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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: PrEP initiation Clear all
Completed No phase listed Observational Accepts healthy volunteers

Increasing PrEP Awareness and Demand Among Black Cisgender Women

NCT05896423
View directory record Official record
Conditions
HIV, PrEP
Interventions
PrEP awareness materials
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
16 Months to 40 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 2, 2025 · Synced Sep 15, 2026, 8:01 AM EDT
Completed Not applicable Interventional Results available

Integrated PrEP Interventions for People Who Inject Drugs in Rural Kentucky

NCT05037513
View directory record Official record
Conditions
HIV Prevention
Interventions
SBCM-PrEP, CDC-PrEP
Behavioral
Lead sponsor
Hilary L Surratt, PhD
Other
Eligibility
18 Years to 99 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 19, 2025 · Synced Sep 15, 2026, 8:01 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Study Evaluating An Integrated Pharmacy Digital Diary and Delivery Strategy to Increase PrEP Use Among MSM and TGW

NCT05474313
View directory record Official record
Conditions
HIV Prevention, Pre-exposure Prophylaxis (PrEP), Risk Reduction, Adherence, Medication
Interventions
PrEP-3D package, Standard of Care
Behavioral
Lead sponsor
Public Health Foundation Enterprises, Inc.
Other
Eligibility
18 Years and older · Male only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 20, 2022 · Synced Sep 15, 2026, 8:01 AM EDT
Not yet recruiting Phase 2 Interventional Accepts healthy volunteers

Combatting HIV Or Other STIs Early (CHOOSE)

NCT07510048
View directory record Official record
Conditions
HIV, STIs, STIs Prevention, HIV Prevention
Interventions
Standard of care and PrEP Choice at Enrollment, Standard of care followed by PrEP Choice at Month 9
Other
Lead sponsor
Westat
Other
Eligibility
13 Years to 24 Years · Male only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
6
States / cities
San Francisco, California • Washington D.C., District of Columbia • Tampa, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 15, 2026, 8:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Life Steps for PrEP for Youth

NCT03805451
View directory record Official record
Conditions
HIV, Pre-exposure Prophylaxis, Medication Adherence
Interventions
Life Steps for PrEP for Youth
Behavioral
Lead sponsor
Fenway Community Health
Other
Eligibility
16 Years to 24 Years · Male only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
3
States / cities
Atlanta, Georgia • Chicago, Illinois • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 21, 2023 · Synced Sep 15, 2026, 8:01 AM EDT
Recruiting Not applicable Interventional

RESTORE Study R61 Phase: Recovery and Engagement for Stimulant Users on Re-entry

NCT07136363
View directory record Official record
Conditions
HIV, Stimulant Use Disorder, Justice Involved Populations, HIV Prevention
Interventions
DynamiCare, Patient Navigation (PN)
Device · Behavioral
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
New Haven, Connecticut • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 15, 2026, 8:01 AM EDT
Completed Phase 4 Interventional Results available

A Within Subjects Comparison of Two Antegrade Flushing Regimens in Children

NCT02435069
View directory record Official record
Conditions
Fecal Incontinence, Neurogenic Bowel
Interventions
Dose Response - NS and USP Glycerin - First Intervention, Effectiveness - NS and USP Glycerin - Second Intervention
Drug
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
3 Years to 12 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Sep 15, 2026, 8:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Electronic Pre-exposure Prophylaxis (PrEP) Initiation and Maintenance Home Care System

NCT03729570
View directory record Official record
Conditions
Pre-exposure Prophylaxis
Interventions
ePrEP
Other
Lead sponsor
Emory University
Other
Eligibility
18 Years to 29 Years · Male only
Enrollment
217 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
4
States / cities
Birmingham, Alabama • Atlanta, Georgia • Jackson, Mississippi + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 17, 2024 · Synced Sep 15, 2026, 8:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving the HIV PrEP Cascade Using an Intervention for Healthcare Providers

NCT03532191
View directory record Official record
Conditions
HIV/AIDS
Interventions
PrEP Optimization Intervention (PrEP-OI)
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
Not listed
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Sep 15, 2026, 8:01 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Test-to-PrEP Study

NCT06927856
View directory record Official record
Conditions
HIV Infections
Interventions
Test-to-PrEP, Access by Referral
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Sep 15, 2026, 8:01 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Predictors of Health Service Utilizations Among Key Population in Washington DC

NCT06046079
View directory record Official record
Conditions
Pre-exposure Prophylaxis, HIV, Health Behavior
Interventions
Not listed
Lead sponsor
Us Helping Us, People Into Living, Inc.
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 9, 2025 · Synced Sep 15, 2026, 8:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Retention in PrEP Care for African American MSM in Mississippi

NCT03256435
View directory record Official record
Conditions
Preventive Medicine, HIV Infections
Interventions
RAMP PrEP initiation, adherence, and retention intervention
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Dec 1, 2021 · Synced Sep 15, 2026, 8:01 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Identification of the Pre-exposure Prophylaxis (PrEP) Cascade for Women.

NCT03705663
View directory record Official record
Conditions
Pre-Exposure Prophylaxis
Interventions
PrEP initiation
Behavioral
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
2
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Dec 14, 2022 · Synced Sep 15, 2026, 8:01 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Integrated Health Services (IHS): A Structural Intervention to Improve HIV/STI Screening and PrEP Navigation in Primary Care

NCT07446764
View directory record Official record
Conditions
HIV, STDs
Interventions
Integrated HIV/STI Testing and PrEP Navigation Model
Behavioral
Lead sponsor
My Brother's Keeper, Inc.
Other
Eligibility
18 Years to 45 Years
Enrollment
700 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2028
U.S. locations
1
States / cities
Ridgeland, Mississippi
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Sep 15, 2026, 8:01 AM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Emtricitabine/Tenofovir Alafenamide Switch Study for Transgender Individuals for HIV Pre-exposure Prophylaxis

NCT04616963
View directory record Official record
Conditions
Hiv, Hormone Therapy
Interventions
Emtricitabine / Tenofovir Disoproxil Oral Tablet 200/300 mg, Emtricitabine Tenofovir Alafenamide 200/25 mg
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 5, 2023 · Synced Sep 15, 2026, 8:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CRUSH-PrEP for Women Project

NCT02852226
View directory record Official record
Conditions
Sexually Transmitted Diseases, HIV
Interventions
Pre Exposure Prophylaxis, Characteristics of women who enroll, referral sources of women who enroll
Other · Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Sep 10, 2019 · Synced Sep 15, 2026, 8:01 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

PrEP4U: Assessing the Effectiveness of Integrated Same-Day Lenacapavir Initiation and Follow-up Choice on PrEP Persistence

NCT07335289
View directory record Official record
Conditions
HIV Pre-exposure Prophylaxis Use
Interventions
Choice of follow up, Follow up via standard clinic
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 15, 2026, 8:01 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

TelePrEP for At-risk Youth in Colorado

NCT05520905
View directory record Official record
Conditions
Hiv
Interventions
TelePrEP
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
14 Years to 24 Years · Male only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 7, 2024 · Synced Sep 15, 2026, 8:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Optimizing PrEP Uptake & Adherence Among Male Sex Workers (MSW) Using a 2-stage Randomization Design

NCT03086057
View directory record Official record
Conditions
Prevention
Interventions
PrEPare for Work: Strength Based Case Management (Stage 1), PrEPare for Work: Adherence Training and Counseling (Stage 2)
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older · Male only
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
2
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 14, 2021 · Synced Sep 15, 2026, 8:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Expanding PrEP By Embedding Unannounced SNAPS Navigators in High STI Testing Clinical Sites

NCT04207151
View directory record Official record
Conditions
Hiv, Sexually Transmitted Infection
Interventions
SNAPS intervention
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Sep 15, 2026, 8:01 AM EDT
Completed Not applicable Interventional

Rural PrEP Delivery

NCT03343223
View directory record Official record
Conditions
HIV/AIDS
Interventions
Intervention Group
Behavioral
Lead sponsor
Michael Ohl
Other
Eligibility
18 Years to 70 Years
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Oct 28, 2020 · Synced Sep 15, 2026, 8:01 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Bringing Medicines for HIV Prevention to a Family Planning Clinic

NCT06930508
View directory record Official record
Conditions
HIV, PrEP
Interventions
Patient participant screening, Physician participant training
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
16 Years and older
Enrollment
83 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 15, 2026, 8:01 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Intervention to Enhance PrEP Persistence

NCT06872307
View directory record Official record
Conditions
HIV Prevention, HIV Infection Primary
Interventions
RAMP-It-Up Initiation, Adherence, and Retention Intervention
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older · Male only
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Jackson, Mississippi • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Sep 15, 2026, 8:01 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Adaptive Intervention Strategies for HIV PrEP Care in Rural People Who Inject Drugs

NCT06666309
View directory record Official record
Conditions
HIV Prevention
Interventions
SBCM-PrEP + Text Messaging, CDC-PrEP + Text Messaging, T-SBCM, Mobile Outreach
Behavioral
Lead sponsor
Hilary L Surratt, PhD
Other
Eligibility
18 Years and older
Enrollment
424 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
4
States / cities
Barbourville, Kentucky • Lexington, Kentucky • Manchester, Kentucky + 1 more
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 15, 2026, 8:01 AM EDT