
Dynamic Air Exchange - Rising Edge Design (DAE-RED), Perforated elastomeric liner, As-prescribed prosthesis
Device
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Conditions
Amputation
Interventions
Powered Prosthesis Training and EMG data collection, Perform Osseointegration (OI) surgery and Targeted Muscle Reinnervation (TMR)
Other · Procedure
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 70 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Completed Not applicable Interventional Accepts healthy volunteers

Adaptive Recalibration of Prosthetic Leg Neural Control System

NCT02355912
Conditions
Amputation
Interventions
Powered knee and ankle prosthesis
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

AI-Powered Artificial Vision for Visual Prostheses

NCT06117332
Conditions
Blindness, Acquired
Interventions
Visual prosthesis
Device
Lead sponsor
University of California, Santa Barbara
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Santa Barbara, California
Completed Not applicable Interventional Accepts healthy volunteers Results available

Functional Performance of Voluntary Opening and Closing Body Powered Prostheses

NCT02136238
Conditions
Upper Limb Amputation
Interventions
Hosmer 5XA voluntary opening hook, TRS Grip 3 voluntary closing hook
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 85 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Tampa, Florida
Completed Early Phase 1 Interventional Accepts healthy volunteers

Virtual Reality Prosthetic Training and Rehabilitation

NCT02666859
Conditions
Amputation of Upper Limb
Interventions
Virtual Reality
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Tampa, Florida
Conditions
Transfemoral Amputation, Limb Loss, Limb Absence
Interventions
Powered prosthetic knee joint, Conventional prosthetic knee joint
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
45 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Amputation; Traumatic, Hand, Amputation, Congenital
Interventions
Point Mini
Device
Lead sponsor
Point Designs
Industry
Eligibility
3 Years to 17 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Lafayette, Colorado • Atlanta, Georgia
Conditions
Prosthesis User, Amputation, Upper Limb Amputation at the Wrist, Upper Limb Amputation Above Elbow (Injury), Upper Limb Amputation Below Elbow (Injury)
Interventions
Qualitative Analysis
Other
Lead sponsor
Louis Stokes VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
178 participants
Timeline
2020 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Not listed Not applicable Interventional Accepts healthy volunteers

Comparing Intact and Residual Amputated Muscle

NCT06182202
Conditions
Amputation
Interventions
Powered Prosthesis
Device
Lead sponsor
North Carolina State University
Other
Eligibility
18 Years to 64 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Raleigh, North Carolina
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Investigation of Motorized Lower-limb Prostheses

NCT07584707
Conditions
Ambulation With the "Take Home" or Passive Prosthesis, Ambulation With the Motorized Prosthesis in the "Off" Configuration, Ambulation With the Motorized Prosthesis in the "Transparent" Condition, Ambulation With the Motorized Prosthesis in the "Powered" Condition
Interventions
Passive prosthesis, Motorized prosthesis
Device
Lead sponsor
Northern Arizona University
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Flagstaff, Arizona
Conditions
Amputation, Transfemoral Amputation
Interventions
Power Knee Firmware Update, Power Knee Current Marketed Firmware
Device
Lead sponsor
Össur Iceland ehf
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Bay City, Michigan